Effects Of Nutritional Ketosis On Parkinsons Disease Evidence And Theories
One of the key correlates of both aging and insulin resistance is the reduced cerebral metabolic rate of glucose as defined by positron emission tomography fluorodeoxyglucose tracer . Cerebral metabolic rate can be gauged indirectly via functional magnetic resonance imaging blood oxygen level-dependent signal. One measure, the amplitude of low-frequency fluctuations , is correlated with cerebral blood flow and studied as a possible index of regional network stability over time. As described by reviews on fasting NK , there are benefits associated with fasting in rodent models of learning and memory associated with PI3K via cyclic AMP response element binding protein and brain-derived neurotrophic factor pathways activated in this state as an evolutionary adaptation for homeostasis and survival. Such pathways provide a mechanistic theory for learning and memory involving brain network stabilization, which may be a target for NK therapy. Evidence for a similar benefit was found via insulin administration, and similarly by fasting, ketogenic diet, and exogenous ketone ester drink, as described below.
Press and pulse model for neurometabolic degenerative disease. Hypothetical intervention begins at week 4 in the home with ketone meter, BP cuff and weekly lab testing, showing improved metabolic syndrome parameters. Instructions to fast and/or exercise produces episodically elevated ketosis
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The Great Controlling Nucleotide Coenzymes
Metabolic pathways plot the conversion of one biochemical to another. This happens as biomolecules are built up to participate in the normal function of cells. Other times biomolecules are broken down into simpler molecules to extract energy or to make a waste product that can be excreted. Dr. Veech had a map of the metabolic pathways that covered a wall in his home office. The two circular pathways of Krebs stand out. All along these pathways one finds compounds entering and leaving the path. One sees the same three to five letter abbreviations for coenzymes appear repeatedly. They seem to come out of nowhere on the path. They are converted to a slightly different set of letters. Not only do the coenzymes change in the reactions, the biochemicals on the main path are changed as well in each reaction. For example, ATP is converted to ADP or vice versa. Sometimes the letter changes are in one direction, sometimes in the other, and sometimes in both directions. NAD converts back and forth to NADH. NADP converts to NADPH. CoA appears to be converted to many forms. Dr. Veech called the coenzymes represented by these letters the great controlling nucleotide coenzymes.
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Key Takeaways From A Ketogenic Diet Review
A ketogenic diet could be an interesting alternative to treat certain conditions and may accelerate weight loss. But it is hard to follow, and it can be heavy on red meat and other fatty, processed, and salty foods that are notoriously unhealthy. We also do not know much about its long-term effects, probably because its so hard to stick with that people cant eat this way for a long time. It is also important to remember that yo-yo diets that lead to rapid weight loss fluctuation are associated with increased mortality. Instead of engaging in the next popular diet that would last only a few weeks to months , try to embrace change that is sustainable over the long term. A balanced, unprocessed diet, rich in very colorful fruits and vegetables, lean meats, fish, whole grains, nuts, seeds, olive oil, and lots of water seems to have the best evidence for a long, healthier, vibrant life.
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Berries And A Ketogenic Diet
Whether you follow a Mediterranean style of eating, the MIND diet or prefer a vegetarian diet berries are a suitable option as part of many diets. They are also suitable as part of a ketogenic or keto diet which some people with Parkinsons may choose to follow. The keto diet is a very high-fat, very low-carbohydrate, moderate protein diet which has been shown to improve certain symptoms of Parkinsons in several small studies7,8,9. On a keto diet, berries can be included in small amounts as they tend to be lower in carbohydrate. For more detailed information on the keto diet and Parkinsons .
Interview With Bill Curtis
This is an excellent interview with William Curtis. I met Mr. Curtis at the Tripping Over the Truth conference in November 2017. Mr. Curtis was diagnosed with Parkinsons in 2010 and has been keeping his symptoms in check using what he calls intermittent ketosis and exogenous ketones. He also has a website. The video is well worth watching if you have or care for someone with Parkinsons.
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Berries And Bowel Health
Berries are a good source of fibre which is another reason why people with Parkinsons should eat them on a regular basis. Constipation is a common non-motor symptom of Parkinsons which can affect quality of life and impact the effectiveness of certain Parkinsons medications. For healthy bowel function a diet containing an adequate amount of fibre and fluid is suggested with at least 25-30 grams of fibre and 6-8 glasses of fluid recommended each day. With a cup of raspberries providing about 6 grams of fibre, a cup of strawberries about 4 grams and a cup of blueberries about 3 grams, eating these fruits is a great way to boost your daily fibre intake! For more detailed information on managing and preventing constipation .
What Can I Do To Help With Swallowing
Make sure you are comfortable at meal times. The following suggestions may help make it easier to eat:
- Take your time and eat in a comfortable, quiet place.
- If you feel you are taking too long and food is getting cold, consider eating smaller, more frequent meals and snacks, or food that is easier to eat.
- You can buy heated plates to keep food warm for longer or consider serving smaller portions so that a second portion can be kept warm or reheated if its safe to do so.
- Posture is important to trigger a good swallow. Try eating sitting upright in your chair.
- Try planning your meals for when your medication is working. Avoid trying to eat large meals when you are off.
- If you wear dentures try to ensure they fit comfortably. Ask for a review by your dentist if you are concerned.
- Try to eat when you are less tired, this may mean moving your main meal to lunchtime rather than in the evening.
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Review Of Possible Use Of A Keto Diet In Pd Treatment
A review focused on the role of ketogenic diets in neurodegenerative diseases was published in the MDPI journal Nutrient in 2019. The goal of the review was to assess the effectiveness of ketogenic diets as part of therapy for neurodegenerative diseases. In PD, dopaminergic neurons in the substantia nigra are affected by a degeneration process leading to motor and non-motor disturbances. The available results of research projects dealing with the use of the KD and ketone bodies in neurodegenerative diseases are fairly promising. At the same time, the majority of studies reviewed were employed in vitro or by using animal models. The number of studies with human participation is rather small, and those that exist feature relatively short therapy duration periods.
Patient Flow And Baseline Characteristics
Details of patient flow, including all study exclusions and withdrawals, are shown in Figure . We randomized 47 patients, of which 44 commenced the diets and 38 completed the study 6 patients withdrew for reasons unrelated to the diets and 3 patients withdrew as a result of dietrelated difficulties. Randomized patient baseline characteristics are shown in Table . There were no significant betweengroup differences in any baseline characteristics.
Except for % variables, values are presented as mean±standard deviation.
Baseline values were obtained by averaging the two baseline clinical visits 1 patient withdrew postrandomization, several hours before their scheduled second baseline visit, so the first visit was used as the baseline value.
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Who Is At Risk For Parkinsons Disease
Parkinsons disease is one of the more common neurodegenerative diseases, presenting in more than 200,000 US cases each year. Parkinsons diseases typically begin to develop around the 6th decade of life. Risk factors include genetics and exposure to environmental toxins.
The genetic component of Parkinsons disease has been heavily researched and with 18 key chromosomal loci being identified. Familial inheritance has been identified as an autosomal recessive mode of inheritance, meaning both parents have to have a PD gene for an individual to develop the disease.
William Curtis’ Natural Treatment For Parkinsons: Coconut Oil Coffee
If you or a loved one are looking for a natural treatment for Parkinsons symptoms, William Curtis has exciting news. William is a sufferer of Parkinson’s disease, and he’s discovered a simple “ketone” drink that relieves his symptoms.
I’ve watched William’s videos, posted on his website. They show him with and without the ketone drink in his body.
Amazingly, the ketone drink removes most of his shaking.
Check out the following video, which first shows him playing the guitar while on his prescribed Parkinson’s medication only. Then it shows him playing after a cup of his ketone coffee.
What a difference!
William plays guitar before, then after, drinking his anti-Parkinson’s ketone coffee
As you can see, after the coffee his shaking is almost gone, and his finger control is remarkable.
Normally his hands and legs shake, even while on his prescribed Parkinson’s medications. But after he drinks his special recipe, William can hold his hands still.
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Recipe For Natural Treatment For Parkinsons Drink
This is not a gimmick. William has tapped into the new science of coconut ketones and found a natural treatment for his Parkinson’s symptoms. Following is William’s recipe as posted on his website ketonesforparkinsons.com:
“Ketone Coffee- Simple Recipe I use for My Parkinson’s. This is what I use personally and it helps my symptoms tremendously. I am not giving medical advice and it might not work for everyone:”
3 Tablespoons of Kerrygold Butter
2 Tablespoons organic whipped heavy cream
1 Tablespoon Organic Coconut Oil
2 packets of Stevia
Organic Coffee or Sugar-free Chocolate Syrup
Best if put in a blender
Please visit William’s site for more about his ketone coffee recipe and experiences.
Thankfully None Of This Is Going To Happen
Which is what I want to tell you about now. So let me start by reassuring you of this:
I feel fine. Absolutely fine.
In some ways, Im happier and more positive than I was before I got that initial shocking diagnosis.
My hands no longer shake. I sleep like a lamb. And I recall all the important details about my life or what I did this morning! with ease.
Second, theres a reason I feel this way. And its to do with how Ive actively worked on my condition.
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Why Jodis Method Works
Remember: standard drug remedies tackle the disease further along the chain at the point where theres a dopamine shortage.
Doctors simply dont address the reason that dopamine is in short supply in the first place.
She addresses the specific reasons why cells in the substantia nigra are dying off.
Then she addresses low dopamine itself.
Then she undoes the symptoms of the illness the part of the disease that you and I experience.
Jodi Knapp cant teach her methods face-to-face to everyone who needs them. So she created a written version of her approach. Its called The Parkinsons Protocol.
And its The Parkinsons Protocol that changed not only my present life it changed my future life too.
Keto For Pd: The William Curtis Story
Mike Mutzel from High-Intensity Health talks to William Curtis about his PD journey and how a ketogenic diet changed his life. Curtis suffered from PD for over 17 years before he started exercising, fasting, and following a low-carb, ketogenic diet that remarkably improved his PD symptoms. Through trial and error, Curtis found the right balance in his diet. The William Curtis program for easing PD symptoms is not appropriate for everyone. For example, PD patients that have balance problems could do more harm to themselves if they followed Curtis diet. After 12 hours of fasting through the night, Curtis has a bulletproof coffee in the morning prepared with butter, heavy cream, coconut oil, and Stevia. This helps his PD symptoms and increases the ketone D-betahydroxybutyrate .
good results in rats
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Parkinsons And Weight Gain
Parkinsons medication does not tend to make people gain weight, but a small number of people may experience impulsive and compulsive behaviour. This is a side effect of some Parkinsons medication, particularly dopamine agonists and, in some cases, levodopa.
Impulsive behaviour is when a person cant resist the temptation to carry out certain activities. These are often activities that give an immediate reward or pleasure, such as gambling, hypersexuality and overeating.
So, someone may eat large amounts of food in a short period of time because they cant control their appetite, and as a result, they gain weight.
If you think youre experiencing this behaviour, speak to your GP, specialist or Parkinsons nurse.
We dont advise anyone to stop taking or to change their Parkinsons medication without the advice of their specialist or Parkinsons nurse.
Any changes have to be made slowly and gradually, and should always be carried out and reviewed by a specialist, because of the risk of side effects and withdrawal symptoms.
Someone experiencing impulsive or compulsive behaviour may not realise they have a problem. So its important that their carer is aware of these side effects.
Deep brain stimulation and weight gain
Some people with Parkinsons may put on weight quickly after having deep brain stimulation, a surgery sometimes used to treat the condition.
If you think youre experiencing this behaviour, speak to your GP, specialist or Parkinsons nurse.
Study Tests Ketogenic Diet For Parkinsons
Can a special high-fat diet help people with Parkinsons disease?
Although researchers havent found a cure for the degenerative disease, theyve found ways to slow its progression from medication to exercise such as boxing.
This year, scientists at the National Institute of Neurological Disorders and Stroke are studying the effects of a specific diet on Parkinsons patients.
Its called a ketogenic diet a high-fat, low-carbohydrate diet in which the body, deprived of carbohydrates, is forced to burn fat. While people on the diet must avoid pasta, bread and sugar, they can eat plenty of butter, cream and nuts.
Its a diet that has less carbohydrates and greater fats than a typical American diet, said Dr. Debra Ehrlich, Chief, NIH Parkinsons Disease Clinic and the studys principal investigator.
Were trying to look at using the ketogenic diet in a population of patients with Parkinsons disease, Ehrlich said. Several previous studies of the ketogenic diet in Parkinsons patients have shown either improved motor functioning or improved memory or cognition.
Our first objective is to see if its feasible and well tolerated in patients with Parkinsons. Our second objective is to see if theres any improvement in Parkinsons symptoms, such as cognition, mobility and motor function.
Includes one-week hospital stay
Theyll receive coaching from our nutrition team, Ehrlich said, and nutritionists will try to work own dietary preferences into the diet.
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What Closes Or Opens The Gate That Lets Pyruvate Into The Mitochondria Energy Process
Four different enzymes start to close the pyruvate dehydrogenase complex gate and two enzymes can open it once partly closed. These enzymes regulate the opening and closing of the gate to let pyruvate into the mitochondria. The control of these enzymes is complex, but we know the gate is often closed in degenerative disease, infections, and trauma.
Dr. Veech knew HB does not go through the PDC to fuel the mitochondria. There are no gates to stop HB from making ATP once it reaches the mitochondria. This means HB can overcome a lack of energy found when the PDC switch turns off the flow of pyruvate fueling the mitochondria.
Dr. Veechs mentor at Harvard, George Cahill, had demonstrated that the brain could use HB for fuel when a person is fasting. Dr. Veech reasoned that HB could help people who have diseases where the gate that lets pyruvate into the mitochondria has been shut down. This includes many degenerative diseases such as Alzheimers and Parkinsons disease.