Alleviates Symptoms Of Anxiety And Depression
Reishi mushroom extract, ranked among nootropic adaptogens, also can reduce the level of anxiety a person experiences. In addition, it creates several effects that can help calm the central nervous system and provide adrenal support.
In addition, it can help calm the mind and support a more profound, restful sleep.
Can Help Prevent Neurological Degeneration
Reishi can also heal or even prevent the onset of Alzheimers disease by reducing the oxidative stress that proteins like Abeta can cause. This is achieved through triterpenes and polysaccharides, which research has shown are among the most powerful ingredients Reishi mushrooms have. Theyre also capable of combating tumor growth, strengthening the immune system and reducing blood pressure.
Caregiving For People Living With Parkinsons
Caring for a loved one with PD can be a challenging job, especially as the disease progresses. Former caregivers of a loved one with PD suggest doing the following : Get prepared, Take care of yourself, Get help , Work to maintain a good relationship with your loved one, and Encourage the person with PD for whom you care, to stay active.
Preparing for caregiving starts with education. Reading this fact sheet is a good start. More resources are available to you in theResources section of this fact sheet. Early Parkinsonâs disease usually requires more emotional support and less hands-on care. It is a good time for family members/caregivers to educate themselves about the disease.
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Transcranial Direct Stimulation In Parkinsons Disease Gait Rehabilitation
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Gait variability seen in Parkinsons Disorders arise due to cortical changes induced by pathophysiology of the disease process. Gait rehabilitation is focused to harness the adapted connections involved actively to control these variations during the disease progression. Gait variabilities seen are attributed to the defective inputs from the Basal Ganglia. However, there is altered activation of other cortical areas that support the deficient control to bring about a movement and maintain some functional mobility.
What Causes Parkinson Disease
Parkinson disease arises from decreased dopamine production in the brain. The absence of dopamine makes it hard for the brain to coordinate muscle movements. Low dopamine also contributes to mood and cognitive problems later in the course of the disease. Experts dont know what triggers the development of Parkinson disease most of the time. Early onset Parkinson disease is often inherited and is the result of certain gene defects.
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- Slightly lighter for extreme hand tremors.
Bioactive Molecules Derived From Parasitic Plants And Fungi
Cistanche salsa is a parasitic plant used as a Chinese traditional medicine containing acteoside, echinacoside, and tubuloside as its major phenylethanoid glycosides . C. salsa extracts containing these bioactive molecules have been shown to restore behavioral deficit and dopamine depletion in strata of MPTP induced C57 mice . They has also been demonstrated to protect dopaminergic neurons in the substantia nigra of PD model mice, which correlated with neurobehavior improvements and TH positive neuronal levels .
Gastrodia elata blume is a saprophytic perennial herb used traditionally as a medicine due to its wide range of therapeutic benefits. Protective effects of GE extract against MPP+-induced cytotoxicity in human dopaminergic SHSY-5Y cells demonstrated that GE extract dose dependently improved cell viability maintenance, attenuated oxidative damage, modulated expression of Bcl-2 and Bax, caspase-3, and limited poly polymerase proteolysis . Recently, MPP+ induced MN9D dopaminergic cells were shown to exhibit antiapoptotic effects following GE extract treatment. The v anillyl alcohol present in GE was considered to act by attenuating the MPP+ induced elevation of ROS levels and decreasing the Bax/Bcl-2 ratio and poly polymerase .
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Parkinsons Disease And Wcag 20
Recognizing the challenges posed by impairments such as Parkinsons disease and other disabilities, web accessibility experts have developed the Web Content Accessibility Guidelines 2.0. The most widely recognized standard for web accessibility, WCAG 2.0 establishes a set of standards at three different compliance levels that websites must follow in order to call themselves accessible.
WCAG 2.0 includes several metrics that are relevant for motor and cognitive disabilities such as Parkinsons, including:
- The websites functionality must be entirely accessible via the use of a keyboard, without requiring specific timings for individual keystrokes. If users can move onto a page element via the keyboard, then they can also move away from it as well.
- Whenever possible, content must not be time-limited, or the user is able to extend or adjust the time limit.
- The websites interface and navigation are consistent across pages. Multiple navigational elements, such as the order of pages in a drop-down list, are always repeated in the same order.
- Any input errors automatically detected by the website are indicated to the user, and the website provides suggestions for correcting the errors.
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Limitation Of The Study
Because of the long period required to obtain the normal aged mice and the COVID-19 pandemic, we failed to complete the survival curve experiment, so we cannot fully determine whether triterpenoids of G. lucidum can prolong the life span. Due to the complexity of the chemical constituents of G. lucidum and the high costs of isolation and purification of single components, the present and previous studies have mostly focused on the study of mixtures. Thus, it is difficult to conduct in-depth conduct investigations into the pharmacological mechanisms involved. In this study of potential pharmacological activities of triterpenoids from G. lucidum, behavioral experiments were performed only in APP/PS1 mice , and only the effects of ganoderic acid A have been evaluated in the 3 × Tg-AD mouse model.
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Is Lions Mane Effective In Treating Ms
Lions mane may be effective in treating MS in the future, however more research is needed, especially on humans.
As previously mentioned, MS causes damage to myelin. Current treatments for MS can reduce the severity of the disease, and slow its progression. However, they do not directly repair damaged myelin.
Researchers and doctors are now trying to form treatment strategies for MS that include neurotrophins, such as NGF, for myelin repair. NGF also regulates key structural proteins that can compromise myelin. NGF also promotes the production of another neurotrophin involved in myelination, called brain-derived neurotrophic factor.
Researchers view NGF as a possible therapeutic candidate in treating white matter disorders such as MS.
Researchers previously demonstrated that lions mane may induce NGF. However, these studies have so far mostly involved animals.
found that rats who received lions mane extract daily experienced faster nerve regeneration.
Another preclinical study has shown promising results as well. Researchers supplied rats with H. erinaceus mycelia enriched with erinacines in daily meals.
Following this, the areas of their brain that correlate with certain brain diseases were damaged. The rats that researchers had pretreated with the substance, had a delay in brain damage. This could lead to improvements in ischemic stroke, Parkinsons disease, Alzheimers disease, and depression.
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Rna Isolation And Real
Total RNA was extracted from primary microglial cells using RNAprep Kit according to the manufacturers specifications. RNA was primed with random 9-mers and converted into cDNA by reverse transcription using AMV reverse transcriptase by following the manufacturers recommended protocol . The resulting cDNA was then subjected to real-time PCR with SYBR Premix Ex Taq containing a final concentration of 1× SYBR Green and 0.2M of the primer set of interest in a 20-l reaction. The PCR mixture was run in the DNA engine Opticon 2 . After an initial 10s 95°C denaturation step, the reaction was run through 35 cycles at 95°C for 5s, 60°C for 30s and 80°C for 1s. Melting curve analysis was executed to ensure the resulting products from the reaction had equivalent and appropriate melting temperatures. The specific primers used are listed in . The quantification of target transcripts was based on a calibration curve. The housekeeping gene -actin was targeted for an internal control gene. The test gene data were normalized by corresponding -actin data.
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What Is Parkinsons Disease
Parkinsons disease belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. Parkinsons disease is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination. Symptoms generally develop slowly over years. Parkinsons symptoms usually begin gradually and get worse over time.
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It is a two-way design with a large silicone handle that facilitates grip. Besides, it is compact with a weight of 130 g. Therefore, it is easy to hold even when the elderly person is recovering from an operation. It also includes high-quality stainless steel cookware which is also durable.
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Preparation Of Mes 235 Cell Membrane Fraction
After exposure to MPP+ 10M for 24h, the MES 23.5 cells were harvested in a buffer containing 0.25-M sucrose, 100-mM PBS, 1-mM MgCl2, 1-mM EDTA and 2-M protease inhibitor PMSF, and homogenized with a glass-teflon homogenizer . Then the homogenate was centrifuged at 8000g for 10min at 4°C to remove the crude nuclear fractions. The supernatants were again centrifuged at 100000g for 60 min at 4°C. The precipitates were homogenized and suspended in culture medium and used as the neuronal membrane fractions.
Neuroprotective Properties Of Lions Mane
An animal study published in the International Journal of Molecular Sciences examined the neuroprotective effects of Hericium erinaceus mycelium extract on PC12 cells.PC12 cells are derived from rats, and are often used in animal research to learn about the underlying mechanisms of brain disorders on a cellular level.The results of this study show that the fruiting bodies aqueous extract of lions mane successfully induced differentiation and formation of PC12 cells.Due to the neuroprotective properties of this adaptogenic mushroom, the mice that were administered the mushroom extract showed significant improvements in cognitive functions and processes.The mushroom extract seemed to improve the results of various tests that measure recognition memory in wildtype mice, including the water maze and the rotarod tests.
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Cerebral Dopamine Neurotrophic Factor
Developed by TreatER, a European Union-funded research and development project which aims to develop a novel treatment for Parkinsons disease using a drug called CDNF .
It is a protein found naturally in the body and may be able to alleviate Parkinsons symptoms and even stop its progression after being implanted into the brain by a neurosurgeon through catheters.
The project is currently the worlds first clinical study in humans testing natural CDNF and its being conducted at three European university hospitals: Karolinska University Hospital and Skane University Hospital in Sweden, and Helsinki University Hospital in Finland.
The team is also trying to identify easier and cheaper ways for the CDNF drug to be inserted into places in the body where it can best treat the symptoms of Parkinsons.
What Are Reishi Mushrooms
What is reishi? What is ganoderma?
Like other disease-fighting mushrooms, reishi mushrooms are a type of fungus that grow outdoors.
Theyre native to several parts of Asia, including China, Korea and Japan. While theyre edible and often described as bitter-tasting with a tough texture, youre much more likely to find them in supplement, tincture or powder form.
Reishi mushrooms, also known by their scientific name Ganoderma lucidum, grow above ground and produce a fruiting body along with connective strands , which are turned into an herbal medicines, tinctures, teas, powders and extracts.
Also known as lingzhi mushroom, you may be surprised to learn just how long lingzhi mushroom benefits have been utilized.
For most of history in Traditional Chinese Medicine, fully grown reishi mushrooms were dried, cut into slices, boiled in hot water and then steeped to make a healing tea/soup. Today, manufacturers of reishi products use a processing technique in which reishi is boiled multiple times at a high pressure, allowing the active ingredients to be extracted to form a tincture.
Thanks to the concentrated compounds that these mushrooms contain, potential reishi mushroom benefits include protection against tumor formation, improved liver function, better heart health, enhanced blood sugar control, and a reduced risk of asthma, allergies and infection.
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Side Effects Of Lions Mane Mushroom
Side effects are a big nuisance on this earth.
Lions mane poses some serious side effects if taken by an asthmatic patient. Lions mane can exacerbate the asthmatic attack as they increase the levels of leukotrienes in the body. The leukotrienes are responsible for bronchoconstriction and inflammation of airways.
So, the lions mane is a no-go zone for someone with asthma.
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Enhanced Autophagy Effects Of Triterpenoids Of G Lucidum On The Brain Of Normal Aged Mice
A mind-tranquilizing effect was the main function of G. lucidum in its traditional application, and in our previous study, we showed that alcohol extracts of G. lucidum could delay the progression of AD by regulating DNA methylation in rodents . Thus, we evaluated other potential effects and mechanisms of the aging brain. Tunnel assays for the detection of apoptotic cells showed there were fewer apoptotic cells in brain tissue samples in the TGL-treated groups than that in the control group . The telomere lengths in brain tissue samples were longer in the female TGL-treated group than that in the female control group . Then we found the expression of phosphorylated-mTOR and LC3A/B were upregulated in the TGL-treated groups . Indicate that triterpenoids of G. lucidum may delay brain aging by delaying telomere shortening, activating autophagy, and other functions.
Figure 3. Effects of triterpenoids of G. lucidum on the brain of normal aged mice. TGL shows an improvement in brain cells apoptosis rate using TUNEL staining TGL shows inhibition of telomere shortening in the brain TGL shows an impact on the mTOR pathway to enhance the autophagy. Data are presented as the means ± SD of more than six independent experiments, and more than three independent experiments in Western blot. *p< 0.05 and **p< 0.01.
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Parkinsons Disease And How It Works
Parkinsons disease is a neurological disorder more specifically, a neurodegenerative disease.
Its unclear what causes it. Scientists state it most likely involves inflammation targeting certain neurons in the brain, thus causing them to degenerate and malfunction.
At first, effects may be unnoticeable but then slowly increase over the years.
Symptoms are different in every person and can emerge differently. But the most prominent symptoms tend to include:
- Sleep disorders
Ganoderma Lucidum Spores On The Treatment Of Parkinson’s Disease Wonders
Ganoderma or red Reishi Spore might help to improve your health. Its biggest medical benefit is the way it strengthens your immune system. It can be considered a preventative medicine instead of a treatment for a certain disease.
Ganoderma Spore makes sense due to its ability to improve the function of the immune system. It is said to help the body adapt to many types of body stresses such as trauma, sleep deprivation, temperature, exposure to toxins, psychological stress, infection, or radiation. It helps the organisms in the body return to a normal, balanced state after illness.
Red Reishi or Ganoderma Spore, acts as regulator that fine-tunes our immune systems. Its main purpose is to detect pathogens such as bacteria and other viruses that attack the body.
A compromised immune system can develop viruses, parasites, bacteria and fungi that cause disease. Repeated use of common antibiotics, anti-viral agents, and anti-fungal medications can cause microbes to develop a resistance to the medications. Consuming red Reishi can eliminate these problems. It’s gaining popularity among many as an adjunct to combating the disagreeable side effects of radiation and chemotherapy associated with cancer treatment.
Red Reishi has exceptional anti-stress qualities that can help improve memory, reduce tension and sharpen your concentration. It is particularly helpful in the treatment of degenerative diseases, such as Alzheimer’s and dementia that affects the elderly.
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