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A Cure For Parkinson’s Disease

What Is The Prognosis

How can we cure Parkinson’s?

The average life expectancy of a person with PD is generally the same as for people who do not have the disease. Fortunately, there are many treatment options available for people with PD. However, in the late stages, PD may no longer respond to medications and can become associated with serious complications such as choking, pneumonia, and falls.

PD is a slowly progressive disorder. It is not possible to predict what course the disease will take for an individual person.

One commonly used scale neurologists use for describing how the symptoms of PD have progressed in a patient is the Hoehn and Yahr scale.

Do Symptoms Get Worse

PD does not affect everyone the same way. The rate of progression and the particular symptoms differ among individuals.

PD symptoms typically begin on one side of the body. However, the disease eventually affects both sides, although symptoms are often less severe on one side than on the other.

Early symptoms of PD may be subtle and occur gradually. Affected people may feel mild tremors or have difficulty getting out of a chair. Activities may take longer to complete than in the past. Muscles stiffen and movement may be slower. The persons face may lack expression and animation . People may notice that they speak too softly or with hesitation, or that their handwriting is slow and looks cramped or small. This very early period may last a long time before the more classical and obvious motor symptoms appear.

As the disease progresses, symptoms may begin to interfere with daily activities. Affected individuals may not be able to hold utensils steady or they may find that the shaking makes reading a newspaper difficult.

People with PD often develop a so-called parkinsonian gait that includes a tendency to lean forward, taking small quick steps as if hurrying , and reduced swinging in one or both arms. They may have trouble initiating movement , and they may stop suddenly as they walk .

Is There A Cure For Parkinsons Disease How Close Is A Cure For Parkinson’s

As of now, there is no known cure for this disease. However, treatments likedrug therapy or brain surgery can help reduce the symptoms and make life easier for patients with Parkinsons Disease.

Although a cure is nowhere near yet, scientists claim that they will find better treatment in years to come, which is expected to happen within the decade. The past two years could have been the years of advancements for new drugs for PD, but the pandemic pushed some plans back.

As part of their advancements in finding the cure, Parkinsons research has launched a virtual biotech for developing and testing new treatments.

Also, they are collaborating with international scientists to share thoughts, scientific discoveries to make testings more efficient and less costly.

Lastly, the research is also searching for other unlooked conditions that may pave the way for PD to develop in people. Searching for other possible options for why the loss of nerve cells is happening.

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Is Parkinsons Disease Inherited

Scientists have discovered gene mutations that are associated with Parkinsons disease.

There is some belief that some cases of early-onset Parkinsons disease disease starting before age 50 may be inherited. Scientists identified a gene mutation in people with Parkinsons disease whose brains contain Lewy bodies, which are clumps of the protein alpha-synuclein. Scientists are trying to understand the function of this protein and its relationship to genetic mutations that are sometimes seen in Parkinsons disease and in people with a type of dementia called Lewy body dementia.

Several other gene mutations have been found to play a role in Parkinsons disease. Mutations in these genes cause abnormal cell functioning, which affects the nerve cells ability to release dopamine and causes nerve cell death. Researchers are still trying to discover what causes these genes to mutate in order to understand how gene mutations influence the development of Parkinsons disease.

Scientists think that about 10% to 15% of persons with Parkinsons disease may have a genetic mutation that predisposes them to development of the disease. There are also environmental factors involved that are not fully understood.

Symptoms And Warning Signs

Parkinsons disease

Symptoms of Parkinsons fall into two major categories: those related to motor functions, and those related to changes in someones mood. The four most common signs and symptoms of Parkinsons disease include:

  • Trembling: This usually presents itself in the arms, jaw, legs and face.
  • Rigidity: Most patients experience stiffness of the bodys core as well as their arms and legs.
  • Bradykinesia: This is the term for slowness of movement. Some patients pause or freeze when moving without being able to start again, and others begin to shuffle when trying to walk.
  • Postural instability : This results in loss of strength, loss of balance and problems with moving muscles or coordinating body parts.

Other symptoms that can also occur, which often impact someones moods and other behaviors, include:

  • Sexual dysfunction

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How Close Are We To A Cure For Parkinsons

Saskia Mair of Parkinsons Lifeinterviews Sohini Chowdhury, Deputy CEO of the Michael J Fox Foundation.

How close do you think the scientific community is to finding a cure for Parkinsons?

Whenever I say the word cure, I kind of put it in quotes. I think its important to remember that a cure can mean different things to different people.

If youre able to improve the symptom management of the disease to an extent where having the disease has very little impact on your day to day life, that could be considered a cure.

If youre able to slow or halt the disease progression so that the moment you get diagnosed, it never progresses beyond that point but youre still taking a pill every day for the rest of your life, that could be a cure.

Theres a recognition now that Parkinsons is not one disease experience. It is a disease experience that is very variable, so we have to be open minded because a cure for one person could be very different than a cure for another person.

I think the fact that this is now accepted in the research community is a good thing for patients. Its not a one size fit all approach. We have finally understood that we need lots of different cures to fit the different patient experiences under the name Parkinsons disease.

In terms of how close we are is it tomorrow? Absolutely not. But theres so many resources, money, scientific knowledge, and brainpower across the world being put forth into this.

Symptoms Of Parkinsons Disease

Parkinsons disease is a progressive disease and the symptoms of this disease are often unnoticeable during the initial stage.

One of the most obvious symptoms of this condition is tremors in the hand or changes in the movement in one side of your body.

Lets discuss them as follows:

Some of the early symptoms of Parkinsons can begin a number of years before motor problems develop.

The earliest signs are a decrease in your ability to smell oranosmia, constipation, small, cramped handwriting, voice changes, and stooped posture.

Moreover, the 4 major motor issues that are noticeable are:Tremor or shaking that occurs at rest, slow movements, stiffness of arms, legs, and trunk.

Problems with balance and tendency to fall are among the motor problems.

Secondary symptoms of this disease are:

Blank facial expressions, a tendency to get stuck when walking, muffled, or low volume speech.

Parkinsons gait is the tendency to take shuffling steps while walking.

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When Will There Be A Cure For Parkinsons Disease

You can tell a lot about a culture from its Armageddon myths, as propagated through pop culture. We have created quite a few across the last few decades, from the dystopian futures of Mad Max and the Terminator to the zombie apocalypses that have come to populate many an end-of-the-world tale. The latter often entail some experiment gone horribly awry, leading to a pandemic far more lethal and gruesome than any ever caused, for example, by influenza. Earlier this year, scientists warned of a possible new pandemic that has nothing to do with diseased bat guano, genetically modified whatever, or ancient Egyptian curses. Parkinsons Disease is on the rise, and so far theres no cure for this rare neurodegenerative disease.

Why Arent We Closer To Finding A Cure For Parkinsons

Breakthrough clinical trial could reverse symptoms of Parkinson’s Disease

Heres a question we and those in our community consider every day: With all of the money that is going toward finding a cure for Parkinsons, why arent we there yet? So, when we had the chance to sit down with Pete Schmidt, a member of our Board and the Vice Dean at the Brody School of Medicine and Associate Vice Chancellor for Health Care Regulatory Affairs at East Carolina University, we asked him this question:

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What Area Of Parkinsons Research Are You Are Excited To Find Out More About

Particularly in this COVID world that were living in, one of the things that is really exciting is were increasingly seeing the role that technology can play in helping to track the disease experience of patients.

In this unprecedented year, weve seen such a such an emphasis on sheltering in place, particularly among our vulnerable populations. We have an online clinical study called Fox Insight and weve really seen an increase in registrations because it shows the potential of being able to participate in research from the safety of your own home, and still contribute to sharing knowledge about the disease.

In the US, weve also seen the embrace of telemedicine as a way to continue to think about managing care but not necessarily having to go into a doctors office. I think all of these experiences, coupled with ongoing advances in sensor technologies or smartphone apps, really show us the way technology can ease the burden, both of managing the disease and participating in research. I think that might be a little bit of a silver lining in a world where there arent very many silver linings at the moment.

Scientists Stunned After Parkinsons Disease Test

Once researchers realized that they could easily create neurons from other types of cells, they decided to see if the method could be used to treat neurodegenerative diseases, such as Parkinsons disease. In Parkinsons, dopamine cells in the brain die. Thus, to assess their method, the researchers used a chemical that poisons dopamine neurons and creates symptoms of Parkinsons disease in mice.

After using the chemical to kill dopamine neurons in the mice, researchers silenced PTB. They found that 30% of astrocytes turned into neurons. Moreover, these newly generated neurons seemed to grow normally and even began to send connections to other parts of the brain, like normal neurons.

When the researchers looked at mouse behavior, they also found that silencing PTB completely restored movement function. Moreover, even though the PTB-silencing treatment was only administered once, the mice did not show any symptoms of Parkinsons disease for the remainder of their lifetime.

I was stunned at what I saw, said study co-author Dr. William Mobley, Distinguished Professor of Neurosciences at UCSDs School of Medicine. This whole new strategy for treating neurodegeneration gives hope that it may be possible to help even those with advanced disease.

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Shocking Facts About Parkinson’s Disease:

1. In 2015, PD affected 6.2 million people and resulted in about 117,400 deaths globally.

2. There’s no known cause of PD.

3. Parkinson’s disease typically occurs in people over the age of 60, of which about one per cent are affected.

4. Males are more often affected than females at a ratio of around 3:2.

5. The disease is named after the English doctor James Parkinson, who published the first detailed description in An Essay on the Shaking Palsy, in 1817.

6. The average life expectancy following diagnosis is between 7 and 14 years.

Complementary And Supportive Therapies

Parkinsons Disease: Types, Symptoms, Causes, Diagnosis ...

A wide variety of complementary and supportive therapies may be used for PD, including:

A healthy diet. At this time there are no specific vitamins, minerals, or other nutrients that have any proven therapeutic value in PD. The National Institute of Neurological Disorders and Stroke and other components of the National Institutes of Health are funding research to determine if caffeine, antioxidants, and other dietary factors may be beneficial for preventing or treating PD. A normal, healthy diet can promote overall well-being for people with PD just as it would for anyone else. Eating a fiber-rich diet and drinking plenty of fluids also can help alleviate constipation. A high protein diet, however, may limit levodopas absorption.

Exercise. Exercise can help people with PD improve their mobility, flexibility, and body strength. It also can improve well-being, balance, minimize gait problems, and strengthen certain muscles so that people can speak and swallow better. General physical activity, such as walking, gardening, swimming, calisthenics, and using exercise machines, can have other benefit. People with PD should always check with their doctors before beginning a new exercise program.

Alternative approaches that are used by some individuals with PD include:

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Surgery For Parkinsons Disease

Based on the severity of the condition and the medical profile, the doctor may recommend surgery as one treatment option for Parkinson’s disease.

There are several types of surgery that may be performed that can help patients with Parkinson’s disease. Most of the treatments are aimed at helping the tremor or rigidity that comes with the disease. In some patients, surgery may decrease the amount of medication that is needed to control the symptoms.

There are three types of surgeries that may be performed for Parkinson’s disease, including the following:

It is important to remember that surgery may help with symptoms of Parkinson’s disease, but does not cure the disease or stop the progression of the disease.

Why Is There Still No Cure For Parkinsons Disease

Despite significant investments in research to fight Parkinsons disease, no treatment targeting regeneration of dopaminergic neurons, or at least slowing the progression of the disease, has been authorized on the market. Promising announcements of the pharmaceutical research laboratories are numerous, but a growing number of patients are asking the question: why is it always for tomorrow, and then the day after tomorrow ?

Live Better Parkinsons has tried to bring some answers to this legitimate question.

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Intake Of Fresh Raw Fruits And Vegetables

Fresh raw fruits and organic vegetables are widely known to provide all the necessary nutrients that cleanse your body. The nutrients include antioxidants, phytonutrients, enzymes, minerals, vitamins, flavonoids, amino acids, anti-inflammatory properties, and fiber. These nutrients are essential for digesting the food and consuming food void of these nutrients can cause a great deal of digestive and intestinal damage.

How Close Do You Think The Scientific Community Is To Finding A Cure For Parkinsons Disease

A Cure for Parkinson’s Disease

Whenever I say the word cure, I kind of put it in quotes. I think its important to remember that a cure can mean different things to different people. If youre able to improve the symptom management of the disease to an extent where having the disease has very little impact on your day to day life, that could be considered a cure. If youre able to slow or halt the disease progression so that the moment you get diagnosed, it never progresses beyond that point but youre still taking a pill every day for the rest of your life, that could be a cure.

Theres a recognition now that Parkinsons disease is not one disease experience. It is a disease experience that is very variable, so we have to be open minded because a cure for one person could be very different than a cure for another person.

I think the fact that this is now accepted in the research community is a good thing for patients. Its not a one size fit all approach. We have finally understood that we need lots of different cures to fit the different patient experiences under the name Parkinsons disease.

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Stages Of Parkinsons Disease

Parkinsons is a progressive disease and the symptoms tend to worsen with time.

Many doctors use the Hoehn and Yahr scale to classify these stages and according to this scale, the symptoms are divided into 5 stages.

It helps the healthcare providers to learn how advanced the signs and symptoms are.Lets discuss them as follows:

Stage 1 Stage 1 is the mildest form and in fact, you may not experience any symptoms that are observable.

Moreover, these symptoms do not interfere with your daily life and taste yet.

However, if you do have symptoms, they may be isolated to one side of the body.

2nd Stage The progression from stage 1 to stage 2 can take months or even years, however, different individuals have different symptoms.

At this moderate stage, you may experience muscle stiffness, tremors, changes in facial expressions, and trembling.

Additionally, the symptoms may also appear on both sides of the body. Changes in posture, gait, and facial expressions are most noticeable in this stage.

3rd Stage This one is the middle stage and the symptoms start to progress.

While the likelihood of development of new symptoms is less, the symptoms tend to be more noticeable.

Movements of your body appear slower, which slows down your activities, balance issues are more significant, thus falling becomes common.

However, individuals at this stage usually maintain their independence and complete their regular activities without much assistance.

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Assembling Your Care Team

Assembling a team that will provide you with physical and emotional support and adapt to your needs over time is one of the best ways to remain healthy. Parkinsons disease is complex and requires an interdisciplinary approach to care. The care team may include, but is not limited to:

  • Movement disorder specialist
  • Rehabilitation specialists including physical, occupational, and speech therapists
  • Nurse

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