Friday, April 12, 2024
Friday, April 12, 2024
HomeExclusiveNad Treatment For Parkinson's Disease

Nad Treatment For Parkinson’s Disease

Nad And Brain Restoration

IV NAD or Nicotinamide Adenine Dinucleotide for Parkinsons Disease

Sirtuins are a family of proteins that play a role in aging by regulating cellular health. Theyre responsible for critical biological functions like DNA expression and aspects of aging.

NAD Activates Sirtuin Enzymes

Sirtuins require NAD in order to be activated. There are seven different sirtuin enzymes that mainly function to turn on or off gene expression. Many of these genes are linked to regulating inflammation, along with enhancing energy metabolism and cell vitality. Sirtuins are known to play a protective role in neurodegeneration, and other inflammatory-related diseases.

Read the Science Magazine article or the Harvard Medical School article entitled Rewinding the Clock to see more about the science of why NAD helps prevent aging.

Nad Therapy For Parkinsons Disease Treatment

NAD therapy can restore your brains levels of the chemical nicotinamide adenine dinucleotide. Usually, every cell in your body produces this chemical. However, for various reasons, your NAD levels may drop. This is important because NAD helps sustain some of your bodys most important functions. That includes the automatic repair of damaged DNA. It also includes controlling your metabolism and the rate at which you age. Low levels of NAD may interfere with these essential processes. During NAD therapy, you receive IV doses of nicotinamide adenine dinucleotide. The amount of the chemical supplied in these doses is high enough to produce a therapeutic effect.

Parkinsons disease is associated with low NAD levels. If you receive NAD therapy during the early stages of the disease, you can reverse this deficit. The net effect is often a slowdown in the progression of Parkinsons. In turn, this slowdown helps you limit your symptoms for as long as possible.

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Nad Treatment Of Parkinsons Disease

If you or someone you love is struggling with Parkinsons disease , contact Dr. Phillip Milgram at .

Parkinsons is a chronic and progressive movement disorder. While the exact cause is unknown, more than one million people are suffering from Parkinsons disease.

NAD and Mitochondrial Dysfunction

As doctors get closer to identifying the cause of Parkinsons disease, mitochondrial dysfunction is emerging as a key contributor to Parkinsons disease.

An NAD infusion like that provided in our center causes NAD levels to rise. As a result, the cells have more energy, and can foster the creation of new mitochondria.

More About NAD

NAD is essential to living is found in every cell of all living things. There is much more NAD in the bodies of babies and growing adults.

NAD reduces inflammation and improves your bodys mix of enzymes. NAD helps the body to repair the brain. NAD helps the body repair DNA.

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Iv Nad And Parkinsons

Intravenous Administration of Nicotinamide Adenine Dinucleotide Alleviates Tremors Associated With Parkinsons Disease: A Case Report.

*L. RUTHERFORD1, S. L. BROOM2, T. OLDS1,3, R. F. MESTAYER1,3, P. NORRIS-MESTAYER11Springfield Wellness Center, Springfield, LA 2Dept Psychology, William Carey Univ., Hattiesburg, MS 3NAD Research, Inc., Springfield, LA

Introduction

A number of pharmacological agents currently exist for treating symptoms associated with Parkinsons Disease , however these drugs are not optimal because they typically target dopamine reuptake in depleted dopaminergic systems. Nicotinamide Adenine Dinucleotide is present in all cells and serves a vital role in cell and mitochondrial function in fact, disruption or depletion of NAD+ is associated with a number of disease states, including those associated with dopaminergic dysfunction. Clinicians in Springfield, LA previously developed an intravenous administration protocol of NAD+ for a patient experiencing symptoms associated with PD. Subsequent observation of a rapid and sustained reduction of Parkinsons symptoms were noted such as gait rigidity, slurred speech, shuffle steps, cognitive impairment and tremors. This previous case study provides rationale for further describing and quantifying the positive effects of IV BR+NAD on symptoms associated with PD.

Methods

Acknowledgements

Thank you to Springfield Wellness Center for providing the setting and clinical staff in support for this project.

New Therapies For Parkinsons Disease

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Despite mounds of research, scientists have previously been unable to pinpoint the exact mechanisms by which dopamine production declines in PD patients. There is growing evidence that exposure to environmental toxins may play a role in the destruction of dopamine-producing neurons, but the precise cause is still unclear.

Now, new research suggests that dysfunction in the mitochondria may be a contributing factor in the cascade of events that destroys dopamine-producing neurons and leads to Parkinsons disease. Low levels of NAD+ are thought to play a role, since the conenzyme is responsible for cellular protection and repair.

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What Does Nad+ Do

NAD+ stands for Nicotinamide Adenine Dinucleotide, and is an essential molecule found in every cell of your body. It is a coenzyme of Vitamin B3 , which means its a small helper molecule that binds to a protein molecule in order to activate an enzyme. Enzymes are responsible for over 5,000 different biochemical reactions throughout the body and NAD+participates in more reactions than any other vitamin-derived molecule.

  • ENERGY PRODUCTION NAD+ helps your cells convert food into energy by acting as an electron transporter during cell metabolism.
  • Repair DNA A constant supply of NAD+ is needed for the activation of PARPs, which detect and repair damaged DNA.
  • Enzyme Activty A class of enzymes called sirtuins help regulate certain metabolic pathways and genetic expressions. Sirtuins are NAD-dependent and the more sirtuin activity, the better for health and longevity. Increased sirtuin activity can help increase metabolism, decrease inflammation, extend cell life, and prevent neurodegeneration.
  • Cell Signaling NAD+ is also released from the intercellular space to the extracellular space for communication. Research is revealing that NAD and ATP may alert the immune response when the cell is under stress or when there is inflammation.
  • Gene Expression

    Overview Of Parkinsons Disease

    Parkinsons is a neurodegenerative movement disorder whose symptoms progressively worsen over time. A broad spectrum of drugs have been developed to treat Parkinsons symptoms, with dismal success rates.

    Parkinsons affects the central nervous system, causing cellular damage in the brain that leads to a severe drop in dopamine levels. Dopamine is an important chemical neurotransmitter that helps to deliver messages between the brain and the body, governing movement.

    Early symptoms of Parkinsons disease include:

    • A slight tremor in one hand
    • Shrinking handwriting
    • Sleep disrupted with night terrors and violent thrashing
    • Reduced balance
    • rinary and fecal incontinence
    • nability to perform activities of daily living like dressing, bathing, and eating

    As Parkinsons approaches its end game, palliative care and hospice with pain management are the final treatment approaches.

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    Why Harvard Medicine Is Calling Nad Iv Therapy The Crown Jewel Of Detox

    Over the past years, NAD IV Therapy has been getting a lot of attention lately as the preferred choice to stop substance addiction due to not only its effectiveness, but also its all-natural and holistic approach.

    According to Emerald Neuro-Recover Centers, Harvard Medicine states that NAD IV Therapy is proven to have an 87% success rate and is considered the crown jewel of detox because of its rapid cleanse and restoration therapies, and it radically repairs cell damage in the brain and body. In addition, Amora Scott, Vice President of Emeralds says The ancient way of treating addiction was to substitute one drug for another, which is only a quick fix. With NAD we can repair the brain and lose the cravings and anxiety of the addiction.

    What Is Nad Therapy

    What’s the latest on Parkinsons Disease

    Nicotinamide Adenine Dinucleotide is a metabolic co-enzyme and is charged with the important job of structuring, repairing, and remodeling every cell in the body. These specialized enzymes require constant replenishment in the body. Unfortunately, drug and alcohol abuse prompt the human brain to reorganize, particularly on a cellular level. This process, known as neuroadaptation, is directly responsible for addiction-related brain damage and depletion of neurotransmitters. NAD IV therapy is said to replenish the drained enzymes and target brain restoration.

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    Role Of Dopamine In Pd

    Dopamine is a neurotransmitter, a chemical released by nerve cells to signal other nerve cells. Dopamine plays a crucial role in multiple functions of the central nervous system including motor control, mood, attention, motivation and pleasure.

    Low levels of dopamine are responsible for the loss of motor control. Early symptoms often present as shaking in the hands and reduced coordination when moving. As the disease advances, patients may lose the ability to walk, chew, swallow and talk. PD often leads to premature death.

    While there are some medications that boost dopamine levels in PD patients, their effects are often short-lived, and their effectiveness on motor control gradually declines and then ceases altogether.

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    Targeting The Brains Energy Metabolism Phase I Trial Of Nicotinamide Riboside Supplements In Parkinsons Disease Offers Encouraging Results

    A clinical trial that formed part of the ChromaDex External Research Program and investigated the companys proprietary Niagen ingredient in patients with Parkinsons disease has offered encouraging results.

    Nicotinamide riboside is a member of the vitamin B3 family, which can be found in foods like fruits, vegetables, meat and milk. It is also used as a nutritional NR supplement to boost cellular levels of NAD .

    Longevity.Technology: NAD is an essential metabolic factor, which is vital to a multitude of cellular processes, including energy metabolism, DNA damage repair, and control of gene expression. However, NAD+ levels decline with age and are thought to be responsible for many age-related conditions such as cardiovascular disease, neurodegenerative diseases and cancer.

    NAD+ boosters like NR supplements have risen in popularity as scientific research continues to gather evidence for their effects on longevity and aging. Studies in animal models have shown that boosting NAD can improve muscle generation, cardiovascular function, and glucose metabolism and increased cellular NAD levels have been linked to a longer and healthier life in animals. Increased NAD levels have also been shown to protect neuronal cells against various forms of stress, and this new study demonstrates that the NAD levels of the human brain can be increased by ingesting NR supplements.

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    Why Does Nad+ Seem To Have This Positive Influence On Neurodegenerative Conditions

    For starters, every cell in each organ system of the body has a critical role. If this role is not met, the cell cannot properly function within that environment to perform its given purpose. If the DNA structure is damaged or the energy source , isnt able to be produced, symptoms of disease will begin manifesting in a variety of ways. In particular, neurons are especially susceptible to energy fluctuations due to mitochondrial dysfunction. In turn, damaged neurons can lead to the pathogenesis of various neurodegenerative diseases.

    NAD+ has the ability to regulate a class of proteins known as sirtuins. Sirtuins play a vital role in regulating anti-inflammatory processes throughout the body and the brain. Many studies have linked the neuroprotective effects of sirtuins and its implications to AS, PD, MS, as well as ALS.

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    What Are The Benefits Of Nad+ Iv Therapy For Parkinsons Disease

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    There are several key benefits of NAD+ IV Therapy For Parkinsons Disease. Some of the biggest benefits include:

    • Reduced tremors
    • Increased mobility, flexibility, and strength
    • An easier time speaking and writing
    • Improved mental clarity, thought processes, and executive functioning
    • Reduced muscle aches and pains
    • A better overall quality of life

    It is important to note that NAD+ infusions are not a cure for Parkinsons Disease however, they can play a key role in a well-rounded treatment process. NAD+ infusions provide the body with a flood of NAD+, which can quickly and efficiently improve the ability of the bodys cells to carry out their important functions. This includes dopamine production and cell signaling. Take a well-rounded approach to the treatment of Parkinsons Disease and invest in NAD+ IV infusion therapy.

    NAD+ 250mg

    We recommend this therapy for antiaging and overall health and wellness, for those patients who are currently healthy and want to optimize their health or aging process.

    NAD+ 500mg

    We recommend this therapy for boosters, health, and wellness patients who may have a chronic disease such as Lyme, mold, or history of autoimmune, have a history of treatment, feeling mildly ill but not completely in a health crisis or nonfunctional. In addition, this is ideal for athletes wanting to boost their athletic performance, and have better results.

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    Nad+ & Parkinsons Disease

    Parkinsons disease is a major cause of disability and death across the globe. Statistics tell us that at least 2 percent of men and women aged 65 and above are at risk, with its prevalence rising with age.

    Evidence reveals that a deficiency in NAD is key in the pathogenesis of Parkinsons disease. This is where NAD+ IV therapy comes into play, as studies suggest that the best way to correct the metabolic defect and treat this disease is by increasing levels of NAD.

    NAD+ IV therapy can help keep Parkinsons symptoms at bay and stop their progression, while helping the body restore cellular function. After receiving NAD+ IV therapy, Parkinsons patients can expect to experience improved mental clarity, emotional balance, and mood.

    A Method Of Addressing The Underlying Chemical Changes In The Brain That The Drugs Or Alcohol Have Caused

    Abstinence, psychological support and switching to other drugs are generally all that are used in drug treatment, in hopes that the brain will gradually recover on its own from the chemical damage. While some degree of brain healing will usually occur after decreasing or discontinuing drug or alcohol use, very often the natural healing is minimal, and the person suffers with continuing emptiness, anxiety, depression, insomnia, cravings, pain, brain fog and/or fatigue.

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    Clinical And Translational Reportthe Nadpark Study: A Randomized Phase I Trial Of Nicotinamide Riboside Supplementation In Parkinsons Disease

    Oral NR increases brain NAD levels in individuals with Parkinsons disease

    NR intake alters cerebral metabolism in Parkinsons disease

    Cerebral NAD increase is associated with clinical improvement in Parkinsons disease

    NR induces transcription of mitochondrial, lysosomal, and proteasomal pathways

    Rewinding The Clock With Nad Treatment

    NADH positive effects on Parkinsons

    NAD encourages new connections in the brain resulting in heightened senses and clarity of thought.

    Scientists at Harvard Medical School have found a way to use NAD in the reversing of accumulated DNA damage. NAD activates the enzyme responsible for DNA repair.

    A recent report from the Harvard Medical School Genetics laboratory found that NAD can help restore youthful levels of DNA repair and even reverse the effects of radiation.

    Read this article in Science Magazine if you want to know more about how NAD regulates protein to protein interactions that are involved in DNA repair.

    This article from Harvard Medical school entitled Rewinding the Clock also goes in depth on how NAD can naturally help reverse the effects of aging.

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    Gene Therapies Targeting Mitochondrial Dysfunction In Parkinsons Disease

    Gene therapy entails the treatment of disease via delivery of a transgene that either replaces or corrects a defective gene or is generally supportive of cells in the disease environment . Gene therapy vectors can be either viral or non-viral .

    Autosomal recessive mutations in the PRKN gene cause loss of function or inactivation of the parkin protein . Overexpression of PRKN has been shown to have a protective effect against numerous cellular insults . For example, overexpression of wild type parkin in a transgenic mouse model was shown to alleviate MPTP-induced dopaminergic neurodegeneration via protection of mitochondria and decreased striatal alpha-synuclein . Furthermore, recombinant AAV vector-mediated intranigral delivery of parkin prevented motor deficits and dopaminergic cell loss in a chronic MPTP-minipump mouse model of PD .

    Loss of function mutations in PINK1 can also lead to autosomal recessive PD . Removal of Drosophila PINK1 homologue function leads to male sterility, apoptotic muscle degeneration, defects in mitochondrial morphology and increased sensitivity to multiple stressors including oxidative stress. In a portion of PINK1 mutants, expression of human PINK1 in the Drosophila testes restores male fertility and normal mitochondrial morphology .

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    Outstanding Questions And Future Perspectives

    Recent studies on animals and human clinical trials have expanded our understanding of NAD+ and NAD+-dependent enzymes in neuroplasticity, brain aging, and neurodegenerative disorders. Emerging evidence suggests NAD+ depletion in brain cells is common during aging and is accentuated in many neurodegenerative disorders including AD, PD, HD, and ALS, and that NAD+ augmentation inhibits pathological features in animal models of these disorders . Emerging findings are revealing a critical role for NAD+ in neural resilience and in the molecular mechanisms of the hallmarks of brain aging. Although NAD+ depletion occurs in vulnerable neuronal populations in several major neurodegenerative diseases, it remains to be established whether impaired NAD+-dependent processes occur upstream and/or downstream of the specific proteopathic lesions that define each of the neurodegenerative diseases .

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    Nad+ Synthesis In Cells

    Nicotinamide adenine dinucleotide is a fundamental molecule in health and disease, as it is central to several cellular bioenergetic functions. NAD+ is synthesized via three major pathways, including de novo biosynthesis, the Preiss-Handler pathway, and the salvage pathway . While the aspartate pathway is the de novo NAD+ pathway in most photosynthetic eukaryotes, the kynurenine pathway is the only de novo NAD+ synthetic pathway in mammals. The kynurenine pathway starts with the catabolism of the amino acid tryptophan that is converted via two steps to the intermediate kynurenine, which can generate NAD+, kynurenic acid, or xanthurenic acid . The kynurenine pathway modulates neuronal functions as it is involved in the synthesis of two fundamental neuro-transmitters as well as regulates N-methyl-D-aspartate receptor activity and free radical production . The kynurenine pathway exhibits double-edged sword effects on neurons with both neuroprotective metabolites and neurotoxic intermediates, including 3-hydroxykynure-nine that generates free radicals, 3-hydroxyanthranilic acid , and quinolinic acid . While kynurenic acid is an NMDA receptor antagonist, quinolinic acid is an NMDA receptor agonist . The ambient levels of these metabolites are determined by different enzymes, which in the brain are preferentially localized in microglia and astrocytes, suggesting necessary glial cell-neuron communication .

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