Billy Connolly: Humor With Parkinson’s
Scottish stand-up comedian and actor Billy Connolly continued on with his career after his Parkinson’s diagnosis in 2013 at age 70. Widely beloved for his off-the-cuff and profanity-laden comedy style, Connolly first found out he had Parkinson’s during a chance meeting in a hotel lobby with a doctor who recognized his symptoms as early signs of the neurological disease. However, his diagnosis didnt deter him, and he continued to perform onstage and on-screen until finally retiring from live performances in 2018.
Alzheimers Disease Death Rate Per 100000
Remember, some countries are doing a better job than others diagnosing neurodegenerative disease. Others are doing a better job than others sweeping these statistics under the rugespecially when it comes to declaring a cause of death on a death certificate. Most families dont fight for Alzheimers disease as a cause of death. Therefore, the statistics above are drastically underreported, but rising rapidly. The true size of the pandemic is unknown.
Alzheimers disease alone is killing 50-100 million people now. Experts suggest that the prevalence of brain disease will quadruple by 2050, if not sooner. Defending yourself with facts and smart choices is your best hope. Keep reading to find out why:
Neil Diamond: Stepping Away From Touring Because Of Parkinsons
Singer Neil Diamond announced on January 22, 2018, that he was retiring from touring because of a recent Parkinsons diagnosis. The news came during his 50th anniversary tour, as Diamond announced he would have to cancel upcoming concert dates in Australia and New Zealand. In a statement on his official website, he said, It is with great reluctance and disappointment that I announce my retirement from concert touring. I have been so honored to bring my shows to the public for the past 50 years.
Diamond reassured fans that he would continue writing and recording music, but he would not perform in front of live audiences in the future. His hits over the years have included Girl, Youll Be a Woman Soon, Sweet Caroline, Cracklin Rosie, Song Sung Blue, and Red, Red Wine.
Diamond was inducted into the Rock and Roll Hall of Fame in 2011 and received a Lifetime Achievement Award at the 2018 Grammy Awards.
Alan Alda: Taking Action Keeping Active
The award-winning M*A*S*H actor broke the news of his Parkinsons diagnosis during an appearance on the CBS This Morning TV news show in July 2018 and hes found that exercise helps him stay positive. You can hold back the progress if you do a lot of specific exercises, so I do a lot of crazy things, he told in 2019. For this Marriage Story actor, these crazy things reportedly include boxing, juggling, tennis, swimming, marching, and biking.
Confirming the news of his diagnosis on Twitter, Alda remained optimistic. I decided to let people know I have to encourage others to take action, he . My life is full. I act, I give talks, I do my podcast, which I love. If you get a diagnosis, keep moving!
Race/sex Demographics Of Parkinson Disease
The mean age-standardized prevalence of Parkinson disease from 1995, and 20002005 was highest among White men and lowest among Asian women .3). The mean age-standardized prevalence of Parkinson disease in Blacks and Asians was approximately 50% lower than the prevalence in Whites, with crude prevalence ratios of 0.58 and 0.62 , respectively, as compared to Whites. Parkinson disease incidence also varied by race, but not as markedly in Blacks, who had a crude incidence ratio of 0.74 .3). The incidence ratio for Asians was similar to the prevalence ratio . The age-standardized prevalence and incidence were greater in men than in women for all races, with a mean prevalence sex ratio of 155 males per 100 females and a mean incidence sex ratio of 146 males per 100 females.
Janet Reno: Public Service With Parkinson’s
The first woman to serve as U.S. attorney general, from 1993 to 2001, Janet Reno was diagnosed with Parkinson’s disease in 1995, just two years after she was nominated to the cabinet position. She was 55 at the time. “Well, my hand was shaking this summer, and I thought it would go away. I thought it was maybe you all picking on me. But it didn’t go away, and so I went and had it checked out,”Reno said during a press conference at the time.
Reno took medication to bring her symptoms under control, and although her Parkinson’s advanced, she was able to guest star as herself in a 2013 episode of The Simpsons, presiding in a trial in which Bart Simpson was the defendant.
Reno died in November 2016 at age 78.
Paraquat Is Prohibited In Many Countries
The European Union, China, and other 30 countries banned paraquat. This fact should be enough to raise some concerns about the weedkillers toxicity here at home. Europeans have decided since 2007 to stop using the dangerous chemical in their never-ending quest to maintain a healthy population and continent. The Union took this decision after research discovered its connection to Parkinsons.
Information about the risks arising from exposure to the herbicide has become public for many years now. Thus, the environmental agency has long been concerned with this subject. In 1997 they reported that people get the most exposure to paraquat when preparing the substance and after application, such as cleaning up spills or disposing of leftovers in their environment.
Although the agency banned the weedkillers use in residential areas, it has found that, nonetheless, it can harm individuals living in rural areas where workers can spray it.
Medications For People With Parkinsons Disease
Symptoms of Parkinsons disease result from the progressive degeneration of nerve cells in the brain and other organs such as the gut, which produce a neurotransmitter called dopamine. This causes a deficiency in the availability of dopamine, which is necessary for smooth and controlled movements. Medication therapy focuses on maximising the availability of dopamine in the brain. Medication regimes are individually tailored to your specific need. Parkinsons medications fit into one of the following broad categories:
- levodopa dopamine replacement therapy
- dopamine agonists mimic the action of dopamine
- COMT inhibitors used along with levodopa. This medication blocks an enzyme known as COMT to prevent levodopa breaking down in the intestine, allowing more of it to reach the brain
- anticholinergics block the effect of another brain chemical to rebalance its levels with dopamine
- amantadine has anticholinergic properties and improves dopamine transmission
- MAO type B inhibitors prevent the metabolism of dopamine within the brain.
Theories About What Causes Parkinsons
The cause of Parkinsons disease is still unknown, although there is some evidence for the role of genetics, environmental factors, or a combination of both. It is also possible that there may be more than one cause of the disease. Scientists generally believe that both genetics and environment interact to cause Parkinsons disease in most people who have it.
Currently, there is an enormous amount of research directed at producing more answers about what causes Parkinsons disease and how it might be prevented or cured. When physicians diagnose Parkinsons, they often describe it as idiopathic . This simply means that the cause of the disease is not known.
Factors That Protect Against Parkinsons Disease
Besides these risk factors, researchers have identified others that are associated with a reduced risk of Parkinson’s disease onset, including:
- Caffeine. People who consume more caffeine appear to have a reduced risk of developing Parkinson’s disease as opposed to those who only consume a little caffeine or none at all.
- Cigarette smoking. A number of studies have found that people who smoke cigarettes are less likely to develop Parkinson’s disease than those who don’t. But, in fact, it may be that some effect of having Parkinson’s disease makes it less likely that a person would want to smoke, so fewer people with the disease are smokers, skewing the data in favor of those who do smoke. And considering that the dangers of cigarette smoking far outweigh the odds that smoking slightly reduces the risk of Parkinson’s disease, it is never recommended as a prevention measure for Parkinson’s disease.
No One Definitive Cause Of Parkinsons
There are no biomarkers or objective screening tests that indicate one has Parkinsons. That said, medical experts have shown that a constellation of factors are linked to it.
Parkinsons causes are likely a blend of genetics and environmental or other unknown factors. About 10 to 20 percent of Parkinsons disease cases are linked to a genetic cause, says Ted Dawson, M.D., Ph.D., director of the Institute for Cell Engineering at Johns Hopkins. The types are either autosomal dominant or autosomal recessive .
But that leaves the majority of Parkinsons cases as idiopathic, which means unknown. We think its probably a combination of environmental exposure to toxins or pesticides and your genetic makeup, says Dawson.
Age. The biggest risk factor for developing Parkinsons is advancing age. The average age of onset is 60.
Gender. Men are more likely to develop Parkinsons disease than women.
Genetics. Individuals with a parent or sibling who is affected have approximately two times the chance of developing Parkinsons. Theres been an enormous amount of new information about genetics and new genes identified over the past 10 or 15 years that have opened up a greater understanding of the disease, says Dawson.
Spatial Analysis Of Parkinson Disease: Bayesian Modeling And Mapping Of Parkinson Disease Incidence And Prevalence
To produce smoothed disease maps, we applied a conditionally autoregressive model to predict county level incidence and prevalence rates of Parkinson disease. This model is derived from a traditional multilevel design, but takes into account spatial adjacency relationships between counties by assuming that neighboring areas had similar spatial variation.
To capture the random effects between counties, we computed the median relative risk and interquartile relative risk . The median relative risk is always greater than or equal to 1 and higher values suggest greater spatial variance. The interquartile relative risk reflects a difference of relative risks between the highest and lowest quartiles of incidence or prevalence. We also performed a high/low Getis-Ord General G cluster analysis to determine the probability of nonrandom grouping of either high or low county prevalence or incidence.
Diagnosis And Management Of Parkinsons Disease
There are no diagnostic tests for Parkinsons. X-rays, scans and blood tests may be used to rule out other conditions. For this reason, getting a diagnosis of Parkinsons may take some time.
No two people with Parkinsons disease will have exactly the same symptoms or treatment. Your doctor or neurologist can help you decide which treatments to use.
People can manage their Parkinsons disease symptoms through:
- seeing a Doctor who specialises in Parkinsons
- multidisciplinary therapy provided for example, by nurses, allied health professionals and counsellors
- deep brain stimulation surgery .
How Many People Does Parkinsons Disease Affect
Parkinsons disease affects 1 in every 500 people in Canada. Over 100,000 Canadians are living with Parkinsons today and approximately 6,600 new cases of PD are diagnosed each year in Canada . Most are diagnosed over the age of 60; however, at least 10% of the Parkinsons population develops symptoms before the age of 50. Approximately four million people worldwide are living with the condition.
Linda Ronstadt: Parkinson’s Took Her Voice But Not Her Spirit
Known for her rich soprano vocals as the lead singer of the 1960s band the Stone Poneys, Linda Ronstadt opened up about her Parkinson’s disease diagnosis to AARP The Magazine in 2013. After two very bad tick bites in the 1980s, Ronstadt says her health never fully recovered but she didn’t visit a neurologist until she was no longer able to sing.
“I didn’t know why I couldn’t sing all I knew was that it was muscular or mechanical. Then when I was diagnosed with , I was finally given the reason. I now understand that no one can sing with Parkinson’s disease. No matter how hard you try. And in my case, I can’t sing a note,” she told AARP.
Environmental Factors And Exposures
Exposure to and a history of head injury have each been linked with PD, but the risks are modest. Never having smoked cigarettes, and never drinking caffeinated beverages, are also associated with small increases in risk of developing PD.
Low concentrations of in the blood is associated with an increased risk of PD.
Different medical drugs have been implicated in cases of parkinsonism. Drug-induced parkinsonism is normally reversible by stopping the offending agent. Drugs include:
The Rise Of Parkinson’s Disease
Neurological disorders are the worlds leading cause of disability. And the fastest growing of these conditions is not Alzheimers but Parkinsons disease.
- The number of people with Parkinsons disease more than doubled from 1990 to 2015 and could double again by 2040. An aging population alone does not account for this rise.
- Air pollution, metal production, certain industrial chemicals, and some synthetic pesticides are linked to Parkinsons. Yet we are doing little to manage known risk factors.
- The authors contend that the United States should ban trichloroethylene, paraquat, and other chemicals linked to Parkinsons, which many other countries have already done.
From 1990 to 2015, the number of people living with Parkinsons more than doubled from 2.6 million to 6.3 million, according to a 2015 study in Lancet Neurology. By 2040, the number is projected to double again to at least 12.9 million, a stunning rise .
The number of people with Parkinsons disease more than doubled between 1990 and 2015 and is projected to double again by 2040.
Figure adapted from E. R. Dorsey and B. R. Bloem, 2018.
Figure adapted from R. Dorsey et al., 2020.
The number of people who succumb to Parkinsons each year has been increasing steadily.
Data from: U.S. National Center for Health Statistics, National Vital Statistics System, Mortality Data.
Christophe Vander Eecken / Reporters / Science Source
Death Rates From Heart Disease Cancer And Other Leading Causes Of Death Are Steady If Not Dropping In Most Countries Due To Advances In Nutrition Medicine And Disease Management Neurodegenerative Disease Is The One Glaring Exception Its Spreading Exponentially In The Us For Example Deaths Attributed To Alzheimers Disease Increased 71 Percent From 2000 To 2013 While Those Attributed To Heart Disease Decreased 14 Percent
These regional variations indicate that the death rate from Alzheimers disease is not random, but one influenced by and/or dietary factors. Regional spikes also reflect the infective nature of Alzheimers disease and other forms of prion disease once they have a foothold within a population. Please visit our tab The Truth for a more thorough explanation.
There are proven strategies to help avert neurodegenerative disease, including smart nutrition, exercise and prion aversion. There is not a cure for prion disease, but smart nutrition can ease the symptoms. Preview and order the now to defend yourself and your family.
Gary Chandler is a prion expert. He is the CEO of Crossbow Communications, author of several books and producer of documentaries about health and environmental issues around the world. Chandler is connecting the dots to the global surge in neurodegenerative disease, including Alzheimers disease, Parkinsons disease, Creutzfeldt-Jakob disease, chronic wasting disease and other forms of prion disease.
Michael Richard Clifford: Parkinson’s In Space
Michael Richard “Rich” Clifford began his career as a NASA astronaut in 1990. He’s since made three space flights, accumulating 665 hours orbiting Earth. Though diagnosed with Parkinson’s disease in 1994, he continued to fly. Clifford was 42 and in apparent good health when he discovered his Parkinson’s disease, signaled at first by difficulty moving his right arm and hand correctly. In 2012, the American Academy of Neurology gave him the Public Leadership in Neurology Award for increasing awareness of Parkinson’s disease and for encouraging people living with Parkinson’s to continue to pursue their dreams.
Everyone with PD handles it differently, said Clifford in an interview with the Michael J. Fox Foundation. Dont let it get in the way of living. Life is too good. Remember, keep going the skys the limit.
Prevalence/incidence Of Parkinson Disease In The Us
The mean prevalence of Parkinson disease per 100,000 Medicare beneficiaries over age 65 from 1995, and 20002005 was 1,588.43 or approximately 1.6% of the elderly population. The mean annual incidence from 2002 to 2005 was 445.79 . The mean prevalence of Parkinson disease steadily increased with age, with no apparent plateau, from 553.52 between ages 6569, to 2,948.93 per 100,000 at ages 85 and above. Similarly, mean Parkinson disease incidence also appears to increase with age, from 124.22 between ages 6569 to 970.19 among those greater than 85 years of age. The incidence and prevalence of Parkinson disease have remained stable over the 10-year period from 1995 to 2005 .
Symptoms Of Parkinsons Disease
The type, number, severity and progression of Parkinsons disease symptoms vary greatly. Every person is affected differently they may not get every symptom.
Some of the more common symptoms are:
- resting tremor
- blood pressure fluctuation
People living with Parkinsons for some time may experience hallucinations , paranoia and delusions . These symptoms are able to be treated so have a talk with your doctor.
Patient Education And Education Of Pd In General
Like other chronic diseases such as diabetes, hypertension and cerebral vascular disease, it is important to educate physicians and patients for PD management. Health education is an effective way for local physician and patients to acquire knowledge of PD, which could improve the early diagnosis and management of PD . Tan et al. performed a study on awareness status of PD among elderly veterans in Beijing. In this study, 80.3% subjects heard the name of PD. As for the prevention knowledge, the awareness rate was 62.1%. In those veterans with prevention knowledge of PD, 52.7% of them learned from media, 72.1% of them learned from word of mouth, and only 11.8% learned from health care professionals . Thanks to communication tools through smartphone, such as Weibo and WeChat, it is much easier to perform patient education. Personal health education and health education to caregivers are effective and need more attention .
Support For People With Parkinsons Disease
Early access to a multidisciplinary support team is important. These teams may include doctors, physiotherapists, occupational therapists, speech therapists, dietitians, social workers and specialist nurses. Members of the team assess the person with Parkinsons disease and identify potential difficulties and possible solutions.There are a limited number of multidisciplinary teams in Victoria that specialise in Parkinsons disease management. But generalist teams are becoming more aware of how to help people with Parkinsons disease.
Linda Ronstadt Ozzy Osbourne And Muhammad Ali Are Just Some Of The Well
Parkinsons disease is a neurodegenerative condition caused by the loss of -producing neurons in the brain, which leads to various neurological and mobility-related symptoms. The Parkinsons Foundation estimates the number of people living with Parkinsons at 1 million in the United States alone, with over 10 million cases worldwide.
In January 2020, Ozzy Osbourne became the latest public figure to announce a Parkinsons diagnosis, helping to raise the profile of this little-understood neurological condition. Read on to learn more about how other celebrities living with Parkinsons disease have managed their condition and the work theyve done to raise awareness.
Ben Petrick: The Major League With Parkinson’s
Ben Petrick dreamed of a stellar baseball career as a catcher with the Colorado Rockies. He played in 240 Major League games, the majority of which came after Parkinson’s disease struck him at age 22 in 2000. He retired from baseball in 2004.
He’s since authored , a book whose title in part references the 40,000 Americans diagnosed with Parkinson’s disease every year. The book also recounts his experiences in Major League Baseball while coping with Parkinson’s disease. According to an ESPN interview, Petrick’s father was also diagnosed with the condition but maintains a positive attitude, saying that although he has Parkinson’s, Parkinson’s doesn’t have him.
Mortality From Parkinsons Disease
With treatment, the life expectancy of people with PD is similar to that of the general population. However, dementia seems to largely impact life expectancy among people with PD, and about 50 percent to 80 percent of people with PD develop dementia in their lifetime. Risk factors for mortality include later age of onset, male sex, severity of motor impairment, presence of psychotic symptoms, and dementia. Early detection of disease, prevention of motor symptom progression, and treatment of dementia can increase life expectancy.8,9
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Rates Of Parkinsons Disease Are Exploding A Common Chemical May Be To Blame
Researchers believe a factor is a chemical used in drycleaning and household products such as shoe polishes and carpet cleaners in the US
Asked about the future of Parkinsons disease in the US, Dr Ray Dorsey says, Were on the tip of a very, very large iceberg.
Dorsey, a neurologist at the University of Rochester Medical Center and author of Ending Parkinsons Disease, believes a Parkinsons epidemic is on the horizon. Parkinsons is already the fastest-growing neurological disorder in the world; in the US, the number of people with Parkinsons has increased 35% the last 10 years, says Dorsey, and We think over the next 25 years it will double again.
Most cases of Parkinsons disease are considered idiopathic they lack a clear cause. Yet researchers increasingly believe that one factor is environmental exposure to trichloroethylene , a chemical compound used in industrial degreasing, dry-cleaning and household products such as some shoe polishes and carpet cleaners.
To date, the clearest evidence around the risk of TCE to human health is derived from workers who are exposed to the chemical in the work-place. A 2008 peer-reviewed in the Annals of Neurology, for example, found that TCE is a risk factor for parkinsonism. And a 2011 study echoed those results, finding a six-fold increase in the risk of developing Parkinsons in individuals exposed in the workplace to trichloroethylene .
Adrienne Matei is a freelance journalist
What Causes Parkinsons Disease
Parkinsons disease is a chronic, progressive neurological disease that currently affects about 1 million Americans. Parkinsons disease involves a small, dark-tinged portion of the brain called the substantia nigra. This is where you produce most of the dopamine your brain uses. Dopamine is the chemical messenger that transmits messages between nerves that control muscle movements as well as those involved in the brains pleasure and reward centers. As we age, its normal for cells in the substantia nigra to die. This process happens in most people at a very slow rate.
But for some people, the loss happens rapidly, which is the start of Parkinsons disease. When 50 to 60 percent of the cells are gone, you begin to see the symptoms of Parkinsons.
Global Parkinsons Disease Therapeutics Market $85 Billion By 2027
The global market for Parkinsons disease therapeutics is expected to reach $8.5 billion by 2027, expanding at a CAGR of 11.5% over the forecast period, driven by aging population, drug price inflation, and introduction of new treatment options.
Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinsons disease. Parkinsons disease is the second most common neurologic disease following Alzheimers disease.
- Parkinsons disease currently affects 13 million people worldwide and, due to an aging population, is estimated to affect 32 million by 2050. Men are 1.5 times more likely to have Parkinsons than women.
According to Global Burden of Diseases, Injuries, and Risk Factors study , over the past three or four decades, in some high-income countries , the risk of Parkinsons disease and parkinsonism has increased.
The Parkinsons disease pipeline is characterized by a high level of both growth and attrition.