Susan Collins First Met Her Husband Tom Daffron When She Was An Intern Years Ago
Thomas Daffron and Susan Collins go back decades as friends and, in the beginning, there was a mentorship type of situation between them. According to a story on Central Maine.com, Collins first met Tom Daffron when he hired her as an intern for former Senator Bill Cohen.
She was 21. It was 1974. According to the article Daffron acted as Collinss mentor both then and as her own political career began to ascend. Somebody once said that the best person to marry is your best friend, says Daffron to the newspaper. This evolved from a working relationship to a friendship when I was working on her campaigns and now to husband and wife.
Hes extraordinarily smart, has a wonderful sense of humor and is a great friend, Collins said to the Bangor Daily News. Those qualities matter a lot to me. Collins does not have children, and it was her first marriage at age 59. Daffron has described himself as a moderate Republican as well and most of the politicians he has worked for belonged to the GOP.
Six Things You Should Know About Senator Susan Collins
Senator Susan Collins, who helped ensure that Brett Kavanaugh was confirmed as a Supreme Court Justice, said on January 27 she would support a call for witnesses in the ongoing impeachment trial for President Trump in light of new information in John Bolton’s book.
Irish American Susan Collins is calling for witnesses in the impeachment trial of President Donald Trump in the wake of new information included in John Bolton’s book
Editor’s Note: On January 27, Senator Susan Collins said in a tweet that she would support a call for witnesses in the ongoing impeachment trial of US President Donald Trump in the wake of new information from John Bolton, the former National Security Advisor of the United States:
My statement on Bolton developments.
Sen. Susan Collins
Later, on January 31, Senator Collins tweeted that she will “vote in support of the motion to allow witnesses and documents to be subpoenaed” during Trump’s impeachment trial:
I will vote in support of the motion to allow witnesses and documents to be subpoenaed. My full statement:
Sen. Susan Collins
Weekly Column: : : : 1jpg
Lyme disease and other tick-borne diseases have become a major public health concern, with cases exploding over the past 15 years. In 2003, Lyme disease infected around 30,000 Americans. Last year, there were an estimated 450,000 cases, a staggering 1,400 percent increase.
In the last year in Maine alone, there were approximately 1,400 new cases of Lyme disease, a sharp increase from the 752 cases in 2010. Other tick-borne diseases are also on the rise in Maine. Babesiosis, a malaria-like disease, has more than doubled in the past five years, and Anaplasmosis, related to ricketts, has more than tripled.
Far too many Americans with Lyme disease experience a complex diagnostic odyssey that takes months or even years. Paula Jackson Jones from Damariscotta shared with me her harrowing tale that took two years, scores of tests, and 23 different physicians before she finally found out that she had Lyme disease.
In addition to the physical and emotional toll that Lyme disease can impose, it is also expensive. Paula is still paying off over $250,000 worth of medical bills she has incurred. Medical costs of Lyme disease are estimated at $1.3 billion per year. When accounting for indirect medical costs, including loss of work, the annual costs balloon to $75 billion per year.
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Miro1 As A Target For Pink1/parkin
An impressive number of studies over the last 30 years shed light on the so-called mitochondrial life cycle, during which these highly dynamic organelles continuously experience fission and fusion events to meet the functional needs of the cells. Maintaining this mitochondrial network requires the coordinated activity of mitochondrial biogenesis and clearance pathways, which ensure the replacement of damaged organelles with metabolically active mitochondria. Consequently, impairing this fine-tuned quality control mechanism leads to the accumulation of dysfunctional mitochondria, which in turn increases oxidative stress and deteriorates cellular activity . Removal of damaged mitochondria is even more important in post-mitotic cells like neurons, which are not able to dilute harmful components through cell division.
In accordance, mitochondrial dysfunction plays an essential role in a large number of neurodegenerative diseases, including PD, and the accurate mitochondrial turnover is now considered a key neuroprotective mechanism against chronic disease conditions .
Collins & Her Husband Married In 2012 When She Was 59
Collins and Daffron 2012. Their marriage occurred when Collins was already a Senator. The ceremony was performed by Rev. Dr. Thomas Bentum at Gray Memorial United Methodist Church in Caribou, Maine, according to The New York Times wedding announcement.
GettyU.S. Senators Susan Collins and Claire McCaskill , the Chairman and Ranking Member of the Senate Aging Committee studied prescription drug price gouging and released a report in 2016. Her theyre with then-President Obama
Collins was 59 at the time. Hillary Clinton held a women-only dinner at her house for Collins that The Washington Post dubbed a bachelorette party. The wedding was described by The Post as a small family wedding.
Collins is the daughter of a former Maine state senator named Donald F. Collins, and his wife, Patricia M. Collins, who served as mayor of Caribou, Maine. It was Daffrons second marriage.
According to Bloomberg, Thomas Daffron served as the Chief Operating Officer of Jefferson Consulting Group, LLC since September 2006. Mr. Daffron oversaw Jefferson Consulting Groups administrative and financial functions as well as the day-to-day operations of the firm.
According to Bloomberg, Daffron once worked for Democratic Arizona Rep. Morris Udall and was a speech writer for Illinois Senator Charles Percy, a Republican.
GettySusan Collins and Brett Kavanaugh
GettySusan Collins is one of two pro-choice Republicans in the Senate.
You can see the lobbying profile for the Jefferson firm here.
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Here Are Six Things To Know About Senator Collins:
1. Senator Collins is a fifth-generation Irish American on both parents sides.
Her mothers name was McGuigan. Her uncle Sam was a prominent Maine judge, and the family operated a sawmill for several generations.
2. Ted Kennedy was one of her closest friends in the Senate.
Senator Edward Kennedy. Credit: Flickr.com
She said they bonded over the love for their Irish mothers.” She attributes her bipartisan friendships to a shared Irish connection with so many Irish American pols.
3. Her hometown Caribou, Maine was a popular destination for many Irish.
Caribou, Maine, in 1940. Credit: Wikipedia/Public Domain
According to the last Census, nearly one-fifth of the people in Caribou trace their roots to Ireland and actively cherish their Irish history, culture, and the contributions their ancestors made to the State of Maine.
4. Her first job was picking potatoes as a teenager.
Collins said she appreciated the connection to Ireland the work held for her.
I am fortunate to have grown up amid the hard work, determination, innovation, and common sense that define this great industry. To me, nothing says home like the sight of potato blossoms stretching as far as the eye can see and the heritage they demonstrate.
5. She suffers from spasmodic dysphonia
6. The Maine Irish Heritage Center honored U.S. Senator Susan Collins with the 2017 Claddagh Award.
. receives the Claddagh Award tonight from Maine Irish Heritage Center. Slainte!
Pat Callaghan
Is Susan Collins Married Does She Have Children
GettySusan Collins’ husband is Thomas Daffron.
With all eyes on Susan Collins, the Maine Senator and moderate Republican whose vote will be crucial in the Brett Kavanaugh vote, some are wondering about her own family.
Is Susan Collins married? Does she have children? Susan Collins is married. She married later in life in 2012, and she does not have children. Collins is married to Thomas Daffron, who was well-known for decades in the halls of Congress, working as a chief of staff for top Republican Senators, including Alaskas Lisa Murkowski, the other moderate Republican on whose vote the Kavanaugh confirmation partly hinges.
Collins announced on Friday that she is voting yes for Kavanaughs nomination. Kavanaugh was confirmed with a vote of 50-48-1. Collins did vote to confirm Kavanaugh.
Heres what you need to know:
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The Recent Bristol Study
This new double-blind investigation of directly administered GDNF took the form of a randomised, placebo-controlled, single-centre trial sponsored by the UK National Health Service which started in 2012 . Patients selected were 3575 years old, had motor symptoms for 5 or more years, with moderate disease severity in the OFF state and motor fluctuations . They all had marked levodopa responsiveness as defined by a> 40% improvement in UPDRS motor score following a levodopa challenge after a practically defined OFF period. Importantly, the major difference with this trial with what had gone before was the use of a new delivery device designed to establish greater coverage of the putamen.
Once implanted with this new intermittent enhanced drug administration system that enabled convection enhanced delivery , patients were randomised. Post-randomisation, patients received a total of 10 study treatments at 4-weekly intervals . At each treatment, 400 L of infusate was delivered per catheter into the post-commissural putamen at a GDNF concentration of 0.2 g/L. Thus, the total GDNF dose given every 4 weeks was 240 g .
Blood sample analyses showed no measurable GDNF plasma concentrations and no GDNF-binding serum antibodies in GDNF-treated patients at any point. This contrasts with the double-blind Amgen study and the earlier open label studies and may relate to the different delivery devices and delivery regimens that were used in each trial.
Analysis Including Only Asian Sites
In the Asian series, not only the SYT11 SNP, but also the ACMSD and MAPT SNPs were monomorphic . Summary effect estimates for the remaining SNPs are shown in . We again observed consistent nominally significant evidence of association for all loci except for STK39 and HLA-DRB5 , which still had an effect size estimate consistent with what was seen in the overall analysis. Results were generally consistent across sites, with the exception of STK39 that showed very large heterogeneity .
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Collins: Trump ‘encouraged’ New Health Care Deal
Collins said that she was stopped everywhere she went in Maine over the past few weeks, saying most wanted her to stay in the Senate.
The people who argued for me to stay in the Senate told me that they felt I was playing such a vital role right now and the times were so tumultuous an contentious that they were worried if I were to leave that the center would sink, Collins said.
At Mass on Saturday, the day after she announced her decision, people stopped her on her walk back to her seat after Communion to thank her. That was an interesting development, she said, laughing.
The women who serve in the Senate hold regular, bipartisan dinners together. While they agree to never discuss what they talk about at those dinners, two attendees admitted that all the women encouraged Collins to remain a legislator.
Were not supposed to talk about what the women talk about when the women have dinner together but we love her service here, Sen. Tammy Baldwin, D-Wisc., said laughing.
Heitkamp, the North Dakota Democrat, feels an affinity for Collins. Both are moderates, albeit from different parties, who have felt both isolated from their party and embraced by the other at times.
Heitkamp, for example, is currently being lobbied by Republicans and the White House to support tax reform, putting her at odds with her own party that remains mostly united in opposition to the Republicans tax framework.
Leigh Ann Caldwell is an NBC News correspondent.
Comparison Of Effect Size Estimates
Five gene loci where both Caucasians and Asian populations were represented showed no difference in effect size estimates that were different beyond chance . Conversely for BST1, the effects were different beyond chance for Asian and Caucasian populations with stronger genetic effects in the former.
Forest plot showing the comparison of effect of each single nucleotide polymorphism in Caucasian and Asian population
Boxes indicate the summary effect estimate. SNPs in 3 loci were monomorphic in the Asian population and thus are not included in the graph. GAK SNP showed deviation from Hardy-Weinberg equilibrium in Asian series and thus excluded from the graph.
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Does Susan Collins Have A Medical Condition Voice Tremors Explored
What medical condition does Susan Collins have? We explore the health of the longstanding Maine Senator.
Sen. Susan Collins, 68, has represented Maine in the Senate since 1997. She is a member of the Republican party. Collins has been re-elected to the Senate four times over the past couple of decades, in 2002, 2008, 2014, and 2020.
Collins was born on 7 December 1952 in Caribou, Maine.
Foreign Policy And National Security
In 2003, Collins voted in favor of the Iraq War Resolution authorizing President Bush to go to war against Iraq. In November 2007, she was one of four Republicans to vote for a Democratic proposal of $50 billion that would condition further spending on a timeline for withdrawing troops, mandating that a withdrawal begin 30 days after the bill was enacted as part of a goal of removing all U.S. troops in Iraq by December 15, 2008. The bill failed to get the 60 votes needed to overcome a filibuster. In April 2008, Collins and Senators Ben Nelson and Evan Bayh met with Bush’s advisor on Iraq and Afghanistan, Douglas Lute, and expressed support for a prohibition on spending for major reconstruction projects, the proposal requiring Iraqis to pay for its security forces to be trained and equipped and reimburse the American military for the estimated $153 million a month the military spent on fueling in combat operations in Iraq. Collins said after the meeting that while the administration did not have a view entirely similar to the senators’, it at least seemed open to their proposal. In June 2014, while growing violence erupted in Iraq under the leadership of Prime Minister Nouri al-Maliki, Collins said the violence would have been slower had a residual NATO force been present in Iraq and that the question was whether airstrikes were effective.
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Gdnf And Parkinsons Disease: Where Next A Summary From A Recent Workshop
Article type: Review Article
Authors: Barker, Roger A.a * | Björklund, Andersb | Gash, Don M.c | Whone, Aland | Van Laar, Ambere | Kordower, Jeffrey H.f | Bankiewicz, Krystofg | Kieburtz, Karlh | Saarma, Marti | Booms, Sigridj | Huttunen, Henri J.j k | Kells, Adrian P.e | Fiandaca, Massimo S.e | Stoessl, A. Jonl | Eidelberg, Davidm | Federoff, Howardn | Voutilainen, Merja H.i | Dexter, David T.o | Eberling, Jamiep | Brundin, Patrikq | Isaacs, Lyndseyr | Mursaleen, Leahr s | Bresolin, Erosr | Carroll, Camillet | Coles, Alasdairu | Fiske, Brianp | Matthews, Helenr | Lungu, Codrinv | Wyse, Richard K.r | Stott, Simonr | Lang, Anthony E.w
Correspondence: Correspondence to: Roger A. Barker, Cambridge Centre for Brain Repair, Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, Cambridge CB2 0PY, UK. Tel.: +44 1223 331160 Fax: +44 1223 331174 E-mail: .
Keywords: GDNF, dopaminergic neurons, NRTN, Parkinsons disease, clinical trials
DOI: 10.3233/JPD-202004
Journal: Journal of Parkinson’s Disease, vol. 10, no. 3, pp. 875-891, 2020
Abstract
The Initial Open Label Trials Of Intraputaminal Injections Of Gdnf Protein
To ensure that GDNF reached the DA terminal plexus within the posterior-dorsal striatum, two small open label studies evaluated direct-to-putamen continuous catheter infusions of GDNF . To effect continuous infusions, GDNF was administered from subcutaneous pumps placed in the abdomen connected to a single catheter to each putamen in a 5-patient cohort in Bristol, UK and to a single-sided unilateral catheter only in a 10-patient cohort studied in Kentucky, USA. The Bristol group initially reported after 6 and 12 months as did the Kentucky group . Doses in the Kentucky study were escalated to 30 g per day and in the Bristol trial, patients doses were on average 30 g per day. Some patients did receive even higher doses but this produced high signal changes on MRI in the putamenchanges which resolved with dose reduction.
Both of these small open label studies reported marked benefits in UPDRS motor scores in the practically defined OFF state with a mean reported improvement of approximately 30%40%. Changes in diary fluctuations were equally encouraging at this open-label stage although it should be noted that the changes were bilateral even in patients who had been in receipt of unilateral infusions for reasons that are not clear.
Based on these encouraging open label observations, a prospective, double-blind, placebo-controlled trial of continuously infusing GDNF to the putamen was initiated.
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