Parkinson’s Diseasewhat Are The Causes Of Parkinson’s Disease
Symptoms manifest due to a malfunction of dopamine neurons
The brain is the central control tower that governs the condition of the body. Messages sent out by the brain are transmitted from one nerve cell to the next by neurotransmitters that pass the message on like a baton during a relay race, causing your body to move in reaction to the message. In Parkinson’s disease, levels of dopamine, a neurotransmitter in a part of the brain called the substantia nigra, decrease, causing a loss of control over body movement. It is still not fully understood what causes the amount of dopamine to decrease. Changes in the brain associated with age and, in some cases, changes related to a person’s genes, are presumed to be the cause. Supplementing the deficient dopamine with medication can lessen the symptoms of Parkinson’s disease.
What Are The Symptoms Of Parkinsons Disease
Symptoms of Parkinsons disease and the rate of decline vary widely from person to person. The most common symptoms include:
Other symptoms include:
- Speech/vocal changes: Speech may be quick, become slurred or be soft in tone. You may hesitate before speaking. The pitch of your voice may become unchanged .
- Handwriting changes: You handwriting may become smaller and more difficult to read.
- Depression and anxiety.
- Sleeping disturbances including disrupted sleep, acting out your dreams, and restless leg syndrome.
- Pain, lack of interest , fatigue, change in weight, vision changes.
- Low blood pressure.
The Nervous System & Dopamine
To understand Parkinson’s, it is helpful to understand how neurons work and how PD affects the brain .
Nerve cells, or neurons, are responsible for sending and receiving nerve impulses or messages between the body and the brain. Try to picture electrical wiring in your home. An electrical circuit is made up of numerous wires connected in such a way that when a light switch is turned on, a light bulb will beam. Similarly, a neuron that is excited will transmit its energy to neurons that are next to it.
Neurons have a cell body with branching arms, called dendrites, which act like antennae and pick up messages. Axons carry messages away from the cell body. Impulses travel from neuron to neuron, from the axon of one cell to the dendrites of another, by crossing over a tiny gap between the two nerve cells called a synapse. Chemical messengers called neurotransmitters allow the electrical impulse to cross the gap.
Neurons talk to each other in the following manner :
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Lack Of Exercise/physical Activities
The idea that exercise might have a role in Parkinsons disease is not new. Researchers have been trying to find a connection between Parkinsons and exercise for many years. They think that those who do regular exercise are less likely affected by the disease than those who dont.
A study published in the Journal of Neurology suggests that higher levels of physical activity may reduce the risk of developing Parkinsons disease. In this study, 125,828 provided information on physical activity in early adulthood. During the follow-up, a total of 387 Parkinsons cases were identified. The study found that the people who didnt develop the disease were mostly involved in some sort of higher levels of physical activity.
Similarly, one meta-analysis that included data from 8 prospective studies has concluded that moderate to vigorous physical activity may have an inverse relationship with a risk of Parkinsons.
Although it is not known how exercise could protect someone from developing Parkinsons, researchers think that it may inhibit abnormal changes in dopamine neurons and contribute to the healthy functioning of brain parts involved in body movement.
What Is Parkinsons Disease Causes Symptoms And Treatment
Parkinsons disease is a slow progressing neurological disorder that is generally seen between 55 and 65 years of age and causes damage to brain cells. The most typical symptoms are frequent tremor in the hands, legs and arms; disrupted balance, slowed movements and loss of coordination occurs. Parkinsons disease patients have rigidity in their arms and legs, and they may suffer from gait and speech problems. Parkinsons is not a fatal disease, however, complications caused by it can lead to fatal outcomes; depression, swallowing and chewing problems, constipation, urinary problems and sleep disorder are common in Parkinsons patients.;In addition, certain drug therapies and surgical methods can provide significant improvements for some patients.
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Can Parkinsons Disease Be Prevented
Unfortunately, no. Parkinsons disease is long-term disease that worsens over time. Although there is no way to prevent or cure the disease , medications may significantly relieve your symptoms. In some patients especially those with later-stage disease, surgery to improve symptoms may be an option.
A Brief Note On Parkinson ‘s Disease And Its Effects On The Central Nervous System Essay
appetizing meal.The life of a person with Parkinsons Disease is much more difficult than the life of a person without the disease. Everyday tasks seem grueling and unattainable. Scenarios, such as the one above, occur every day and wreak havoc on innocent peoples lives. Even though the number of patients with PD continues to rise, the government still does not provide the adequate funding to answer questions surrounding Parkinsons Disease.Parkinsons Disease is a chronic and progressive disorder
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Balance Impairment And Falls In Parkinsons Disease
One of the most challenging symptoms of Parkinsons disease that fundamentally affects quality of life is balance impairment that can lead to falls.
Falls are one of the major causes of emergency room visits and hospitalizations for people with PD, so finding ways to prevent as many falls as possible is a high priority for people with PD. Thankfully there are things you can do to improve your stability and decrease the likelihood of falling, and well share some helpful tips and advice below.
Problems With Balance Or Walking
Bradykinesia can also contribute to increasing instability, walking difficulties and changes in gait. An early symptom of this is a decrease in the natural swing of one or both arms when walking. As things progress, the steps you take may become slower and smaller, and you may start shuffling your feet.
Some people with Parkinsons disease may also experience freezing episodes where it can feel like their feet are stuck in place, which can increase the risk of falling.
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How Does Environment Come Into It
Your environment is a hard one to pin down. Partly, that’s because it covers a lot of ground. It’s everything that’s not your genes, which could mean where you live, what you eat, chemicals you’ve come into contact with, and more.
Not only that, but it could take years for the effects from something in your environment to show up. So far, doctors have a lot of clues but no smoking gun. So you could have people who live or work in an area around chemicals tied to Parkinson’s, but many of them don’t get it.
Some research shows links between Parkinson’s and:
- Agent Orange, a chemical used to destroy trees and crops in the Vietnam War.
- Certain chemicals used in farming, such as insecticides, herbicides, and fungicides.
- Some metals and chemicals used in factories, such as manganese, lead, and trichlorethylene .
These can come into play based on where you live, what you do for work, or if you served in the military. Sometimes, these chemicals seep into well water, so that’s one more way they can affect you.
Deep Brain Stimulation Surgery For Parkinson’s Disease At Ucla
If you’ve been diagnosed with Parkinson’s, your doctor will first prescribe medication. There are many drugs available that improve symptoms, but they have many side effects, including nausea, hallucinations and impulsive behavior. Some patients respond well to medications for years before seeing side effects. In these patients, the drugs may start to wear off quickly, or they may become extremely sensitive to the drugs and experience too much movement
Deep brain stimulation is a surgical option available to patients who are intolerant of medications or who experience serious side effects. This procedure involves implanting electrodes, or wires, deep inside the brain to change irregular brain activity. As a result, it improves motor function in patients with Parkinson’s disease. It is used more often to treat Parkinson’s disease than any other movement disorder.
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What Role Do Genes Play
Your genes are like your body’s instruction book. So if you get a change in one of them, it can make your body work in a slightly different way. Sometimes, that means you’re more likely to get a certain disease.
There are several genetic mutations that can raise your risk for Parkinson’s, each by a little bit. They have a part in about 1 in 10 cases.
If you have one or more of these changes, it doesn’t mean you’ll get Parkinson’s. Some people will, but many won’t, and doctors don’t know why. It may have to do with other genes or something in your environment.
Is Parkinsons Disease Inherited
Scientists have discovered gene mutations that are associated with Parkinsons disease.
There is some belief that some cases of early-onset Parkinsons disease disease starting before age 50 may be inherited. Scientists identified a gene mutation in people with Parkinsons disease whose brains contain Lewy bodies, which are clumps of the protein alpha-synuclein. Scientists are trying to understand the function of this protein and its relationship to genetic mutations that are sometimes seen in Parkinsons disease and in people with a type of dementia called Lewy body dementia.
Several other gene mutations have been found to play a role in Parkinsons disease. Mutations in these genes cause abnormal cell functioning, which affects the nerve cells ability to release dopamine and causes nerve cell death. Researchers are still trying to discover what causes these genes to mutate in order to understand how gene mutations influence the development of Parkinsons disease.
Scientists think that about 10% to 15% of persons with Parkinsons disease may have a genetic mutation that predisposes them to development of the disease. There are also environmental factors involved that are not fully understood.
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How Is Parkinsons Disease Treated
There is no cure for Parkinsons disease. However, medications and other treatments can help relieve some of your symptoms. Exercise can help your Parkinsons symptoms significantly. In addition, physical therapy, occupational therapy and speech-language therapy can help with walking and balance problems, eating and swallowing challenges and speech problems. Surgery is an option for some patients.
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What Causes Parkinsons Disease
Parkinsons disease is a chronic, progressive neurological disease that currently affects about 1 million Americans. Parkinsons disease involves a small, dark-tinged portion of the brain called the substantia nigra. This is where you produce most of the dopamine your brain uses. Dopamine is the chemical messenger that transmits messages between nerves that control muscle movements as well as those involved in the brains pleasure and reward centers. As we age, its normal for cells in the substantia nigra to die. This process happens in most people at a very slow rate.
But for some people, the loss happens rapidly, which is the start of Parkinsons disease. When 50 to 60 percent of the cells are gone, you begin to see the symptoms of Parkinsons.
Treatments For Parkinsons Disease
There are several types of treatments for Parkinsons Disease. Drugs and medications that make the disease easier to live with: Cognitive stimulation, which includes helping someone with Parkinsons learn new skills or concentrating on an activity that they want to do. Mimicking some of the things someone with Parkinsons has lost singing, dancing, playing an instrument, painting, etc. Vigorously exercising, preferably using an elliptical trainer, stationary bike, or other equipment. Or just changing their daily routine and adding more movement. Dietary supplements that may help the symptoms of Parkinsons disease: Folate and iron. Ginkgo biloba. Zinbryta. This is not a complete list of Parkinsons Disease treatments.
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Deep Brain Stimulation For Parkinson’s: Am I A Candidate
Deep brain stimulation is not a cure, but it can relieve your symptoms from Parkinson’s disease when medications are not an option. Only you and your doctor can decide if this surgical procedure is right for you. You may be a candidate for deep brain stimulation if:
- You have idiopathic Parkinson’s disease. Patients with atypical parkinsonism are not candidates.
- You have good motor function and independence during your best “on” state when taking the drug Sinemet.
Medication Of Parkinsons Disease
Although there are general guidelines available for doctors to choose treatment regime for Parkinsons disease, doctors may prefer different applications based on the individual. Selection of drug therapy, current symptoms, other existing health conditions and age are among the determining factors. Drug doses varies significantly depending on individual needs and metabolism of each patient.
As Parkinsons disease is caused by dopamine deficiency in the brain, some Parkinsons drugs mimic the effect of dopamine. These drugs are called dopaminergic drugs. Such drugs help to reduce muscle rigidity, improve speed and movement coordination and decrease tremors. It must be noted that drugs are a part of the general plan in Parkinsons treatment.
Some drugs that are used for the treatment of Parkinsons disease and mimics the dopamine deficiency in the brain are: Levodopa, KOMT inhibitors, MAO-B inhibitors, Dopamine receptor agonists, anticholinergic drugs and amantadines.
What Treatments Are Available
Many Parkinson’s patients enjoy an active lifestyle and a normal life expectancy. Maintaining a healthy lifestyle by eating a balanced diet and staying physically active contributes to overall health and well-being. Parkinson’s disease can be managed with self-care, medication, and surgery.
Self careExercise is as important as medication in the treatment of PD. It helps maintain flexibility and improves balance and range of motion. Patients may want to join a support group and continue enjoyable activities to improve their quality of life. Equally important is the health and well being of the family and caregivers who are also coping with PD. For additional pointers, see Coping With Parkinsons Disease.
These are some practical tips patients can use:
Medications There are several types of medications used to manage Parkinson’s. These medications may be used alone or in combination with each other, depending if your symptoms are mild or advanced.
After a time on medication, patients may notice that each dose wears off before the next dose can be taken or erratic fluctuations in dose effect . Anti-Parkinsons drugs can cause dyskinesia, which are involuntary jerking or swaying movements that typically occur at peak dosage and are caused by an overload of dopamine medication. Sometimes dyskinesia can be more troublesome than the Parkinsons symptoms.
Medicines For Parkinsons Disease
Medicines prescribed for Parkinsons include:
- Drugs that increase the level of dopamine in the brain
- Drugs that affect other brain chemicals in the body
- Drugs that help control nonmotor symptoms
The main therapy for Parkinsons is Levodopa, also called L-dopa. Nerve cells use levodopa to make dopamine to replenish the brains dwindling supply. Usually, people take levodopa along with another medication called carbidopa. Carbidopa delays the conversion of levodopa into dopamine until it reaches the brain. Carbidopa prevents or reduces some of the side effects of levodopa therapysuch as nausea, vomiting, low blood pressure, and restlessnessand reduces the amount of levodopa needed to improve symptoms.
When a tablet of levodopa is swallowed, the drug doesnt make its way directly to the brain where it is needed. It is absorbed in the small intestine and makes its way into the blood stream. From there, the blood takes the drug all around your body. And it is here that the early levodopa tablets had their unwanted effects.
Outside the brain, your body contain proteins that break down levodopa. This means much of the drug is deactivated before it even has the chance to get into your brain. The first of these proteins, called DOPA decarboxylase, is the protein that turns levodopa into dopamine. Inside the brain this protein vital for the drug to work, but when levodopa is turned into dopamine outside the brain it causes people to feel nauseous.
Making dopamine stick around
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What Are The Causes Of Parkinson’s Disease
The causes of Parkinsons disease include:
- Genetics and family history
- Frequent exposure to pesticides such as insecticides, herbicides, and fungicides
- Lewy bodies that are abnormal clumps of proteins found in the brain stem of people with Parkinsons disease which affect brain functions
- Loss of dopamine production in the brain when cells that produce dopamine are damaged
- Advanced age
Types Of Hallucinations In People With Parkinsons Disease
Hallucinations involve the five senses: sight, smell, touch, hearing, and taste.
People with hallucinations have sensory experiences that feel real to them, but are not actually happening and are not apparent to anyone else.
Types of hallucinations include:
- Auditory: Hearing things
- Gustatory: Tasting things
For people who experience Parkinsons-related hallucinations, the hallucinations are usually visual. They are typically non-threatening, but less commonly they can be of a threatening nature.
Often people with Parkinsons disease psychosis see small people or animals, or;loved ones who have already died. They are not interacting with them, just being observed.
Auditory hallucinations are more common in people with schizophrenia, but can happen with Parkinsons disease. With Parkinsons disease, auditory hallucinations are usually accompanied by visual hallucinations.
More specific types of hallucinations experienced by people with Parkinsons disease include:
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