Wednesday, December 7, 2022
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Huntington’s And Parkinson’s Symptoms

When Should I Call My Healthcare Provider

Parkinson’s & Huntington’s: What’s the difference?

If you have Huntington disease, it is important to closely monitor you condition, and contact your healthcare provider if you notice any of the following symptoms:

  • Increasing difficulty with motor tasks such as walking
  • Trouble swallowing
  • Mood changes, such as increasing symptoms of depression or feelings of suicide

Specialization In Movement Disorders

Dr. Farbman specializes in Movement Disorders, a class of neurological diseases that include Parkinsons, Huntingtons, dystonia, ataxias, and tremors. With Parkinsons Disease, Farbman likens the diagnostic and evaluation of patients as putting together the pieces of a puzzle, a puzzle he enjoys solving. Parkinsons patients might experience a fall, yet that symptom can be related to several other diseases. Ruling out other diseases helps ultimately form the diagnosis, along with presentation of some specific symptoms common to the disease.

Genetic Testing For Huntington Disease

The genetic mutation that causes Huntington disease is located on chromosome 4. It involves repetition of a particular section of the genetic code in the DNA.

The gene for Huntington disease is dominant. Thus, having only one copy of the abnormal gene, inherited from one parent, is sufficient to cause the disease. Almost all people with the disease have only one copy of the abnormal gene. Children of such people have a 50% chance of inheriting the abnormal gene and thus the disease.

People who have a parent or grandparent with Huntington disease can find out whether they have inherited the gene for the disease by taking a genetic test. For the test, a blood sample is taken and analyzed. Such people may or may not want to know whether they have inherited the gene. This issue should be discussed with an expert in genetic counseling before genetic testing.

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How Is Huntingtons Disease Diagnosed

Doctors use a variety of tools to diagnose Huntingtons disease. They will start with a physical exam to observe your symptoms. They will ask questions about symptoms and your family medical history. A brain imaging test, such as CT or MRI, can show abnormalities in the brain. A lab can detect the Huntingtons disease gene with a simple blood test.

Why 2 Types Of Parkinsons Disease Are Plausible

Dementia caused by Parkinson

Study coauthor Per Borghammer, MD, PhD, a professor of clinical medicine at Aarhus University, tells Verywell that its unclear why this might happen, and points out that this is a hypothesis at this point. However, he and his research team have some theories.

One theory is that the type of Parkinsons that starts in the intestines is triggered by the gut microbiome, as well as inflammatory states and infections. In addition, the person probably needs to be vulnerable, have some risk genes, Borghammer says. That can include being older, which is a known risk factor for Parkinsons disease, he says.

When it comes to brain-first Parkinsons disease, Borghammer thinks the onset is also probably triggered by certain genes, along with aging.

With both types of Parkinsons disease, the disease process likely starts with bad luck, Borghammer says. In short, the first pathology is simply a random event and, if the person is vulnerable, the pathological process may multiply and spread out of control, he says. Borghammer compares this to the way cancer develops. The first cancer cell is most likely created by random eventsrandom mutationsbut then it multiplies and spreads, he says.

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As the person ages, he or she is prone to catch some diseases because of the several changes that take place in their body. Various organs in the human body undergo changes, and these changes are either beneficial to the body or lead to a disease or disorder. Considering the brain alone, a human brain at a certain human age group undergoes changes that lead to various changes. Two of these diseases are 1. Huntingtons disease, and 2. Parkinsons disease.

Main Differences Between Huntingtons And Parkinsons

  • Huntingtons disease is a genetic disorder and is inherited from the parents to the offspring. On the other hand, Parkinsons disease is a non-genetic disease.
  • The genetic disorder or disease that is inherited from a parent to an offspring due to the presence of an abnormal gene in the offsprings body is known as Huntingtons disease, on the other hand, The disease that occurs to a person due to the less production of dopamine from the nerve cells from the brain due to either genetic composition or environmental impacts is known as the Parkinsons disease.
  • Huntingtons disease is caused by the presence of abnormal genes in the offsprings body. On the other hand, Parkinsons disease is caused by a decrease in the production of dopamine.
  • Huntingtons disease can not be cured. On the other hand, Parkinsons disease can be cured.
  • Huntingtons disease can not be prevented as it is a genetic disorder. On the other hand, Parkinsons disease can be prevented.
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    What Is Parkinsons Disease

    Parkinsons disease is a degenerative disorder of the central nervous system mainly affecting the motor system. The motor symptoms of Parkinsons disease result from the degeneration of dopamine generating cells in the substantia nigra in the midbrain. The causes of this cell death are poorly understood. Early in the course of the disease, the most obvious symptoms are shaking, rigidity, slowness of movement and difficulty in walking and gait. Later, thinking and behavioral problems arise, with dementia commonly occurring in the advanced stages of the disease. Depression is the most common psychiatric symptom. Other symptoms include sensory, sleep problems and emotionally related problems.

    Parkinsons disease is more common in older people, and most cases occur after the age of 50 when it is seen in young, it is called young onset Parkinsons disease.Diagnosis is by medical history and physical examination. There is no cure for PD, but medications, surgery, and multidisciplinary management can provide relief from the disabling symptoms. The main classes of drugs useful for treating motor symptoms are levodopa, dopamine agonists, and MAO-B inhibitors. These drugs too can cause disabling side effects. Deep brain stimulation has been tried as a treatment modality with some success.

    Depression With Huntingtons Disease

    Parkinson’s, Alzheimer’s, and Huntington’s Disease – Medical-Surgical – Nervous System -@Level Up RN

    Due to the nature and lower life expectancy of Huntingtons disease, it is common for a diagnosis to lead to depression. Patients with Huntingtons are at a higher risk of suicide.

    If you are struggling with your Huntingtons diagnosis or prognosis, contact the Substance Abuse and Mental Health Services Administration National Helpline online or call 1-800-662-4357 to seek help.

    If you are having suicidal thoughts, dial 988 to contact the 988 Suicide & Crisis Lifeline and connect with a trained counselor. If you or a loved one are in immediate danger, call 911.

    For more mental health resources, including a helpful list of links and hotline numbers, see our National Helpline Database.

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    What Are The Risk Factors For Huntington Disease

    If you have the Huntington disease gene, you will develop the disease at some point during your life. The age of onset of Huntington disease varies greatly from person to person, but most people develop it in their 30s or 40s.

    Huntington disease is a rare disorder. More than 15,000 Americans currently have the disease, but many more are at risk of developing it.

    Huntingtons Disease | Generations of Care and Search for a Cure

    The Johns Hopkins Huntingtons Disease Center for Excellence is honored to have served multiple generation of families for the past forty years in HD history. Join neurologist Jee Bang, Clinical Director of Johns Hopkins Huntington Disease Center of Excellence, to learn more about Huntingtons Disease and efforts underway for families affected by the disease now and in the future.

    Dementia By Any Other Namestill Doesnt Smell Sweet

    When dealing with a loved one with dementia, remember the person not the disease. When dealing with challenging behavior, remember its the disease, not the person

    Weve already established that dementia is not a natural part of aging. If you see Grandpa who may be living an at assisted living facility forgetting things, its important to figure out why. It might be as simple as a urinary tract infection or a problem with medicationor maybe hes had too many life changes at once.

    But sometimes its a byproduct of another illness, like Parkinsons or Huntingtons. And those kinds of dementias may need to be handled differently.

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    Possible Link To Alzheimers

    Though Alzheimers, Huntingtons, and Parkinsons are distinctly different diseases, some evidence has emerged that shows a common link between the three.

    All three diseases have proteins within the cells that do not assemble properly. Though the molecular and cellular changes that occur in each disease vary greatly, this protein degradation has been shown to precede early clinical signs in each disease. This is promising news, as more studies are being done to determine whether this can either predict or prevent these neurodegenerative diseases.

    Cerebral Dopamine Neurotrophic Factor And Mesencephalic Astrocyte

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    In 2003, a protein called mesencephalic astrocyte-derived neurotrophic factor was characterized and demonstrated to promote survival of embryonic dopaminergic neurons in vitro . Then, a homologous protein called CDNF was discovered with a protective role for dopaminergic neurons. Several studies evidence the protective role of CDNF and MANF in dopaminergic neurons against the injury caused by -syn oligomers . The intrastriatal injection of CDNF prevents the loss of TH-positive neurons in a 6-OHDA-lesioned rat model of PD , and protected dopaminergic neurons in 6-OHDA and MPTP mouse models of PD . MANF has been tested in the 6-OHDA-lesioned rat model showing beneficial effects . CDNF and MANF diffuse to the brain significantly better than GDNF, and CDNF was more efficient in reducing amphetamine-induced ipsilateral rotations in the 6-OHDA rat PD model in comparison with GDNF treatment . In 6-OHDA-lesioned monkeys, PET imaging showed a significant increase of DA transporter ligand-binding activity in lesioned animals treated with CDNF .

    The first phase III clinical trial using CDNF in PD patients is being conducted since 2017. In this study, an implanted drug delivery system for Ipu of recombinant human CDNF is used in patients with idiopathic mild-advanced PD . Additionally, another phase III clinical trial to evaluate the beneficial effects of CDNF in PD patients is still on course . Currently, the delivery of CDNF for HD treatment has not been described.

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    Environmental And Genetic Factors

    It’s not very clear what brings on most neurodegenerative diseases. Most of these conditions are thought to be caused by a combination of environmental and genetic factors like long-term exposure to toxins and certain chemicals.

    In some cases, relatives can pass down mutated genes that can cause you to develop a neurodegenerative disease.

    Huntingtons Disease Vs Alzheimers

    Huntingtons disease is a cause of chorea usually appearing in the middle years of life and later becoming complicated with psychiatric and cognitive abnormalities Alzheimers disease is a neurodegenerative condition of the brain which is characterized by the atrophy of brain tissues, and it has been identified as the most common cause of dementia. Impairment

    • Anosognosia

    Management There is no disease-modifying drug at present. Progressive neurodegeneration leads to dementia and death after 10-20 years. There is no definitive treatment for the Alzheimers disease.

    Cholinesterase inhibitors can be given to control the neuropsychiatric manifestations such as depression.

    Memantatidine has also proven to be effective in controlling the disease progression and symptoms.

    Anti-depressants are prescribed when necessary along with the drugs such as zolpidem that can that can minimize the sleep disturbances.

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    What Makes Them Different

    MS and Parkinsonâs have different causes. They usually start to affect you at different ages, too.

    MS often affects people between ages 20 and 50, but children get it, too. Parkinsonâs usually starts at age 60 or older, but some younger adults get it.

    MS is an autoimmune disease. That means your bodyâs immune system goes haywire for some reason. It attacks and destroys myelin. As myelin breaks down, your nerves and nerve fibers get frayed.

    In Parkinsonâs, certain brain cells start to die off. Your brain makes less and less of a chemical called dopamine that helps control your movement. As your levels dip, you lose more of this control.

    Some genes may put you at risk for Parkinsonâs, especially as you age. Thereâs a small chance that people who are exposed to toxic chemicals like pesticides or weed killers can get it, too.

    These symptoms are more common if you have MS. They not usually found in Parkinsonâs:

    • Dizziness or vertigo, where you feel like the room spins around and you lose your balance

    Key Difference Huntingtons Disease Vs Alzheimers

    Neurodegenerative Disorder II – Parkinson’s and Huntington’s

    Huntingtons disease is a cause of chorea, usually appearing in the middle years of life and later becoming complicated with psychiatric and cognitive abnormalities. Alzheimers disease is a neurodegenerative condition of the brain, which is characterized by the atrophy of brain tissues and it has been identified as the most common cause of dementia. In Huntingtons disease, there is a predominant motor impairment which is not observed in the Alzheimers disease. This is the key difference between Huntingtons disease and Alzheimers.

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    Huntingtons Disease Dementiaa Not

    If and when the day comes that I may forget who you are, please promise that you wont forget that I am still me.

    Remember the song This Land Is Your Land? It was written by Woody Guthrie.

    In the 1940s, his behavior changed violently, affecting his work, his relationships, his life. It wasnt till the early 1950s that they figured out why.

    He had Huntingtons Disease Dementia.

    When Do Huntingtons Disease Dementia Symptoms Start?

    Huntingtons Disease is much rarer than many of the other dementias weve talked about. In 2019, statistics stated HD diagnoses as

    • 2.7 people per 100,000 worldwide,
    • 10 per 100,000 in Europe,
    • 9 per 100,000 in America, and
    • fascinatingly, 21 per 100,000 in Egypt.

    For those who have it, symptoms usually show up in their 30s and 40s, but they can start younger, even as early as two years old, or as late as 80.

    What Are the Symptoms of Huntingtons Disease Dementia?

    Like Parkinsons, Huntingtons Disease is first a motor disease.

    The biggest recognizable symptom?

    • Involuntary, uncontrolled, jerky, flailed movements of the arms, legs, head, face, and upper body.

    But it also weakens

    • Mood swings
    • OCD

    All Huntingtons symptoms start out mild in its early stage. The person can generally care for his own needs . But by the middle stage, he may need help.

    What Causes Huntingtons Disease Dementia?

    Different from what we know about Parkinsons, Alzheimers, Lewy Body, and vascular dementias, Huntingtons Disease is a genetic disorder.

    Why?

    Mechanism Of Injury / Pathological Process

    The most obvious neuropathology in HD occurs within the neostriatum , comprising gross atrophy of the caudate nucleus and putamen, accompanied by selective neuronal loss and astrogliosis . Marked neuronal loss also is seen in deep layers of the cerebral cortex. Other regions, including the globus pallidus, thalamus, subthalamic nucleus, substantia nigra, and cerebellum, show varying degrees of atrophy depending on the stage of the disease.

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    Compare And Contrast Parkinsons And Huntingtons Disease

    My father had neer been given to hopeful self-delusion, and he wasnt now. Dopastat relay race messages to the. She had handed the phone to her boss. Compare and contrast parkinsons disease and huntingtons disease, referring to symptoms, diagnosing, causes and genius regions. Amyotrophic lateral induration , better known as lou gehrigs disease, is a motor nerve cell disease that progresses rattling fast. Multiple tias over a short point will involve no driving for 3 months. For balmy symptoms like sleep disturbances, try gym roger huntington sessions, running game, cycling, lawn tennis, high energy department parkinsons programmes, electrical circuit grooming or boot camp classes. It can besides be utile as people live with the world of living with a cognitive disorder and explicate plans for the future tense with a learning ability disease. Frailty correspondent shawna seth thomas what may be behind warrens precipitous decline over the past two months. In parkinsons disease , the ill-famed stooped posture has turn a shaping aesthetic.

    Meditation has helped a not bad deal with my work, but i wouldnt say that im a buddhist. As for giving him antiparkinsons medications to assist with his motility, that is out of the question. Seed line mutations, spell those that we pick up during life history and that are commonly particular to a particular tissue or reed organ in the body , are named .

    When Diseases Become Dementias: Parkinsons And Huntingtons

    Huntington

    Elizabeth Daghfal is a writer, teacher, speaker, and community volunteer. When she isn’t teaching or writing– Who are we kidding? Her husband and five kids say she’s ALWAYS teaching and writing. She has a passion to help people who are struggling and is happy to say her shoulders are drip-dry. Born and raised in the South, she now lives in Wisconsin and loves it–except for the fifteen months of winter. Read more about her at elizabethdaghfal.com.

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    Living With Huntingtons Disease

    Huntingtons disease is progressive. That means it gets worse over time. Living with the disorder means preparing for the symptoms to worsen. Eventually you will need help with everyday activities. These include getting around your home, hygiene, eating, and decision-making. A trusted advisor can help with important decisions and in monitoring changes in your behavior.

    People with Huntingtons disease usually die within 15 to 20 years of their diagnosis. The most common causes of death are infections and injuries related to falls.

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