Tuesday, October 3, 2023
Tuesday, October 3, 2023
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Can You Have Lewy Body Dementia Without Parkinson’s

What Are The Treatments For Lewy Body Dementia

Living With Lewy Body Dementia and Parkinsonism | Patient Perspectives | Being Patient Alzheimer’s

There is no cure for LBD, but treatments can help with the symptoms:

  • Medicines may help with some of the cognitive, movement, and psychiatric symptoms
  • Physical therapy can help with movement problems
  • Occupational therapy may help find ways to more easily do everyday activities
  • Speech therapy may help with swallowing difficulties and trouble speaking loudly and clearly
  • Mental health counseling can help people with LBD and their families learn how to manage difficult emotions and behaviors. It can also help them plan for the future.
  • Music or art therapy may reduce anxiety and improve well-being

Support groups can also be helpful for people with LBD and their caregivers. Support groups can give emotional and social support. They are also a place where people can share tips about how to deal with day-to-day challenges.

NIH: National Institute of Neurological Disorders and Stroke

Who Gets Parkinson’s Disease Dementia

No two cases of Parkinson’s are exactly alike, so it’s hard to say for sure who will develop Parkinson’s disease dementia and who will not. However, researchers have identified several factors that may increase a person’s risk for Parkinson’s disease dementia, including:

  • Older age, especially at the time Parkinson’s symptoms began
  • Being a man
  • Advancing to late-stage Parkinson’s disease
  • Experiencing visual hallucinations

Are There Medicines To Treat Dlb

Though there is no cure for DLB yet, there are medications that help manage the symptoms. These medications are called cholinesterase inhibitors, and they can help if a person with DLB is having memory problems. Some examples of these medicines are donepezil, rivastigmine and galantamine. If a person with DLB has movement symptoms they may be treated with medications used for Parkinsons disease, such as levodopa. Sleep problems may be managed by sleep medications including melatonin.

Because people with DLB are usually very sensitive to medications, any new medication, even one that is not being used for the brain, needs to be reviewed with the persons provider to avoid potential contraindication.

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Dementia With Lewy Bodies And Parkinson Disease Dementia

10 Symptoms of Lewy Body Dementia (LBD)

, MD, PhD, Department of Neurology, University of Mississippi Medical Center

Dementia with Lewy bodiesParkinson disease dementia

Dementia is chronic, global, usually irreversible deterioration of cognition.

Dementia with Lewy bodies is the 3rd most common dementia. Age of onset is typically > 60.

Lewy bodies are spherical, eosinophilic, neuronal cytoplasmic inclusions composed of aggregates of alpha-synuclein, a synaptic protein. They occur in the cortex of some patients who have dementia with Lewy bodies. Neurotransmitter levels and neuronal pathways between the striatum and the neocortex are abnormal.

Lewy bodies also occur in the substantia nigra of patients with Parkinson disease, and dementia may develop late in the disease. About 40% of patients with Parkinson disease develop Parkinson disease dementia, usually after age 70 and about 10 to 15 years after Parkinson disease has been diagnosed.

Because Lewy bodies occur in dementia with Lewy bodies and in Parkinson disease dementia, some experts think that the two disorders may be part of a more generalized synucleinopathy affecting the central and peripheral nervous systems. Lewy bodies sometimes occur in patients with Alzheimer disease, and patients with dementia with Lewy bodies may have neuritic plaques and neurofibrillary tangles. Dementia with Lewy bodies, Parkinson disease, and Alzheimer disease overlap considerably. Further research is needed to clarify the relationships among them.

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Coping With A Diagnosis

Being diagnosed with dementia can be an overwhelming experience. While there is no cure at present for LBD, or any medications aimed at specifically treating LBD, doctors are able to treat many of its symptoms. There are also a number of self-help strategies that can help improve symptoms.

If youve been diagnosed with LBD, its normal to feel many strong and painful emotions, including anger, fear, and uncertainty about the future.

Take time to adjust. As with any major life change, its important to give yourself time to adjust. Expect ups and downs as you do. You may feel that youve come to terms with your new situation for a while, and then suddenly feel overwhelmed by stress again.

Reach out for support.;Living with Lewy body dementia is not easy, but there is help for this journey. The more support you have from family and friends, the better youll be able to cope with symptoms.

Talk to your loved ones about your wishes. Its never easy to talk about how you want your healthcare handled when youre unable to make decisions for yourself. But its important to let your loved one know what is important to you. Thinking about your choices today can improve your quality of life in the future and ease the burden on your family.

Slowing the progression of symptoms

The same healthy lifestyle changes that are used to prevent dementia can also be useful in slowing the advancement of LBD symptoms.

Tests For Dementia With Lewy Bodies

There’s no single test for dementia with Lewy bodies.

The following may be needed to make a diagnosis:

  • an assessment of symptoms for example, whether there are typical symptoms of dementia with Lewy bodies
  • an assessment of mental abilities this will usually involve a number of tasks and questions
  • blood tests to rule out conditions with similar symptoms
  • brain scans, such as an MRI scan, CT scan or a SPECT scan these can detect signs of dementia or other problems with the brain

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Understanding Lewy Body Dementia

Lewy body dementia consists of two different conditions: dementia with Lewy bodies and Parkinson’s disease dementia. The two share many of the same symptoms and may often be considered to be the same.

However, one significant factor in;how Lewy body dementia progresses is related to which disease is actually present. In Parkinson’s disease dementia, the physical challenges are usually evident first, while in dementia with Lewy bodies, cognitive changes may appear earlier than, about the same time, or shortly after,;the physical changes develop.

Two Of The Following Are Present :

3 Dementia Lewy Bodies | Atypical Parkinsonism (DLB, PSP, MSA, CBS/CBD) Symposium
  • Fluctuating cognition: Mental problems varying during the day, especially attention and alertness.;
  • Visual hallucinations: Detailed and well-formed visions, which occur and recur.;
  • RBD: Physically acting out dreams while asleep.

A DLB diagnosis is even more likely if the individual also experiences any of the following: repeated falls, fainting, brief loss of consciousness, delusions, apathy, anxiety, problems with temperature and blood pressure regulation, urinary incontinence, and chronic constipation, loss of smell, or sensitivity to neuroleptic medications that are given to control hallucinations and other psychiatric symptoms.

Finally, the timing of symptoms is a reliable clue:;if cognitive symptoms appear before or within a year of motor symptoms, DLB is more likely the cause than Parkinson√Ęs disease. Signs of stroke or vascular dementia usually negate the likelihood of DLB.

Testing is usually done to rule out other possible causes of dementia, motor, or behavioral symptoms. Brain imaging can detect brain shrinkage and help rule out stroke, fluid on the brain , or subdural hematoma. Blood and other tests might show vitamin B12 deficiency, thyroid problems, syphilis, HIV, or vascular disease. Depression is also a common cause of dementia-like symptoms. Additional tests can include an electroencephalogram or spinal tap .

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Difference Between Parkinsons Disease Dementia And Dementia With Lewy Bodies

Technically, the difference between these two conditions lies in how quickly the cognitive difficulties and hallucinations develop in relation to the movement issues. In DLB, the cognitive difficulties and hallucinations develop much sooner in the disease course than in PDD, sometimes even prior to the movement difficulties. Because of the similarities between PD, PDD, and DLB, current thinking in the medical community is that they should be viewed as related diseases which fall along a continuum of Lewy body disorders.

Extending The Seeding Process Enabled The Reconstitution Of Lb

Altogether, our results suggest that the neuronal seeding model recapitulates many of the key events and processes that govern ?-syn seeding, aggregation, and LB formation . This model also allows disentangling of the two processes of fibril formation and LB formation, thus paving the way for systematic investigation of the molecular and cellular determinants of each process and their contributions to neuronal dysfunction and degeneration.

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Fauci Flu Shots Massively Accelerate Progression Of Prion Diseases

Under normal circumstances without a vaccine, the progression of prion diseases, which is demarcated by the abnormal folding of certain proteins, takes many years. After a Fauci Flu shot, however, that process greatly accelerates you might say at warp speed.

Classen believes that Chinese Virus injections could be piggybacking on mild prion disease that is already in motion in some people, while in others the shots could be actively prompting the misfolding of essential RNA and DNA binding proteins called TDP-43 and FUS, thus catalyzing a toxic chain reaction process.

It is probably a little bit different in every persons body depending on their unique biology, but the end result is still the same: neurodegeneration. For some it happens quickly and in others more slowly, but the common denominator is that it happens.

Classen also says that the vaccine spike proteins could be causing other protein, including proteins already in cells, to form what he describes as abnormal clumps called Lewy bodies that can lead to relatively rapid cell death.

Research has shown that the development of Lewy bodies in monkeys exposed to the Chinese Virus resulted in some or all of the motor symptoms of Parkinsons disease.

All this pain and suffering to maybe avoid a case of the sniffles? Tragic and idiotic.

As injected people continue to fall ill and die from Chinese Virus injections, we will keep you informed about it at ChemicalViolence.com.

How Is Lewy Body Dementia Treated Is There A Cure

Nomenclature of Lewy body diseases. Parkinsons disease ...

There is no cure for Lewy body dementia . Medications and nonmedical therapies, like physical, occupational and speech therapies, manage symptoms as much as possible.

Medications called cholinesterase inhibitors help manage the cognitive symptoms of LBD. Memantine may also be helpful. Symptoms of Parkinsonism, like tremors, are usually treated with levodopa, a drug commonly used to treat Parkinsons disease.

You or your loved one may also benefit from treatments like physical therapy or speech therapy. These treatments help retain physical function and improve muscle strength.

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What Is Lewy Body Dementia

LBD is a chronic, neurodegenerative cognitive disorder, and is the 3rd most common form of dementia.3 Unlike most other forms of dementia, people with LBD have Lewy bodies in the brain. Lewy bodies are abnormally-folded proteins found in the nerve cells of the brain.2 Patients with LBD may experience memory/cognitive problems, visual hallucinations, and Parkinsonism symptoms.4

Seeing Things That Are Not There

Does lewy body dementia affect vision? Yes, visual spatial problems in lewy body dementia do occur. Vivid visual hallucinations can be one of the very early signs of Lewy body dementia. Individuals may see animals, people or objects that arent really there. Other hallucinations can include sound, smell and touch- all can be very distressing for the person affected and for those that love and care for them.

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Ways To Decrease The Risk Of Parkinsons And Alzheimers

There is currently no cure for either disease. Parkinsons is considered a more treatable condition, however, especially in the early stages of the disease. Treatments include medication, physical therapy, and lifestyle modifications such as dietary changes. Research continues to suggest that a brain-healthy lifestyle can help prevent both Alzheimers and Parkinsons. Here are some basic guidelines:

  • Adopt a healthy diet with good nutrition. Brain-healthy diets, such as the Mediterranean or DASH diet have proven to make a difference. Diets with fresh vegetables and fruits, whole grains, olive oil, beans, fish, poultry and dairy can protect against cardiovascular disease, diabetes, and cancer, and promote cognitive health. By reducing inflammation and oxidative stress, these diets promote cognitive health. They can mitigate the risks of Alzheimers and Parkinsons disease. Stay away from processed meats, butter and heavy cream, saturated fat. Too much sugar is also dangerous. Sugar is an inflammatory that can also lead to unhealthy weight gain.
  • Fitness and exercise. At least 30 minutes of moderate aerobic exercise, 3-4 days a week, is considered a preventative measure. Build physical activity into the daily routine. It doesnt have to be high impact; it can be walking, riding a stationary bike, or swimming.
  • How Is Dementia With Lewy Bodies Different Than Parkinsons Disease

    Parkinsons and Lewy Body Dementia

    It is worthy of note that dementia is often present with Parkinsons disease, but not everyone who has this brain disorder will have this symptom. When it is present, people will first experience a movement disorder, with symptoms such as slowed movement, muscle stiffness, tremor and a shuffling walk. Subsequently, they will experience the cognitive symptoms of dementia, which include changes in mood and behavior. Another important aspect to keep in mind is that dementia with Lewy bodies is the umbrella term for two similar diagnoses, namely dementia with Lewy bodies and Parkinsons disease dementia.

    The difference between the two conditions is that the former is a type of dementia that results in difficulties with memory and thinking that are serious enough to disrupt everyday activities, whereas the latter is used to describe dementia that occurs with Parkinsons disease several years after the patient received their diagnosis. Therefore, dementia with Lewy bodies occurs suddenly, while dementia that may occur in people with Parkinsons disease arises later in the condition. Consequently, it is essential for medical professionals to make the difference between dementia with Lewy bodies and dementia that is present in people with Parkinsons disease in order to assign a correct diagnosis.

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    What Are The Signs And Symptoms Of Parkinson’s Disease Dementia

    Parkinson’s disease dementia can’t be diagnosed conclusively by a single test. Instead, doctors may use multiple tests and consider a range of Parkinson’s disease dementia criteria, including symptoms like:

    • Feelings of disorientation or confusion
    • Agitation or irritability

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    Not all cases of cognitive impairment are severesome people with Parkinson’s disease can still manage their work and personal life just fine. But once a person has Parkinson’s disease dementia, it usually means that they can no longer go about their daily life as they once did.;

    The Importance Of A Biomarker For Lewy Body Dementia Diagnosis And Treatment

    Discovering LBD biomarkers would have significant benefits. Once its possible to identify with certainty which people have the disease, drawing comparisons between their profiles can ultimately lead to improved diagnosis, treatment, and ways to study the effectiveness of treatment.

    We have a diagnostic gap with Lewy body dementia, says Dr. Higginbotham. Having something thats really accessible and can distinguish it easily and cost-effectively from Alzheimers would be really, really helpful.

    There is currently no treatment or therapeutics for LBD, especially for the cognitive symptoms that can often be so debilitating. The big lovely idea, which I think is very reachable, is that we want this to translate into something for treatment, says Dr. Higginbotham. By identifying biomarkers in the brain and diagnosing Lewy body dementia, doctors will be able to better develop individualized treatments, monitor disease progression, and determine the brains response to treatment.

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    Launching A Career In Lewy Body Dementia Research

    Dr. Higginbotham is committed to clinical research in Lewy body diseases. These are degenerative diseases including dementia with Lewy bodies, Alzheimers, and Parkinsons that all accumulate proteins in the brain. Her interest in neurology began shortly after she started medical school when her grandmother was diagnosed with Parkinsons disease. The lab she joined introduced her not only to tools and data sets for researching Alzheimers disease but also to her mentors, Allan Levy, MD, PhD, and Nicholas Seyfried, PhD.

    When she first worked in the lab during medical school, Dr. Higginbotham learned about using proteomics and mass spectrometry, both analytical tools, to compare the protein levels in Alzheimers disease brain tissue with those in healthy brain tissue. These tools group different proteins together and produce organized data sets. The tools help researchers identify similarities in the brain, blood, and cerebrospinal fluid.

    Her goal is to identify a biomarker, or measurable substance, that will indicate LBD and provide a definitive diagnosis. Finding a biomarker will also help doctors apply appropriate treatment and monitor the diseases progression. She has teamed up with a big proteomics lab responsible for Alzheimers research and is using their advanced techniques for detecting and analyzing protein levels to look at Lewy body dementia.

    How Is Lewy Body Disease Diagnosed

    Dementia with Lewy Bodies: and Parkinson

    This type of dementia is diagnosed by taking a careful history of the pattern of symptoms, and by excluding other possible causes such as Vascular dementia and Alzheimer’s disease. A brain scan may reveal brain degeneration, but the Lewy bodies can only be identified by examination of brain tissue after death.

    Lewy body disease;is similar to Alzheimer’s disease in many ways, and in the past it has sometimes been difficult to distinguish the two. It has only recently been accepted as a disease in its own right.;It can occur by itself or together with Alzheimer’s disease and/or Vascular dementia. It may be hard to distinguish;Lewy body disease;from Parkinson’s disease, and some people with Parkinson’s disease develop a dementia which is similar to that seen in Lewy body disease.

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