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Thursday, June 16, 2022
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What Can You Do To Prevent Parkinson’s Disease

Exercise Helps Prevent Fight Parkinson’s Disease From The Harvard Health Letter

Can we prevent dyskinesia in Parkinson’s?

Parkinson’s is a brain disease that affects the body and how it moves. Early symptoms include tremors, a shuffling gait, and an overall slowing of physical movement. Yet exercise may be one of the best and most underutilized ways of combating the condition, according to the March 2012 .

Several prospective studies that followed tens of thousands of people for many years have shown a correlation between exercise earlier in life and a reduced chance of developing Parkinson’s later on. Exercising in your 30s and 40s decades before Parkinson’s typically occurs may reduce the risk of getting Parkinson’s disease by about 30%, notes the Health Letter. Some experts believe the exercise must be vigorous to make a difference. However, because this kind of research can’t prove cause and effect, there is the possibility of “reverse causation”: that is, exercise may not prevent Parkinson’s disease, but instead a very early “preclinical” form of the disease, without clear symptoms, may make people less willing or able to exercise in the first place.

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What Are The Risk Factors For Parkinsons Disease

Risk factors for Parkinsons disease include:

Genetics

People with a first-degree relative with Parkinsons are at an increased risk for the disease possibly as much as 9 percent greater.

Fifteen to 25 percent of people with Parkinsons have a known relative with the disease, but a condition called familial Parkinsons, which has a known genetic link, is relatively rare.

The average age of onset is 60 years, and the incidence rises with advancing age. About 10 percent of people have early-onset or young-onset disease, which begins before age 50.

Gender

Parkinsons affects about 50 percent more men than women, for unknown reasons.

Pesticide Exposure

Exposure to some pesticides has been shown to raise the risk of developing Parkinsons.

Problematic chemicals include organochlorine pesticides like DDT, dieldrin, and chlordane. Rotenone and permethrin have also been implicated.

Fungicide and Herbicide Exposure

Exposure to the fungicide maneb or the herbicides 2,4-dichlorophenoxyacetic acid , paraquat, or Agent Orange may raise the risk of Parkinsons.

The U.S. Veterans Health Administration considers Parkinsons to be a possible service-related illness if the person was exposed to significant amounts of Agent Orange.

Head Injuries

Head injuries may contribute to the development of Parkinsons in some people.

Coffee and Smoking

People who drink coffee or smoke tobacco have been found to have a lower risk of Parkinsons disease, for reasons that remain unclear.

History Of Parkinsons Disease

Symptoms and possible treatments for Parkinsons were discussed in texts related to Ayurveda, an ancient Indian medical practice thats been around since as early as 5,000 B.C. A Parkinsons-like condition was also mentioned in the first Chinese medical text, Huang Di Nei Jing Su Wen, more than 2,500 years ago.

Parkinsons disease was formally recognized in an 1817 paper, An Essay on the Shaking Palsy, by James Parkinson, MD, a London doctor and member of the Royal College of Surgeons.

Dr. Parkinson observed what are now known as the classic symptoms of Parkinsons disease, including tremors, rigidity, and postural instability. He theorized that the disease developed because of a problem in the brains medulla region.

Parkinsons essay received little attention until 1861, when French neurologist Jean-Martin Charcot and his colleagues distinguished the disease from other neurological conditions and termed it Parkinsons disease.

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Have You Ever Thought How Challenging Drinking A Glass Of Water Can Be For Someone Suffering From Parkinsons Disease

On World Health Day, youll likely read about how healthy habits like exercising or drinking more water, can improve your health. While these are helpful tips and important topics to cover, we decided to take things a step further. What if you couldnt drink that glass of water by yourself? It can be daunting to consider, but this scenario can become all-too-real for a person suffering from Parkinsons disease. There are 10 million people in the world suffering from this disorder which is why, today, we decided to share with you how Parkinsons Disease can affect mobility and balance, and what can be done when the disorder is detected in its early stages. That is why raising awareness for this degenerative disease is important, and, while there is still much research to be done, we have high hopes that researchers will find a way to reduce the symptoms of Parkinsons disease, and eventually find a cure. This is becoming more and more urgent, given the fact that life expectancy is rising and the number of individuals with Parkinsons disease will only increase in the future. But is there another solution in sight?

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Effects Of Parkinson’s Disease On The Body Include:

How to Prevent Parkinson
  • Tremors.
  • Continue regular daily activities to help maintain mobility.
  • Lead as normal a life as possible, not restricting activities that are still possible.
  • Establish a regular exercise program consisting of stretching and weight bearing.
  • Walking 30 minutes each day can be a realistic goal.
  • Seek advice from a rehabilitation specialist as soon as possible for help determining an exercise level, overcoming problems with balance and safety, difficulties with speech, or for fatigue and stress management.
  • Adaptive training and use of quad-canes or straight canes, and other mechanical aids help with balance problems.
  • Try to avoid unnecessary stress in your life. Leading a healthy life, eating regularly, sleeping regularly, and exercising will help keep you fit both mentally and physically.
  • All symptoms of Parkinson’s disease get worse under stress.
  • Ask the doctor about regulating treatments so that treatments are more effective during peak work conditions.

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Management Of Medical Problems

Poor health management may result in Parkinsons disease problems during later years of human life. Obesity has a close connection with altered levels of dopamine in the human brain and in midlife it triples the risk related to the development of Parkinsons disease. Manage your medical problems properly to prevent Parkinsons disease.

Therapy Regimen By Comparing The Effects Of Different Intensities Of Physical Activity On Pd

The light physical activity reduces tumor necrosis factor alpha in the skeletal muscle and the thiobarbituric acid reactive substances in the soleus muscles . Linke’s study found that physical activity can not only reduce the expression of inflammatory cytokines in the blood but also enhance the activity of free radical scavengers . Schulze’s findings suggest that physical activity enhances mitochondrial biogenesis in the vascular endothelium through a shear stress-dependent mechanism . Vettor’s findings demonstrate that physical activity promotes endothelial NO synthase- dependent mitochondrial biogenesis in the heart, which behaves as an essential step in cardiac glucose transport . The light activity can reduce oxidative stress and enhance mitochondrial biogenesis in skeletal muscle, blood, and heart. These protective effects can improve autonomic dysfunction , sleep quality , and depression in PD patients.

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Causes And Risk Factors Of Parkinsons Disease

Most cases of Parkinsons disease are idiopathic, meaning the cause is unclear.

Its widely believed that a person with Parkinsons may have been genetically vulnerable to the disease, and that one or more unknown factors in the environment eventually triggered the disease.

Most of the symptoms of Parkinsons disease come from the loss of neurons in an area of your brain called the substantia nigra.

Normally, the neurons in this part of the brain make the chemical messenger dopamine, which allows communication with another area of the brain, the corpus striatum.

This communication helps produce smooth, purposeful movement. When the neurons in the substantia nigra die, the resulting loss of communication leads to the motor symptoms of Parkinsons.

Although the cause of this cell death is unknown, many researchers believe that the cells are killed by clumped proteins called Lewy bodies.

Naturalremedy For Parkinsons #7 Omega

How to Avoid / Prevent Parkinson’s Dyskinesia

Animal based omega-3 fatty acids are a powerful weapon inthe fight against Parkinsons disease. One of the main fatty acids, DHA, is oneof the essential building blocks for the human brain. Half of your brain andeyes are made up of fat and a large proportion of this is DHA fat.

Omega-3 fatty acids have the unique ability to cross theblood-brain barrier, something most conventional drugs cannot do. They helpincrease dopamine levels and reduce neuroinflammation in the brain, while atthe same time, stimulating neuron growth. So basically, EPA and DHA help preventbrain cell damage and keep the nervous system in tip top working order! 4

Best sources of animal based omega-3s are either fishoil, cod liver oil or krill oil. High strength krill oil is the preferred option as thiscontains a substance called Astaxanthin. Astaxanthin is a potent brain food nutrientthat has been shown to prevent neurodegeneration and inflammation of the brain.For dosages, take AT LEAST the highest recommended amount listed on the bottle the same goes with fish oil or cod liver oil. You cant overdose on thesesupplements so theres nothing to be concerned about. In fact, the more omega-3syou can get into you the better the results!

In addition to this, try and eat some cold water fattyfish such as salmon, tuna, mackerel, sardines or herring 3-4 times a week foran extra supply of DHA and EPA.

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What Lifestyle Changes Can I Make To Ease Parkinsons Symptoms

Exercise: Exercise helps improve muscle strength, balance, coordination, flexibility, and tremor. It is also strongly believed to improve memory, thinking and reduce the risk of falls and decrease anxiety and depression. One study in persons with Parkinsons disease showed that 2.5 hours of exercise per week resulted in improved ability to move and a slower decline in quality of life compared to those who didnt exercise or didnt start until later in the course of their disease. Some exercises to consider include strengthening or resistance training, stretching exercises or aerobics . All types of exercise are helpful.

Eat a healthy, balanced diet: This is not only good for your general health but can ease some of the non-movement related symptoms of Parkinsons, such as constipation. Eating foods high in fiber in particular can relieve constipation. The Mediterranean diet is one example of a healthy diet.

Preventing falls and maintaining balance: Falls are a frequent complication of Parkinson’s. While you can do many things to reduce your risk of falling, the two most important are: 1) to work with your doctor to ensure that your treatments whether medicines or deep brain stimulation are optimal and 2) to consult with a physical therapist who can assess your walking and balance. The physical therapist is the expert when it comes to recommending assistive devices or exercise to improve safety and preventing falls.

Risk Factors And Protective Factors Of Parkinson’s Disease

The risk factors of pathogenicity and morbidity in PD are various. We have found that dairy consumption is positively correlated with the incidence of PD through a series of studies related to aging, cancer prevention, and nutrition . The risk of PD in the study sample from the Honolulu-Asian Ageing Study and Cancer Prevention and II Nutritional Research increased with the extension of plantation time . This result is consistent with agricultural health research, which indicates that exposure to pesticides increases the risk of PD. Pesticides could cause oxidative stress and disturb mitochondrial function . Traumatic brain injury can lead to disruption of the blood-brain barrier, impaired mitochondrial function, and accumulation of brain -syn protein, all of these may lead to an increased risk of PD after exposure to such injury . A cohort study in Finland found that overweight or obesity will bring a high-risk factor for PD .

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How Does Parkinsons Disease Progress

The Parkinsons Foundation states there are typical patterns of progression of Parkinsons disease that can be defined in 5 stages:

  • Symptoms are mild and do not interfere with the persons quality of life.
  • Symptoms worsen and daily activities become more difficult and take more time to complete.
  • Considered to be mid-stage Parkinsons disease. The individual loses balance, moves more slowly, and falls are common. Symptoms impair daily activities, for example dressing, eating, and brushing teeth.
  • Symptoms become severe and the individual needs assistance walking and performing daily activities.
  • The most advanced stage of Parkinsons disease. The individual is unable to walk and will need full-time assistance.
  • With proper treatment, most individuals with Parkinsons disease can lead long, productive lives for many years after diagnosis. In fact, life expectancy for those affected by Parkinsons is about the same as for people without the disease. Its the quality of life of those affected by Parkinsons disease that suffers, so how can we tackle all the challenges the disease poses to ones quality of life?

    Physical Exercise Can Reduce The Accumulation Of The

    Understanding Parkinsonâs Disease

    The -syn protein is the main pathogenic protein of PD, which is acidic synaptophysin expressed in the vertebrate presynaptic. In the central nervous system , many neurodegenerative diseases are associated with the exiting of the -syn protein in the cytoplasm and nucleus . Aggregation of -syn is a crucial risk factor for PD, multiple system atrophy , and Lewy body dementia . In previous studies, physical exercise was found to have a positive effect on neurodegenerative diseases such as Huntington’s disease, Alzheimer’s disease, and PD . Physical exercise could reduce the loss of dopaminergic neurons, increase synaptic connections, and upregulate neurotrophic factor levels to improve PD dyskinesia . Physical exercise could downregulate -Syn protein levels and neuronal apoptosis , which could reduce inflammation and mitochondrial dysfunction to restore the motor function in PD patients. Overexpression of -synuclein also resulted in significant impairment on hippocampal neurogenesis-dependent pattern separation . Voluntary running exercise could prevent deterioration and improve cognition through the decrease of -Syn protein overexpression. This can be further substantiated by an effect of running on neurogenesis levels in the dorsal dentate gyrus, suggesting that the functional effects of running on pattern separation were mediated via increased neurogenesis . However, the exact molecular mechanisms of exercise-induced -syn protein level decrease are unrevealed.

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    Multiple Physical Activities Can Improve Motor And Nonmotor Symptoms Of Parkinson’s Disease

    Mehrholz et al. and Herman et al.’s study found that running can improve gait and physical fitness and better safety . Aguiar et al. indicated that regular dancing has the benefit of balance and mobility in PD patients . The rhythmic music used in dancing could activate neurons that are conducive to motor control, accompanied by increasing blood flow in the hippocampus, frontal, temporal, and parietal cortex. This promotion of neural plasticity improves movement, balance, and cognition of the body . Also, Tai Chi and Qigong could upgrade the motor function and balance ability of patients with mild to moderate PD . Yoga provides modest improvements in motor functions, mobility, balance, flexibility, and strength in upper and lower limbs, while helps reduce the fear of falls in Parkinson’s patients .

    The Symptoms Of Parkinsons Disease

    Some symptoms of PD are difficult to detect even by the specialists, while others are obvious to even untrained eyes. Parkinsons symptoms are different for every patient. Like any other chronic diseases, the degree that the disease worsen differs in every individual depending on their genes, diet, lifestyle and their exposure to environmental toxins.

    Some of the common symptoms of Parkinsons:

    • Constipation
    • Trouble sleeping
    • Low blood pressure, feeling dizzy or fainting

    As a result of this disease that is a deterioration of brain health and the central nervous system, if left untreated, some sufferers may also experience other brain issues such as Alzheimers Disease, dementia, severe depression and anxieties that may result in suicidal thoughts.

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    Surgery And Deep Brain Stimulation

    Deep brain stimulation is a treatment for Parkinsonâs disease that uses an implantable pacemaker-like device to deliver electrical pulses to parts of the brain involved in movement. The DBS system consists of leads precisely inserted into a specific brain target, the neurostimulator implanted in the chest, and extension wires that connect the leads to the neurostimulator. Though implantation of the system requires a neurosurgical procedure, the treatment itself consists of long-term electrical stimulation. Advantages of DBS include its ability to reduce the high doses of medications , its adjustability , and its reversibility DBS was approved by the Food and Drug Administration as a treatment for PD in 2002 and according to Medtronic , more than 80,000 patients have undergone DBS surgery worldwide.

    Typical candidates are those who have motor fluctuations or periods of âoffâ time with troublesome symptoms alternating with periods of âonâ time with good symptom control, and also with possible periods of excessive movement .

    Not all patients with Parkinsonâs disease are good candidates for treatment with DBS. Approximately 10â20% of patients considered for possible treatment with DBS include those:

    Related Diagnosis: Lewy Body Dementia

    How can we cure Parkinson’s?

    Current research is helping to differentiate dementia related conditions in relationship to Parkinsonâs disease. Doctorâs use a 12-month arbitrary rule to aid in diagnosis. When dementia is present before or within 1 year of Parkinsonâs motor symptoms developing, an individual is diagnosed with DLB. Those who have an existing diagnosis of Parkinsonâs for more than a year, and later develop dementia, are diagnosed with PDD.

    In the simplest terms, Lewy bodies are abnormal clumps of proteins that develop in nerve cells. Cholinesterase inhibitors, medications originally developed for Alzheimerâs disease, are the standard treatment today for cognitive DLB and PDD symptoms. Early diagnosis is important, as DLB patients may respond differently than Alzheimerâs disease patients to certain drug, behavioral, and dementia care treatments.

    This challenging, multi-system disorder involving movement, cognition, behavior, sleep, and autonomic function requires a comprehensive treatment approach to maximize the quality of life for both the care recipient and their caregiver. It is very important to pay attention to symptoms of dementia and to search for an expert clinician who can diagnose the condition accurately.

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