Tuesday, June 11, 2024
Tuesday, June 11, 2024
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Parkinson’s And Frequent Urination

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How does Parkinson’s disease affect the urinary system?

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Symptoms Of Urinary Retention

The symptoms of urinary retention are not always obvious but may include

  • Hesitancy really having to strain to pass urine
  • Strong feelings of urgency and frequency and when passing urine only a small amount comes out
  • A urinary stream that is very weak and intermittent

Whilst your bladder is not emptying properly there is a risk that the residual urine in the bladder will become infected. This could cause further complications and problems if it isnt removed regularly. It is important to seek help if you experience any of the above symptoms.

It is a good idea to keep a record of your bladder activity in a bladder diary for a few days before your appointment with your doctor or nurse.

Your Doctor or Healthcare Professional may recommend the following tests:

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Circadian Rhythm Disturbances And Nocturia

The suprachiasmatic nucleus of the hypothalamus controls the circadian rhythm by regulating melatonin release from the pineal gland in response to the environmental light/dark cycle.44 Neurodegeneration and cell death occurring in PD has been shown to affect structures involved in circadian rhythm control, such as the hypothalamus. It has been shown that mice overexpressing synuclein exhibit a reduced SCN firing rate, potentially weakening their ability to communicate neural and hormonal signals from the central clock.45 Sleep disturbances are common in PD,46, 47, 48 and alterations in the circadian rhythm have been demonstrated in PD, even at the early stages.49, 50

In health, there exists a circadian rhythm for urine production, and, as a result, roughly less than 25% of 24hour urine is produced during the night. This is thought to be mediated through release of AVP and melatonin and is known to be affected with aging.51 Production of urine is influenced by the circadian regulation of sodium and free water handling.52 Diurnal release of hormones are regulated through the pituitary and increased plasma levels of arginine vasopressin at night.51 A loss of this diurnal response has been observed in otherwise elderly healthy individuals reporting NP.42 A loss of circadian regulation of urine production results in limited reabsorption of free water and diuresis. Reduced AVP secretion is linked not only to nocturnal polyuria,39, 53 but also to nocturnal enuresis.53

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Coping With Urinary Problems In Parkinsons Disease

If you have Parkinsons disease, you may end up having to deal with urinary problems which research shows are common in addition to other symptoms of Parkinsons disease.Since urinary symptoms can lead to other problems, such as disrupted sleep and disruption to social activities, its important to be aware of these problems and know what you can do to help with this

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Cardiovascular Dysautonomia And Nocturia

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An association is known to exist between orthostatic hypotension and nocturia10, 57 and nocturnal polyuria.51 In health, blood pressure is known to decrease at night, and this is often absent in patients with PD reporting autonomic failure.58 This may be mediated through inappropriate mineralocorticoid receptor activation.55 Consequent to this, pressure natriuresis occurs, resulting in increased urine output and the patient reports nocturia. OH and supine hypertension frequently coexist in PD,59 and older age, akineticrigid motor subtype, and preexisting hypertension are independent risk factors for supine hypertension. Improvement of nocturia, however, has not been a consistent finding in studies evaluating treatments for supine hypertension,55, 60, 61 and therefore cardiovascular dysautonomia is likely to be only one of several mechanisms responsible for nocturia in PD.

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What Are The Symptoms Of A Uti

Sometimes, you can have a UTI and feel no symptoms at all. However, UTIs often cause symptoms such as aburning pain during urination, strong-smelling urine, or a strong, persistent urge to urinate.

Other symptoms may include:

  • Pressure in the lower pelvis
  • Mental changes or confusion

If the infection impacts your kidneys instead of your bladder and urethra, you may experience different symptoms, such as nausea, back or side pain, chills, and vomiting.

What Are The Symptoms

The most common urinary symptoms people with Parkinsons experience include:1

  • Frequent need to urinate
  • Trouble delaying urination once aware of the need, creating a sense of urinary urgency
  • Less frequently, difficulty initiating a stream or emptying the bladder

I have experienced the first 2 symptoms listed, along with leaking or sputtering. Not all the time, but episodically and almost every day.

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What Causes Frequent Urination In Men

There are a lot of conditions behind frequent urination and sometimes, it just boils down to how you drink and process fluids. In general, there are two categories of urinary symptoms of frequent urination.

If your bladder fills too quickly or if your bladder doesnt hold a lot, youre going to have urinary frequency and you might have urinary urgency. We call those storage symptoms, says Dr. Bajic. Then, theres a separate set of symptoms of what we call voiding symptoms. These are ones that are more related to having difficulty trying to empty the bladder like having a weak urinary stream or a sensation of incomplete emptying.

Here are some common causes of frequent urination that show symptoms of each:

What Does Frequent Urination Mean

Addressing Incontinence Concerns with Parkinson√Ęs Disease

Frequent urination looks different for everyone, and it isnt always a sign of trouble brewing. As Dr. Bajic explains, whether or not youre urinating too much comes down to whether or not youre bothered by it.

Most of the people that are complaining about frequent urination might be bothered by urinating every hour, two hours, or sometimes even three hours, he says. Youre either bothered by it because its annoying or because its interfering with your ability to do certain things or activities.

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Management Strategies To Prevent Uti In Pd

Although there is little in the way of high-quality data to prevent UTI in PD, several measures can be considered as part of a multifaceted approach. In general, all patients with PD and urinary retention should be counseled on maintaining adequate hygiene including perineal cleanliness and, if required, aseptic catheterization techniques . In addition, regular scheduled bladder and bowel emptying should be encouraged to reduce urinary retention and inadvertent fecal contamination from stool incontinence. There should be a low threshold to treat comorbid medical conditions that increase the risk of urinary retention and UTI, such as benign prostatic hyperplasia or diabetes, and adjustment of medications that promote urinary retention . More PD-specific research is urgently needed to address this important issue.

Table 1

Concomitant conditions that lead to recurrent UTI and recommendations for prevention

Table 2

Summary of interventions and recommendations from European Association of Urology

How Does Parkinsons Impact The Risk Of Getting Utis

In Parkinsons, the brains control of the urinary sphincter can become disrupted, leading to difficulty holding urine. As a result, people with Parkinsons may experience storage symptoms, which can increase the frequency and/or urgency of urination and lead to nocturia when you wake up multiple times at night to go to the bathroom. Another set of urinary symptoms, called voiding symptoms, can cause urination hesitancy, straining, interrupted stream, and double voiding . You may experience symptoms in both sets, which puts you at a higher risk of developing a UTI.

Voiding symptoms often go unnoticed for longer than storage symptoms do, and they can play a significant role in the development of UTIs. For example, if they keep you from fully emptying your bladder each time you urinate or keep you from urinating as often as you should, bacteria can grow and spread in the remaining urine, leading to UTIs.

Parkinsons motor symptoms can also impact your ability to urinate as frequently. Slowness and stiffness can make it difficult to get to the bathroom. In addition, if you experience significant balance issues, you may not travel to the bathroom as often as you need to for fear of falling.

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What Treatments Are Available For Utis

The first line of treatment for many people who develop UTIs is a course of antibiotics. Often, this is the only treatment needed. Several different antibiotics can treat UTIs, and your provider will use results from a urine sample to determine which is right for you.

If the UTI is considered complicated , your doctor might prescribe a higher dose of antibiotics. If the infection is severe or in your kidneys, your physician may refer you to the hospital for high-dose antibiotics administered through an IV.

Addressing Practical Aspects Of Eating And Drinking

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Some people with Parkinsons have problems chewing and swallowing. This can make it difficult to eat a diet with plenty of fibre. A speech and language therapist can give advice about this. Ask your GP, specialist or Parkinsons nurse for a referral. If it takes a long time to eat and your meal goes cold, eat smaller portions and go back for seconds that have been kept warm. You can also get special plates that keep your meals hot the Disabled Living Foundation has more information.

An occupational therapist will also be able to give you some tips and practical advice.

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With My Bladder Problems

Signals from the brain may control bladder function, and dopamine plays an important role through exerting an inhibitory effect on the bladder reflex. When dopamine levels decrease in Parkinsons disease, there may be a loss of control over the reflex meaning that the bladder is no longer inhibited and may take on a life of its own.Once it takes on a life of its own it may begin to misbehave. It is likely that alterations in other chemicals in the brain may also contribute to the bladder problems in Parkinsons.

There may be of course other causes for bladder symptoms in individuals with Parkinsons and therefore it is important to investigate symptoms before concluding that they are Parkinsons related.

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Eligibility Criteria And Study Selection

Studies were eligible if they met the following criteria: published in peer-reviewed English journals participants were diagnosed according to UK Parkinson’s Disease Society Brain Bank Diagnostic Criteria or MDS clinical diagnostic criteria for Parkinson’s disease reporting the prevalence of LUTS or LUTS subtypes LUTS or LUTS subtypes assessed by validated scales administered by experienced clinicians, self-report questionnaire, or published criteria from classification codes/definition prospective cohort study or cross-sectional study.

The studies were excluded if they: did not provide full text included insufficient or unclear fragmented data for analysis enrolled patients who have been diagnosed with prostate carcinoma, uncontrolled diabetes, as well as any other diseases that cause urinary problems, or taken drugs such as diuretics with small sample size . duplicated publications systematic reviews, meta-analyses, letters, protocols. When results on the same dataset were reported in several publications, only the most complete publication was included in the analysis. Two independent observers evaluated the results and resolved any disagreement by discussion or with recourse to a third arbitrator .

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Prevalence Of Nocturia In Pd

Questionnaire based studies generally report a high prevalence of nocturia, with figures ranging between 76%12 and 86%,13, 14 though one study reported a prevalence of only 34.6%.15 In a study of 115 PD patients using a questionnaire on pelvic organ functions, Sakakibara et al. reported nocturia in 53% of men and 63% of women with PD.16

Nocturia has been reported in 34.6% of PD patients using a semistructured interview in 1,072 consecutive patients with PD in the large, multicentric PRIAMO study.15

This apparent variability in prevalence between studies could be put down to several factors, including differences in the demographic features of the cohort of patients being studied, and the occurrence of medical comorbidities. LUT symptoms are more prevalent with advancing disease and were most frequent in patients at H & Y stage 4 to 5 with a reported prevalence of around 90%.15 Moreover, the term nocturia has been applied differently in studies and the prevalence varies according to the definition being used. The International Continence Society made an attempt to standardize the definition of nocturia in 2002 and, based on a consensual approach, put forward the complaint that the individual has to wake at night one or more times to void.17

How Common Is Urinary Dysfunction

Parkinson’s Disease and the Bladder

According to studies, 30 to 40 percent of people with Parkinson’s have urinary difficulties or urinary dysfunction. However, urinary incontinence is less common, developing in about 15 percent of people with Parkinson’s.1

I have Parkinsons related urinary dysfunction. I have had issues talking about it. Im now dealing with the problems. There. Ive said it. How about you?

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Storage Symptoms In Pd

The pooled prevalence of storage symptoms was 59%. Polyuria was the most prevalent type of LUTS in the patients with PD followed by OAB , nocturia , frequency , urgency , and incontinence . The results were almost the same with those reported previously . OAB was the second most prevalent storage symptom. It was urinary urgency, usually accompanied by increased daytime frequency and/or nocturia, with urinary incontinence or without according to the International Continence Society report .

Storage symptoms were frequent in PD because degeneration of dopaminergic neurons might lead to urination irritative symptoms in PD . Striatum functionally controlled the urine storage. Disruption of D1-GABAergic direct striatal output pathway may cause bladder hyperactivity in PD which had been validated in SPECT and animal studies . Besides, objective assessment with urodynamics showed that detrusor overactivity occur in 4593% of PD patients, which was the most prevalent cause to OAB in PD .

We found that the prevalence of urinary incontinence was 31% in the male PD patients, whereas 43% in female patients with PD. These results suggest that both age and gender influence the outcome of estimated prevalence.

The majority of studies were rated as low quality because of small sample sizes and other reason, although the results were robust in sensitivity analysis. Accounting for aforementioned factors, the prevalence results of urinary incontinence should be interpreted with caution.

What Is The Cause

While motor problems of the body and limbs are often the most visible symptom of PD, other symptoms occur as well. Parkinsons disease can affect the autonomic nervous system. This is the nervous system responsible for automatic bodily functions like bowel movements and urination.2

The area of the brain that is most heavily damaged by PD makes dopamine. Dopamine is a chemical messenger that allows for smooth and controlled muscle movement. Also, protein deposits in the brain called Lewy bodies contribute to autonomic nervous system problems in PD.9

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Incomplete Emptying Of The Bladder

Parkinsons disease may also make it harder for you to empty your bladder completely. This occurs less frequently than the need for frequent urination, but it still affects many people with Parkinsons.

Your muscles are the culprit of this problem. When you urinate, you relax certain muscles, and Parkinsons can make it difficult to relax those muscles. Sometimes, it takes a long time to relax enough, and people may not spend long enough in the bathroom to empty their bladder.

Unfortunately, medications dont always help fully with bladder emptying in Parkinsons disease patients, although the drug urocholine or other medications designed to treat urinary retention may help. different.

Some people with urinary retention have to use a catheter to empty their bladder. If this is the case for you, your healthcare provider can instruct you on how to use the catheter.

Why Talk About It

Parkinson disease pathwayRat Genome Database

Because of stigma, embarrassment, and the misconception that urinary problems are just part of getting old, urinary dysfunction is underreported by people with Parkinsons as well as the general population.2

One type of urinary problem is overactive bladder, or the sudden, uncontrolled need or urge to urinate. Some people will experience the need to pass urine multiple times a day and night, while some will leak urine when they feel the urge to urinate.3

Urinary dysfunction, at a minimum, negatively affects quality of life and can lead to difficult to treat urinary tract infections, sepsis, and death.4

Quality of life effects include higher risk for falls due to having to urinate at night and increased isolation due to embarrassment and social stigmas. About 50 percent of nursing home admissions list urinary dysfunction as a major factor in admissions.5

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Why Do Urgency And Frequency Occur

Bladder difficulties in Parkinsons are related to changes in the level of dopamine affecting the function of the bladder muscle. Parkinsons is also thought to affect the nerve pathway between the bladder and the part of the brain controlling bladder function. Some of the symptoms that affect bladder control are related to the level of dopamine in your body which will rise and fall depending on your medication level.

Other conditions such as weak pelvic floor muscles or an enlarged prostate will contribute to bladder symptoms. Constipation can also worsen bladder symptoms by putting pressure on the bladder.

Parkinsons Disease And Your Bladder

Many diagnosed with Parkinsons disease experience urinary tract issues. A Michigan Medicine urologist discusses treatment options for patients to consider.

Anne Pelletier-Cameron, M.D., often jokes to her patients that shes a female plumber of the lower urinary tract. On a more professional note, however, shes a urologist in the Michigan Medicine Department of Urology.

In this role, Pelletier-Cameron treats patients with a variety of lower urinary tract symptoms. Some of her patients have been diagnosed with Parkinsons disease, a progressive nervous system disorder that impacts movement. But the breakdown of nerve cells that characterize Parkinsons disease can also cause non-movement symptoms, including bladder issues.

Half of all women and 17% of men will experience urinary incontinence, or the inability to hold urine, she says, noting that for Parkinsons disease patients, those numbers escalate.

Many of my PD patients end up having other bladder problems, including issues with urgency and frequency, says Pelletier-Cameron. Nocturia, or the need to urinate many times during the night, is also common, along with difficulty in emptying the bladder.

Pelletier-Cameron says the impact of bladder symptoms cant be ignored.

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