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What Does Parkinson’s Disease Cause

What Is Parkinson Disease

What causes Parkinson’s?

Parkinson;disease is a movement disorder. It can cause the muscles to tighten and become rigid This makes it hard to walk and do other daily activities. People with Parkinsons disease also have tremors and may develop cognitive problems, including memory loss and dementia.

Parkinson;disease is most common in people who are older than 50. The average age at which it occurs is 60. But some younger people may also get Parkinson disease. When it affects someone younger than age 50, it’s called early-onset Parkinson disease. You may be more likely to get early-onset Parkinson disease if someone in your family has it. The older you are, the greater your risk of developing Parkinson disease. It’s also much more common in men than in women.

Parkinson disease is a chronic and progressive disease.; It doesn’t go away and continues to get worse over time.

What Is Parkinsons Disease Symptoms Causes Diagnosis Treatment And Prevention

The causes and symptoms of Parkinsons disease can vary from person to person. While there is no cure, there are medications and treatments to help manage the condition.

Parkinsons disease is a movement disorder that happens when nerve cells in a certain part of the brain are no longer making the chemical;dopamine.

The condition is also sometimes known as paralysis agitans or shaking palsy.

The Parkinsons Foundation estimates that 60,000 Americans are diagnosed with Parkinsons every year. However, the true number of people who develop the disease may be much higher.

What Is Parkinsons Disease

Parkinsons disease is a nervous system disease that affects your ability to control movement. The disease usually starts out slowly and worsens over time. If you have Parkinsons disease, you may shake, have muscle stiffness, and have trouble walking and maintaining your balance and coordination. As the disease worsens, you may have trouble talking, sleeping, have mental and memory problems, experience behavioral changes and have other symptoms.

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Motor Circuit In Parkinson Disease

The basal ganglia motor circuit modulates the cortical output necessary for normal movement .

Signals from the cerebral cortex are processed through the basal ganglia-thalamocortical motor circuit and return to the same area via a feedback pathway. Output from the motor circuit is directed through the internal segment of the globus pallidus and the substantia nigra pars reticulata . This inhibitory output is directed to the thalamocortical pathway and suppresses movement.

Two pathways exist within the basal ganglia circuit, the direct and indirect pathways, as follows:

  • In the direct pathway, outflow from the striatum directly inhibits the GPi and SNr; striatal neurons containing D1 receptors constitute the direct pathway and project to the GPi/SNr

  • The indirect pathway contains inhibitory connections between the striatum and the external segment of the globus pallidus and between the GPe and the subthalamic nucleus ; striatal neurons with D2 receptors are part of the indirect pathway and project to the GPe

The STN exerts an excitatory influence on the GPi and SNr. The GPi/SNr sends inhibitory output to the ventral lateral nucleus of the thalamus. Dopamine is released from nigrostriatal neurons to activate the direct pathway and inhibit the indirect pathway. In Parkinson disease, decreased striatal dopamine causes increased inhibitory output from the GPi/SNr via both the direct and indirect pathways .

Surgical Treatment For Parkinsons

8 Ways Parkinsons Disease Affects Your Movement

This is advised when the disease progresses and the medications are no longer controlling the symptoms of PD adequately.

  • As the disease progresses, Levodopa still works, but the brains response to the medication becomes less predictable. Levodopa may take longer to kick in and may wear off earlier, requiring patients to take medication more frequently during the day. Higher doses of levodopa are associated with abnormal involuntary movements, known as dyskinesias . Unpredictable medication effect results in OFF time when patients feel stiff, rigid, stuck, frozen, slow, or fatigued, compared to ON time when movements are smooth and closer to normal.
  • Treatment options as the disease progresses include taking levodopa more frequently; making the medication last longer by adding medications to reduce the metabolism of levodopa, or dopamine adding or changing to long-acting forms of levodopa , or adding or changing to long-acting forms of dopamine agonist . Amantadine can be added to reduce dyskinesia. As these options are being considered and implemented, its time to consider deep brain stimulation surgery .
  • Deep brain stimulation surgery is FDA-approved for the treatment of motor complications in Parkinsons disease and is not experimental. DBS is not a last-resort treatment. It has been shown that DBS is more beneficial when performed earlier in the course of the disease compared to waiting for disability.

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What Are The Surgical Treatments For Parkinsons Disease

Most patients with Parkinsons disease can maintain a good quality of life with medications. However, as the disease worsens, medications may no longer be effective in some patients. In these patients, the effectiveness of medications becomes unpredictable reducing symptoms during on periods and no longer controlling symptoms during off periods, which usually occur when the medication is wearing off and just before the next dose is to be taken. Sometimes these variations can be managed with changes in medications. However, sometimes they cant. Based on the type and severity of your symptoms, the failure of adjustments in your medications, the decline in your quality of life and your overall health, your doctor may discuss some of the available surgical options.

In Summary Reduce Your Stress

The most important thing we can do for our long-term health, both physical and cognitive, is to reduce the stress in our bodies. All stress physical, emotional and chemical causes inflammation and long-term damage throughout the body.

Whether youre seeking Parkinsons prevention techniques or ways to alleviate symptoms, any of the above dietary and lifestyle practices can have long-term health benefits. Drinking green tea, eating organic, local vegetables, and regular aerobic exercise all significantly reduce the long-term cumulative damage done by stress.

Learn more about health services offered at Judson by !

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What Changes Can Occur

There are several ways PD may affect speech:

  • The voice may get softer, breathy, or hoarse, causing others difficulty hearing what is said.
  • Speech may be slurred.
  • Speech may be mumbled or expressed rapidly.
  • The tone of the voice may become monotone, lacking the normal ups and downs.
  • The person may have difficulty finding the right words, causing speech to be slower.
  • The person may have difficulty participating in fast-paced conversations.1

Some of the medical terms that describe the speech changes that can occur with PD include:

  • Dysarthria, which is a motor speech disorder or impairment in speaking due to PD affecting the muscles required for speech
  • Hypophonia, which means soft speech, is an abnormally weak voice caused by the weakening muscles
  • Tachyphemia, also known as cluttering, is characterized by an excessively fast speed of talking and a rapid stammering that makes it difficult to understand the person speaking2,3

Treatment For Parkinsons Disease And Sex Issues

Causes of Parkinsons Disease | Causes Of Tremors

Treatment for erectile dysfunction in men might include medications like Viagra, as well as physical or psychological therapy. In some cases, surgical implants may also be used. Womens sexual health in Parkinsons is slightly more complex due to their hormonal makeup.

Treatment options for women are somewhat restricted, but they include adding lubrication and seeing a therapist. Many women find timing sex during their ON periods to be helpful.

In terms of reproductive health, there is no evidence to suggest that Parkinson’s disease causes problems with pregnancy although there have been no studies into the safety of PD medication during pregnancy.

Parkinsons disease and sex can be challenging, but there are plenty of treatments and solutions that can work for both men and women. Its important to communicate with your partner and talk through any feelings you might be experiencing, especially if youre struggling with body image or confidence issues. Navigating sex during Parkinsons disease can be difficult for partners, too, so remember to keep the dialogue open in your relationship.

APA ReferenceSmith, E. . Parkinsons Disease and Sex Issues: Libido, Sex Drive, HealthyPlace. Retrieved on 2021, August 26 from https://www.healthyplace.com/parkinsons-disease/effects/parkinsons-disease-and-sex-issues-libido-sex-drive

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What Causes Parkinson Disease

Parkinson disease arises from decreased dopamine production in the brain. The absence of dopamine makes it hard for the brain to coordinate muscle movements. Low dopamine also contributes to mood and cognitive problems later in the course of the disease. Experts don’t know what triggers the development of Parkinson disease most of the time. Early onset Parkinson disease is often inherited and is the result of certain gene defects.

What Drug Treatments Are Commonly Prescribed For Pain

Dopamine agonists are often the neurologists first weapon to alleviate Parkinsons-related pain. Levodopa is used to treat many types of pain due to Parkinsons because it treats the motor symptoms such as rigidity and dystonia that are causing them. ;Other medicines called analgesics can also be used to treat pain. When talking with your doctor, it is critical to let her know about all of the medications you are taking including over the counter drugs, herbs, vitamins and mineral supplements. Without complete information, your doctor may prescribe a drug that could have serious adverse effects.

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Symptoms That Are Commonly Associated With Pd

These symptoms include sleep disorders, abnormalities in blood pressure, urinary problems, constipation, depression, and anxiety. Even though these symptoms are so commonly seen in PD, they are also commonly associated with other issues that have nothing to do with PD, so it is vital to keep an open mind about their cause. If any symptom is new or worsening, it could be an indication of a new medical problem. For example, urinary problems are extremely common in PD, but may be a sign of an enlarged prostate, which can be treated in an entirely different way.

The Genetics Of Parkinsons

Parkinson

A 2020 study including 1,676 people with Parkinsons in mainland China suggested that genes play a role in the development of the condition. An estimated 10 to 15 percent of people with Parkinsons have a family history of the condition.

In fact, a number of specific genes have been linked to the development of Parkinsons.

How do genetics factor into Parkinsons in some families? According to Genetics Home Reference, one possible way is through the mutation of genes responsible for producing dopamine and certain proteins essential for brain function.

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Symptoms Of Parkinson’s Disease

The symptoms of Parkinson’s disease usually develop gradually and are mild at first.

There are many different symptoms associated with Parkinson’s disease. Some of the more common symptoms are described below.

However,;the order in which these develop and their severity is different for each individual.;It’s unlikely that;a person;with Parkinson’s disease would experience all or;most of these.

Medicines For Parkinson’s Disease

Medicines prescribed for Parkinson’s include:

  • Drugs that increase the level of dopamine in the brain
  • Drugs that affect other brain chemicals in the body
  • Drugs that help control nonmotor symptoms

The main therapy for Parkinson’s is levodopa, also called L-dopa. Nerve cells use levodopa to make dopamine to replenish the brain’s dwindling supply. Usually, people take levodopa along with another medication called carbidopa. Carbidopa prevents or reduces some of the side effects of levodopa therapysuch as nausea, vomiting, low blood pressure, and restlessnessand reduces the amount of levodopa needed to improve symptoms.

People with Parkinson’s should never stop taking levodopa without telling their doctor. Suddenly stopping the drug may have serious side effects, such as being unable to move or having difficulty breathing.

Other medicines used to treat Parkinsons symptoms include:

  • Dopamine agonists to mimic the role of dopamine in the brain
  • MAO-B inhibitors to slow down an enzyme that breaks down dopamine in the brain
  • COMT inhibitors to help break down dopamine
  • Amantadine, an old antiviral drug, to reduce involuntary movements
  • Anticholinergic drugs to reduce tremors and muscle rigidity

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How Does Parkinsons Disease Affect The Brain

The part of the brain that is affected is called the basal ganglia, which functions like the autopilot of your brain, facilitating subconscious movements.;Because PD causes the brain cells in this deep circuitry to deteriorate, patients natural movements become slow and stiff. Many patients describe feeling as if they had aged overnight.

Symptoms That May Be Related To Pd But That Few People Know About

Parkinson’s Disease – Causes, Symptoms & Treatment

People with PD and care partners may suspect that a particular symptom is related to PD, but they cant find information about it, so they are not sure. Two symptoms that pop up in this category are runny nose and breathing problems, which well focus on today. Of course, if these are new symptoms for you, they could be indicative of a new problem, including infection with COVID-19, so make sure to get yourself checked out by your doctor. However, if all else is ruled out, PD could be to blame. Excessive sweating and specific skin disorders are in this category as well and have been addressed previously.

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What Are The Risk Factors For Parkinsons Disease

Risk factors for Parkinsons disease include:

Genetics

People with a first-degree relative with Parkinsons are at an increased risk for the disease possibly as much as 9 percent greater.

Fifteen to 25 percent of people with Parkinsons have a known relative with the disease, but a condition called familial Parkinsons, which has a known genetic link, is relatively rare.

The average age of onset is 60 years, and the incidence rises with advancing age. About 10 percent of people have early-onset or young-onset disease, which begins before age 50.

Gender

Parkinsons affects about 50 percent more men than women, for unknown reasons.

Pesticide Exposure

Exposure to some pesticides has been shown to raise the risk of developing Parkinsons.

Problematic chemicals include organochlorine pesticides like DDT, dieldrin, and chlordane. Rotenone and permethrin have also been implicated.

Fungicide and Herbicide Exposure

Exposure to the fungicide maneb or the herbicides 2,4-dichlorophenoxyacetic acid , paraquat, or Agent Orange may raise the risk of Parkinsons.

The U.S. Veterans Health Administration considers Parkinsons to be a possible service-related illness if the person was exposed to significant amounts of Agent Orange.

Head Injuries

Head injuries may contribute to the development of Parkinsons in some people.

Coffee and Smoking

People who drink coffee or smoke tobacco have been found to have a lower risk of Parkinsons disease, for reasons that remain unclear.

What Is Parkinson’s Disease

Parkinsons disease is a degenerative, progressive disorder that affects nerve cells in deep parts of the brain called the basal ganglia and the substantia nigra. Nerve cells in the substantia nigra produce the neurotransmitter dopamine and are responsible for relaying messages that plan and control body movement. For reasons not yet understood, the dopamine-producing nerve cells of the substantia nigra begin to die off in some individuals. When 80 percent of dopamine is lost, PD symptoms such as tremor, slowness of movement, stiffness, and balance problems occur.

Body movement is controlled by a complex chain of decisions involving inter-connected groups of nerve cells called ganglia. Information comes to a central area of the brain called the striatum, which works with the substantia nigra to send impulses back and forth from the spinal cord to the brain. The basal ganglia and cerebellum are responsible for ensuring that movement is carried out in a smooth, fluid manner .

The action of dopamine is opposed by another neurotransmitter called acetylcholine. In PD the nerve cells that produce dopamine are dying. The PD symptoms of tremor and stiffness occur when the nerve cells fire and there isn’t enough dopamine to transmit messages. High levels of glutamate, another neurotransmitter, also appear in PD as the body tries to compensate for the lack of dopamine.

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How Is Parkinsons Disease Dementia Diagnosed

No single test can diagnose Parkinsons disease dementia. Instead, doctors rely on a series or combination of tests and indicators.

Your neurologist will likely diagnose you with Parkinsons and then track your progression. They may monitor you for signs of dementia. As you get older, your risk for Parkinsons dementia increases.

Your doctor is more likely to conduct regular testing to monitor your cognitive functions, memory recall, and mental health.

Exercise And Healthy Eating

Parkinson

Regular exercise is particularly important in helping relieve muscle stiffness, improving your mood, and relieving stress.

There are many activities you can do to help keep yourself fit, ranging from more active sports like tennis and cycling, to less strenuous activities such as walking, gardening and yoga.

You should also try to eat a balanced diet containing all the food groups to give your body the nutrition it needs to stay healthy.

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What Are The Complications Of Parkinson Disease

Parkinson disease causes physical symptoms at first. Problems with cognitive function, including forgetfulness and trouble with concentration, may arise later. As the disease gets worse with time, many people develop dementia. This can cause profound memory loss and makes it hard to maintain relationships.

Parkinson disease dementia can cause problems with:

  • Speaking and communicating with others
  • Problem solving
  • Forgetfulness
  • Paying attention

If you have Parkinson disease and dementia, in time, you likely won’t be able to live by yourself. Dementia affects your ability to care of yourself, even if you can still physically do daily tasks.

Experts don’t understand how or why dementia often occurs with Parkinson disease. Its clear, though, that dementia and problems with cognitive function are linked to changes in the brain that cause problems with movement. As with Parkinson disease, dementia occurs when nerve cells degenerate, leading to chemical changes in the brain. Parkinson disease dementia may be treated with medicines also used to treat Alzheimer’s disease, another type of dementia.

What Is Obtained The First Symptom Of Parkinson Disease

Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement. In the early stages of Parkinsons disease, your face may show little or no expression. Your arms may not swing when you walk.

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