Wednesday, November 30, 2022
Wednesday, November 30, 2022
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What Causes Parkinson’s Dementia

Can Parkinsons Dementia Be Reversed

Overlapping causes of dementia: Alzheimers, Parkinsons, stroke, ALS, Lou Gehrig’s

No specific cure has been identified for Parkinsons Disease Dementia. Rather, treatments have been aimed at reducing the symptoms of dementia and helping the patient maintain a high quality of life. Doctors treating patients of PD Dementia generally prescribe medications such as:

  • Antidepressants
  • Cholinesterase inhibitors
  • Clonazepam and L-dopa

Serotonin reuptake inhibitors are known to reduce depression symptoms. The ones widely prescribed by doctors include:

  • Prozac
  • Zoloft and
  • Lexapro

Cholinesterase inhibitors help reduce the effects of cognitive decline in people with dementia whereas Clonazepam helps enhance sleep quality. L-dopa helps reduce movement issues caused by PD but runs the risk of making confusion and dementia symptoms worse.

Doctors treating PD Dementia patients may also prescribe antipsychotic drugs but generally do so with caution, the reason being these reduce psychotic episodes but increase Parkinsons symptoms. The use of these drugs may also cause increased confusion and change in consciousness. For the record, Pimavanserin and Nuplazid have been identified as effective antipsychotic drugs.

What Other Things Help

There are various ways to help a person with PDD. Speech therapy may help improve communication between people with PDD and others. Physical therapy may help strengthen and stretch stiff muscles and help to prevent falls.

Research has shown that physical exercise helps to enhance brain health and improves mood and general fitness. A balanced diet, enough sleep and limited alcohol intake are other important ways to promote good brain health. Other illnesses that affect the brain, such as diabetes, high blood pressure and high cholesterol, should also be treated if present.

Who Gets Parkinson’s Disease Dementia

No two cases of Parkinson’s are exactly alike, so it’s hard to say for sure who will develop Parkinson’s disease dementia and who will not. However, researchers have identified several factors that may increase a person’s risk for Parkinson’s disease dementia, including:

  • Older age, especially at the time Parkinson’s symptoms began
  • Being a man
  • Advancing to late-stage Parkinson’s disease
  • Experiencing visual hallucinations

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Dysexecutive Symptoms May Emerge When Inter

How dysfunction in the fronto-striatal and mesocortical dopaminergic networks may interact to cause dysexecutive symptoms in PDD is unclear. However the results of suggest that it is supervening dysfunction in the mesocortical projections to the insular upon existing fronto-striatal network disruption that heralds major executive impairment. Indeed there is limited evidence suggesting some redundancy between the two systems in early Parkinsons disease: in one study patients performing a set-shifting task did not display behavioural impairment despite fronto-striatal hypoactivation on functional MRI, possibly because they displayed concurrent hyper-activation in the insular and fronto-parietal networks, which was not present in controls . Using functional MRI, also noted a relative increase in blood-oxygen level-dependent activity within frontal regions in patients during a matching task. Although this evidence is indirect it suggests that the mesocortical network may partially compensate for fronto-striatal dysfunction in early disease, until it too is damaged, compensation is lost, and a full-blown dysexecutive syndrome develops. Such a proposal is compatible with, and extends, the hypothesis proposed by others that deficient interplay between the fronto-striatal and mesocortical dopamine networks underlies the dysexecutive syndrome of Parkinsons disease .

Pdd Vs Dementia With Lewy Bodies

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Another type of dementia is called Dementia with Lewy Bodies , which has similar symptoms to PDD. DLB is associated with abnormal deposits of a protein called alpha-synuclein in the brain. Lewy bodies are also found in the brains of people diagnosed with PDD.

However, DLB is diagnosed when cognitive decline happens before the motor symptoms of Parkinsons, or when motor symptoms and cognitive decline occur and progress closely together.

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How Can We Manage Hallucinations

It may not be necessary to treat all hallucinations of a person with PDD. Hallucinations are often harmless, and it is okay to allow them to happen, as long as they are not disruptive or upsetting to the person or surroundings. Sometimes, recognizing the hallucination and then switching the topic might be an efficient way of handling frustrations that occur because of a hallucination. If hallucinations need medical treatment, your provider may be able to discuss and suggest some options. However, many of the medications used to treat hallucinations may make movement symptoms worse.

How Is Parkinsons Disease Dementia Different From Alzheimers Disease

Parkinsons disease Dementia must not be confused with Alzheimers disease. Dementia is a hallmark feature of Alzheimers whereas a patient may not necessarily contract Dementia if he happens to contract Parkinsons. Having mentioned that, Dementia does have a greater social and occupational impact on the functioning of people when it affects someone with Parkinsons as compared to Alzheimers.

This is due to the combination of motor and cognitive impairments. Parkinsons directly affects problem-solving functions in a person, besides other aspects such as the speed of thinking, memory, and mood. Parkinsons Dementia Aggression can also be related to Lewy bodies, where sticky clumps of protein are found in the nerve cells of people diagnosed with Parkinsons.

Finally, it must be known to all those associated with Parkinsons in any capacity, whether be it a patient or a caregiver, that majority of people with Parkinsons may experience some of the other forms of cognitive impairment over time. Though cases vary from person to person, the development of Dementia in those diagnosed with Parkinsons cannot be predicted. To put it in numbers, 30 percent of people with Parkinsons never develop dementia as a part of their progression.

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Parkinsons Disease Dementia: Synergistic Effects Of Alpha

  • 1Traditional Chinese Medicine Innovation Research Center, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Shenzhen, China
  • 2 Shenzhen Baoan Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China

Comparison With Other Dementias

Dealing with Dementia in Parkinson’s Disease

Dementia is the result of physical changes in the brain that can lead to memory loss and an inability to think clearly.

Several types of dementia exist, including:

PD dementia has different symptoms to other types.

Alzheimers dementia, for example, impairs memory and language. PD dementiam on the other hand, affects problem-solving, the speed at which thoughts occur, memory, and mood, alongside other important cognitive functions.

Dementia with Lewy bodies and Parkinsons disease dementia are similar in that the Lewy Bodies might be present in both forms.

However, whether the disease causes Lewy bodies or if Lewy bodies cause the disease symptoms is unclear. Researchers also believe that the way the Lewy bodies form in Parkinsons disease dementia is different from those in Lewy body dementia.

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What Happens In Pdd

People with PDD may have trouble focusing, remembering things or making sound judgments. They may develop depression, anxiety or irritability. They may also hallucinate and see people, objects or animals that are not there. Sleep disturbances are common in PDD and can include difficulties with sleep/wake cycle or REM behavior disorder, which involves acting out dreams.

PDD is a disease that changes with time. A person with PDD can live many years with the disease. Research suggests that a person with PDD may live an average of 57 years with the disease, although this can vary from person to person.

Memory And Thinking Problems

You may experience forgetfulness, slowed thinking and difficulty concentrating. You might find it harder to follow conversations, and remember some words and names. This can make communication difficult.

You may also find it increasingly difficult to make decisions, plan activities and solve problems. This can make everyday activities harder.

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How Is Age Related To Pdd

Both PD and PDD are more common with increasing age. Most people with PD start having movement symptoms between ages 50 and 85, although some people have shown signs earlier. Up to 80% of people with PD eventually develop dementia. The average time from onset of movement problems to the development of dementia is about 10 years.

Degeneration In The Mesocortical Dopamine Network Contributes To Executive Dysfunction

Dementia

However, dopamine-dependent neural circuitry underlying executive deficits in Parkinsons disease may not be limited to the fronto-striatal network alone. The mesocortical dopamine network originates in the midbrain ventral tegmental area and projects diffusely to neocortical areas, particularly prefrontal, insular and cingulate cortices . Release of dopamine from this network modulates prefrontal D2 receptors and thereby facilitates cognitive flexibility, a core feature of executive processing . Insular cortex in particular is considered to mediate such flexibility, acting as a hub to recruit other cognitive circuits such as the fronto-parietal network . In support of this, insular lesions in human patients have been shown to impair performance on tasks requiring cognitive flexibility .

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Lewy Body Dementia Vs Parkinsons Disease Dementia

Diagnoses of Lewy body dementia include dementia with Lewy bodies and Parkinsons disease dementia. Symptoms in both of these diagnoses can be similar.

Lewy body dementia is a progressive dementia caused by abnormal deposits of a protein called alpha-synuclein in the brain. Lewy bodies are also seen in Parkinsons disease.

The overlap in symptoms between Lewy body dementia and Parkinsons disease dementia include movement symptoms, rigid muscles, and problems with thinking and reasoning.

This seems to indicate that they could be linked to the same abnormalities, though more research is needed to confirm that.

The later stages of Parkinsons disease have more severe symptoms that may require help moving around, around-the-clock care, or a wheelchair. Quality of life can decline rapidly.

Risks of infection, incontinence, pneumonia, falls, insomnia, and choking increase.

Hospice care, memory care, home health aides, social workers, and support counselors can be a help in later stages.

Parkinsons disease itself isnt fatal, but complications can be.

Research has shown a median survival rate of about

How Is Parkinson Disease Diagnosed

Parkinson disease can be hard to diagnose. No single test can identify it. Parkinson can be easily mistaken for another health condition. A healthcare provider will usually take a medical history, including a family history to find out if anyone else in your family has Parkinson’s disease. He or she will also do a neurological exam. Sometimes, an MRI or CT scan, or some other imaging scan of the brain can identify other problems or rule out other diseases.

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How Can We Support The Sleep/wake Cycle Of Pdd

For people with PDD who are confused about the day-night cycle, some daily strategies can be helpful. At night, starting a lights out routine that happens at the same hour every day, where all curtains are closed and lights are turned off, can help the person understand that it is sleep time. During the day, opening the curtains, allowing the person with PDD to spend as much time in the daylight as possible, avoiding naps, and organizing stimulating activities, can be helpful. Having lots of calendars and clocks in every room might also help a person with PDD be less confused about the time of day.

Living With Parkinsons Disease

Carol The Caregiver – Parkinson’s dementia

You can take some measures and ease your life while living with Parkinsons disease:

  • Set an exercise routine for yourself. Exercises can help in keeping muscles flexible and mobile. Also, exercise releases natural brain chemicals that can improve emotional and mental states.
  • High protein food can maintain the health of your brain
  • You can join physical therapies. Your physical therapist can advice some of the light strengthening exercises according to your condition
  • Speech therapies can always work when communication becomes difficult due to the disease.
  • Handle your hallucinations. Hallucinations are often harmless but sometimes they can upset you too much. Try to recognize your hallucinations and then change the topic.
  • Limit your alcohol intake.
  • Other illnesses such as diabetes, high blood pressure, and high cholesterol affect the brain and they should be treated.

Please be aware of your familys disease history. Condition like Parkinsons disease can be controlled initially. If you are around a person with Parkinsons disease dementia, make sure to give them love and strength.

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Fauci Flu Shots Massively Accelerate Progression Of Prion Diseases

Under normal circumstances without a vaccine, the progression of prion diseases, which is demarcated by the abnormal folding of certain proteins, takes many years. After a Fauci Flu shot, however, that process greatly accelerates you might say at warp speed.

Classen believes that Chinese Virus injections could be piggybacking on mild prion disease that is already in motion in some people, while in others the shots could be actively prompting the misfolding of essential RNA and DNA binding proteins called TDP-43 and FUS, thus catalyzing a toxic chain reaction process.

It is probably a little bit different in every persons body depending on their unique biology, but the end result is still the same: neurodegeneration. For some it happens quickly and in others more slowly, but the common denominator is that it happens.

Classen also says that the vaccine spike proteins could be causing other protein, including proteins already in cells, to form what he describes as abnormal clumps called Lewy bodies that can lead to relatively rapid cell death.

Research has shown that the development of Lewy bodies in monkeys exposed to the Chinese Virus resulted in some or all of the motor symptoms of Parkinsons disease.

All this pain and suffering to maybe avoid a case of the sniffles? Tragic and idiotic.

As injected people continue to fall ill and die from Chinese Virus injections, we will keep you informed about it at ChemicalViolence.com.

What Are The Symptoms Of Parkinson’s Disease Dementia

Cognitive impairment in Parkinson’s disease may range from a single isolated symptom to severe dementia.

  • The appearance of a single cognitive symptom does not mean that dementia will develop.
  • Cognitive symptoms in Parkinson’s disease usually appear years after physical symptoms are noted.
  • Cognitive symptoms early in the disease suggest dementia with Parkinsonian features, a somewhat different condition.

Cognitive symptoms in Parkinson’s disease include the following:

  • Loss of decision-making ability
  • Loss of short- and long-term memory
  • Difficulty putting a sequence of events in correct order
  • Problems using complex language and comprehending others’ complex language

Persons with Parkinson’s disease, with or without dementia, may often respond slowly to questions and requests. They may become dependent, fearful, indecisive, and passive. As the disease progresses, many people with Parkinson’s disease may become increasingly dependent on spouses or caregivers.

Major mental disorders are common in Parkinson’s disease. Two or more of these may appear together in the same person.

The combination of depression, dementia, and Parkinson’s disease usually means a faster cognitive decline and more severe disability. Hallucinations, delusions, agitation, and manic states can occur as adverse effects of drug treatment of Parkinson’s disease, this might complicate the diagnosis of Parkinson’s dementia.

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What Causes Parkinson Disease And Alzheimers

Parkinsons dementia is caused by impaired physical activities where the dopamine & serotonin gets damaged by the disease.

On the other hand, with Alzheimers, the two types of brain proteins tangles & plaques store up & kill the brain cells.

Moreover, the disease reduces learning capacity, comprehension & judgmental skills.

Well, distinguishing between the treatmentits necessary to determine the best treatment approach, though, Dr. Vivek Pratap Singhis known for the finestParkinsons disease treatment in Patna.

So, you must consult him once

What Causes Parkinson’s Disease Dementia

WONG MEDICAL CENTRE IPOH ?: PARKINSON DISEASE

Doctors don’t yet know the exact cause of Parkinson’s disease dementia, but they think it has to do with an accumulation of a protein called alpha-synuclein. When it builds up in the brain, it can create clumps called “Lewy bodies” in nerve cells, causing them to die.

The death of those cells usually results in the motor symptoms typically associated with Parkinson’s disease. As Parkinson’s disease progresses, those Lewy bodies may eventually damage the brain and cause problems with memory and thinking.

While many people with Parkinson’s disease experience cognitive changes, not all of them will go on to develop dementia. It’s estimated that between 50% and 80% of individuals with the disease eventually develop Parkinson’s disease dementia, usually in the later stages of the disease.

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Behavioral And Mood Symptoms Of Lewy Body Dementia

Changes in behavior and mood are possible in LBD and may worsen as the persons thinking abilities decline. These changes may include:

  • Depression
  • Apathy, or a lack of interest in normal daily activities or events and less social interaction
  • Anxiety and related behaviors, such as asking the same questions over and over or being angry or fearful when a loved one is not present
  • Agitation, or restlessness, and related behaviors, such as pacing, hand wringing, an inability to get settled, constant repeating of words or phrases, or irritability
  • Delusions, or strongly held false beliefs or opinions not based on evidence. For example, a person may think his or her spouse is having an affair or that relatives long dead are still living.
  • Paranoia, or an extreme, irrational distrust of others, such as suspicion that people are taking or hiding things

Is The Dementia Caused By Parkinsons Or Something Else

Indications that dementia may be caused by something other than Parkinsons disease include agitation, delusions , and language difficulties. If the onset of cognitive symptoms is sudden, theyre more likely due to something other than Parkinsons diseaseeven reversible causes such as infection, a vitamin B12 deficiency, or an underactive thyroid gland.

Depression can mimic dementia by causing similar symptoms such as apathy, memory problems, and concentration difficulties. Since depression is very common in Parkinsons patients, its important to recognize the signs and symptoms of depression in older adults.

Parkinsons disease dementia vs. other dementias

Other types of dementia that can be commonly mistaken for Parkinsons disease dementia include:

Lewy Body Dementia is characterized by fluctuations in alertness and attention, recurrent visual hallucinations, and Parkinsonian motor symptoms like rigidity and the loss of spontaneous movement. In this disorder, cognitive problems such as hallucinations tend to occur much earlier in the course of the disease and often precede difficulties with walking and motor control.

Alzheimers disease and Parkinsons disease are both common in the elderly, especially in those over 85. Patients with Parkinsons who develop dementia may even develop Alzheimers dementia as well. Therefore, its important to be aware of the signs of Alzheimers Disease and how its treated.

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