Is It Safe Safety Of Commercial Stem Cell Clinic Work
Safety data is also limited, although there have been some publicized lawsuits claiming that these treatments resulted in harm. Stem cell researchers in general question whether cells harvested in such a way contain sufficient amounts of adult-derived stem cells to be meaningful. It is also unclear how this type of procedure would target the stem cells to the correct location. If stem cells are introduced in the nose for example, it is unclear how they would find their way to the basal ganglia and make the correct connection in order to help a person with Parkinsons disease.
In order for the medical community to accept this type of treatment as safe and beneficial, it would need to be shown to work in a placebo-controlled clinical trial for which participants do not pay, are aware of the known risks and benefits, and are carefully monitored throughout the trial. In addition, the trial would need to track adverse events, as well as record and share the outcomes of trial participants as they compare to the group of patients receiving a placebo treatment. So far this has not happened. The FDA is in fact studying mesenchymal stem cells in the laboratory in order to determine the best way to use them to help people, but these studies have not yet led to approved treatments. Most recently, the FDA filed federal complaints against two clinics that are marketing stem cell products without regulatory approval.
What Are The Complications Of Parkinson Disease
Parkinson disease causes physical symptoms at first. Problems with cognitive function, including forgetfulness and trouble with concentration, may arise later. As the disease gets worse with time, many people develop dementia. This can cause profound memory loss and makes it hard to maintain relationships.
Parkinson disease dementia can cause problems with:
- Speaking and communicating with others
- Problem solving
- Paying attention
If you have Parkinson disease and dementia, in time, you likely won’t be able to live by yourself. Dementia affects your ability to care of yourself, even if you can still physically do daily tasks.
Experts don’t understand how or why dementia often occurs with Parkinson disease. Its clear, though, that dementia and problems with cognitive function are linked to changes in the brain that cause problems with movement. As with Parkinson disease, dementia occurs when nerve cells degenerate, leading to chemical changes in the brain. Parkinson disease dementia may be treated with medicines also used to treat Alzheimer’s disease, another type of dementia.
Research And Statistics: Who Has Parkinsons Disease
According to the Parkinsons Foundation, nearly 1 million people in the United States are living with the disease. More than 10 million people worldwide have Parkinsons.
About 4 percent of people with Parkinsons are diagnosed before age 50.
Men are 1.5 times more likely to develop the disease than women.
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What Are The Risk Factors For Parkinsons Disease
Risk factors for Parkinsons disease include:
People with a first-degree relative with Parkinsons are at an increased risk for the disease possibly as much as 9 percent greater.
Fifteen to 25 percent of people with Parkinsons have a known relative with the disease, but a condition called familial Parkinsons, which has a known genetic link, is relatively rare.
The average age of onset is 60 years, and the incidence rises with advancing age. About 10 percent of people have early-onset or young-onset disease, which begins before age 50.
Parkinsons affects about 50 percent more men than women, for unknown reasons.
Exposure to some pesticides has been shown to raise the risk of developing Parkinsons.
Problematic chemicals include organochlorine pesticides like DDT, dieldrin, and chlordane. Rotenone and permethrin have also been implicated.
Fungicide and Herbicide Exposure
Exposure to the fungicide maneb or the herbicides 2,4-dichlorophenoxyacetic acid , paraquat, or Agent Orange may raise the risk of Parkinsons.
The U.S. Veterans Health Administration considers Parkinsons to be a possible service-related illness if the person was exposed to significant amounts of Agent Orange.
Head injuries may contribute to the development of Parkinsons in some people.
Coffee and Smoking
People who drink coffee or smoke tobacco have been found to have a lower risk of Parkinsons disease, for reasons that remain unclear.
Adding Treatments To Your Medication Regimen
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Home Remedyfor Parkinsons #5 Vitamin D & Vitamin E:
Inflammation and low immunity are two powerful factorsthat contribute to the development and worsening of Parkinsons disease. Bothvitamin D and vitamin E are strong anti-inflammatories and immune boosters. VitaminD & E also protect our brain cells and can even help damaged neurons regenerate. A deficiency of these key vitamins has also been linked to brain difficultiessuch as poor memory and recall attainability.
In regards to PD, a study of 157 Parkinsons patientsfound that the vast majority of them had severe to chronic vitamin Ddeficiencies. The findings, published in the Archives of Neurology in March of 2011, revealed a strong linkbetween inadequate levels of vitamin D and the onset of early Parkinson’sdisease.4
Back in 2002, another study was published in the Archives of Neurology which tracked themental decline of 3,000 men and women diagnosed with Parkinsons disease over a period of 7 years. The study found the participants whose supplemental vitamin E intakewas higher experienced a 36% reduction in theseverity of their symptoms compared to the rest of the group. Another study, whichappeared in the Lancet Neurology onlinemagazine in 2005, showed that vitamin E may actually prevent Parkinsonsdisease from developing in the first place! 8
Where to Get Your Vitamin D and Vitamin E From?
Environmental And Genetic Factors
Scientists are also working to learn more about environmental factors and genetic factors that might contribute to the risk of developing Parkinsons. One recent genetic research breakthrough is the development of a DNA chip called NeuroX, which could potentially determine a persons risk, but more research is needed.
Parkinsons disease is the result of complicated combination of interconnected events, as described it. Since aging is the most common risk factor, future treatments may need to take degeneration of certain neurons into account.
Risk Factors And Causes
There isnt one single cause of Parkinsons that has been proven at this time. Researchers believe a loss of the neurotransmitter dopamine, neurological damage, inflammation and brain cell deterioration are among the primary factors that trigger Parkinsons development. But why exactly patients develop these problems is a complex issue that remains up for debate.
What is known is that certain risk factors can make someone more susceptible to developing Parkinsons disease, which can include:
- Being a man, especially during older age. Research suggests that men in their 50s and 60s are most likely to develop Parkinsons.
- Genetic susceptibility: Studies have now identified several gene mutations that can put someone at a greater risk. Parkinsons has also been found to run in families, and having a sibling or parent increases someones risk.
- Damage to the area of the brain called the substantia nigra, which produces brain cells that are responsible for making dopamine.
- Toxicity and exposure to chemicals, including pesticides present on produce from non-organic farming. Living in a rural area and drinking well-water that might contain chemicals is another environmental risk factor.
- Poor diet, nutrient deficiencies, food allergies and an unhealthy lifestyle.
- Hormonal imbalances and other medical conditions that affect cognitive health and increase inflammation.
Focused Ultrasound Therapy To Treat Tremor
Focused Ultrasound is used to treat Parkinsons patients experiencing tremor that does not respond to medication.
In medical terms this procedure is known as a non-invasive thalamotomy.
During the Focused Ultrasound procedure, the patient is awake. No general anaesthesia or surgical incisions are required.
A frame is placed on the patients head with local anaesthetic and the patient lies in a Magnetic Resonance Imaging scanner. If required some sedation can be given to help maximise comfort and relaxation during the procedure.
Doctors then use brain scans to direct ultrasound beams to the target location in the thalamus region of the brain.
The thalamus is a small structure within the brain located just above the brain stem. It has nerve connections with both cerebral cortex and the midbrain. The main function of the thalamus is to relay motor and sensory signals to the cerebral cortex.
The focused ultrasound sends 1024 individual ultrasound beams through the brain that intersect at a single target point in the thalamus to destroy the tremor-causing cells without damaging the surrounding normal tissue.
This is all monitored in real time on the MRI and by repeatedly checking the patient and until the tremor has been treated.
When the treatment is over there is an immediate and significant reduction in tremor.
In Australia, Focused Ultrasound therapy is administered by St Vincents Hospital where it is known as the Neuravive Procedure.
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How Is Parkinson’s Disease Treated
No treatment can stop or reverse the breakdown of nerve cells that causes Parkinson’s disease. But there are many treatments that can help your symptoms and improve your quality of life.
Your age, work status, family, and living situation can all affect decisions about when to start treatment, what types of treatment to use, and when to make changes in treatment. As your medical condition changes, you may need regular changes in your treatment to balance quality-of-life issues, side effects of treatment, and treatment costs.
You’ll need to see members of your health care team regularly to adjust your treatment as your condition changes.
Treatments for Parkinson’s include:
Figuring Out Causes Of Fatigue
The first step in easing the fatigue associated with Parkinsons disease is to rule out other causes of tiredness, says Liana Rosenthal, M.D., assistant professor of neurology at the Johns Hopkins University School of Medicine and director of clinical core at the Morris K. Udall Center Parkinsons Disease Research Center of Excellence. We evaluate patients to see if there are other things contributing to the fatigue besides their disease, she says.
Sometimes patients may be referred to a sleep specialist for an evaluation. That can help identify causes of tiredness, like sleep apnea. Rosenthal says: Our aim is to first treat any sleep issues, like insomnia, sleep apnea or other causes of poor sleep. Once we treat and address those issues, we can see if fatigue still persists.
What Is Parkinsons Disease
Parkinsons disease is a nervous system disease that affects your ability to control movement. The disease usually starts out slowly and worsens over time. If you have Parkinsons disease, you may shake, have muscle stiffness, and have trouble walking and maintaining your balance and coordination. As the disease worsens, you may have trouble talking, sleeping, have mental and memory problems, experience behavioral changes and have other symptoms.
How Commercial Stem Cell Clinics Work
A typical treatment at one of these clinics involves removing fat cells from the abdomen , treating the cells in various ways in order to isolate mesenchymal stem cells or stromal cells from the removed tissue, and finally injecting these cells back into the body. The cells are re-introduced into the body in different locations depending on which disease is being targeted. Such treatments are performed for a fee, sometimes a large one, and are not covered by insurance.
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Uncertain Responses To Cbd
Both men completed the CBD trial. Neither felt any positive effects after taking the drug, although their experiences were different.
Mullen thinks he got the placebo. I kept wanting to feel something different, he said, but I didnt feel anything. He is anxious to see the results of the trial and added that he would still be willing to take CBD to treat his Parkinsons disease symptoms.
Preusser is convinced that he did get the CBD, explaining that after the first administration he felt lightheaded. Things werent quite as concrete and were more ethereal than how I commonly perceive my surroundings, he said.
The dizziness forced him to go to another room at the clinic to lie down. He said at his second visit, he got half the dose, which seemed to diminish the side effect.
But like Mullen, Preusser said he derived no benefit from whatever he took. I didnt notice any diminishment of my tremor or change in my level of cognition, he said. He remains open, however, to the idea that CBD could help some people with Parkinsons disease.
I understand that every patient is different, he said. It may work miracles for the next guy. For me, not so, but there may be a point when I might reconsider or something may prompt a different assessment.
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Surgery For People With Parkinsons Disease
Deep brain stimulation surgery is an option to treat Parkinsons disease symptoms, but it is not suitable for everyone. There are strict criteria and guidelines on who can be a candidate for surgery, and this is something that only your doctor and you can decide. Surgery may be considered early or late in the progression of Parkinsons. When performing deep-brain stimulation surgery, the surgeon places an electrode in the part of the brain most effected by Parkinsons disease. Electrical impulses are introduced to the brain, which has the effect of normalising the brains electrical activity reducing the symptoms of Parkinsons disease. The electrical impulse is introduced using a pacemaker-like device called a stimulator. Thalamotomy and pallidotomy are operations where the surgeon makes an incision on part of the brain. These surgeries aim to alleviate some forms of tremor or unusual movement, but they are rarely performed now.
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Other Common Prescribed Agents
There are descriptions of OH occurring with other medications such as amantadine , and acetylcholinesterase inhibitors . The evidence with anticholinergics is less clear, not increasing OH frequency , but affecting cardiovascular reflexes . The COMT inhibitors entacapone and tolcapone , as well as DOPA-decarboxylase inhibitors, showed no clear influence on OH , except in one study where entacapone showed a protective effect .
Is Medical Marijuana An Option For Me
What’s next for a person with PD who wants to know if medical marijuana is an option? “Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for PD,” said Dr. Michael S. Okun, the Parkinson’s Foundation National Medical Advisor.
Research is still needed to determine how medical marijuana should be administered and how its long-term use can affect symptoms of PD. To keep patients safe, states that legalize medical marijuana will eventually need to develop training programs for doctors and medical teams that prescribe medical marijuana. Consult your doctor to see if medical marijuana is an option for you.
The Parkinsons Foundation is designed to help guide the PD community in making informed decisions about using cannabis for Parkinsons. The statement is based on the input from 46 experts who attended the Foundations first-ever medical marijuana convening. Read it now.
Page reviewed by Dr. Bhavana Patel, Movement Disorders Fellow at the University of Florida, a Parkinsons Foundation Center of Excellence.
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Medical Treatment Of Parkinsons Disease
Enormous progress has been made in the treatment of Parkinsons disease over the past half century, but levodopa remains the most potent drug for controlling PD symptoms . Prior to instituting medical therapy, a correct diagnosis of PD must be established and the level of impairment determined . Each patients therapy is to be individualized, and diverse drugs other than levodopa are presently available. Among these are the dopamine agonists , catechol-o-methyl-transferase inhibitors and nondopaminergic agents . Head-to-head comparisons of drugs within classes are rare, and the differences that have emerged are related to the effects on motor fluctuations, dyskinesias, on/off times and adverse effects of the specific agents within each class .
What Is Parkinson Disease
Parkinson disease is a movement disorder. It can cause the muscles to tighten and become rigid This makes it hard to walk and do other daily activities. People with Parkinsons disease also have tremors and may develop cognitive problems, including memory loss and dementia.
Parkinson disease is most common in people who are older than 50. The average age at which it occurs is 60. But some younger people may also get Parkinson disease. When it affects someone younger than age 50, it’s called early-onset Parkinson disease. You may be more likely to get early-onset Parkinson disease if someone in your family has it. The older you are, the greater your risk of developing Parkinson disease. It’s also much more common in men than in women.
Parkinson disease is a chronic and progressive disease. It doesn’t go away and continues to get worse over time.