Mitochondria Microbiota And Marijuana
The microbiome also plays an important role in the health of our mitochondria, which are present in every cell in the brain and body . Mitochondria function not only as the cells power plant they also are involved in regulating cell repair and cell death. Dysfunction of the mitochondria, resulting in high levels of oxidative stress, is intrinsic to PD neurodegeneration. Microbes produce inflammatory chemicals in the gut that seep into the bloodstream and damage mitochondria, contributing to disease pathogenesis not only in PD but many neurological and metabolic disorders, including obesity, type-2 diabetes, and Alzheimers.
The evidence that gut dysbiosis can foster the development of PD raises the possibility that those with the disease could benefit by manipulating their intestinal bacteria and improving their microbiome. Enhancing ones diet with fermented foods and probiotic supplements may improve gut health and relieve constipation, while also reducing anxiety, depression and memory problems that afflict PD patients.
Cannabis therapeutics may also help to manage PD symptoms and slow the progression of the disease. Acclaimed neurologist Sir William Gowers was the first to mention cannabis as a treatment for tremors in 1888. In his Manual of Diseases of the Nervous System, Grower noted that oral consumption of an Indian hemp extract quieted tremors temporarily, and after a year of chronic use the patients tremors nearly ceased.
Studies Show Cbd Is Effective For Parkinsons Disease
The findings below suggest that CBD may promote several vital processes relevant to the prevention and treatment of Parkinsons Disease, such as:
- Antioxidant protection of neurons
- Psychosis treatment
- Overall quality of life improvements.
As mentioned, the endocannabinoid system is active in the area of the brain affected by Parkinsons Disease, but CBD also interacts with outside receptors to address PD symptoms.
For example, University of Louisville researchers discovered that CBD acts as an inverse agonist at GPR 6 receptors , which have been associated with dopamine reduction.
Through these mechanisms and others, CBD is showing promise as a viable treatment for PD symptoms.
Heres what the research has to say.
What Are The Signs And Symptoms Of Parkinsons Disease
Symptoms of Parkinsons progress slowly and incrementally, often taking years to advance from one stage to the next.
As mentioned, the variability of symptoms is largely credited to the area of the brain affected by PD, meaning the following issues may differ proportionally from person to person:
Signs of Parkinsons Disease include difficulty sleeping, loss of smell, dizziness or fainting, and hunched posture.
The postural concern brings us to the issue of secondary problems associated with PD.
When progressed enough to restrict mobility to a wheelchair or a walker, PD can indirectly worsen tissue rigidity in weight-bearing joints important to healthy mobility, like the hips, knees, and vertebral joints.
Confinement to a wheelchair also invites skin integrity problems and general cardiovascular health decline.
Some of the signs and symptoms above occur as part of the normal aging process, which is why physicians pay close attention to the severity and frequency of the symptoms before officially diagnosing anyone with PD.
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Even Sleeping Beauty Would Be Jealous
There are many PD patients who experience various forms of sleep disorders. One of the more common of these disorders is REM sleep behaviour disorder . It is a parasomnia where the patient loses muscle atonia during REM sleep, and it is associated with nightmares.
Fortunately, there is good news for those suffering with this condition. An article in the Journal of Clinical Pharmacy and Therapeutics states that that treatment with CBD provides relief from RBD-related events.
What Cbd Oil Means For Parkinsons Patients
In sum: the research is not definitive but there are some promising indicators and early study seems to show that CBD might help mitigate some of PDs most unpleasant symptoms.
Parkinsons disease is a neurodegenerative disorder in which neurons that control body movements in the brain are destroyed or die.
Existing research, although limited, suggests that CBD may help address non-motor symptoms of PD like depression, sleep disruption, pain, and anxiety.
It has also been linked to a reduction of tremors, muscle spasms, and psychosis symptoms, as well as an overall improvement in the patients quality of life.
Top garners optimal results: people with PD might want to consider the top ways of consuming CBD like topicals, edibles, tinctures, beverages, and vaping.
Patients should also understand that CBD use may result in a few side effects like tiredness, diarrhea, drop in blood pressure, changes in appetite, drowsiness, lightheadedness, and sometimes changes in weight. The good thing is that they are usually very mild.
Moreover, no CBD medication has so far been cleared or approved by the FDA for Parkinsons disease. Perhaps that is because preliminary research is thin, fairly new, and sometimes inconclusive.
More work should be done. For now, it is imperative that you consult your doctor if you are a Parkinsons patient considering CBD oil treatments.
Comparing Cbd With Levodopa For Parkinsons
Levodopa is an established treatment for Parkinsons disease. Although its not perfect, its currently the most effective treatment for PD. It helps boost the level of dopamine in the brain.
Levodopa is effective at targeting the motor symptoms of the condition, such as tremors or muscle stiffness.
However, this medicine does little to combat the nonmotor symptoms of Parkinsons disease. These are the problems that can significantly affect a persons daily life. They include anxiety, sleep disturbance, fatigue, irritation, and depression.
Furthermore, prolonged use of levodopa may result in side effects like elevated anxiety, agitation, confusion, and nausea. It may also trigger tremors that result from the medication itself, not PD.
CBD appears to help with those nonmotor symptoms and potential side effects, rather than physical problems. A study with more than 200 participants found that regular use of cannabis was highly effective on non-motor symptoms of Parkinsons Disease. However, this study included a combination of THC with CBD, not CBD oil alone.
Is Cbd Considered Safe
In November of 2017, the World Health Organization met at Geneva, Switzerland to hold the 39th Meeting of the Expert Committee on Drug Dependence where CBD was discussed at length. WHO stated in their international disclosure that CBD is âsafe, well-tolerated, and not associated with any significant adverse public health effects.â They further stated that it does not induce a physical dependency nor is there any potential risk for substance abuse. WHO also recognized CBDâs therapeutic application by declaring it as an effective treatment for epilepsy patients as well as for many other conditions including both Parkinsonâs and Alzheimerâs diseases.
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Cbd Improves Quality Of Life With Pd
Living with Parkinsons isnt easy. This disease, which only gets worse with time, can seriously jeopardize a persons ability to lead a normal life. Luckily, studies show that CBD treatment can offer some relief.
For instance, a study of 21 PD patients who were given CBD and a placebo found that the participants who received CBD experienced improvements in their quality of life after just 6 weeks.
Another study on CBD oil and Parkinsons that included 119 patients also pointed out that CBD plays a significant role in the patients well-being and their quality of life. In this study, participants were given a placebo and CBD and although motor and general symptoms did not improve, findings showed a higher quality of life scores.
What Products Are People Using
The most common cannabis-derived product people with Parkinson’s used was CBD oil. People interested in using a cannabis-derived product in the future said this is what they’d consider using.
If the side effects are less than traditional Parkinson’s drugs, then I would want to try cannabis. Person with Parkinson’s who has never used a cannabis-derived product
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Study Probes Whether Cbd Helps For Parkinsons Disease Symptoms
In November 2012, Colorado got plenty of buzz as the first state in the nation to pass an amendment legalizing marijuana. The retail sale of recreational marijuana followed in January 2014. Shops peddling the drug soon sprouted across the landscape from street corners to strip malls.
But if marijuana is now a fixture of everyday life in Colorado, questions about it continue. One of the most intriguing is the potential cannabis has to treat a host of ailments, including inflammatory bowel disorder, chronic pain, sleep loss, epilepsy and Parkinsons disease. With legalization, researchers finally had an opportunity to lead controlled clinical trials to test the anecdotal evidence patients have offered of marijuanas medical benefits.
There have been many obstacles, however, as Dr. Maureen Leehey, a neurologist at the UCHealth Neurosciences Center and Professor of Neurology with the University of Colorado School of Medicine, can attest. Her experience illustrates the difficulties of conducting evidence-based research into the medical effectiveness of marijuana. Despite its popularity, the drug still must clear significant regulatory hurdles before research yields any solid answers about its benefits to patients.
What The Experts Say
Fernanda F. Peres is the leading author on a 2018 review of CBD as a treatment for Parkinson’s disease and other movement disorders, published in Frontiers in Pharmacology.
Peres is convinced that CBD holds strong potential in the treatment of PD.
We have data pointing to CBD’s beneficial effects on non-motor symptoms. Using CBD in addition to antiparkinsonian medications is a future possibility, in my opinion.
Peres points out that first-line medications for PD, such as carbidopa-levodopa, improve the motor symptoms, but can lead to significant adverse effects such as psychotic symptoms or involuntary movements.
CBD, on the other hand only causes mild side effects, such as fatigue or a dry mouth in some individuals. Although there is currently a lack of clinical evidence in human studies, Peres believes that earlier diagnoses of Parkinson’s disease will enable the neuroprotective properties of CBD to work better.
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Is Medical Marijuana An Option For Me
What’s next for a person with PD who wants to know if medical marijuana is an option? “Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for PD,” said Dr. Michael S. Okun, the Parkinson’s Foundation National Medical Advisor.
Research is still needed to determine how medical marijuana should be administered and how its long-term use can affect symptoms of PD. To keep patients safe, states that legalize medical marijuana will eventually need to develop training programs for doctors and medical teams that prescribe medical marijuana. Consult your doctor to see if medical marijuana is an option for you.
The Parkinsons Foundation is designed to help guide the PD community in making informed decisions about using cannabis for Parkinsons. The statement is based on the input from 46 experts who attended the Foundations first-ever medical marijuana convening. Read it now.
Page reviewed by Dr. Bhavana Patel, Movement Disorders Fellow at the University of Florida, a Parkinsons Foundation Center of Excellence.
Cbd Oil For Anxiety Tremors
In a recent study published by the Journal of Psychopharmacology, the authors found that CBD reduced anxiety and tremor amplitude among PD patients. The research team used a dose of 300 mg CBD/day, which provided significant benefits for heart rate, blood pressure, and frequency of tremors among the subjects.
The scientists also noted a reduction in anxiety-related tremors during a simulated public speaking test.
Other studies implicate that CBD can have therapeutic benefits for people with anxiety disorders and neuropsychiatric conditions.
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Whats The Virtual Biotech
The Parkinsons Virtual Biotech is our best chance of turning promising discoveries into real treatments for people with Parkinsons.
A biotech is a company that uses the latest technology and expertise to take the best scientific discoveries and turn them into new medical treatments.
Our Virtual Biotech operates in the same way but instead of doing it for profit, like a standard biotech, were doing it for people affected by Parkinson’s. We dont own our own labs, hi-tech specialist equipment or employ a team of scientists because this would be enormously expensive. Instead, were taking an efficient approach. Partnering with institutions and pharmaceutical companies worldwide that already have the expertise, tools and infrastructure. In a chronically underfunded area, this means more money can be put into promising treatments.
This project is the first clinical trial to go through the Virtual Biotech and the 6th project overall.
Watch the video below to find out more about the Parkinson’s Virtual Biotech.
Symptoms Of Parkinsons Disease
The symptoms of Parkinsons Disease vary from one person to another, depending on their age, pre-existing physical conditions, and more. Common symptoms of this disease include the following:
- Tremors and uncontrolled movements
- Cognitive issues
- Poor automatic movements etc.
Overall, Parkinsons can cause a sea change to your life since you will gradually lose control of your body. You may also face confusion, thinking problems, and more. All of these often lead to depression and behavioral changes. Medicines help to control such symptoms.
However, it is to be noted that medicines conventionally used to manage the symptoms of Parkinsons Disease also have a set of side effects on the patients mind and body. That is why a large number of patients now want to use alternative options for this condition.
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Are You Going Psychotic Trying To Treat Psychosis
Psychosis is an unpleasant symptom of PD. However, in an interesting article found in the European Archives of Psychiatry and Clinical Neuroscience, CBD produced significant therapeutic effects with symptoms of psychosis in patients with PD.
Depending on its severity, psychosis can be an extremely serious threat to the health and well being of an individual. Because of these dangers, treatment of PD patients with symptoms of psychosis should seriously consider the use of CBD as a highly effective medication.
Best Type Of Cbd To Use For Tremors
There are three main types of CBD you can choose from: full-spectrum CBD, broad-spectrum CBD, and CBD isolate.
Full-spectrum CBD is made from the whole hemp plant, and as such, it contains all the cannabinoids present in hemps, such as CBD, CBN, CBG, CBC, and trace amounts of THC. It also contains a lot of terpenes, which are volatile molecules that modulate the activity of cannabinoids.
These compounds create a unique synergy known as the entourage effect. This concept was brought up in 1988 and further elaborated on in 2011 by E.B. Russo, an esteemed neuroscientist and cannabis expert. In the entourage effect, the sum of all active ingredients in the plant is more potent therapeutically than each compound in isolation.
Therefore, if you want to reap the most benefits of your CBD oil, opt for full-spectrum extracts.
Broad-spectrum CBD is very similar to its full-spectrum counterpart, but it doesnt contain any THC. The intoxicating ingredient has been removed after initial extraction so that the user can benefit from some of the entourage effects without worrying about failing a drug test.
You can also choose CBD isolate, which is pure CBD that has been crystallized and infused into the same product formats as the other types of CBD. The advantage of CBD isolates over other types of CBD oils is the lack of flavor and aroma that being said, theres also an obvious downside the lack of entourage effect.
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Finding Your Minimum Effective Dose: How Much Cbd Do I Take And How Often
Due to FDA regulations we cannot give specific advice on how to use CBD for a particular condition such as Parkinsons disease. Fortunately though, the process to find a minimum effective dose of CBD for any condition, is very simple. The key to finding the most effective dosage is by using what is called, a Stepwise Dosing procedure.
Stepwise Dosing is a process by which you first establish a baseline dosage, then adjust the dosage incrementally over a set period of time until you find your effective dose.
It is important to recognize that everyone responds a little differently to CBD so there is no set dose for everyone or every condition. By following a stepwise dosing procedure you can find the most effective dosage of CBD for you.
Sublingual Usage Of Cbd Oil
If you want to experience the effects of CBD faster, you can take it sublingually. Place the oil under your tongue and hold it there for 60 to 90 seconds before you swallow. Since this type of usage bypasses your digestive tract, you will feel it more quickly.
In a few minutes, you will feel the effects of a sublingual dosage, and they will last for several hours. You can use pastes, sprays, drops, or tinctures to take CBD sublingually.
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The Benefits And Research Around Cbd Are Still Emerging
Claudia Chaves, MD, is board-certified in cerebrovascular disease and neurology with a subspecialty certification in vascular neurology. She is an associate professor of neurology at Tufts Medical School and medical director of the Lahey Clinic Multiple Sclerosis Center in Lexington, Massachusetts.
With the legalization of medical marijuana, many states are approving the use of it in a non-traditional way to treat the symptoms of certain conditions, including Parkinsons disease. Marijuana has two major components to ittetrahydrocannabinol and cannabidiol . Both may help with nausea and muscle pain or spasms, but unlike THC, CBD doesnt give you the high feeling marijuana is most commonly known for. This makes it an enticing, natural way for many to help treat their Parkinsons disease symptoms. Whats more, is that because CBD is a natural compound from the Cannabis sativa plant, using it may also leave you side effect-free, unlike many prescription medications.
Cbd Side Effects And Risks
In most studies, CBD is tolerated well. It rarely causes side effects, and the ones that do happen tend to be mild. They include tiredness, changes in appetite, and diarrhea or nausea.
However, CBD can interact with prescription and over-the-counter medications. Talk to your doctor before taking CBD, especially if youre on medications that contain a grapefruit warning. CBD and grapefruit have a similar effect on certain enzymes related to drug metabolism.
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