Causes Of Parkinson’s Disease
The causes of Parkinsons disease are still greatly unknown. Scientists who have studied this disorder estimate that 10-15% of cases come from genetics after seeing a series of genetic mutations that were common in Parkinsons patients.;
Doctors suspect that environmental factors and lifestyle choices may have effects on the severity of Parkinsons disease symptoms. Exposure to chemicals like pesticides may increase the likelihood of developing Parkinsons disease. On the other hand, a good diet and regular exercise may decrease your chances.
What Are The Latest Approved Treatments For Parkinsons Disease
Several medicines have been approved for the treatment of Parkinsons disease. Here are some of the available medicines for Parkinsons disease:
Nuplazid was approved for the treatment of patients with hallucinations and delusions associated with Parkinsons disease psychosis by the Food and Drugs Administration on April 29, 2016. On December 3, 2020 The approved an update to the prescribing information for Nuplazid that will allow the medication to be taken more easily by Parkinsons patients who have difficulty swallowing.
Ongentys is a medication used for the treatment of Parkinson disease. It is indicated for the treatment of adult patients with Parkinson disease. It is used as an add-on to levodopa/DOPA decarboxylase inhibitors in patients who are having fluctuations in the control of their condition.
Opicapone was approved for treating patients with Parkinsons Disease as an add-on to levodopa/DOPA decarboxylase inhibitors in patients who are having fluctuations in the control of their condition by the European Medicines Agency on June 24, 2016 and by the Food and Drug Administration on April 24, 2020.
Nourianz/Nouriast was approved by the Food and Drug Administration , USA, on August 27, 2019 and by the Pharmaceuticals and Medical Devices Agency , Japan, in June 2013.
Parkinsons Foundation Centers Of Excellence And Medicinal Marijuana
The Parkinsons Foundation, in partnership with Northwestern University researchers, studied attitudes about cannabis at 40;Centers of Excellence. To the best of our knowledge, this is the first study to provide data on the practices, beliefs and attitudes of expert PD physicians concerning cannabis use.;;
The results were interesting: most experts said they knew what cannabis did, but disagreed on the details. While there is no general agreement on what the benefits might be for people with PD, the survey confirmed that cannabis is a popular subject within Parkinsons Foundation centers as 95 percent of neurologists reported patients have asked them to prescribe it.
Cannabis study results also included:
- Only 23 percent of physicians had any formal education on the subject of cannabis , thus 93 percent of physicians want cannabis taught in medical school.
- Physicians reported that 80 percent of their patients with PD have used cannabis.
- Only 10 percent of physicians have recommended the use of cannabis to patients with PD.
- In terms of memory: 75 percent of physicians felt that cannabis would have negative effects on short-term memory and 55 percent felt that cannabis could have negative;effects on long-term memory
- Only 11 percent of physicians have recommended use of cannabis in the last year
This graph shows how physicians expect cannabis would improve, worsen, or show no effect to PD-related symptoms given their expertise and observations of patients with PD.
Tips To Slow Or Stop Progression
Some suggest that you may be able to delay some of the effects of Parkinsons disease through regular physical activity. Ideally this would include a combination of exercise that includes:
- aerobic activity
- balance training
- functional activities
The NINDS has funded a number of studies to learn more about the impact of exercise, including whether exercise might help people delay the need for medication.
What Is Parkinsons Disease
Parkinsons disease is a progressive brain disorder that causes shaking and muscle stiffness, and slows movement. It develops when neurons in a particular part of the brain stop working properly and are lost over time. These neurons produce an important chemical called dopamine. Dopamine is used by the brain to send messages across brain areas to help control movement. Eventually, the brain cannot make enough dopamine to control the movement properly.1,2
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Surgery For Parkinsons Disease
Based on the severity of the condition and the medical profile, the doctor may recommend surgery as one treatment option for Parkinson’s disease.
There are several types of surgery that may be performed that can help patients with Parkinson’s disease. Most of the treatments are aimed at helping the tremor or rigidity that comes with the disease. In some patients, surgery may decrease the amount of medication that is needed to control the symptoms.
There are three types of surgeries that may be performed for Parkinson’s disease, including the following:
It is important to remember that surgery may help with symptoms of Parkinson’s disease, but does not cure the disease or stop the progression of the disease.
Exploring Alternative Therapies For Parkinsons Disease
Because no two Parkinsons disease patients are alike, a Michigan Medicine neurologist encourages patients to consider conventional and alternative treatment options.
There may very well be similarities between given patients, but every patient is unique, he says. Everybody is very different in their overall needs, as well as in their responses to treatments and medications.
For this reason, when it comes to the topic of alternative therapies for treating Parkinsons disease, Spears believes that patients are the best educators. There may be that one patient on the Internet who responds remarkably well to marijuana, but that may not be the case for the next person, he says.
Spears also wants to clear the air on how he views alternative therapies: Not as a last resort for PD patients, but as a diverse group of medical therapies, interventions, treatments, practices or products that dont fall under the category of conventional Western treatment practices.
Too often, patients believe that alternative therapies are a doctors way of saying, We’ve exhausted all conventional measures. One last desperate option is to put you on an alternative medicine.
This, he says, is not the case.
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Parkinson’s Disease Symptoms Everyone Should Know
Parkinsons disease symptoms can include tremor and trouble with movement, along with emotional and cognitive changes.
Parkinson’s disease symptoms can vary significantly from person to person. Some people may have range of motor symptoms, like tremor, stiffness, and slow movements. Others may also experience the non-motor symptoms of Parkinson’s disease, such as anxiety, cognitive changes, and loss of smell.
It has to do with a chemical messenger known as dopamine, which plays a role in the brain’s ability to control movement, coordination, and emotional responses. In Parkinson’s disease, the brain cells that produce dopamine either stop doing their job or they die out, resulting in both motor and non-motor symptoms. ; It’s not always easy to tell if someone you care about has Parkinson’s disease. Let’s take a closer look at the symptoms of the disease and signs that someone should make an appointment with their doctor.
What Lifestyle Changes Can I Make To Ease Parkinsons Symptoms
Exercise: Exercise helps improve muscle strength, balance, coordination, flexibility, and tremor. It is also strongly believed to improve memory, thinking and reduce the risk of falls and decrease anxiety and depression. One study in persons with Parkinsons disease showed that 2.5 hours of exercise per week resulted in improved ability to move and a slower decline in quality of life compared to those who didnt exercise or didnt start until later in the course of their disease. Some exercises to consider include strengthening or resistance training, stretching exercises or aerobics . All types of exercise are helpful.
Eat a healthy, balanced diet: This is not only good for your general health but can ease some of the non-movement related symptoms of Parkinsons, such as constipation. Eating foods high in fiber in particular can relieve constipation. The Mediterranean diet is one example of a healthy diet.
Preventing falls and maintaining balance: Falls are a frequent complication of Parkinson’s. While you can do many things to reduce your risk of falling, the two most important are: 1) to work with your doctor to ensure that your treatments whether medicines or deep brain stimulation are optimal; and 2) to consult with a physical therapist who can assess your walking and balance. The physical therapist is the expert when it comes to recommending assistive devices or exercise to improve safety and preventing falls.
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How Do I Prevent Falls From Common Hazards
- Floors: Remove all loose wires, cords, and throw rugs. Minimize clutter. Make sure rugs are anchored and smooth. Keep furniture in its usual place.
- Bathroom: Install grab bars and non-skid tape in the tub or shower. Use non-skid bath mats on the floor or install wall-to-wall carpeting.
- Lighting: Make sure halls, stairways, and entrances are well-lit. Install a night light in your bathroom or hallway and staircase. Turn lights on if you get up in the middle of the night. Make sure lamps or light switches are within reach of the bed if you have to get up during the night.
- Kitchen: Install non-skid rubber mats near the sink and stove. Clean spills immediately.
- Stairs: Make sure treads, rails, and rugs are secure. Install a rail on both sides of the stairs. If stairs are a threat, it might be helpful to arrange most of your activities on the lower level to reduce the number of times you must climb the stairs.
- Entrances and doorways: Install metal handles on the walls adjacent to the doorknobs of all doors to make it more secure as you travel through the doorway.
Assembling Your Care Team
Assembling a team that will provide you with physical and emotional support and adapt to your needs over time is one of the best ways to remain healthy. Parkinsons disease is complex and requires an interdisciplinary approach to care. The care team may include, but is not limited to:
- Movement disorder specialist
- Rehabilitation specialists including physical, occupational, and speech therapists
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Symptomatic And Neuroprotective Therapy
Pharmacologic treatment of Parkinson disease can be divided into symptomatic and neuroprotective therapy. At this time, there is no proven neuroprotective or disease-modifying therapy.
Levodopa, coupled with carbidopa, a peripheral decarboxylase inhibitor , remains the gold standard of symptomatic treatment for Parkinson disease. Carbidopa inhibits the decarboxylation of levodopa to dopamine in the systemic circulation, allowing for greater levodopa distribution into the central nervous system. Levodopa provides the greatest antiparkinsonian benefit for motor signs and symptoms, with the fewest adverse effects in the short term; however, its long-term use is associated with the development of motor fluctuations and dyskinesias. Once fluctuations and dyskinesias become problematic, they are difficult to resolve.
Monoamine oxidase -B inhibitors can be considered for initial treatment of early disease. These drugs provide mild symptomatic benefit, have excellent adverse effect profiles, and, according to a Cochrane review, have improved long-term outcomes in quality-of-life indicators by 20-25%.
Neuroprotective therapy aims to slow, block, or reverse disease progression; such therapies are defined as those that slow underlying loss of dopamine neurons. Although no therapy has been proven to be neuroprotective, there remains interest in the long-term effects of MAO-B inhibitors. Other agents currently under investigation include creatine and isradipine.
What Will A Cure For Parkinson’s Look Like
Because Parkinson’s varies so much from person to person, there may not be a single ‘cure’.
Instead we may need a range of different therapies to meet the needs of the individual and their specific form of the condition.
This mix may include treatments, therapies and strategies that can:
- slow or stop the progression of the condition
- replace or repair lost or damaged brain cells
- control and manage particular symptoms
- diagnose Parkinson’s at the earliest possible stage.
And this could involve medical treatments, such as drugs and surgical approaches, as well as lifestyle changes, for example to diet and exercise.
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Is Medical Marijuana An Option For Me
What’s next for a person with PD who wants to know if medical marijuana is an option? “Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for PD,” said Dr. Michael S. Okun, the Parkinson’s Foundation National Medical Advisor.
Research is still needed to determine how medical marijuana should be administered and how its long-term use can affect symptoms of PD. To keep patients safe, states that legalize medical marijuana will eventually need to develop training programs for doctors and medical teams that prescribe medical marijuana. Consult your doctor to see if medical marijuana is an option for you.
The Parkinsons Foundation is designed to;help guide the PD community in making informed decisions about using cannabis for Parkinsons. The statement is based on the input from 46 experts who attended the Foundations first-ever medical marijuana convening. Read it now.;
Page reviewed by Dr. Bhavana Patel, Movement Disorders Fellow at the University of Florida, a Parkinsons Foundation Center of Excellence.
Naturalremedy For Parkinsons #10 Foods You Must Avoid
There are certain foods that are known to worsen thesymptoms of Parkinsons and certain foods that are known to help. Healthadvocate, Dr Joseph Mercola, says that Parkinsons disease is primarily relatedto poor lifestyle choices, particularly poor dietary habits. Increasing yourbodys natural dopamine levels is also extremely important in your fight againstPD.
The foods and liquids you should be eating and drinkingmore of to help you along include:
·;;;;;;;;Clean Filtered Water Clean filtered water helpsto flush toxins from the body and hydrate the cells .Try and aim to drink at least two liters of water every day, and under nocircumstances drink tap water! Tap water is laced with toxic fluoride and otherchemicals and heavy metals so NEVER drink it. Buy yourself a good quality waterfilter. Its worth the investment. ;;
·;;;;;;;;Whole Foods and Raw Foods Eat plenty oforganic mixed berries, green leafy vegetables, liver , fish,eggs, nuts and seeds such as chia and flaxseeds, along with plenty of herbs andspices. When it comes to buying any of these remember fresh is alwaysbest.;;
·;;;;;;;;Consume Lots of Probiotics Good gutbacteria are needed for strong immunity and healthy digestive function, whichin turn produces healthy brain and nerve function. You can learn how to makeyour own probiotic rich foods such as kefir, sauerkraut, kombucha and yogurt hereCultures for Health.;;
The foods you should be avoiding or not eating at allinclude:
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Symptoms Of Parkinsons Disease
Parkinson’s disease has four main symptoms:
- Tremor in hands, arms, legs, jaw, or head
- Stiffness of the limbs and trunk
- Slowness of movement
- Impaired balance and coordination, sometimes leading to falls
Symptoms of Parkinsons and the rate of progression differ among individuals. Sometimes people dismiss early symptoms of Parkinson’s as the effects of normal aging. In most cases, there are no medical tests to definitively detect the disease, so it can be difficult to diagnose accurately.
Early symptoms of Parkinson’s disease are subtle and occur gradually. For example, affected people may feel mild tremors or have difficulty getting out of a chair. They may notice that they speak too softly, or that their handwriting is slow and looks cramped or small. Friends or family members may be the first to notice changes in someone with early Parkinson’s. They may see that the person’s face lacks expression and animation, or that the person does not move an arm or leg normally.
People with Parkinson’s often develop a parkinsonian gait that includes a tendency to lean forward, small quick steps as if hurrying forward, and reduced swinging of the arms. They also may have trouble initiating or continuing movement.
Natural Treatment For Parkinsons #1 Cannabis/medicalmarijuana:
Cannabis, aka medical marijuana, is an incredibletreatment for Parkinsons disease. You can have a Parkinsons patient shakingviolently and uncontrollably, and yet within 30-40 minutes of self-administering with some cannabis, their symptoms will almost completely disappear. Watch this short 2minute video from Parkinsons sufferer, Ian Frizell, who shows you what he waslike before self-medicating with cannabis and then again after. The change is truly astonishing!;
Taylor French is another Parkinsons patient thatundergoes a remarkable transformation once he ingests what he calls nutritional vegetable extract . This guy has an advanced form ofParkinsons and is normally confined to a wheelchair with limited use of hisbody due to stiff and rigid muscles . But after ingestingsome cannabis hes able to walk, and incredibly, in his video he even getsinto his car and drives off down the road!
You can view it here
Elyse Del Francia also tells the story of her Parkinsonssuffering husband, and the time she decided to smother his morning pancakes withsome canabutter. She said
Within45 minutes of eating a pancake with marijuana on it, he stopped shaking. Thatwas my lightbulb moment. Thats when I knew that I was onto something thatwould relieve his pain and suffering, because its horrible, horrible, to haveParkinsons Disease and not have any relief. I feel that this is something thathelps so many people in so many ways with pain and suffering.;5
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Risk Factors And Causes
There isnt one single cause of Parkinsons that has been proven at this time. Researchers believe a loss of the neurotransmitter dopamine, neurological damage, inflammation and brain cell deterioration are among the primary factors that trigger Parkinsons development. But why exactly patients develop these problems is a complex issue that remains up for debate.
What is known is that certain risk factors can make someone more susceptible to developing Parkinsons disease, which can include:;
- Being a man, especially during older age. Research suggests that men in their 50s and 60s are most likely to develop Parkinsons.
- Genetic susceptibility: Studies have now identified several gene mutations that can put someone at a greater risk. Parkinsons has also been found to run in families, and having a sibling or parent increases someones risk.
- Damage to the area of the brain called the substantia nigra, which produces brain cells that are responsible for making dopamine.
- Toxicity and exposure to chemicals, including pesticides present on produce;from non-organic farming.;Living in a rural area and drinking well-water that might contain chemicals is another environmental risk factor.
- Poor diet, nutrient deficiencies, food allergies and an unhealthy lifestyle.
- Hormonal imbalances and other medical conditions that affect cognitive health and increase inflammation.