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Atypical Parkinsonism Or ‘parkinson’s Plus Syndromes’
“Parkinson’s Plus Syndromes” are less common than Parkinson’s disease.
Some atypical parkinsonism syndromes include:
Multiple system atrophy This is a category of several disorders in which one or more body systems deteriorate.
Your doctor may classify you as having MSA-P, in which parkinsonian symptoms are dominant or MSA-C, in which dysfunction of the cerebellum is dominant.
The names of some of these syndromes include olivopontocerebellar atrophy , Shy-Drager syndrome , and striatonigral degeneration .
Progressive supranuclear palsy Symptoms of this condition usually begin after age 50 and proceed more rapidly than Parkinson’s disease.
In people with PSP, problems with eye movement can lead to blurry vision. Falls tend to occur early in the course of the disease, and dementia may occur later in the disease.
Corticobasal degeneration This condition may cause jerking and loss of control in a limb, often without weakness in that limb.
If you have this disorder, you may be given Botox to help your limb relax.
In this condition, the same Lewy bodies occur in the brain as in Parkinson’s disease, but in multiple areas of the brain.
If you have LBD, you may experience speech problems, hallucinations, and gradual cognitive decline.
What Is Parkinsons Disease
Parkinsons disease is a neurological condition afflicting about one percent of men and women over the age of seventy years old.
Individuals with Parkinsons disease have tremor of the hands, rigidity, poor balance, and mild intellectual deterioration. The tremor is most apparent at rest and is less severe with movement. Shaking or tremors are an early symptom of Parkinsons disease. Progression leads to trembling in arms, legs, jaw, and rigidity or stiffness of the limbs.
Research has shown that Parkinsons disease occurs when a small region in the brain, called the substantia nigra, begins to deteriorate. The neurons of the substantia nigra use the brain chemical dopamine. Tremors begin to happen and movement slows when you have inhibited dopamine function.
Dopamine is broken down in the brain by an enzyme called monoamine oxidase . When the activity of MAO is inhibited, dopamine stays around longer, and this is beneficial to those with Parkinsons disease.
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How Hard Should I Exercise If I Have Parkinson’s Disease
A rating of perceived exertion is a good way to measure intensity. On a scale from 0 to 10, 0 would be how you feel while sitting or lying down, while 10 would be the maximum effort you can give. Building up to an effort between 5 to 8 means you are exercising at a high intensity. A good gauge is, if you can have a conversation with someone while exercising, you should probably increase your intensity.
Could You Possibly Do The Same And Reverse Your Parkinson’s Disease
I am not a doctor, nor have I ever had any medical training!I am merely a Parkinson’s Patient, who has had the good fortune to have been able to reverse many of his movement symptoms!
YES! You possibly can… and I urge you to follow this path!
- The unique lifestyle modification protocol I use.
- The unique Brain exercises I use.
- The exact physical exercises I use, to reverse my Parkinson’s.
- How you will see life, when you start to feel better, and why it is important to exercise.
- The special dietary advice I follow .
- The knowledge of the silent killer, that you might not even be aware of.
- How to improve your sleep, and in the process, have more energy.
- How to focus your mind, and take back control of your movements.
- What type of Parkinson’s medication is capable of slowing down the progression of your PD, and what types aren’t.
I am going to urge you again. These are the exact steps that I, John Pepper, and countless others, have followed to successfully reverse Parkinson’s disease.In all my research, which spans well over the last 20 years, and hundreds of hours of my own time – not even mentioning the countless hours other experts have put in – I have found this to be the only way I know of to successfully reverse Parkinson’s disease.
I offer every one of you the exact Blueprint, that I have followed, for Reversing my Parkinson’s disease.
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A Completely New Way To Replace Lost Cells
Parkinson’s UK Deputy Director of Research David Dexter said:
“Replacing the cells that are lost in Parkinson’s is a possible way to reverse its symptoms, and could one day be a cure for the condition.
“This research is hugely promising, as it offers a completely new way to replace cells that are lost in Parkinson’s.
“However, the location of the new cells created through this process could make it difficult to control the delivery of dopamine to the brain.
“Further development of this technique is now needed, so it encourages dopamine to be produced and released in a controlled manner, like the original brain cells.
“If successful, it would turn this approach into a viable therapy that could improve the lives of people with Parkinson’s and, ultimately, lead to the cure that millions are waiting for.”
Types Of Exercise Suitable For Parkinsons Disease Patients
If you have Parkinsons disease, there are a lot of health benefits that come along with exercise. Staying active can help you sleep, strengthen your muscles and joints, reduce stress and depression, and improve posture, balance, and gait.
But what sort of exercise should you do? The types of exercise you choose will depend, to some degree, on the severity of your Parkinsons disease and your overall health. According to the Parkinsons Disease Clinic and Research Center at the University of California, the exercises should be varied and incorporate changing directions through unplanned movement, cardiovascular exercise, balance, strength training and rhythmical exercises.
Unplanned and Random MovementThe exercises listed require the person to change tempo and direction regularly. These will challenge a person mentally as well as physically as they require concentration to perform.
- Walking, hiking or jogging
- Racket sports such as badminton, table tennis, squash
- Yoga or Tai Chi
- Swimming in different strokes
How Far Have We Come
There are only a few examples in history where a single approach has provided a cure for everyone with a condition, and Parkinsons will be no different. It will involve different treatments and therapies at different times for different people. But the multiple pieces of this puzzle are starting to come together, and we are starting to make breakthroughs that could relieve symptoms for the rest of life.
Parkinsons is a progressive neurological condition that affects about 145,000 people in the UK and an estimated 714 million people worldwide. There is currently no cure, and we desperately need better treatments.
You can help us speed up the development of new and better treatments, and a cure for Parkinsons by donating to groundbreaking research today.
When Should I Start Exercising
Right now! Everyone should exercise more, whether they have PD or not.
In PD, a special kind of neuron that produces the chemical transmitter dopamine gets damaged and lost. However, there is a lag between the time when neuron loss begins and when PD movement symptoms start to show. By the time most people are diagnosed, as much as 40 to 60 percent of their dopamine neurons are already gone. The reason people with PD dont experience symptoms until they reach this point is that the brain can compensate for the loss of dopamine neurons by adapting. In fact, the brain reshapes itself throughout life in response to experience. Scientists call this ability to change and compensate “experience-dependent neuroplasticity.”
To find exercise classes in your area call the Parkinsons Foundation Helpline at 1-800-4PD-INFO .
Page reviewed by Dr. Bhavana Patel, Movement Disorders Fellow at the University of Florida, a Parkinsons Foundation Center of Excellence.
*Please note that not all content is available in both languages. If you are interested in receiving Spanish communications, we recommend selecting both” to stay best informed on the Foundation’s work and the latest in PD news.
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Neuroprotective Benefits Of Exercise
Exercise is an important part of healthy living for everyone, however, for people with Parkinsons disease exercise is not only healthy, but a vital component to maintaining balance, mobility and daily living activities, along with a potential neuroprotective effect. The Parkinsons Foundation Quality Improvement Initative studied exercise as part a Parkinson’s Outcomes Project study.
Every Center of Excellence agrees that they believe exercise is important to good outcomes in PD, and data supports that. Exercising enhances the sense of wellbeing, even across different disease stages and severities. There is a growing consensus among researchers about the short and long-term benefits of exercise for people with PD.
Motor Function Improvements From Exercise
Other exercise modalities have also been shown to improve specific motor functions in patients with PD. Cycling for 3 months improved gait in sedentary patients with PD.19,20 Forced exercise of the lower extremities during tandem cycling resulted in improvements both in global and fine motor function.21 Progressive resistance exercise training consisting of weight-bearing exercises 2 times per week for 24 months showed that long-term supervised exercise improved bradykinesia, overall motor scores, and general functional performance in patients with PD at a 24-month follow-up.22 A comparison of tai chi to stretching or strength training 2 times per week for 3 months demonstrated that tai chi reduced the incidence of falls. Compared to stretching, tai chi also improved UPDRS scores at 6-month follow-up .16 Various exercise modalities improve motor symptoms or delay worsening of symptoms in PD, and there is no clear single method that is superior.
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Can Parkinsons Disease Be Reversed
- The Health & Wellness Center703-354-7336
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Walking May Improve Symptoms
Study author Dr. Ergun Y. Uc, of the University of Iowa in Iowa City and the Veterans Affairs Medical Center of Iowa City, says that results suggest walking may provide a safe and easily accessible way of improving the symptoms of Parkinsons disease and quality of life.
People with mild-moderate Parkinsons who do not have dementia and are able to walk independently without a cane or walker can safely follow the recommended exercise guidelines for healthy adults, which includes 150 minutes per week of moderate intensity aerobic activity, and experience benefits.
This study has its limitations. The range of participants in the research is a relatively small number, and the study did not run for a particularly long period of time. Without a control group to draw comparison with, it is unknown as to whether other factors could have influenced the findings.
The authors admit that further studies will be required in order to confirm these results. They state that future directions and challenges for this area of research include conducting controlled and longer-term studies, and investigating the effects of different types of personal training.
As a disease currently without a cure, it is vital that research continues in this field, with the hope of improving treatment methods for what is a difficult condition for both doctors and patients to grapple with.
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Why Do You Need To Exercise
Research shows that exercise is important for Parkinsons patients:
- It changes the course of the diagnosis and slows progression it can even reverse some symptoms.
- Exercise promotes neuroplasticity–the ability of the brain to form new connections–its like muscle memory that improves the skill with practice.
- Exercise increases secretions of trophic factors, chemicals that nourish brain cells.
- Exercise in midlife appears to reduce the later risk of getting Parkinsons.
- Aerobic exercise reduces the risk of physical and cognitive decline. Studies have shown that exercisers have an increased volume in certain areas of the brain, including the cerebellum, which is important for coordination, the cortex, which is essential for planning and executing movements, and the hippocampus, which is vital to memory.
- Aerobic exercises have shown improved brain connections on MRI and CT scans, increasing dopamine reception.
Exercise Helps Prevent Fight Parkinson’s Disease From The Harvard Health Letter
Parkinson’s is a brain disease that affects the body and how it moves. Early symptoms include tremors, a shuffling gait, and an overall slowing of physical movement. Yet exercise may be one of the best and most underutilized ways of combating the condition, according to the March 2012 .
Several prospective studies that followed tens of thousands of people for many years have shown a correlation between exercise earlier in life and a reduced chance of developing Parkinson’s later on. Exercising in your 30s and 40s decades before Parkinson’s typically occurs may reduce the risk of getting Parkinson’s disease by about 30%, notes the Health Letter. Some experts believe the exercise must be vigorous to make a difference. However, because this kind of research can’t prove cause and effect, there is the possibility of “reverse causation”: that is, exercise may not prevent Parkinson’s disease, but instead a very early “preclinical” form of the disease, without clear symptoms, may make people less willing or able to exercise in the first place.
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New Treatment May Have The Potential To Slow Stop Or Reverse Parkinson Disease
Results from a recent study suggest that a revolutionary treatment may have the potential to slow, stop, or even reverse the progression of Parkinson disease.
Results from a February study of a revolutionary treatment suggest that it may be possible to slow, stop, or even reverse the progression of Parkinson disease, according to findings in the Journal of Parkinsons Disease.
The 3-part, experimental study investigated whether using a novel delivery system to increase levels of glial cell line-derived neurotrophic factor can regenerate dying dopamine brain cells in patients with Parkinson disease and even reverse their condition. GDNF is a naturally occurring protein that promotes the survival of many types of neurons.
I believe that this approach could be the first neuro-restorative treatment for people living with Parkinson’s, which is, of course, an extremely exciting prospect, Steven Gill, MB, MS, FRCS, who designed the infusion device used in the study, said in a statement.
Initially, 6 patients enrolled in a pilot study which evaluated the safety of the treatment approach. After the pilot study, 35 additional individuals participated in a subsequent 9-month double-blind trial. Half of the participants were randomly assigned to receive monthly infusions of GDNF while the other half received placebos.
Designing Clinical Trials For Exercise
Exercise trials present unique opportunities and challenges for investigators and subjects. From an individual subject standpoint, being involved in an exercise trial provides them with the chance to become more physically active, and develop a structured training plan with increased supervision and external motivation. The role of exercise in PD has attained great interest in both research and public forums . For investigators, this increased enthusiasm for exercise may translate into quicker subject recruitment and improved adherence to protocol. Moreover, these trials may be comparatively easy to initiate with less regulatory, intellectual property, and financial hurdles compared to trials investigating new pharmaceutical agents or medical devices. For all parties involved, these trials have lower safety concerns, with several studies demonstrating no or minimal morbidity in individuals with PD, as reviewed in . Lastly, the increased utility of ehealth technology lends itself nicely to designing new exercise trials, as will be expanded upon below.
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So Why Is Finding A Cure So Difficult
In the 1960s, when levodopa was first discovered, it was heralded as a cure for Parkinsons. Researchers had identified that Parkinsons symptoms were due to a lack of dopamine in the brain and had discovered a treatment that replaces this missing chemical messenger. For the first time, they had a drug with the ability to reduce and relieve symptoms of the condition. Today, levodopa is still the gold standard for Parkinsons treatment. When it comes to effective medical treatment it is actually very good, particularly in the early stages.
However, no current Parkinsons medication could be called a cure. Despite numerous improvements that have been made over the last 50 years, which make these drugs more effective and longer lasting, in the long term, these medications fail to completely relieve the symptoms of Parkinsons. The condition continues to have an ever-increasing impact on quality of life and, for many of the 145,000 people in the UK with Parkinsons, is a battle that is fought every day. Additionally, there are many symptoms, particularly non-motor symptoms like sleep problems, anxiety and pain, that are not adequately controlled by any medication. And these too progress as the condition becomes more severe.
When it comes to slowing Parkinsons, we can slow the progression of symptoms with exercise, but research has yet to provide a treatment that stops further damage to the brain. But the reasons why are actually quite simple, and can be overcome.