How Cbd Oil Works To Alleviate Symptoms Of Parkinsons Disease
According to a 2017 study, the manipulation of the endocannabinoid system may have an essential role in the treatment of the symptoms of Parkinsons disease.
The ECS modulates several physiological functions, like mood, motor control, and cognition. The cannabinoid receptors of the ECS, particularly cannabinoid receptor 1, are abundant in the basal ganglia.
The study suggests that manipulating the ECS could improve motor symptoms and other Parkinsons disease symptoms.
One way to manipulate the ECS is through the introduction of laboratory-derived or medical marijuana-derived cannabinoids in the body. The primary cannabinoids that come from the marijuana plant are CBD and THC.
It has been suggested in the studies mentioned above that CBD might be helpful in the treatment of Parkinsons disease.
Common symptoms of Parkinsons disease include the following:
- Skin problems
Parkinsons disease may, later on, develop into Parkinsons disease dementia. This condition affects a persons cognitive functions, including remembering things, paying attention, or communicating with others.
CBD for Inflammation
According to Dr. Rebecca Gilbert, Vice President and Chief Scientific Officer of the American Parkinson Disease Association, inflammation has an essential role in the progression of Parkinsons disease.
The abnormal deposits of Lewy bodies can trigger inflammatory responses, which can result in further disease progression.
CBD for Anxiety and Depression
How Do You Use Cbd Oil For Parkinsons
CBD products are available in different forms like edibles, topicals, oral tinctures, etc. Lets take a quick look at how you can consume CBD for Parkinsons.
- Oil/Tincture: These can be consumed sublingually or swallowed and ingested. It shows quick effects and is helpful for people who have a problem swallowing.
- Vape Pens: This CBD oil is vaporized and smoked, like a regular vaping pen. It is quick but may cause sore throat, coughing, etc., and even damage lung tissues.
- Edibles: Gummies and candies infused with CBD can be a tasty way of consuming CBD. But their effects are slower, and the dosage may be inaccurate.
- Capsules/Pills: CBD pills or capsules may be great for people who may have problems administering liquid CBD because of tremors, though the result is slow.
- Topicals: CBD-infused lotions, creams, serums, etc., can be applied on the skin directly to help with pain and stiffness, though the results of topicals are slow.
The fastest and the most popular form of CBD product is tincture. You have to place a few drops of the product under the tongue and wait for about half a minute. Then, swallow it. Some unique tinctures have multiple applications as an ingestible or topical oil.
Clinical Trial Uses Cbd As A Parkinsons Disease Treatment
A study by Sao Paulo and Belo Horizonte University neuroscientists found that CBD improved quality of life for patients administered 300mg/day of the supplement.
The 21 participants were divided into three groups and given a placebo, 75mg/day of CBD, or 300mg/day of CBD before being assessed for motor function, quality of life, and neuroprotective effects using various scales.
Quality of life was the only statistically significant difference between placebo and experimental groups, but the researchers called for studies with larger samples and specific objectives to further investigate the possible links between CBD supplementation and motor function.
Why Is Cbd Controversial
The use of CBD is legally gray, as marijuana is illegal at the federal level. However, the 2018 U.S. Farm Bill legalized the use of CBD produced via the cultivation of hemp with THC levels below 0.3 percent.
You also can use a medical marijuana card to obtain CBD in some states. Nevertheless, a few states currently forbid the use of CBD. Check to see if CBD is legal in your state here.
Because CBD is unregulated at the federal level, it can be difficult to determine the amount of THC in certain products. Purchasing CBD products from reputable brands that conduct third-party testing is currently the safest option.
Cbd As A Treatment For Parkinsons
CBD hasnt been used in people with Parkinsons disease long-term, and research into the benefits of this cannabinoid only began a few decades ago.
That means research is limited, and often, the studies that have been done are very small. Scientists and doctors need to conduct larger-scale efforts to confirm any benefits.
However, some studies suggest CBD may have some positive effects, especially when it comes to nonmotor symptoms, such as depression, anxiety, and sleep disorders.
What Does The Fda Say About Using Cbd Oil For Parkinsons
CBD oil hasnt been approved by the FDA as a treatment for Parkinsons disease. In fact, there are no FDA-approved cannabis treatments for this condition as of today. However, the FDA did acknowledge a CBD-based medication, Epidiolex, to treat two types of drug-resistant epilepsy.
Researchers from the University of Colorado are using Epidiolex to analyze its benefits on people with Parkinsons-triggered tremor. The study is currently in its second stage.
Is Cbd Oil Effective On Patients With Parkinsons Disease
It has many benefits that include the reduction of anxiety, depression, stiffness, and rigidity of the muscles and joints, tremors, and improvement in sleep. CBD oil not just reduces anxiety but also minimizes the inflammation and pain in joints due to stiff muscles and joints. It also reduces the hallucination that is the side effects of this disease. CBD improves the life of the patient miraculously.
Is There An Alternative Way
People are increasingly turning to plant medicine for a low-cost, holistic approach to treating their tremors. Anti-seizure medications and tranquilizers are common prescriptions to treat tremors that can have heavy side effects on the body. Cannabis and CBD are also anti-seizure compounds that can have tranquilizing effects that tend to soothe the body.
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In regards to Parkinsons, Dr. Fernandez states, its important to remember that everyones experience with Parkinsons is different, and treating it is about targeting the symptoms, he says. The most important thing is getting a good evaluation by a neurologist or Parkinsons expert to make sure youre on the right path. He emphasizes that treatment is symptom dependent and drugs are prescribed based on how much the tremors interfere with someones life.
The cause of Parkinsons is largely unknown, but doctors do know that dopamine is not produced in high enough quantities in Parkinsons patients. Dopamine, a neurotransmitter, is naturally produced in the brain and is important in regulating movement in the body. CBD interacts with dopamine receptors and opioid receptors, but more research is needed to thoroughly understand this reaction.
Which Cbd Oil Is Best For Parkinsons Disease
There are many trustworthy brands of CBD tinctures available on the market. Some of the products trusted by people with Parkinsons Disease are Nuleaf Naturals Full Spectrum Cbd Oil, Joy Organics CBD Oil, CBDistillery Pure CBD Oil Tincture, Hemp Bombs Premium CBD Oil, Pure Hemp Full Spectrum, and more.
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Which Cbd Item Is Right For You
It really depends upon what your objective is and why youre taking CBD to begin with.
Some individuals dont want to consume anything and therefore prefer a topical CBD cream or lotion. You can apply it to muscles, joints, and ligaments and still obtain a nice, localized release.
The largest differences between tinctures, edibles, and vape pens are rate of delivery as well as how long the effects last. Vape relief is faster yet wears off much faster as well normally in about 2 hours. Say you wake up in the morning and pulled your back out, you might wish to take CBD via a vape pen, which delivers in 10 minutes.
Tinctures and edibles take longer to work yet last four or five hours. A tincture looks like a little liquid that you put under your tongue, and you feel relief within half an hour. If you prefer to taste something, you choose an edible, whether its a capsule, gummy, or baked good.
When purchasing CBD, we recommend you keep these things in mind:
The Challenge Of Regulating Cbd Products
Practically, CBD products can be obtained relatively easily at health food stores and online. They are not considered drugs , and therefore are not regulated by the Food and Drug Administration . This can be very problematic because without FDA oversight:
- There is no assurance that what is stated on the package is what is being sold. For example, even if the bottle says it is pure CBD, the product may contain other chemicals from the cannabis plant, or a higher amount of THC than advertised
- The manufacturing process, which is also not regulated, may introduce contaminants
- There is no assurance that the dosage written on the bottle is correct
- Medication interactions between CBD products and other drugs are not clear to consumers
The FDA is aware of the health claims that are made by manufacturers about various products and issues warnings to companies who market CBD products with unsubstantiated health claims.
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Benefits And Uses Of Cbd Oil
Cannabidiol is a popular natural remedy used for many common ailments.
Better known as CBD, it is one of over 100 chemical compounds known as cannabinoids found in the cannabis or marijuana plant, Cannabis sativa .
Tetrahydrocannabinol is the main psychoactive cannabinoid found in cannabis, and causes the sensation of getting high thats often associated with marijuana. However, unlike THC, CBD is not psychoactive.
This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of marijuana or certain pharmaceutical drugs.
CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil.
Its gaining momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain and anxiety.
Here are seven health benefits of CBD oil that are backed by scientific evidence.
Cannabinoids For Pain In Parkinsons Disease
Pain is a constant companion for as many as 10 percent of people with Parkinsons disease. Unfortunately, most of them cant tolerate the sleepiness and confusion regular pain medications induce.
Thats why Dr. Susan Fox, a Toronto neurologist and professor at the University of Toronto, is investigating a different source of pain relief. Fox is conducting a pilot study, along with her colleague Dr. Tiago Mestre in Ottawa, to see whether 15 people with Parkinsons disease will benefit from oils made from cannabinoidsthe active compounds in marijuana.
Currently, people with Parkinsons may experience pain in their muscles and joints because of the stiffness and rigidity the illness causes. Some also report a sharp pain, often in their legs or feet, that is more puzzling because doctors cant determine its exact cause.
Some people call it central pain, says Fox. Its probably mediated by some brain mechanism reflective of Parkinsons. People express this as an unpleasant burning, stabbing pain, and its very difficult to treat.
Fox, who treats people with Parkinsons at Toronto Western Hospitals Movement Disorders Clinic, hopes her study will discover whether people with Parkinsons can tolerate oils, and experience less pain after using them. She also wants to identify the best strength and dosage for people to use.
Almost every day, one of her patients asks her about trying marijuana to relieve their tremors or rigidity.
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How Do I Know What Dosage Of Cbd Oil To Use
The first step is that you establish a baseline then adjust the dosage over some time until you get your effective dose. You should consider that there is no set dosage of the CBSD oil as different patients respond to different dosages. But, we assure you that by following the procedure you will get your effective dose. Consult your doctor if you are having a problem getting to know the effective dose.
How Cbd Oil Compares To Alternative Treatments For Parkinsons Disease
There are various alternative treatments for Parkinsons disease. These include massages, acupuncture, yoga, and meditation.
While these alternative remedies have therapeutic benefits, especially on Parkinsons symptoms, like chronic pain due to movement impairments, CBD use proves to have more benefits.
CBD may aid in alleviating some of the motor and non-motor symptoms of Parkinsons disease, as shown in the studies previously mentioned.
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Dosing With Sublingual Cbd Oils
Once you have established a minimum effective dose using the stepwise dosing procedure, the following chart will help you determine which sublingual oil potency will best meet your daily dosage requirement. To find the best product match for your dosage simply match your daily dosage to the row on the chart labeled 30 Day Supply in Bottle. For example: If you need 15mg CBD daily then according to the chart you would need a 450mg product. The chart also acts as a guide to how to use the glass dropper to measure out CBD in milligrams.
What Are The Benefits Of Cbd
Many people are looking foralternatives to pharmaceuticals with extremeside effects medicinemore in synch with natural processes. By tapping into how we work naturally on a deep level, CBD can providerelief for chronicpain, stress and anxiety, inflammation, depressionand manyotherconditions.Best Cbd Gummies For Parkinsons DiseaseSubstantial scientificresearch much of it funded by the U.S. governmentandmountinganecdotal accounts from clients and medical professionals highlight CBDs potential as a treatment for a vast array of conditions, consisting of :
- Autoimmune diseases
- Neurological problems
- Metabolic disorder
- Skin disease
CBD has actually confirmed neuroprotective impacts and its anti-cancer properties are being examined at numerous academic research centers in the USA and elsewhere. A 2010 brain cancer study by California researchers discovered that CBD boosts the inhibitory effects of THC on human glioblastoma cell spreading and survival. This means that CBD makes THC even more potent as an anticancer substance. Additionally in 2010, German scientists reported that CBD stimulates neurogenesis, the development of brand-newbrain cells, in adult mammals. Best Cbd Gummies For Parkinsons Disease
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Cbd Vs Traditional Alzheimers Medications
As stated earlier, there is no cure for Parkinsonâs disease. This is unfortunate, but there are many pharmaceuticals available today that claim to help control the symptoms. Pharmaceuticals, by definition, are compounds that are manufactured specifically for medical use. A perfect example is Xanax, a popular pharmaceutical that is used to help treat tremors â but with terrible possible adverse side-effects:
These pharmaceutical medications may not work the same for everyone â and those who do find relief may not have long-term success. This is because over time the body gradually builds a chemical tolerance, requiring stronger doses the longer the medication is used. Another potential issue is that the drug may eventually lose its effectiveness, which results in recurring symptoms.
Mology Calmness Inducing Cbd Tincture
This CBD tincture by Mology is specially designed and formulated to help in promoting tranquility. The 250 milligrams of Calm-Ology Tincture bottle contain full-spectrum CBD extract from the American-grown hemp plant.
It also contains other calming ingredients like safflower oil, elderberry, and French vanilla. By adding it to your daily wellness schedule, you can relax and calm down your mood and anxiety.
For better application, this pocket-sized bottle contains an easy-drop applicator. This CBD product has not been used to test it on animals and is prepared devoid of any gluten and paraben.
Moreover, the Mology is a dedicated institution indulged in harnessing natures power through science so that you can unlock the full potential of your body and mind.
- Free from Gluten and Paraben
- Animals are not used for testing purpose
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Cbd Oil For Elderly Tremors
More studies are needed to determine if CBD can be used as monotherapy to manage tremors and other symptoms among the elderly and patients with PD.
However, some neuroscientists acknowledge that CBD may act as a neuroprotectant that helps with PD. A study published in the British Pharmacological Society mentioned that CBD could modulate neurotransmission and prompt neurogenesis .
These effects were tested as a monotherapy, and in conjunction with other cannabinoids, among patients with Huntingtons disease, multiple sclerosis, and Parkinsons Disease.
Possible Side Effects Of Cbd Oil
Most studies have concluded that CBD is a safe and well-tolerated substance. The WHO issued a complete report on the safety and efficacy of cannabidiol, supporting the earlier findings. CBD rarely causes any side effects, and if they do happen, they tend to be mild.
The side effects of CBD oil include:
- Dry mouth
CBD can also interact with prescription and non-prescription medications, so make sure to always consult your doctor before taking CBD, especially if youre on medications that are metabolized by the Cytochrome P450 system. If your doctor tells you not to eat grapefruit along with your meds, the same rule applies to CBD because they use an identical mechanism, blocking the p450 system from metabolizing the active ingredients in those medications.
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Reducing Depression And Psychotic Disorders
People with Parkinson’s disease are prone to anxiety disorders that can lead to depression and even episodes of psychosis, especially if patients are not well supported and isolated from social events. Indeed, it is estimated that 50% of patients suffer from this. CBD can reduce these disorders thanks to its anti-inflammatory, pain-relieving and soothing effects.
Cbd Side Effects And Risks
In most studies, CBD is tolerated well. It rarely causes side effects, and the ones that do happen tend to be mild. They include tiredness, changes in appetite, and diarrhea or nausea.
However, CBD can interact with prescription and over-the-counter medications. Talk to your doctor before taking CBD, especially if youre on medications that contain a grapefruit warning. CBD and grapefruit have a similar effect on certain enzymes related to drug metabolism.
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How Parkinsons Disease Affects Your Brain
Weve already covered the macro-level concepts as it regards how Parkinsons works, but everyday consumers and researchers alike need to learn the underlying mechanisms involved in both a healthy and Parkinsons-affected brain in order to appreciate how therapeutic agents like cannabidiol can help.
How Your Brain Is Supposed to Work
The billions of nerve cells in your brain use cable-like extensions called axons to transmit impulses from one neuron to the next.
When an outgoing impulse or message reaches the end of an axon, it approaches a gap between the sending and receiving nerves known as the synapse.
The impulse is then ferried across the synapse by a specific chemical messenger, or neurotransmitterdopamine in this instance.
Once the dopamine accomplishes its job of getting the impulse across the synapse to the receiving neuron, it is broken down by enzymes.
How Your Brain Works with Parkinsons Disease
In the case of PD, the cells that produce dopamine die off for an unknown reason.
When the dopamine deficiency reaches 80 percent, the more readily recognizable symptoms of tremors and rigidity begin to manifest as communication between neurons is seriously impaired.
The immune system activates microglia in response to the rampant destruction of dopamine-producing cells microglia are a type of immune cell that cause inflammation and further damage to neurons when overstimulated.
How does cannabidiol counteract these harmful developments, you might be wondering?