Friday, May 17, 2024
Friday, May 17, 2024
HomeEffectSide Effects Of Sinemet For Parkinson's

Side Effects Of Sinemet For Parkinson’s

Accessible Medication Containers And Labels

What are the most common side effects of Parkinson’s disease medications?

If its hard for you to read the label on your prescription, tell your doctor or pharmacist. Certain pharmacies may provide medication labels that:

  • have large print
  • contain a code you can scan with a smartphone to change the text into audio

Your doctor or pharmacist may be able to recommend a pharmacy that offers these options if your current pharmacy doesnt.

Also, if youre having trouble opening your medication bottles, let your pharmacist know. They may be able to put Sinemet in an easy-open container. Your pharmacist may also recommend tools to help make it simpler to open the drugs container.

Parkinsons Treatment For Motor Symptoms

The majority of medications developed specifically to treat Parkinsons disease target common motor symptoms. Many of these treatments are designed to increase the level of the dopamine, a neurotransmitter that transfers signals between nerve cells. Dopamine is involved in regulating signals for movement, which is reduced in the brains of Parkinsons disease patients.

What Form Does This Medication Come In

Sinemet is no longer being manufactured for sale in Canada. For brands that may still be available, search under levodopa-carbidopa. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.

You May Like: What Are The Earliest Signs Of Parkinson’s Disease

How Should I Use This Medication

Treatment with levodopa – carbidopa should be started slowly and increased gradually to reduce the risk of side effects while gaining maximum benefit from the medication.

The recommended starting dose for people not already taking levodopa is 1 tablet, containing 100 mg of levodopa and 25 mg of carbidopa, 3 times a day. Your doctor will usually increase the dosage by 1 tablet daily every 3 days until the best results occur with the least amount of side effects. When the dose rises above 3 tablets daily, the dose should be divided into 4 to 6 daily doses. The maximum daily dose of levodopa is 1,500 mg.

If you have already been taking levodopa and are starting levodopa – carbidopa, the dose will be much lower than the dose of levodopa taken as a single medication.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The controlled release form of this medication should be swallowed whole with fluids. Do not crush or chew the medication as this will destroy the time-release property of the medication.

Store this medication at room temperature, and protect it from light and moisture. Keep it out of the reach of children.

Side Effects And Problems With Dopamine Agonists


Common side effects of dopamine agonists include:

If you are taking Cabergoline , Pergolide or Bromocriptine your neurologist or GP will have to arrange a chest CT scan or ultrasound of your heart yearly as over time these medications may effect heart or lung tissue.

This precaution does not apply to the other dopamine agonists available in Australia.

Recommended Reading: Side Effects Of Parkinson Medications

Side Effects And Problems Of Anticholinergics

Another reason these drugs are not a first choice for treating Parkinsons are their side effects. Some people may experience confusion, a dry mouth, constipation and blurred vision when taking anticholinergics.

Anticholinergics may interfere with levodopa absorption in the small bowel, which reduces the effectiveness of Madopar or Sinemet, forms of the drug levodopa.

Anticholinergics are not usually prescribed to older people with Parkinsons because there is an increased risk of memory loss and, in men, problems urinating.

Dont Miss: How To Help A Person With Parkinson Disease

Who Can And Cannot Take Co

Co-careldopa can be taken by adults . It is sometimes prescribed for children to treat a movement disorder called dystonia.

It is not suitable for some people. To make sure co-careldopais safe for you, tell your doctor if you:

  • have had an allergic reaction to co-careldopa, levodopa, carbidopa or any other medicines in the past
  • have lung disease or asthma
  • have problems with your adrenal glands , liver or kidneys
  • are pregnant, trying to get pregnant or breastfeeding

Co-careldopa can affect the results of blood tests and urine tests. Remind your doctor that you’re taking co-careldopa if you need to have any tests.

Recommended Reading: What Does Parkinson’s Disease Look Like

What Other Drugs Could Interact With This Medication

There may be an interaction between levodopa – carbidopa and any of the following:

  • angiotensin converting enzyme inhibitors
  • angiotensin receptor blockers
  • beta-adrenergic blockers
  • calcium channel blockers
  • methylphenidate
  • multivitamins with minerals
  • phosphodiesterase 5 inhibitors
  • tricyclic antidepressants

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter , and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

What Does Sinemet Cost

Neurologist’s tips for taking SINEMET

Costs of prescription drugs can vary depending on many factors. These include what your insurance plan covers and which pharmacy you use.

Sinemet is available as a generic drug that contains both carbidopa and levodopa. Generics usually cost less than brand-name drugs. Talk with your doctor if youd like to know more about taking generic carbidopa and levodopa.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Medicine Assistance Tools website to see if they have support options.

You can also check out this article to learn more about saving money on prescriptions.

Dont take more Sinemet than your doctor prescribes. Taking more than this can lead to serious side effects.

Don’t Miss: What Does Parkinson’s Do

Why Is Sinemet Cr No Longer Available

Sinemet CR isnt available because its no longer being produced by Sinemets manufacturer, Merck.

With a CR formulation, small amounts of the drug are released into your body at a time. This helps keep the amount of drug in your body consistent over time. In comparison, Sinemet is immediate-release , which means the drug is released all at once after you take a dose. Effects of IR drugs may not last as long as do those of ER drugs.

Production of Sinemet CR didnt stop due to a problem with the safety of the drug. In fact, Merck has said that if you have Sinemet CR at home, you can continue taking it.

The reason Sinemet CR is no longer produced is because only a very small number of people used it. Instead, the majority of people used the generic form of Sinemet CR . And the generic form is still available.

If you have questions about Sinemet CR or the best form of medication for you, talk with your doctor.

How Do Decarboxylase Inhibitors Work

Decarboxylase inhibitors are a class of medications used to treat symptoms of Parkinsons disease.

The direct cause of Parkinson’s disease or Parkinsonian-like syndrome is the deficiency of the neurotransmitterdopaminein the brain. Antiparkinson medications aim to prolong the action of dopamine in the brain by:

  • Replacing dopamine
  • Inhibiting dopamine breakdown
  • Sensitizing dopamine receptors to stimulate dopamine release

Decarboxylase is an enzyme that initiates the breakdown of levodopa after exerting its effect. Decarboxylase inhibitors block the action of decarboxylase, thereby preventing the breakdown of levodopa, which in turn, increases the availability of levodopa at the blood-brain barrier, thus allowing a lower dose of levodopa. Levodopa gets converted into dopamine in the brain and restores the depleted dopamine levels.

Read Also: How Long Can A Person Live With Parkinson’s

Drug And Medication Therapies

The purpose of treating Parkinsons is to reduce the effect of symptoms on your daily life. Without treatment, you will eventually find that the symptoms make it hard to perform daily activities. Symptoms, such as shaking and stiffness, may cause discomfort the risk of injury from falls may increase, and swallowing may become more difficult. People are encouraged to maintain open and ongoing discussions with their Parkinsons healthcare team when exploring treatment options.

Medication will help you function, but may cause side effects. It is important to find the right balance between the medications benefits and side effects. Everyone with Parkinsons is unique and will experience different symptoms, which means the treatment you receive will be geared to your specific needs. Drugs for Parkinsons work on the brains complex chemistry and may need to be taken several times a day. Use them as prescribed and do not alter your doses without consulting your doctor. Current treatment neither cures Parkinsons nor stops it from advancing.

Medication Tips For Treating Parkinsons Disease

Sinemet Parkinsons Disease

Your doctor will determine the best combination of Parkinsons disease medications for you, as well as how and when to take them. There are also some general guidelines to consider:

  • Keep a Parkinsons disease medication list and note down how and when you should take each drug. This can be helpful if memory problems crop up and someone else has to administer medications for you.
  • Always take your medications as your doctor prescribes. Write it down or bring a family member to your appointment if you think youll forget.
  • Store your medications in a dry, safe place, unless your doctor advises you to keep them in the fridge.
  • Throw away expired medications.
  • Remember to order your prescriptions in advance.
  • Always take extra medication with you when you travel.
  • Dont change your dose or stop taking your medication unless your doctor tells you to.
  • Take your medication at the same time every day. Keep them in a pill case and set an alarm to remind yourself to take them, especially if you live alone.
  • Physical exercise can help the body absorb medication, so try to move as much as possible.

If you have any questions about this Parkinsons disease medication list, consult your doctor. He or she will be able to answer your questions and advise you on how and when to take your medication. You should also seek medical advice if youre struggling with the side-effects of a particular drug or you want to try something different.

See Also:

Recommended Reading: Voice Amplifiers For Parkinsons

Also Check: What To Buy Someone With Parkinson’s

Questions About Sinemets Dosage

Below is a list of common questions related to Sinemets dosage.

  • What if I miss a dose of Sinemet? If you miss a dose of Sinemet, talk with your doctor or pharmacist. Theyll recommend whether you should take the missed dose or skip it.
  • Will I need to use Sinemet long term? Yes. If Sinemet is working well for you without causing bothersome side effects, youll likely take it long term.
  • How long does Sinemet take to work? You should notice your symptoms beginning to ease within 30 minutes of taking Sinemet.

Find answers to some common questions about Sinemet.

Consuming Alcohol During Sinemet Treatment

Its not known if alcohol interacts with Sinemet. Alcohol may worsen or increase your risk of certain side effects with Sinemet. These include:

  • drowsiness or falling asleep suddenly
  • stomach bleeding
  • low blood pressure

For this reason, it may be best to avoid drinking alcohol while taking Sinemet. If you drink alcohol, talk with your doctor before taking Sinemet. They can let you know how much alcohol, if any, is safe to consume.

Read Also: Can Chemo Cause Parkinson’s Disease

Sinemet: What To Discuss With Your Doctor

Talk with your doctor or pharmacist for additional information about Sinemet. If you have questions about the drugs side effects, your pharmacist or a healthcare professional can help answer them.

In addition to discussing Sinemet with your doctor, you may find the following articles helpful in learning more.

  • Overview of Sinemet. To read an overview of Sinemet, see this article.
  • Drug comparison. Find information about how Sinemet compares with Rytary and Stalevo.
  • Details about Parkinsons disease. To learn more about Parkinsons disease, which Sinemet is used to treat, see this article.

Disclaimer: Healthgrades has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

How To Cope With Side Effects

Parkinson’s Medications – Part 1: Levodopa

What to do about:

  • loss of appetite, feeling or being sick having a low-protein snack with your medicine may help if youre feeling or being sick. If you lose your appetite, eat when you would usually expect to be hungry. It may help to eat smaller meals, more often than usual. If you are being sick, take small sips of water to avoid dehydration.
  • feeling dizzy if you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so you do not faint, then sit until you feel better. Do not drive, cycle, or use tools or machines if you feel dizzy or tired. Do not drink alcohol as it may make you feel worse.
  • problems sleeping avoid big meals, smoking, or drinking alcohol, tea or coffee in the evening. Try not to watch TV or use your mobile phone before going to bed, and relax for an hour before bedtime. Do not take any sleep remedies, including herbal medicines, without talking to a pharmacist or your specialist nurse first.
  • uncontrollable twitching, twisting orwrithingmovements let your doctor or specialist nurse know as soon as possible

Don’t Miss: Does Parkinson’s Disease Cause Pain

Parkinsons Disease Medications: The Facts

There have been many developments in Parkinsons disease treatments in recent years. As such, doctors now have a greater understanding of traditional Parkinsons disease medications and their side-effects. Scientists have also developed new drugs to help control tremors, slowed movement and other Parkinsons symptoms.

Before we explore the best medication for Parkinsons disease, its important to address the facts. Firstly, Parkinsons disease medications cannot cure your condition, nor will they slow down the progression of your symptoms. These medications are prescribed to help patients live independently and improve their quality of life.

Its important to note that some patients do not respond well to Parkinsons disease medications. In this case, there are plenty of other treatment options to consider such as homeopathic remedies, physical therapy and surgical intervention. Again, none of these treatments provides a cure, but they can help ease or control your symptoms.

Cerebral Effects Of Chronic Stress In Pd

As outlined earlier, chronic stress influences the brain both at the systems level and at the molecular level . Through these changes, chronic stress may affect PD brains by increasing the susceptibility to depressive and anxiety disorders, while also potentially impacting the already injured dopaminergic nigrostriatal system in patients with PD. Although this remains highly speculative at this stage, the following mechanisms may contribute to these effects.

FIG. 2

Another way in which stress might influence PD disease progression is by depleting compensatory mechanisms. In PD, clinical symptoms usually become apparent when > 50% of dopaminergic cells are lost. This suggests that compensatory mechanisms must take place in the early phase of PD to prevent overt clinical symptoms. These compensatory mechanisms are thought to take place both in the striatal dopamine system and at the level of large-scale brain networks. Under stressful conditions, the residual dopaminergic function is compromised, and attentional resources are depleted, in a similar way as dual tasking does. This may âunmaskâ clinical symptoms that were not seen before or increase the severity of already manifest symptoms.

Also Check: Judy Woodruff Health Problems

Recommended Reading: Special Walker For Parkinson’s Patients

What Other Information Should I Know

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to levodopa and carbidopa.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking levodopa and carbidopa.

Levodopa and carbidopa can lose its effect completely over time or only at certain times during the day. Call your doctor if your Parkinsons disease symptoms worsen or vary in severity.

As your condition improves and it is easier for you to move, be careful not to overdo physical activities. Increase your activity gradually to avoid falls and injuries.

Levodopa and carbidopa can cause false results in urine tests for sugar and ketones .

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription

It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


Popular Articles