Adopt A Regular Sleep Rhythm
Optimizing your circadian rhythm and improving your sleep promotes brain health and may reduce your risk of developing Parkinsons disease. To optimize your rhythm, create a regular sleepwake schedule and sleep in a room that is completely dark and free of light pollution from electronic devices. Avoid using blue light-emitting devices, such as computers and cell phones, several hours before bed. If you must use these devices, wear a pair of blue light-blocking glasses while doing so; the glasses prevent blue light from disrupting your sleep rhythm.
Stooping Or Hunching Over
Are you not standing up as straight as you used to? If you or your family or friends notice that you seem to be stooping, leaning or slouching when you stand, it could be a sign of Parkinson’s disease .
What is normal?If you have pain from an injury or if you are sick, it might cause you to stand crookedly. Also, a problem with your bones can make you hunch over.
Glutathione And Glutathione Peroxidase Protect Against Neurodegeneration
Another approach to ameliorate cellular deterioration caused by ROS in PD is to raise the intracellular levels of the tripeptide glutathione . Antioxidant defenses in SN are relatively low, compared to other regions of CNS, due to low levels of GSH, particularly during the early stages of PD when extravesicular DA and its degradation products may act as a GSH depleting agents . N-acetylcysteine shows antioxidant properties by restoring cellular GSH, which participate in important endogenous antioxidant systems. In experimental studies NAC has been reported to protect against PD development .
Glutathione acts either alone or together with an appropriate enzyme system, viz. glutathione peroxidases , to reduce ROS. Also, GSH detoxifies xenobiotics and maintains sulfhydryl proteins in a reduced state . The antioxidant characteristics of GSH have been demonstrated in several models of oxidative stress, including models using buthionine-sulfoximine to deplete GSH . In these studies, the GSH depletion increased oxidative stress in whole cells as well as in mitochondrial fractions. Depletion of GSH with BSO potentiated the MPTP-induced tyrosine hydroxylase-positive neuron death in pars compacta of SN . Furthermore, NAC treatment after MPTP or rotenone exposure in the GSH-depleted models, restored mitochondrial complex 1 and protected against DA loss in SN .
It is tempting to suggest that supplementation with NAC in adequate doses to patients with PD may inhibit disease progression.
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Genetics Coffee Consumption And Parkinson’s Disease
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Office of Public Health GenomicsCenters for Disease Control and Prevention
Parkinson does follow a broad pattern. While it moves at different paces for different people, changes tend to come on slowly. Symptoms usually get worse over time, and new ones probably will pop up along the way.
Parkinsonâs doesnât always affect how long you live. But it can change your quality of life in a major way. After about 10 years, most people will have at least one major issue, like dementia or a physical disability.
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Eat Wisely And Choose Whole Foods
A diet based on whole, nutrient-dense foods is an excellent first step for reducing your risk of Parkinsons disease. A high intake of fresh vegetables, fruits, nuts and seeds, fish, olive oil, coconut oil, fresh herbs, and spices is associated with a reduced risk of PD development and slower disease progression. Eating plenty of vegetables and fiber boosts levels of an anti-inflammatory group of gut bacteria that are inversely associated with Parkinsons disease and may play a protective role against neurodegenerative processes in the brain.
Choose organic foods over conventionally grown foods as much as possible. Eating organic reduces your exposure to neurotoxic pesticides and herbicides. If you cant buy all organic food, refer to the Environmental Working Groups Dirty Dozen and Clean Fifteen lists to determine which types of conventional produce are lowest in pesticide residues and are safe to buy non-organic.
What Parkinsons Looks Like In The Brain
PD is a progressive disease of the nervous system in which;a persons brain gradually stops producing the neurotransmitter, dopamine. With less and less dopamine, they lose the ability to regulate their movements, body, and emotions. The condition is associated with degeneration of the basal ganglia of the brain and alterations in other parts of the brain and neurotransmitters.
PD progresses slowly in most people with symptoms often taking years to develop, and many can live for years with the disease.;PD itself isnt fatal. However, complications from it are serious and can lead to death.;The four main-movement related;symptoms of Parkinsons are:
- Tremor, which means shaking or trembling. Tremor may affect your hands, arms, or legs.
- Stiff muscles.
- Problems with balance or walking.
Many other problems, such as depression, constipation, sleep disturbances, and cognitive issues, may be present.
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What And How Can Physical Activity Prevention Function On Parkinsons Disease
1Laboratory of Brain Function and Disease, Institute for Brain Sciences Research, School of Life Sciences, Henan University, China
2School of Physical Education, Henan University, Kaifeng, 475004 Henan, China
3Henan International Joint Laboratory of Nuclear Protein Regulation, Kaifeng 475004, China
Parkinsons disease is a second common neurodegenerative disease all over the world . Most of the patients are between 50 and 60 years old. As the aging of population increases, the risk of Parkinsons disease increases accordingly, and the incidence in young- and middle-aged people increases. As a chronic disease, PD has a long course and is prone to recurrence. The reduction of dopamine is the leading cause of PD in previous studies . The consequent loss of the neurotransmitter DA in the striatum leads to the primary motor symptoms of PD, namely, bradykinesia, tremor, rigidity, and postural instability . At present, the clinical trials are valid only for symptom management; no medications have proved effective in stopping the disease process . Therefore, revealing the pathological mechanism of PD is extremely important for the effective prevention and treatment of this disease.
2. Epidemiology Study of Parkinsons Disease
2.1. Incidence of Parkinsons Disease
2.2. Risk Factors and Protective Factors of Parkinsons Disease
3. Physical Activity Prevention and Parkinsons Disease
Conflicts of Interest
Incidence Of Parkinson’s Disease
A study of data from 2005 to 2018 indicated that PD is one of the most common neurodegenerative diseases worldwide . The influence factors in the study of PD were mainly divided into prospective studies and case-control studies. In the world’s high-income countries, the median incidence of PD is 14/100,000, and the rate is 160/100,000 in people aged 65 or older . Among the 40-year-old American population, the risk of PD in men is about 2%, while in women is 1.3% . The age-adjusted prevalence of PD reflects morbidity and mortality, which in Africa is lower than that in Europe, the United States, and Asia . Currently, there are fewer morbidity data related to racial or ethnic, but the incidence varies according to the current research. A study from a large medical institution in the United States indicated that the incidence in Blacks is higher than that in Whites. The age-adjusted and gender-adjusted incidence of PD was highest among Hispanics , followed by non-Hispanic whites , Asian , and Blacks . Another study based on beneficiaries of US health insurance suggested that the incidence of PD in Whites was also higher than that in Blacks or Asians . The incidence of PD increases with age and reaches a maximum at 80 years old. In the Chinese population aged 60 years, the incidence of PD is more than 1%.
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Tips For Daily Living
If you are already living with Parkinsons disease, here are some tips to manage it:
- Exercise your brain. Read, work on crossword puzzle, do Sudoku, or engage in other activities that use your brain.
- Get moving. If you feel comfortable walking, swimming, or riding an exercise bike, go for itand try to do it on a regular basis.
- Try tai chi. We think of tai chi as a mind-body exercise, and it is, but it also has roots as a martial art in China. A 2012 study found that practicing tai chi helped people with moderate Parkinsons disease maintain stability and balance. And a 2014 study found that tai chi can help people reduce their risk of falling. It incorporates a flowing series of coordinated movements to help you maintain flexibility, strength and balance, and it can be easily adapted to meet your abilities.
- Practice yoga. You dont have to perform headstands or other physically challenging poses to get significant benefits from practicing yoga. You can improve your balance, mobility, flexibility, and strength with a form thats adapted for you.
- Find a support group. Whether you prefer an online support group or a group that meets in person, a support group can be an invaluable resource for helping you live with Parkinsons disease.
Eight Causes Of Parkinsons Disease
Many scientists and doctors dream of developing a cure for Parkinsons disease. However, the reality is that Parkinsons disease is caused by multiple factors and therefore is unlikely to respond to a single therapy.
we can make more progress and improve quality of life by addressing the many underlying causes of Parkinsons disease
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Natural Remedy For Parkinsons #4 Chlorella And Borax:
If you have a neurological disease such as Parkinsons orAlzheimers, the importance of removing heavy metals from the body especiallyfrom the brain and nervous system cannot be overstated. Heavy metalsaccumulate in the brain and nervous system at a rapid rate and cause damage tothe neurological pathways and brain inflammation. Fluoride is one ofthe worst, however, mercury, lead, aluminium and cadmium are also extremely dangerous.Chlorella and borax not only remove these heavy metals completely, theycontinue to prevent further toxic build-ups.
Chlorella is a miracle blue-green algae and one of themost powerful detoxifiers and chelators yet discovered. Whenits combined with cilantro, its benefits are enhancedsignificantly. A Russian study found that chlorella, combined with cilantro,was able to remove all heavy metals from the body, including fluoride and mercury,with no adverse or harmful side effects. You can purchase chlorellain powdered form online or from most health food stores. Just make sure you buythe Broken Cell Wall Chlorella as this is the strongest and most bio-available.For dosage recommendations, simply follow the directions on the container.
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Reduce Stress At Work
Studies show that chronic psychological stress increases the risk of Parkinsons disease. Chronic stress can cause inflammation of the brain which kills dopamine-producing neurons.
We spend most of our lives at work or working in an office space. We take our stress from work and bring it home with us. One of the most important things a person can do for his or her overall health is to reduce stress. Physical and emotional stress can lead to many diseases and issues with the brain. Focusing on ways of alleviating daily stress will is a key habit to prevent Parkinsons Disease.
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Get Enough Vitamin D And Omega 3s
Parkinsons is an inflammatory disease of the brain. Researchers have studied the anti-inflammatory effects of omega-3 fatty acids which have shown to prevent the degeneration of brain cells. A 2008 study done in Canada shows that omega- 3 helps to protect the cognitive system from a loss of dopamine.
Vitamin D comes from the sun, it also comes from animal fat. Consuming the proper amounts of Vitamin D allows for your body to absorb calcium and phosphorus. Vitamin D also helps boost the bodies immunity, increases bone health, allows for the body to absorb minerals, protects the body from dementia, boosts energy, and effects the mood and mental health. Studies have proven that consuming the proper amounts of Vitamin D can help to prevent Parkinsons Disease.
Eat Fresh Raw Vegetables
If you needed more reasons to eat your vegetables, this should be the clincher. Studies show that increased amounts of the B vitamin folic acid, found primarily in vegetables, can significantly reduce the risk of Parkinsons.
The best sources of folic acid are simultaneously some of the healthiest foods on the planet, namely dark green vegetables like broccoli, spinach, collard greens, brussels sprouts, asparagus and okra all of which can be grown in your backyard! This B vitamin can also be found in avocado, legumes and lentils.
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Physical Activity And Exercise
People involved in moderate to vigorous type of physical activities usually experience low prevalence of Parkinsons disease in a significant way. If a person has already developed Parkinsons disease problem, he may not expect to cure it completely, but in case a person opts to perform daily exercise, he or she may expect to avoid low neurotransmitters levels in their bodies. Regular workout to exit sweat regularly is obviously the best thing, which a person may perform for his healthy brain.
Movement of your body increases the flow of blood towards the brain to elevate oxygen levels to activate biochemical changes and to protect the new resultant neurons based on bathing them within the nerve growth factor. These conditions encourage growth of your brain and change it by simply forming a large number of neural pathways as well as synaptic connections, known popularly as neuro plasticity. Be active and prevent Parkinsons disease.
Can Parkinsons Disease Be Prevented
Unfortunately, no. Parkinsons disease is long-term disease that worsens over time. Although there is no way to prevent or cure the disease , medications may significantly relieve your symptoms. In some patients especially those with later-stage disease, surgery to improve symptoms may be an option.
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Optimise Your Diet Reduce Your Toxic Load
While the cause of Parkinsons is not known, environmental toxins such as pesticides and herbicides are implicated. Researchers have found levels of these chemicals to be higher in the brains of Parkinsons sufferers and incidence of Parkinsons is higher in areas with greater use of these chemicals. It makes sense to avoid any environmental toxins that you can. Also, consider your intake of dietary toxins such as alcohol and caffeine avoiding or reducing these may reduce the load on your bodys detoxification pathways.
Causes And Risk Factors Of Parkinsons Disease
Most cases of Parkinsons disease are idiopathic, meaning the cause is unclear.
Its widely believed that a person with Parkinsons may have been genetically vulnerable to the disease, and that one or more unknown factors in the environment eventually triggered the disease.
Most of the;symptoms of Parkinsons;disease come from the loss of neurons in an area of your brain called the substantia nigra.;
Normally, the neurons in this part of the brain make the chemical messenger dopamine, which allows communication with another area of the brain, the corpus striatum.
This communication helps produce smooth, purposeful movement. When the neurons in the substantia nigra die, the resulting loss of communication leads to the motor symptoms of Parkinsons.
Although the cause of this cell death is unknown, many researchers believe that the cells are killed by clumped proteins called Lewy;bodies.
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How Can My Aging Loved One Avoid Parkinsons Naturally
By Natalie Hodge 9 am on October 30, 2019
More than 1.5 million people in the United States have Parkinsons, and this pervasive disease can impact almost every aspect of an individuals health. While doctors havent come up with a permanent cure for Parkinsons, theyve identified a few natural strategies that can be used to minimize the risk of developing this neurodegenerative disorder.
Physical Exercise Can Reduce Inflammation And Oxidative Stress
Accumulation of the -syn protein in neurons leads to inflammation in the brain . Aggregation of -Syn induced the production of proinflammatory cytokines, which are toxic and thus cause cell death of dopaminergic neurons . Therefore, reducing the inflammatory response may be an effective way to deal with PD. Several studies found that physical exercise can improve the oxidative metabolism and the expression of antioxidant enzymes in the brain of mice . Tuon et al. indicated that physical exercise was beneficial in reducing the production of proinflammatory proteins and inflammation in the brain of PD mice . This result is consistent with previous studies by Sung et al. and Al-Jarrah et al., which suggested that physical exercise could decrease the level of proinflammatory proteins in the striatum and hippocampus in the PD experimental model through reducing the activity of microglia .
Based on the above studies, we speculate that multiple pathways are involved in the regulation of physical exercise in PD animal experiments, such as alleviate the production of proinflammatory factors in the musculoskeletal muscle, reduce the expression of inflammatory factors in the brain, reduce the inflammatory response, and regulate oxidative stress .
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