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Mrna Vaccine And Parkinson’s Disease

Is There Any Reason Why You Shouldnt Get The Vaccine If You Have Parkinsons

How to invest in mRNA vaccines that could revolutionise medicine | Counting the Cost

At this time, an allergic reaction to any component of the COVID-19 vaccine or a history of allergic reactions after vaccinations is the only major reason not to have a COVID-19 vaccine.

If you have a history of blood clots, are taking immunosuppressive medications, or are actively sick with a fever, you should discuss the timing, dosage, and type of vaccine with a doctor.

Case Series And Literature Reports

The first patient is a 46-year-old man, with a 9-year PD history, successfully implanted with bilateral Subthalamic Deep Brain Stimulation in May 2019. In April 2021, he received two doses of mRNA-1273 vaccine , without experiencing side effects. On December 2021 symptoms were well controlled with levodopa/benserazide 100/25 mg 5 times a day, selegiline 10 mg, and stimulation set at 130 Hz, 60 s, 3.1 mA , and 2.6 mA . The same night of the mRNA-1273 booster he experienced motor and non-motor symptoms worsening , without flu symptoms. He added three night doses of levodopa/benserazide, with onset of dyskinesia but incomplete wearing-off control. Six days later, we evaluated regular DBS functioning: in MED-OFF/STIM-ON condition, the MDS-Unified Parkinsons Disease Rating Scale III score was 61, the Non-Motor Symptoms Scale score was 66, and Montreal Cognitive Assessment score was 26. Motor symptoms improved increasing stimulation intensity : MDS-UPDRS III score decreased to 36 in MED-OFF/STIM-ON, and to 8 in MED-ON/STIM-ON . The patient achieved good wearing-off control in the following days, also returning to usual therapeutic regimen: mild dyskinesia resolved after restoring previous stimulation settings.

Few other data are available in literature, with four cases of PD symptoms worsening and three cases of new movement disorders in healthy people .

Should I Still Wear A Mask In Crowded Areas After I Get The Vaccine

According to the CDC, fully vaccinated people generally dont need to wear a mask in outdoor locations. As far as indoor settings, the CDC recommends checking the local infection rates and transmission levels in your area.

In areas or times of high transmission, wearing a mask indoors in crowded areas may be recommended to offer you additional protection from a SARS-CoV-2 infection.

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Frequently Asked Questions About The Covid 19 Vaccines

Frequently Asked Questions about the COVID 19 Vaccines

The information included in the Q & A was obtained from the Center for Disease Control, the Coronavirus, COVID 19 Vaccine, State of Michigan and the Childrens Hospital of Philadelphia Vaccine Education Center. The information was reviewed and approved by the physicians on the Michigan Parkinson Foundation Board of Directors.

Policy statement from Michigan Parkinson Foundation Medical Advisory Board of Directors

Many patients with Parkinsons are older and at higher risk of poor outcomes if they contract COVID 19. The risks of the disease greatly outweigh the risks of the vaccine. People should also be encouraged do get their flu vaccines. There is a reason almost all health care workers are required to get it to protect our patients, even if we are not in high risk groups.

How do the new COVID-19 vaccines work? Vaccines work by introducing an element into the body that itself cant cause illness but is recognized as an infection by the immune system. The immune system then responds to the element, giving the body the ability to defend against the actual infection should it encounter it in the future.

mRNA is easier to manufacture in a laboratory in large quantities than a weakened virus and using mRNA technology allowed for the rapid creation of the vaccines, which typically take many years to develop.

How do mRNA vaccines work?

Once I have been vaccinated against coronavirus, am I exempt from lockdown restrictions?

New Study: Parkinson’s Foundation Center Of Excellence Sheds Light On Covid Vaccine And Parkinson’s

COVID

Life as we knew it changed on January 30, 2020. That was that day when the World Health Organization officially declared the COVID-19 outbreak to be a Public Health Emergency of International Concern. Caused by Severe Acute Respiratory Syndrome Coronavirus 2 , COVID-19 can result in serious, life-threatening complications, regardless of ones age, race, health status, geographical location, or socio-economic income and including people with Parkinsons disease. In this article, well examine a new study from a Parkinsons Foundation Center of Excellence, Nijmegen Parkinsons Center in the Netherlands, which recommends the COVID-19 vaccination for people with Parkinsons, unless there is a specific contraindication.

Overall, we know that people with PD who contract COVID-19 are more likely to experience severe respiratory issues and have more difficulty recovering from COVID-19 particularly among those with advanced PD, compared to people who do not have PD. Another additional concern for those with PD is that COVID-19 may trigger a worsening of both motor and non-motor symptoms and also may increase the risks of mental health challenges. These mental health challenges are known to be higher for people with PD living under social isolation, higher stress levels and without adequate exercise.

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Parkinsons Process Nipped In The Rna Bud

A well-tended world can turn into an unweeded garden, Hamlet moaned. Tragically, he turned out to be better at moaning over things rank and gross in nature than at getting a grip on his predicament. Refusing to follow Hamlets example, scientists based at Scripps Research have shown that they can get a handle on their own version of an unwelcome weeda protein that aggregates in Lewy bodies and culminates in Parkinsons disease.

This protein, -synuclein, is deemed undruggable. It is an intrinsically disordered protein that lacks binding pockets for small molecules. Rather than let -synuclein be expressed, by which point it may become all but unmanageable, the Scripps Research scientists, together with colleagues from other institutions, decided to nip it in the budthe RNA bud. That is, the scientists chose to target the mRNA that encodes -synuclein. Preventing mRNA from being processed by ribosomes, they discovered, is cytoprotective.

The scientists, led by Matthew D. Disney, PhD, professor, department of chemistry at Scripps, designed a small molecule that selectively targets the messenger RNA that encodes -synuclein protein and selectively inhibits its translation. This small molecule, called synucleozid, stops the ribosome from detecting the messenger RNA template, thus preventing -synucleins translation.

Study Illuminates Possible Link Between Covid

Adapted from ACS Chemical Neuroscience 2021, DOI: 10.1021/acschemneuro.1c00666

Scientists have pondered possible linkages between COVID-19 and the onset of Parkinsons disease for more than a year. Now a report published in ACS Chemical Neuroscience details that correlation. The findings may have far-reaching consequences for any COVID-19 vaccines in development that are based upon targeting the well-conserved SARS-CoV-2 nucleocapsid protein.

First author Slav A. Semerdzhiev and colleagues from the University of Twente in The Netherlands showed through in vitro work that the SARS-CoV-2 N- protein interacts with a neuronal protein called -synuclein and speeds the formation of amyloid fibrils, which are a defining feature of Parkinsons disease.

The SARS-CoV-2 virus is known to cause neurological problems, including headaches, brain fog and loss of smell, in addition to respiratory symptoms. Loss of smell also is an early symptom of Parkinsons disease. What researchers didnt know was whether those neurological issues were caused by the virus entering the brain or by chemical signals released in the brain by the immune system in response to the virus.

To gain a better understanding of the issue, Semerdzhiev and colleagues studied the interactions of the SARS-CoV-2 spike protein and the N-protein in terms of their effects on -synuclein aggregation. The S- and N-proteins are the two most common proteins in the SARS-CoV-2 virus.

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What Does It Mean

Both the Pfizer/BioNTech and Moderna mRNA vaccines met the high standards required for use authorization after rigorous data scrutiny and validation as required in the normal US FDA vaccine approval process. This process is essential in determining not only safety and efficacy, but also that the vaccine benefits outweigh its risks. Today, in the United States, the death toll from COVID-19 topped 500,000 people worldwide, it has been associated with more than 2,462,000 deaths.

Based upon the available data, the incidence of side effects in persons with PD have not been different than in the general population. The approved mRNA-based vaccines, Pfizer/BioNTech and Moderna:

  • do not interact with the neurodegenerative process in PD
  • have been shown to be highly effective in preventing the severe and even the mild forms of the disease
  • help the body more rapidly clear the infection. High efficacy has been demonstrated regardless of race, gender, age, and medical conditions. How big of deal is greater than 90 percent efficacy? During the 2019-20 flu season in the United States, the overall effectiveness of the seasonal flu vaccine in children and adults was about 45 percent.
  • Finally, as stated by the experts, Bloem et al., , even after being fully vaccinated, it is important that persons with PD continue complying with the public health guidelines to reduce exposure and transmission of COVID-19 as recommended by WHO and the CDC.

    Learn More

    References

    The Claim: Children Shouldn’t Receive The Covid

    The possibilities of mRNA vaccines beyond COVID-19

    The majority of Americans are fully vaccinated against COVID-19 including 55% of children ages 12-17, according to the Centers for Disease Control and Prevention. But online, skepticism persists about the safety of the shots for young people.

    “MIT Scientist Warns Parents NOT TO GIVE CHILDREN Vaccine, Could Cause Crippling Neurodegenerative Disease In Young People,” reads the headline of a Jan. 18 article from the Geller Report, a website run by Pamela Geller. The activist has previously sharedfalse and misleading claims on social media.

    The article, which accumulated more than 300 shares within 10 days, cites a Fox News clip featuring Stephanie Seneff. The computer science researcher said during a Jan. 13 broadcast that parents “should do everything they can” to avoid getting their children vaccinated against COVID-19.

    After someone receives the vaccine, many of the immune cells responding to the shot “end up in the spleen, which is where you want them to be to produce the antibodies,” Seneff, a senior research scientist at the MIT Computer Science and Artificial Intelligence Laboratory, told host Laura Ingraham.

    “But the problem is that those germinal centers in the spleen are really the center place where Parkinson’s disease develops and probably many other neurodegenerative diseases,” she said.

    Fact check:COVID-19 vaccines primarily designed to prevent serious illness, death

    But this claim is baseless.

    USA TODAY reached out to Geller for comment.

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    Is It Safe To Get A Covid

    Yes, it is safe to get a COVID-19 vaccine if you have Parkinsons.

    The Centers for Disease Control and Prevention recommends vaccination with one of the three COVID-19 vaccines that have been approved for everyone over age 18 and authorized for emergency use for everyone ages 5 and older, including people with certain chronic health conditions.

    While there are some exceptions and modifications to vaccinations in people with certain diseases, Parkinsons disease is not one that comes with modified vaccine conditions or guidance.

    Vaccines And Prion Disease

    Before I discuss all these claims, I have to answer the question: What are prions? Prion diseases are more properly referred to as transmissible spongiform encephalopathies and represent a rare form of progressive neurodegenerative disorders that can affect both humans and animals. The most famous prion diseases in animals are bovine spongiform encephalopathy , scrapie, and chronic wasting disease in humans, Creutzfeldt-Jakob Disease and kuru. These diseases have a long incubation period and produce in the brain characteristic spongiform changes associated with loss of neurons with no inflammatory response. The causative agents for these diseases are prions. According to the CDC:

    The term prions refers to abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins called prion proteins that are found most abundantly in the brain. The functions of these normal prion proteins are still not completely understood. The abnormal folding of the prion proteins leads to brain damage and the characteristic signs and symptoms of the disease. Prion diseases are usually rapidly progressive and always fatal.

    The BSE inquirys report calls for vaccines to be investigated as a possible route of transmission. But it concedes that this will be hampered by the fact that systematic records of the action taken in response to BSE in respect of individual medical products are lacking.

    And:

    And:

    And:

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    Parkinson’s Disease And Pathogenesis

    The loss of dopaminergic neurons in the substantia nigra in the brain, which further leads to the progressive and severe motor impairment, is the most important feature of Parkinson’s disease. The results of more than a decade of research indicate that protein -synuclein , which is normally expressed at the neuronal terminals, may be involved in the development of PD. A series of studies have found that modification or accumulation of this protein caused by mutations or a large increase in the number of the gene encoding -syn contributes greatly to the occurrence of PD. Studies in animals have also indicated that prion-like spread of -syn protein may induce PD-like neurodegeneration. In addition to the -syn gene and the role of protein in the development of PD, neuroinflammation is also a very important factor in the pathogenesis of PD. Microglia can ensure the stable production of reactive oxygen species, IL-1, TNF, and IL-6 in the brain, and its chronic activation can lead to continuous damage to neurons dealing with abnormal state of -syn. Moreover, the interaction of microglia with the peripheral immune system could cause infiltrating immune cells to produce deleterious immune response. The involvement of peripheral immune responses in PD also provides an idea for the treatment of PD, which is to control microglia-induced neuroinflammation by vaccination.

    Implications For Persons Living With Parkinsons Disease

    Five things you need to know about: mRNA vaccine safety

    Vaccines with proven efficacy and what appears to be a satisfactory safety profile are now hopefully going to significantly contribute to ending the COVID-19 pandemic that has already taken many lives. The question remains as to what the impact of COVID-19 vaccination is for the worldwide population of people living with PD. In this regard, it is important to emphasize that as of today, there are currently no scientific data that have specifically looked at the efficacy and safety of COVID 19 vaccination for persons with PD. Any specific claims about the efficacy and safety for this specific population therefore have to be made cautiously, and are merely based upon extrapolating the evidence from general elderly populations, and the experience as progressively more people with PD are being vaccinated worldwide.

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    Immunosuppressive Medications May Affect Scheduling Or Dosage

    People who are immunocompromised from a natural disease process or a medication may need different scheduling or doses of the COVID-19 vaccine, but medications that suppress the immune system are not usually part of the treatment plan for Parkinsons disease.

    Theres some evidence that immunosuppressive medications may have a protective or possibly even therapeutic effect against neurodegenerative diseases like Parkinsons, but this idea is still being studied.

    In one study, some people with Parkinsons disease reported an improvement in motor symptoms for up to a week after vaccination, but more research needs to be done on why and what benefit mRNA vaccines might have for people with this disorder.

    Talk with a doctor about vaccination dosing or timing if you are taking immunosuppressants for the treatment of other conditions.

    Development Of Vaccines Against Pd

    At present, the design ideas of PD vaccine can be divided into two strategies, one is to produce antibodies against -syn, and the other is to produce T cell responses that can regulate neuroinflammatory reactions. The main goal of the former is to remove the accumulated -syn, while the latter targets microglia. Immunization with some non-PD related antigens such as COP-1, MOG, VIP, BCG, CFS, and -syn can reduce the death of neuronal cells and regulate the microglia response. In addition, an increase in the number of Tregs cells in the spleen, an increase in DA levels, and even a recovery of dopaminergic neurons was observed after vaccination.

    Neurodegenerative diseases, especially Parkinson’s disease, seriously affect the quality of life of patients and the risk of death is high, so the development of effective PD vaccine is imperative. Creative Biolabs has many years of experience in the field of vaccines. We have also conducted in-depth research on vaccines for neurodegenerative diseases. Countless successful cases that we helped researchers to favorably complete their research tasks have proven that Creative Biolabs is the most reliable partner for your vaccine development!

    All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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    How Well Does The Covid

    COVID-19 vaccination is recommended in people with Parkinsons disease to prevent severe illness, hospitalization, or death. There are no data to suggest the vaccine is more or less effective for people with Parkinsons compared with the general population.

    mRNA vaccines are more than 94 percent effective at preventing COVID-19, including severe disease, while the viral vector vaccine is about 70 percent effective . Efficacy can vary from person to person and based on what variant of SARS-CoV-2 you are exposed to.

    Each vaccine type has its own efficacy, and how well the vaccine works can depend more on what medications you are taking and your specific immune response than on the fact that you have Parkinsons disease.

    At this time, Parkinsons disease and its therapies are not believed to enhance or reduce the effect of COVID-19 vaccines, and the vaccines will not interfere with standard therapies for Parkinsons.

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