Wednesday, December 7, 2022
Wednesday, December 7, 2022
HomeCureHow Does Parkinson's Kill

How Does Parkinson’s Kill

Caring For Someone With Parkinsons

Fungus Among Us: High Ochratoxin A Found in People with Parkinsonism

Practice patience and understanding when dealing with Parkinsons. You may be very frustrated and challenged as a caregiver, but those with Parkinsons are just as frustrated. Their physical and mental conditions can be debilitating, depressing, and humiliating.

Diet and nutrition can have a huge impact on the health and comfort of a Parkinson patient. Eating well, getting more rest, sleeping well, fresh air, and exercise can make a difference. Getting the right medication and complementary therapies is also important.

As Parkinsons impacts a patients motor skills, modifications to the living environment may have to be made to accommodate wheelchairs and limited mobility issues. Professional in-home assistance for Parkinsons can allow Parkinson patients to remain independent and can enhance quality of life.

Most importantly, seek help and support from family, friends, and caregiving support groups. Take advantage of the resources in your community. Shouldering all the burden can take a toll on a caregiver.

Take care of yourself or you wont be able to take care of your loved one. Follow the preventive advice provided above for yourself as well, and take deep breaths!

Resources

Both Similar And Different To Viruses

In further experiments, the team found a way that might reduce oligomer toxicity. They found that altering its protein sequence made the oligomer less able to stick to the cell membrane.

The researchers likened the behavior of the oligomers and their propensity to stick to the walls of brain cells as similar to the way that viruses enter cells. The difference is that while a virus then adapts the cell machinery to its own end, the oligomer just disrupts it.

Dr. De Simone also suggests that oligomers are able to attach themselves to cell membranes because of an accident of nature that gives them the same features as normal membrane proteins that help with brain signaling.

Just having this information doesnt mean that we can now go and make a drug, but obviously if we can understand why these clumps of proteins behave the way they do, we can make faster scientific progress towards treating Parkinsons disease.

Dr. Giuliana Fusco

What Are The Symptoms Of End

Stage four for Parkinsons disease is often called advanced Parkinsons disease because people in this stage experience severe and incapacitating symptoms. This is when medication doesnt help as much and serious disabilities set in.

Theres an increased severity in:

  • How you speak a softer voice that trails off.
  • Falling and trouble with balance and coordination.
  • Freezing a sudden, but temporary inability to move, when you start to walk or change direction.
  • Moving without assistance or a wheelchair.
  • Other symptoms such as constipation, depression, loss of smell, low blood pressure when going to stand up, pain, and sleep issues.

Many times someone with advanced PD cant live on their own and needs help with daily tasks.

Stage five is the final stage of Parkinsons, and assistance will be needed in all areas of daily life as motor skills are seriously impaired. You may:

  • Experience stiffness in your legs. It may make it impossible to walk or stand without help.
  • Need a wheelchair at all times or are bedridden.
  • Need round-the-clock nursing care for all activities.
  • Experience hallucinations and delusions.

As Parkinsons disease progresses into these advanced stages, its symptoms can often become increasingly difficult to manage. Whether you or your loved one with end-stage Parkinsons lives at home, in an assisted living facility or a nursing home, hospice services can optimize your quality of life and that of your family members as well.

Also Check: What Is The Life Expectancy Of Someone With Parkinson’s

This Was The First Sign Of Parkinson’s Alan Alda Noticed

For most of the ’70s, Alan Alda starred as Hawkeye, the chief surgeon on the beloved series, M*A*S*H. But he’s so much more than his classic character. Also a stage actor, filmmaker, author, and activist, Alda has made a career out of forming connections with others. At the age of 85, the six-time Emmy award winner is still performing and hosting his own podcast, among other pursuits. In 2015, Alda was diagnosed with Parkinson’s disease . And while he didn’t publicly reveal his diagnosis until three years later, he’s since talked openly about his experiences with the disease and how he keeps moving forward despite it. He also shared the early sign that led to his diagnosis and how it involved his wife of 64 years, Arlene Alda. To hear more about the actor’s history with Parkinson’s and how it’s affecting him today, read on.

RELATED: This Was the First Sign of Parkinson’s That Michael J. Fox Noticed.

What Does Kill People With Parkinsons

Why Does Parkinsons Kill Brain Cells?

While no one dies directly from Parkinsons, you may be asking yourself what does typically cause death in Parkinsons patients. The two of the biggest causes of death for people with Parkinsons are Falls and Pneumonia:

Falls Parkinsons patients are typically at an increased risk of falls due to postural instability and other symptoms of Parkinsons. This poses a great risk to those with PD because falls are the leading cause of injury-related deaths among those 65 years or older according to the CDC. It is important to take precautions to limit the risk of falling in your home. This can be done by wearing special grip socks to prevent slipping or installing handrails in high-risk areas like the shower or staircase. In addition, you should talk with your doctor about getting a physical therapy evaluation periodically to strengthen your balance reflexes and help you develop other strategies to keep you safe in the home.

Don’t Miss: I Think I Have Parkinson’s

Parkinsons Doesnt Always Cause Dementia

While cognitive decline is common in both Alzheimers and Parkinsons, it is less likely to occur in Parkinsons patients. According to studies, only half of those with Parkinsons develop cognitive difficulties. This can range from mild forgetfulness to full-blown dementia.

When dementia does manifest itself with Parkinson, it occurs in the subcortical area of the brain. Alzheimers dementia occurs in the cortical area of the brain. As a result of this, the clinical symptoms of these two dementias can be somewhat different.

What Other Conditions Have Similar Symptoms And Signs Of Parkinsons Disease

Other neurological diseases may cause symptoms similar to Parkinsons disease. The term Parkinsonism refers to a patient that has symptoms similar to Parkinsons.

Early in the disease process, it can be tough to make an assertive diagnosis and difference between Parkinsons and Parkinson-like diseases.

Often the correct diagnosis is made after further symptoms develop, and the physician can monitor the course of the disease.

The development of additional symptoms and the course of the illness generally points towards the correct diagnosis. These are the most common neurological diseases that can produce Parkinson-like symptoms.

  • Progressive Supranuclear Palsy
  • Lewy Body disease or Dementia with Lewy bodies
  • Corticobasal degeneration or corticobasal ganglionic degeneration

Nonetheless, doctors should think of other causes rather than Parkinsons disease when events like this happen.

  • Poor response to dopamine
  • Early loss of balance or vision problems
  • Prominent intellectual decline dementia
  • Rapid onset or progression of the disease

Actually, though it is a disease that is not clearly understood, there are specific organizations like Parkinsons UK that dedicate themselves to doing research.

These organizations look forward to following the natural course of the disease and developing clinical trials for patients in an attempt to find a cure.

Read Also: What Are The Four Cardinal Signs Of Parkinson’s Disease

How Quickly Does Parkinsons Progress

Parkinsons disease is slowly progressive, and each case may be different. People may have symptoms for a year or two before a doctor makes a diagnosis.

The longer the symptoms are present, the easier it is to predict how a person with Parkinsons disease will do. In those with tremors and symptoms on one side of the body, the disease typically advances more slowly than in those without tremors who have symptoms that affect both sides of the body.

While the life expectancy of these patients reduces, people with Parkinsons disease usually function quite well for many years. However, these patients are at risk of suffering dementia, or from developing instability that could lead to falls.

This condition is by far the most treatable of all neurodegenerative disorders. A doctor may indicate treatment to help control symptoms.

For example, there are cases where people can function better in their daily lives five years later after they start medication.

The treatment includes exercise and changes in lifestyle. As well as medication with carbidopa-levodopa or dopamine agonists to improve body functionality.

There are surgical options as well, like deep brain stimulation, surgeons implant electrodes in the brain, and they receive electrical pulses, which reduces symptoms.

However, symptoms and responses to treatment vary from person to person, so it is not possible to accurately predict how Parkinsons disease will progress.

The Reality Of Managing Symptoms

How can we cure Parkinson’s?

Dr. Benjamin Walter, of the Center for Neuro-Restoration at Cleveland Clinic, said that the average person isnt accustomed to the strict regimen of multiple medications a day thats part of everyday life for people with Parkinsons.

Most people feel burdened just taking an antibiotic, which can be difficult to remember. Now, imagine someone who has Parkinsons the minimal dosing is usually three times a day, Walter said.

He explained that the need to frequently take medication is because it usually only lasts in a persons bloodstream for 90 minutes.

Once the medication gets into the brain, its converted to dopamine and stored in dopamine neurons, which recycles and reuses that medication over and over until it is depleted. Now, its not uncommon to have patients on meds four or five times a day, he said.

Walter stressed that when discussing Parkinsons and off periods, no two people are the same.

Parkinsons is a highly variable disease. Some people will experience different motor symptoms and tremors than others.

For example, some people freeze when they walk, while others dont.

He said the off periods can be terrifying for many people and also cause a different symptom anxiety.

Walter said that its important for those taking care of a person with Parkinsons to understand how dangerous off periods can be.

He stressed the importance of making sure patients get their medications on schedule so that everything is kept in working order.

You May Like: What Essential Oils Are Good For Parkinson’s Disease

Two Areas In Which Parkinsons Disease May Bring About Death

I. Falls

PD patients are at an increased risk of falling and bad falls can lead to death. This usually occurs as a complication of a fall that requires hospitalization, particularly if it involves surgery. While most people do not fracture their hips when they fall, some do, and hip surgery, while routine, is still major surgery. It carries the risk of infection, delirium related to pain medications and anesthesia, heart failure, pneumonia, blood clots in the legs that then go to the lungs, and general weakness from immobility. Hip fractures are probably the main cause for death for those who fall, but people can fracture other bones and require surgery. They may fracture their ribs, which leads to reduced coughing, because of the pain, and an increased risk of lung infections . It is surprisingly uncommon for Parkinsons Disease patients to die from brain injuries related to falls, but it still may occur.

II. Pneumonia

PD patients also may develop pneumonias completely unrelated to difficulties with swallowing, just like their non-PD friends and relatives.

He Has Said That He Lives A Full Life With His Disease

When Alda publicly announced that he had Parkinson’s on CBS This Morning in July 2018, he said that he didn’t experience any other symptoms until a few months after his diagnosis. When promoting his podcast, Clear + Vivid, he began to notice a frequent twitch in his thumb, which encouraged him to speak out about his medical condition.

“I thought, ‘It’s probably only a matter of time before somebody does a story about this from a sad turn point of view,’ but that’s not where I am,” he said on the morning show.

Continuing to work while managing his Parkinson’s inspired him to open up, as well. “The reason I want to talk about it in public is that I was diagnosed three and a half years ago and I’ve had a full life since then,” he added.

Along with his interview podcast, which is about connection and communication, Alda stayed busy in other ways after his diagnosis. He said on CBS This Morning that he was still giving talks at the Alan Alda Center for Communicating Science, which was established in 2009 at Stony Brook University and uses improvisational theater to help scientists, doctors, and other professionals communicate. In 2017, Alda published his third autobiography, If I Understood You, Would I Have This Look on My Face? My Adventures in the Art and Science of Relating and Communicating. And he’s also continued acting. He played recurring roles in the shows Ray Donovan and The Good Fight and also appeared as a gentle divorce lawyer in 2019’s .

Recommended Reading: Mucuna Pruriens Parkinson’s

Do All Parkinsons Patients Develop Dementia

Although dementia is a hallmark of Alzheimers disease, dementia may occur in Parkinsons disease affecting approximately 70% of the patients.

Dementia describes a set of symptoms that cause is a significant loss in brain function. It produces a greater impact on patients on patients with Parkinsons than in Alzheimers patients as they have to deal with motor and cognitive impairment.

Alzheimers affect memory and language in general terms. Still, in Parkinsons, it affects problem-solving capacity, speed of thinking, memory, and they run with mild cognitive impairment.

Notably, Parkinsons disease dementia is a common thing among patients with this condition. The vast majority of them may experience some form of cognitive impairment over time.

Though it is a unique process for each person, several risk factors may lead to dementia symptoms and dementia itself.

  • Increasing age.
  • Exposure to psychological stress
  • Low education level and low socioeconomic status

Disease duration has as well a direct correlation with the development of dementia on these patients. The more time the patient has this disease, the risk of developing dementia increases.

Also, Parkinsons dementia has a direct correlation with Lewy bodies. Most people develop dementia as a progression of the disease rather than having Parkinsons and Alzheimers. Nonetheless, a doctor with a neurology specialist should examine the patient to give an assertive diagnosis to the condition.

What Is Parkinsons Disease

Too much protein may kill brain cells as Parkinson

Before looking into the relationship between Parkinsons and death lets quickly review what Parkinsons is and how it affects the body.

Parkinsons Disease is a chronic neurologic condition which causes a gradual loss of the nerve cells in the brain that produce the neurotransmitter dopamine. Because dopamine carries signals to the part of the brain that control movement and coordination, decreased dopamine levels lead to the cardinal motor symptoms of Parkinsons disease like resting tremor, stiffness or slow movements. Because other parts of the brain and other neurotransmitters can be affected in Parkinsons disease, other symptoms can occur as well like lightheadedness, constipation and others. To learn more about Parkinsons .

Recommended Reading: 10 Early Warning Signs Of Parkinson Disease

Why Does Parkinsons Kill Brain Cells

Around 60,000 people in the US get diagnosed with Parkinsons disease every year. There are also many people whose Parkinsons goes undetected. After all, the symptoms of this disease are hard to recognize.

But how does this disease work? Why does Parkinsons kill brain cells and what can medical science do about it?

What Are Off Periods

These off periods are a time when dopamine is going low in the brain, and when medicine usually levodopa, which is the gold standard oral pill is wearing off or not kicking in when it should be, Dr. Robert Hauser, director of the Parkinsons & Movement Disorder Center and a professor in the college of medicine neurology at University of South Florida, told Healthline.

Symptoms such as the loss of motor function can return during off periods. This can be dangerous, particularly if an off period strikes when a person is walking up the steps to their front door or is in a similar situation.

For those who are newly-diagnosed , off periods can present a major obstacle to overcome if they arent aware of the risks and the need to maintain a strict medication schedule.

Also Check: How To Use Hemp Oil For Parkinson’s

Is Parkinsons Disease Fatal

It is important to understand that PD is not considered a fatal condition. As is the case with Alzheimers disease and other forms of dementia, complications and a patients comorbid conditions are more life-threatening than PD itself. For example, because Parkinsons affects movement, balance and coordination, a patients risk of falling increases as the disease progresses. Falls are notoriously dangerous and a leading cause of injury and death among older adults. Difficulty swallowing, known as dysphagia, is another complication that can develop at any point throughout ones journey with PD, and this can cause aspiration pneumoniaanother leading cause of death in patients.

Read:Dysphagia: How to Help a Loved One Eat and Drink Safely

Because a persons overall health is an important factor in how Parkinsons progresses, lifestyle choices are vitally important for prolonging both functionality and longevity. Regular exercise, a healthy diet, careful management of preexisting conditions and prevention of new medical issues is crucial.

It is important to work with a well-rounded medical team to understand PD symptoms, explore treatment options and devise a personalized care plan for improving ones overall health, maintaining a high quality of life, and preventing complications.

Who Has Just Been Diagnosed With Parkinson’s

Parkinsons Disease Research and Deep Brain Stimulation Surgery

Linda Ronstadt, Ozzy Osbourne, and Muhammad Ali are just some of the well-known figures who have been diagnosed with Parkinson’s disease. Parkinson’s disease is a neurodegenerative condition caused by the loss of dopamine-producing neurons in the brain, which leads to various neurological and mobility-related symptoms.

You May Like: Sam Waterston Parkinson’s 2018

RELATED ARTICLES

Popular Articles