Other Treatments For Parkinsons
The primary goals in treating PD are to alleviate symptoms and improve quality of life. Treatment may also prevent disease progression.
If taking marijuana isnt feasible, there are other options available. Numerous types and combinations of conventional medications may also be used. Examples include:
- amantadine , which is used in early stages
What Might Cbd Do For Parkies
CBD has shown potential in early studies for reducing dyskinetic activity in people with PD and treating motor symptoms in various neurodegenerative conditions.
According to a 2018 review study published by the journal Frontiers in Pharmacology, Cannabidiol is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. Data also suggest that CBD could potentially play a protective role in the treatment of certain movement disorders. Results are promising, but further studies are needed to clarify the efficacy of CBD.
How Cbd Can Slow Pd Progression
Neither CBD nor any medication or supplement to date can reverse or cure Parkinsons symptomatology.
Researchers are hopeful, however, that CBD may slow the progression of the disease by facilitating dopamine recovery through CB2 stimulation, exerting antioxidant effects , suppressing the inflammatory response, and modulating excitotoxicity as mentioned.
In other words, CBD cant re-synthesize what was lost, but it can fight the causes of dopaminergic cell death to buy the patient a potentially significant amount of time before the disease progresses.
Establishing a CBD routine before the onset of Parkinsons may be an entirely different affair with more exciting implications, e.g., prevention, a prospect that has researchers investigating CBDs many properties with renewed fervor.
Physicians often share the sentiment that prevention is the best cure, but the tricky element in this equation is taking the initiative before the problem arises, and not after.
In either case, before or after PD onset, cannabidiol may help people of all demographics improve their quality of life and overall health in more ways than one.
Does Cbd Oil Help With Hand Tremors
As mentioned, CBD interacts with the ECS, which is a broad system of receptors and neurotransmitters that work to maintain homeostasis between essential bodily functions including muscle movement.
When CBD regulates these receptors, it produces relaxing and antispasmodic effects it can also block the release of pro-inflammatory proteins known to damage the nervous system.
Through these pathways, CBD can ease symptoms of tremors on top of effectively acting as a neuroprotectant.
One study on mice showed that CBD produced superior results in tremor relief without showing any life-threatening side effects or causing impairment. The authors also determine what receptors may be involved in these effects, suggesting that CBD engages with the 5-HT1A receptor to prevent tremors by activating the TRPV1 receptor.
Many of the prescription drugs that people usually take for tremors carry a risk of dangerous side effects. CBD, in turn, comes with anti-tremor properties and has a good safety profile with only minor side effects when overdosed.
Types Of Parkinsons And Parkinsonism
So many symptoms are associated with Parkinsons because there are a lot of different types. The major types are Corticobasal Degeneration , Dementia with Lewy Bodies , drug-induced parkinsonism, Essential Tremor, Multiple System Atrophy , Progressive Supranuclear Palsy , Vascular parkinsonism.
Every type has a different set of symptoms. Conventional treatment is approximately the same for each.
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Hempika And Cbd For Parkinsons Disease
Parkinsons is a scary disease to be diagnosed with, and there will be a lot of questions and unknowns as you live with this disease. The one thing that might relieve you is knowing there are alternatives to the dangerous and scary medications that are traditionally prescribed.
You should talk to your doctor about using CBD for Parkinsons disease. When youre ready to buy and try it out, shop with Hempika.
How Can Cannabidiol Affect Parkinsons Symptoms
Current treatments for psychosis about Parkinsons disease work by blocking dopamine receptors in the brain, which can make other symptoms of Parkinsons, such as tremor, worse. Whats exciting about cannabidiol is that it seems to act in a different way without causing any other side effects. However, the clinical trial will determine how accurate this is for people with Parkinsons.
CBD is also found to help treat other disease symptoms such as depression, anxiety, pain and various sleep disorders. Research shows that CBD in your bedtime routine can help support your sleeping cycle and enhance your sleep.
The endocannabinoid system plays a role in maintaining certain body functions, such as mood, appetite, sleep, and regulating circadian rhythms. Regarding how they may affect sleep, some research indicates that the cannabinoid CBD may interact with specific receptors, potentially affecting the sleep/wake cycle.
CBD may also decrease anxiety and pain, which can interfere with restful sleep. While most over-the-counter remedies, such as herbal therapies, can only offer mild effects, CBD has shown to be extremely effective in fighting anxiety. Studies show that CBD oil may help treat anxiety and alleviate depression by altering serotonin levels in the brain.
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Risks And Benefits For People With Pd
There are risks and benefits associated with the use of cannabis for people with PD. Benefits include a possible improvement in anxiety, pain, sleep dysfunction, weight loss and nausea. Potential adverse effects include impaired cognition , dizziness, blurred vision, mood and behavioral changes, loss of balance and hallucinations. Chronic use of marijuana can increase the risk of mood disorders, particularly among young users, and lung cancer.
Researchers issue caution for people with PD who use cannabis particularly because of its effect on thinking. PD can impair the executive function the ability to make plans and limit risky behavior. People with a medical condition that impairs executive function should be cautious about using any medication that can compound this effect.
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What Does The Future Hold
Cannabis may be a future Parkinsons treatment but for now, we need conclusive evidence of the benefits and to better understand appropriate formulations and dosages, the side-effects and interactions with other medications, and any long-term risks. A lot more research is required both in the lab and in clinical trials, including into specific molecules isolated from the plant, in order to achieve these goals.
Content last reviewed: August 2018
Stages Of Parkinsons Disease
Parkinsons is slow, progressive, and different for everyone.
Despite its broad variability in terms of presentation, each stage of the disease is characterized by one or more hallmark characteristics.
- Mild tremors may present, often affecting just one side of the body at first.
- Handwriting becomes smaller and less precise.
- Sleeping difficulties.
Most patients who arent dealing with severe comorbidities or generally poor health will not experience mobility issues in stage one.
- One-sided tremors and rigidity may now affect both sides of the body.
- Tremors are still mild but may be more noticeable.
- Mobility may be moderately compromised.
Tremors in the upper extremities may become severe enough at this stage to make activities of daily living like tying shoes, washing dishes, and other chores more difficult.
- Possible balance impairment increased fall risk
- Lower tolerance for weight-bearing mobility and chores
- Forward-flexed posture becomes apparent
Some patients may have a walker at this stage, and they could have trouble initiating and stopping movements.
- Severe tremors, rigidity, and mobility impairments requiring a walker and/or wheelchair.
- Handwriting gets smaller and sloppier, and the patients speaking volume declines .
- Balance, fine and gross motor control, and reflexes all continue to decline.
With steady rehab, some patients in stage four can manage with a walker alone, but many will need a wheelchair.
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Medical Marijuana And Legislation By State
Thirty-eight states and Washington, DC have passed legislation allowing the use of marijuana-based products as a medical intervention. In some states where medical marijuana is legalized, consumers must register to possess and use cannabis. Other states require consumers to acquire a document from a physician stating that the person has an approved condition. Under federal law doctors cannot prescribe cannabis, but many states authorize them to issue certifications that allow people to obtain medical marijuana.
Cbd As An Antioxidant
Among its several functions, inflammation acts as a kind of call-to-arms for other immune cells.
After the cytokines have done their job, other immune cells rush to the inflamed area to attempt tissue repair in various ways.
Some of these immune cells release reactive oxygen species , which increases the ratio of free radicals to antioxidants in the body
This imbalance is the defining trait of oxidative stress, which leads to premature cell damage and death as well as, in a circular fashion, more inflammation.
We already have to contend with free radical production from other sources, including dietary and environmental influences, cellular processes like the breakdown of dopamine, and the natural aging process, which is why its wise to seek out antioxidant-rich foods and supplements.
CBD is one such supplement, as evidenced in this Complutense University of Madrid study involving PD-infected rats.
The researchers detected that CBD administration caused an upregulation of mRNA levels for Cu,ZN-superoxide dismutase, which is an enzyme that our bodies use to fight off oxidative damage and slow degeneration.
CBD can even neutralize reactive oxygen species, which are molecules that steal electrons from healthy neighbors and turn them into free radicals, by donating this electron without becoming reactive themselves.
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Where Does Cbd Come From
CBD, like most cannabinoids , is found in Hemp and Marijuana plants. Because CBD products need to contain less than 0.3 percent THC, CBD is extracted from Industrial Hemp. Our premium CBD is extracted from Industrial Hemp grown on American Farms that is free of pesticides, herbicides and heavy metals.
Using Cbd For Treating Parkinsons Disease Symptoms
Without clinical trial data however, we do not know whether CBD is safe and effective for a particular symptom, and if it is, what CBD formulation and dosage is best to be used for a particular symptom.
We also dont know the side effect profile of CBD in people with PD. At baseline, people with PD may have various non-motor symptoms that may make them more prone to side effects from CBD, including fatigue and nausea.
If you would like to try CBD for one of your PD symptoms, have a conversation with your movement disorders specialist about it. Your doctor may be willing to oversee your trying it, or may feel that it is too risky for you without evidence that it will help. At the very least, he/she can make sure that there are no drug interactions between CBD and anything else that you take and discuss with you any potential side effects that you need to be aware of.
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Can You Use Cbd Oil As A Prevention For Parkinsons
Studies have suggested that CBD may be able to help prevent Parkinsons disease, but the current data comes only from animal models.
The research also suggests that CBD can do nothing to help treat PD after its onset. Based on this, it may only be useful as a preventive supplement.
However, most clinical trials only use CBD after a person is diagnosed with Parkinsons disease. This is important because about 60 percent of the dopamine-receptive neurons in the brain are already destroyed by the time a person begins showing the symptoms of their condition.
Its also difficult to predict who will develop Parkinsons and who will be more resistant to this disease. There are only a few preventive strategies, and thus far, we dont know if CBD can help everyone.
Our Position On The Use Of Medical Marijuana And Medicinal Cannabis In Parkinsons
There are many endorsements of cannabinoids for Parkinsons symptoms in the social media. However, the science tells a different story.
Statement of Position
Further research into the efficacy and safety of medicinal cannabis in the treatment of symptoms in Parkinsons disease is necessary before Fight Parkinsons will advocate its use for people with Parkinsons disease.
Medicinal Use of Cannabis
The two main active ingredients used for medical care are tetrahydrocannabinoids or THC and cannabidiol or CBD. Both are referred to as cannabinoids. THC is the part that produces the high favoured by recreational users of cannabis and may have benefits in reducing nausea. CBD produces no highand may be used to treat pain inflammatory conditions and seizures. Generally, the use of either form of medicinal cannabis is for symptom relief and is not a cure.
The Evidence Base for Medicinal Cannabis
Many people with a range of serious conditions such as cancer have reported symptom benefits from cannabis or medical marijuana. A review of current scientific research suggested there was reasonable evidence that cannabinoids can help symptoms of chronic pain and spasticity including that experienced in Multiple Sclerosis. In other conditions, such as in nausea and vomiting due to chemotherapy, weight gain in HIV infection, sleep disorders, and Tourette syndrome use of cannabinoids remains unproven.
Changing Legal Framework
Prescribing of Medicinal Cannabis
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How Parkinsons Disease Affects Your Brain
Weve already covered the macro-level concepts as it regards how Parkinsons works, but everyday consumers and researchers alike need to learn the underlying mechanisms involved in both a healthy and Parkinsons-affected brain in order to appreciate how therapeutic agents like cannabidiol can help.
How Your Brain Is Supposed to Work
The billions of nerve cells in your brain use cable-like extensions called axons to transmit impulses from one neuron to the next.
When an outgoing impulse or message reaches the end of an axon, it approaches a gap between the sending and receiving nerves known as the synapse.
The impulse is then ferried across the synapse by a specific chemical messenger, or neurotransmitterdopamine in this instance.
Once the dopamine accomplishes its job of getting the impulse across the synapse to the receiving neuron, it is broken down by enzymes.
How Your Brain Works with Parkinsons Disease
In the case of PD, the cells that produce dopamine die off for an unknown reason.
When the dopamine deficiency reaches 80 percent, the more readily recognizable symptoms of tremors and rigidity begin to manifest as communication between neurons is seriously impaired.
The immune system activates microglia in response to the rampant destruction of dopamine-producing cells microglia are a type of immune cell that cause inflammation and further damage to neurons when overstimulated.
How does cannabidiol counteract these harmful developments, you might be wondering?
An Active Response To Parkinsons Diagnosis
Both Dennis Mullen, 71, of Westminster, and Mel Preusser, 78, of Denver, take an active role in managing their Parkinsons disease. They exercise regularly, watch their diets and educate themselves about their condition through reading, classes and support groups.
Mullen ran his own FedEx Ground business until his 2010 diagnosis forced him to retire because the job required extensive walking. Since then hes battled tremors, stiffness and muscle freezing that occasionally stymie him during routine activities like trips to the pantry.
He admits that his initial diagnosis of Parkinsons disease left him depressed. But his wife and kids helped him shed those feelings.
I said I wont let this get me down, Mullen said. Im a fighter.
He said he works to stay abreast of the latest information about Parkinsons disease.
I take a bunch of different ideas and try them, he said. You have to grasp the things that are out there and try to keep up to date on what is working and not working for people.
His vigilance alerted him to articles about CBD being used to treat seizures in kids and later its possible help for people with Parkinsons disease. That led him to Leeheys study.
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The Science Behind Marijuana
What is the science and pharmacology behind marijuana, and can it be used to treat Parkinson’s symptoms?
The endocannabinoid system is located in the brain and made up of the endocannabinoids and cannabinoid receptors on neurons . The endocannabinoid system helps regulate many functions, including memory, pleasure, concentration, movement, appetite, and pain.
Researchers began to show enthusiasm to study cannabis in relation to PD after people with PD gave anecdotal reports and posted on social media as to how cannabis allegedly reduced their tremors. Some researchers think that cannabis might be neuroprotective , though there have not yet been studies in humans that demonstrate this effect.
Cannabinoids have also been studied for use in treating other symptoms, like bradykinesia and dyskinesia . Despite some promising preclinical findings, researchers have not found any meaningful or conclusive benefits of cannabis for people with PD.