Parkinsons Disease Pipeline Offers Promising New Options For Treatment
DelveInsights Parkinsons Disease Pipeline Insight report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in the Parkinsons Disease pipeline landscapes.
Los Angeles, USA, Jan. 17, 2022 Parkinsons Disease Pipeline Offers Promising New Options for Treatment | DelveInsight
DelveInsights Parkinsons Disease Pipeline Insight report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in the Parkinsons Disease pipeline landscapes.
The report comprises Parkinsons Disease pipeline drug profiles, including clinical and non-clinical stage products. It also includes the Parkinsons Disease therapeutics assessment by product type, stage, route of administration, and molecule type and further highlights the inactive Parkinsons Disease pipeline products.
Get an overview of pipeline landscape @ Parkinsons Disease Clinical Trials Analysis
Parkinsons Disease is a progressive disorder caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement.
· Combination· Mono/Combination
Key Questions regarding Current Parkinsons Disease Treatment Landscape and Emerging Therapies Answered in the Pipeline Report
What Medications And Treatments Are Used
Medication treatments for Parkinsons disease fall into two categories: Direct treatments and symptom treatments. Direct treatments target Parkinsons itself. Symptom treatments only treat certain effects of the disease.
Medications
Medications that treat Parkinsons disease do so in multiple ways. Because of that, drugs that do one or more of the following are most likely:
Several medications treat specific symptoms of Parkinson’s disease. Symptoms treated often include the following:
- Erectile and sexual dysfunction.
- Hallucinations and other psychosis symptoms.
Deep brain stimulation
In years past, surgery was an option to intentionally damage and scar a part of your brain that was malfunctioning because of Parkinsons disease. Today, that same effect is possible using deep-brain stimulation, which uses an implanted device to deliver a mild electrical current to those same areas.
The major advantage is that deep-brain stimulation is reversible, while intentional scarring damage is not. This treatment approach is almost always an option in later stages of Parkinson’s disease when levodopa therapy becomes less effective, and in people who have tremor that doesnt seem to respond to the usual medications.
Experimental treatments
Researchers are exploring other possible treatments that could help with Parkinsons disease. While these arent widely available, they do offer hope to people with this condition. Some of the experimental treatment approaches include:
Other Therapies To Consider
Trained therapists across a number of disciplines can work with you to develop exercises and lifestyle strategies to improve specific challenges youre having as a result of Parkinsons disease. You dont have to wait until youre struggling to seek out a therapist its important to intervene early. These lifestyle changes will hopefully benefit you now and down the road.37
Physical Therapy
A physical therapist can help you do exercises to improve your balance, gait, coordination and dealing with symptoms like freezing. For example, a physical therapist can teach you to cope with freezing episodes by using a laser which projects a line on the ground, stepping over such lines on the ground to cue your brain to start moving again, and walking assisted by rhythmic musical cues.13
One specific type of physical therapy for Parkinsons is LSVT BIG, which utilizes overexaggerated movements to retrain your bodys smaller, slower movements caused by Parkinsons. For example, buttoning a button with more purposeful, forceful movements, like youre angry at the buttons, can help you button faster.22 Some research found LSVT BIG to be more effective at improving your movement abilities than general exercise.24
Occupational Therapy
Occupational therapists teach you how to do everyday activities that have become difficult for you. For example, how to do daily tasks when you have a tremor and how to keep track of when your food has gone bad after you lose your sense of smell.13
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Is Medical Marijuana An Option For Me
What’s next for a person with PD who wants to know if medical marijuana is an option? “Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for PD,” said Dr. Michael S. Okun, the Parkinson’s Foundation National Medical Advisor.
Research is still needed to determine how medical marijuana should be administered and how its long-term use can affect symptoms of PD. To keep people safe, states that legalize medical marijuana will eventually need to develop training programs for doctors and medical teams that prescribe medical marijuana. Consult your doctor to see if medical marijuana is an option for you.
The Parkinsons Foundation Consensus Statement on the Use of Medical Cannabis for Parkinsons Disease is designed to help guide the PD community in making informed decisions about using cannabis for Parkinsons. The statement is based on the input from 46 experts who attended the Foundations first-ever medical marijuana convening. Read it now.
Page reviewed by Dr. Chauncey Spears, Clinical Assistant Professor and Dr. Sydney M. Spagna, Clinical Fellow at the University of Michigan.
Naturalremedy For Parkinsons #10 Foods You Must Avoid
There are certain foods that are known to worsen thesymptoms of Parkinsons and certain foods that are known to help. Healthadvocate, Dr Joseph Mercola, says that Parkinsons disease is primarily relatedto poor lifestyle choices, particularly poor dietary habits. Increasing yourbodys natural dopamine levels is also extremely important in your fight againstPD.
The foods and liquids you should be eating and drinkingmore of to help you along include:
· Clean Filtered Water Clean filtered water helpsto flush toxins from the body and hydrate the cells .Try and aim to drink at least two liters of water every day, and under nocircumstances drink tap water! Tap water is laced with toxic fluoride and otherchemicals and heavy metals so NEVER drink it. Buy yourself a good quality waterfilter. Its worth the investment.
· Whole Foods and Raw Foods Eat plenty oforganic mixed berries, green leafy vegetables, liver , fish,eggs, nuts and seeds such as chia and flaxseeds, along with plenty of herbs andspices. When it comes to buying any of these remember fresh is alwaysbest.
· Consume Lots of Probiotics Good gutbacteria are needed for strong immunity and healthy digestive function, whichin turn produces healthy brain and nerve function. You can learn how to makeyour own probiotic rich foods such as kefir, sauerkraut, kombucha and yogurt hereCultures for Health.
The foods you should be avoiding or not eating at allinclude:
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How Do You Know You Have Parkinsons Disease
There is no definitive way to diagnose Parkinsons disease. Your doctor will ask questions about the onset of your symptoms and assess your movement to make referrals to specialists who can make a formal diagnosis.
You can expect to see a neurologist who can complete a neurologic examination. This may include brain imaging, an MRI, or a PET scan to see activity in the area of the brain typically affected by Parkinsons disease.
Your doctor may also refer you to a movement disorder specialist. Seeing subspecialists is very important to avoid being misdiagnosed. Highly trained specialists can provide their expertise in specific areas of medicine where a precise diagnosis isnt possible from blood work or another definitive test.
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Important Points About The New Medications
With multiple new medications available for the treatment of PD, there is more hope than ever that Parkinsons symptoms can be successfully managed for many years. A few things to consider:
- For people whose symptoms are difficult to control, these new treatments are welcome additions to what was previously available and many people with PD have been using these new medications with significant benefit.
- On the other hand, many of the newly-approved medications have the same mechanisms of action as older medications so they are not breaking new ground in treating symptoms.
- In addition, for some people, the effect on symptoms may be mild or not substantial.
These caveats may mean that your physician has not suggested a medication change for you. It is also important to note that despite all the new medications, carbidopa/levodopa remains the most potent medication to treat the motor symptoms of PD.
If your doctor does choose to try one of the new options, there may be multiple paths that your doctor can take when contemplating a medication adjustment. Often trial and error is the only way to determine the best medication regimen for you, so you may need to practice some patience as you work together with your doctor to determine what works or doesnt work.
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What Is Parkinsons Disease Psychosis
Hallucinations and delusions are the most common symptoms of Parkinsons psychosis. Hallucinations involve a person seeing, hearing, feeling, smelling, or tasting something that isnt really present. Most hallucinations in PD psychosis are visual, where someone sees a person or an animal.
Delusions are ongoing thoughts that are not based in the real world. A person with delusions does not intentionally try to have these thoughts. These may include being jealous, feeling persecuted, or fixating on ones own body or health.
When describing their first hallucination, one MyParkinsonsTeam member said, In my living room I saw a little boy covered in fur. Lasted a good eight seconds, vivid and defined. I wasnt startled, just curious and absolutely believed it was real until it vanished.
Learn more about recognizing hallucinations and delusions.
Diagnosing Parkinsons Disease Psychosis
To properly diagnose psychosis in Parkinsons, a health care provider will rule out other diseases and disorders that can also cause psychosis, such as dementia with Lewy bodies, schizophrenia, delirium, or major depression with psychosis.
PD psychosis can be a side effect of Parkinsons medicine. Psychosis can also emerge as part of the brain changes involved in Parkinsons as the disease progresses.
Once your health care provider has confirmed that the psychosis hasnt come from another disease or disorder, theyll also make sure of the following:
- The person with PD has, in fact, been experiencing hallucinations or delusions.
- Parkinsons symptoms began before any of the psychosis symptoms.
- The psychosis symptoms have been happening either continually or every now and then for at least one month.
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Medical Treatment Of Parkinsons Disease
Enormous progress has been made in the treatment of Parkinsons disease over the past half century, but levodopa remains the most potent drug for controlling PD symptoms . Prior to instituting medical therapy, a correct diagnosis of PD must be established and the level of impairment determined . Each patients therapy is to be individualized, and diverse drugs other than levodopa are presently available. Among these are the dopamine agonists , catechol-o-methyl-transferase inhibitors and nondopaminergic agents . Head-to-head comparisons of drugs within classes are rare, and the differences that have emerged are related to the effects on motor fluctuations, dyskinesias, on/off times and adverse effects of the specific agents within each class .
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Top Ways To Treat Parkinsons Disease
This content was developed in partnership with the Parkinsons Foundation.
Every person living with Parkinsons disease experiences symptoms, disease progression and treatments that are unique to them. There is no single treatment plan that works for everyone.
The most common way to treat and manage PD symptoms include medications, exercise, rehabilitation therapies and surgical procedures. Treatment plans should be tailored to respond to an individuals symptoms and personal circumstances. While there is currently no cure for PD, the goals of treatment are to minimize symptoms and improve overall quality of life.
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Surgery: Deep Brain Stimulation For Parkinsons Disease
Deep brain stimulation is a surgery used to control Parkinsons motor symptoms including tremor, slowness of movement and stiffness. DBS was FDA-approved for Parkinsons disease in 2002 and works by delivering electrical pulses to specific areas of your brain that control movement. These electrical pulses disrupt the abnormal nerve signaling happening in your brain . By interrupting the abnormal signals, DBS can improve your motor symptoms, reduce on/off fluctuations and reduce the severity of dyskinesia .16 Some new research suggests DBS used in people with early-onset Parkinsons may actually slow down the progression of tremors.14
If you undergo DBS, you will likely be awake for the first part of the surgery, although DBS can in some cases be performed under general anesthesia, while youre asleep.9 Talk to your doctor about which option makes the most sense for your body. Heres what you might expect if you and your doctor decide DBS is right for you.
The first step is placing a halo a metal ring screwed into your head that keeps your head from moving. Local anesthesia is provided so it is not painful. However, some surgeries are now frameless and dont require a halo. Then, youll receive a local anesthetic while a small hole is made in your skull, near your ear. Through this hole, a wire connected to an electrode is placed in one or both sides of your brain in the areas that control movement. The wire and electrode are very thin.8
Natural Remedy For Parkinsons #4 Chlorella And Borax:
If you have a neurological disease such as Parkinsons orAlzheimers, the importance of removing heavy metals from the body especiallyfrom the brain and nervous system cannot be overstated. Heavy metalsaccumulate in the brain and nervous system at a rapid rate and cause damage tothe neurological pathways and brain inflammation. Fluoride is one ofthe worst, however, mercury, lead, aluminium and cadmium are also extremely dangerous.Chlorella and borax not only remove these heavy metals completely, theycontinue to prevent further toxic build-ups.
Chlorella is a miracle blue-green algae and one of themost powerful detoxifiers and chelators yet discovered. Whenits combined with cilantro, its benefits are enhancedsignificantly. A Russian study found that chlorella, combined with cilantro,was able to remove all heavy metals from the body, including fluoride and mercury,with no adverse or harmful side effects. You can purchase chlorellain powdered form online or from most health food stores. Just make sure you buythe Broken Cell Wall Chlorella as this is the strongest and most bio-available.For dosage recommendations, simply follow the directions on the container.
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What Are The Early Warning Signs Of Parkinson’s Disease
Parkinsons warning signs can be motor symptoms like slow movements, tremors or stiffness. However, they can also be non-motor symptoms. Many of the possible non-motor symptoms can appear years or even decades ahead of motor symptoms. However, non-motor symptoms can also be vague, making it difficult to connect them to Parkinson’s disease.
Non-motor symptoms that might be early warning signs include:
- Sleep problems such as periodic limb movement disorder , rapid eye movement behavior disorder and restless legs syndrome.
How Is It Diagnosed
Diagnosing Parkinson’s disease is mostly a clinical process, meaning it relies heavily on a healthcare provider examining your symptoms, asking you questions and reviewing your medical history. Some diagnostic and lab tests are possible, but these are usually needed to rule out other conditions or certain causes. However, most lab tests aren’t necessary unless you don’t respond to treatment for Parkinson’s disease, which can indicate you have another condition.
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When Should I See My Healthcare Provider Or When Should I Seek Care
You should see your healthcare provider as recommended, or if you notice changes in your symptoms or the effectiveness of your medication. Adjustments to medications and dosages can make a huge difference in how Parkinsons affects your life.
When should I go to ER?
Your healthcare provider can give you guidance and information on signs or symptoms that mean you should go to the hospital or seek medical care. In general, you should seek care if you fall, especially when you lose consciousness or might have an injury to your head, neck, chest, back or abdomen.
Medical Marijuana And Legislation By State
Thirty-eight states and Washington, DC have passed legislation allowing the use of marijuana-based products as a medical intervention. In some states where medical marijuana is legalized, consumers must register to possess and use cannabis. Other states require consumers to acquire a document from a physician stating that the person has an approved condition. Under federal law doctors cannot prescribe cannabis, but many states authorize them to issue certifications that allow people to obtain medical marijuana.
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Poorly Tolerated Or Unproven Treatments
Until recently, the only available treatments for psychosis consisted of reducing dopaminergic tone. At its extreme, this consisted of removing all antiparkinsonian medications for a period of time, a so-called drug holiday. As Friedman observed, however, this was not a holiday in the usual sense, since motor function quickly worsened . In fact, patients could develop a neuroleptic malignant syndromelike presentation, which occasionally could be lethal. Dopamine D2-like receptor antagonists prior to the 1990s all had unacceptable motor side effects.
In the 1990s and 2000s, newer antipsychotics were tried eagerly in PD psychosis in hopes of better tolerability . Like their predecessors, they block dopamine at D2-like receptors, but have more complex pharmacology, often including serotonin 5HT2 receptor antagonism or lower affinity for striatal D2Rs, and cause fewer motor side effects in patients with schizophrenia . Small, open trials with remoxipride and zotepine generally seemed positive, but several patients experienced intolerable motor side effects . Risperidone at low dose showed some promise in early reports , but intolerable motor side effects in others . In the only controlled trial with risperidone in PD, it was more effective than clozapine but less well tolerated . In controlled trials, olanzapine proved superior to placebo for PD psychosis , but worsened motor function .