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HomeSide EffectsCan Parkinson's Disease Be Cured

Can Parkinson’s Disease Be Cured

Naturaltreatment For Parkinsons #9 Exercise And Other Alternative Therapies:

How can we cure Parkinson’s?

Regular exercise has been shown to help Parkinsonssufferers by reducing muscle stiffness, increasing mobility, and enhancing postureand balance. Exercise also increases oxygen levels and neurotransmitters, alongwith releasing potent mood elevating chemicals called endorphins.

The type of exercise performed for PD is crucial. Aqua orwater aerobics can be particularly useful as traditional exercise is usuallyquite difficult for many Parkinsons sufferers. Muscle decline, loss of strength,stiffness and loss of balance can make conventional exercises difficult toperform. The great thing about aqua aerobics is it still has the same benefits as other exercise regimens,but the risk of falling is eliminated.

Other types of exercises that can be beneficial for PDsufferers include Tai Chi, Yoga, dancing, walking, aerobic/jazzercise classes,and general stretching.

For more information on the different exercise programsavailable for Parkinsons patients, you can check out this website ;Exercise and Physical Therapy for ParkinsonsDisease

When Will There Be A Cure For Parkinsons Disease

You can tell a lot about a culture from its Armageddon myths, as propagated through pop culture. We have created quite a few across the last few decades, from the dystopian futures of Mad Max and the Terminator to the zombie apocalypses that have come to populate many an end-of-the-world tale. The latter often entail some experiment gone horribly awry, leading to a pandemic far more lethal and gruesome than any ever caused, for example, by influenza. Earlier this year, scientists warned of a possible new pandemic that has nothing to do with diseased bat guano, genetically modified whatever, or ancient Egyptian curses. Parkinsons Disease is on the rise, and so far theres;no cure for this rare neurodegenerative disease.

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What Is Parkinson’s Disease

Parkinsons disease is movement disorder of the nervous system that worsens over time. As nerve cells in parts of the brain weaken or are damaged or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. As these symptoms become more obvious, people may have difficulty walking, talking, or completing other simple tasks. Not everyone with one or more of these symptoms has PD, as the symptoms appear in other diseases as well.

No cure for PD exists today, but research is ongoing and medications or surgery can often provide substantial improvement with motor symptoms.

Problems With Energy Production

Can Parkinsons Disease be cured through Stem Cells?

Around the same time, our research revealed that the brains of people with Parkinsons also have problems with tiny energy-producing batteries called mitochondria.

Every cell in our body has mitochondria, which make energy to keep cells alive. When they stop working properly, the cells get sick and die. So were funding research into drugs that support these batteries and keep them working longer.

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Home Remedyfor Parkinsons #5 Vitamin D & Vitamin E:

Inflammation and low immunity are two powerful factorsthat contribute to the development and worsening of Parkinsons disease. Bothvitamin D and vitamin E are strong anti-inflammatories and immune boosters. VitaminD & E also protect our brain cells and can even help damaged neurons regenerate. A deficiency of these key vitamins has also been linked to brain difficultiessuch as poor memory and recall attainability.;

In regards to PD, a study of 157 Parkinsons patientsfound that the vast majority of them had severe to chronic vitamin Ddeficiencies. The findings, published in the Archives of Neurology in March of 2011, revealed a strong linkbetween inadequate levels of vitamin D and the onset of early Parkinson’sdisease.4

Back in 2002, another study was published in the Archives of Neurology which tracked themental decline of 3,000 men and women diagnosed with Parkinsons disease over a period of 7 years. The study found the participants whose supplemental vitamin E intakewas higher experienced a 36% reduction in theseverity of their symptoms compared to the rest of the group. Another study, whichappeared in the Lancet Neurology onlinemagazine in 2005, showed that vitamin E may actually prevent Parkinsonsdisease from developing in the first place! 8;

Where to Get Your Vitamin D and Vitamin E From?

The Symptoms Of Parkinsons Disease

Some symptoms of PD are difficult to detect even by the specialists, while others are obvious to even untrained eyes. Parkinsons symptoms are different for every patient. Like any other chronic diseases, the degree that the disease worsen;differs in;every individual depending on their genes, diet, lifestyle and their exposure to environmental toxins.

Some of the common symptoms of Parkinsons:

  • Constipation
  • Trouble;sleeping
  • Low blood pressure, feeling dizzy or fainting

As a result of this disease that;is a deterioration of brain health and the central nervous system, if left untreated, some sufferers may also experience other brain issues such as Alzheimers Disease, dementia, severe depression and anxieties that may result in suicidal thoughts.

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Home Remedyfor Parkinsons #8 Green Tea:

Green tea contains theanine, a nutrient that increasesdopamine levels in the brain, and polyphenol antioxidants that help fight free radicals. Three separate studies all found that regularlydrinking tea can either delay or prevent the development of PD. A retrospectivestudy also found that drinking three or more cups of tea a day can delay the onsetof motor symptoms. And a 2007 study found that green tea polyphenols protect braincells and dopamine neurons, and this positive effect increases with the moregreen tea consumed. 10

The minimum amount that should be drank every day is 3cups, with 6-9 cups a day being the ideal.Matcha green tea is the most potent and beneficial so try and purchase this ifyou can. A strong cup of coffee first thing in the morning is thought tobe effective for reducing the symptoms of Parkinsons disease as well, however,we recommend you stick with green tea, or even a strong cup of black tea ifyou can for the theanine and EGCGs.;

How Is Parkinson’s Disease Managed

Is there a cure for Parkinson’s disease? How is is treated?

Your doctors will tailor your treatment based on your individual circumstances. You will manage your condition best if you have the support of a team, which may include a general practitioner, neurologist, physiotherapist, occupational therapist, psychologist, specialist nurse and dietitian.

While there is no cure for Parkinson’s disease, symptoms can be treated with a combination of the following.

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If Replacing Dopamine In The Brain Via Carbidopa/levodopa Helps Reduce And Sometimes Completely Eliminate Parkinsons Symptoms Why Arent We Closer To Finding A Cure Is Parkinsons Truly Caused By A Lack Of Dopamine

Heres what he said:

In 1817, James Parkinson wrote the article that first described the disease, called;An Essay on the Shaking Palsy.; This essay, and our understanding of the disease from the earliest days until the 1970s, focused on the major clinical symptoms of Parkinsons that emerge from how the disease impacts the;dopamine;system, notably the dopamine-producing neurons of the part of the brain called the;substantia nigra,;which basically means, black stuff, named in the days when anatomists just cut up corpses and named what they saw with little insight.

In the late 1960s and 1970s, clinical researchers figured out that they could treat Parkinsons with;dopamine replacement therapy. Parkinsons was thus a disease of dopamine and therefore, we could focus on the dopamine system in treatments of Parkinsons. End of story, right?

Wrong.

Focusing on dopamine for Parkinsons is like saying that global warming is a problem of temperature. Cooling the air wouldnt solve the problem of climate change and;replacing dopamine;doesnt cure Parkinsons.;;Parkinsons is largely a disease of neurons, and to stop/fix/cure Parkinsons, we need to stop that disease from making neurons sick.

The neurons are being made sick by being polluted with too much of a protein called alpha-synuclein. This protein seems to principally affect dopamine neurons in Parkinsons, but as the disease advances, it can harm other neurons, too.

Why?

Can Parkinsons Disease Be Cured

Parkinsons disease was first described more than 200 years ago by James Parkinson. Unfortunately, theres no cure yet for Parkinsons disease. However, modern treatments can help people with the condition significantly reduce and manage their symptoms. New treatments are constantly being developed to improve the quality of life and prognosis for people with Parkinsons disease.

Scientists use genetic and molecular techniques to understand more about Parkinsons disease and the mutations associated with it. Researchers have also theorized that gut microbiota, which play a vital role in neurodevelopment, may be linked to the development of Parkinsons disease. Abnormal proteins, such as -synuclein, have also been linked to the condition.

Advancements have focused on understanding and treating the early, pre-symptomatic phases of Parkinsons disease. Researchers have developed less-invasive technologies, such as focused ultrasound or gamma knife procedures, for people with Parkinsons disease. These technologies can pinpoint and treat focal lesions in the brain without affecting healthy tissue.

Other studies focus on finding new medications that can cross the bloodbrain barrier to deliver drugs more effectively into affected tissues.;

Medications can help manage the symptoms caused by Parkinsons disease. These medications include:

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Medications For People With Parkinsons Disease

Symptoms of Parkinsons disease result from the progressive degeneration of nerve cells in the brain and other organs such as the gut, which produce a neurotransmitter called dopamine. This causes a deficiency in the availability of dopamine, which is necessary for smooth and controlled movements.;Medication therapy focuses on maximising the availability of dopamine in the brain. Medication regimes are individually tailored to your specific need. Parkinsons medications fit into one of the following broad categories:;

  • levodopa dopamine replacement therapy
  • dopamine agonists mimic the action of dopamine
  • COMT inhibitors used along with levodopa. This medication blocks an enzyme known as COMT to prevent levodopa breaking down in the intestine, allowing more of it to reach the brain
  • anticholinergics block the effect of another brain chemical to rebalance its levels with dopamine
  • amantadine has anticholinergic properties and improves dopamine transmission
  • MAO type B inhibitors prevent the metabolism of dopamine within the brain.

The Future Of Parkinsons Disease: What We Know

Can Parkinsons Disease be cured through Stem Cells?

In the past 50 years, researchers have made vital discoveries about Parkinsons medications and treatments, and we now have a better understanding of what causes Parkinsons disease including its genetic component. With the right investment, researchers predict we will be able to find a Parkinsons disease cure in a matter of years, not decades.

Researchers also recognize that, as the disease presents so differently in each patient, there may not be a single “cure” for Parkinson’s disease. However, scientists believe that the right combination of treatments, therapies and strategies could stop the progression of the disease entirely.

Clinical trials are taking place in the following areas:

  • Stem cell treatment: This approach will use healthy, live cells to replace or repair the damage in the brains of Parkinsons patients .
  • Gene therapies: This treatment will use genetics to reprogram cells in the brain and change their behavior, helping them stay healthy for longer. ;
  • Growth and development of brain cells: This approach will use naturally-occurring molecules to help brain cells survive.
  • Medications: Scientists are testing existing medicines that are used to treat other conditions, such as high blood pressure, diabetes and cancer, to see if they pose any benefits for people with Parkinson’s disease.

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Why Isnt Parkinsons Disease Curable

With decades of research into this illness, why havent scientists found a cure for Parkinsons disease? Unfortunately, the brain isn’t straightforward, and every case of Parkinson’s presents slightly differently. As such, there are no specific biomarkers for the disease, making it hard to diagnose and even harder to treat.

The bottom line is, there is still a lot about the brain that we don’t understand. Parkinson’s is a complex disease and many unanswered questions about Parkinson’s remain. On top of all of this, recruitment for clinical trials can be difficult, and many get delayed for this reason.

Its Not Just One Condition There Are Multiple Types Of Parkinsons

Like cancer, we are starting to understand the importance of subtyping Parkinsons and developing tailored treatments that will be more successful than a one size fits all approach. Better understanding is coming from large scale studies that follow vast numbers of people with the condition over time. And we are starting to see how the subtypes of Parkinsons have different symptoms, progression rates and even different responses to medication.

To effectively treat Parkinsons, we probably need to tackle each of these subtypes differently, providing the right treatments and support to suit the individual and their form of Parkinsons. And this starts with understanding more about how we classify and identify these different types.

You can read more about research into personalised treatments in our recent blog Precision medicine for Parkinsons, how close are we?

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How Is Parkinsons Disease Treated

There is no cure for Parkinsons disease. However, medications and other treatments can help relieve some of your symptoms. Exercise can help your Parkinsons symptoms significantly. In addition, physical therapy, occupational therapy and speech-language therapy can help with walking and balance problems, eating and swallowing challenges and speech problems. Surgery is an option for some patients.

How Is Parkinsons Disease Diagnosed

Diagnosing Parkinsons disease is sometimes difficult, since early symptoms can mimic other disorders and there are no specific blood or other laboratory tests to diagnose the disease. Imaging tests, such as CT or MRI scans, may be used to rule out other disorders that cause similar symptoms.

To diagnose Parkinsons disease, you will be asked about your medical history and family history of neurologic disorders as well as your current symptoms, medications and possible exposure to toxins. Your doctor will look for signs of tremor and muscle rigidity, watch you walk, check your posture and coordination and look for slowness of movement.

If you think you may have Parkinsons disease, you should probably see a neurologist, preferably a movement disorders-trained neurologist. The treatment decisions made early in the illness can affect the long-term success of the treatment.

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Key Programs And Resources

The Parkinsons Disease Biomarkers Programs , a major NINDS initiative, is aimed at discovering ways to identify individuals at risk for developing PD and Lewy Body Dementia and to track the progression of the disease. It funds research and collects human biological samples and clinical data to identify biomarkers that will speed the development of novel therapeutics for PD. Goals are improving clinical trials and earlier diagnosis and treatment. Projects are actively recruiting volunteers at sites across the U.S. NINDS also collaborates with the Michael J. Fox Foundation for Parkinsons Research on BioFIND, a project collecting biological samples and clinical data from healthy volunteers and those with PD. For more information about the PDBP and how you can get involved, please visit the PDBP website.

The NINDS Morris K. Udall Centers of Excellence for Parkinsons Disease Research program supports research centers across the country that work collaboratively to study PD disease mechanisms, the genetic contributions to PD, and potential therapeutic targets and treatment strategies.

The NINDS Intramural Research Program conducts clinical studies to better understand PD mechanisms and develop novel and improve treatments.

The NINDS Biospecimens Repositories store and distribute DNA, cells, blood samples, cerebrospinal fluid, and autopsy tissue to PD researchers around the world.

Diagnosis And Management Of Parkinsons Disease

Can Parkinsons Disease be cured through Stem Cells?

There are no diagnostic tests for Parkinsons. X-rays, scans and blood tests may be used to rule out other conditions. For this reason, getting a diagnosis of Parkinsons may take some time.;;

No two people with Parkinsons disease will have exactly the same symptoms or treatment. Your doctor or neurologist can help you decide which treatments to use.

People can manage their Parkinsons disease symptoms through:;

  • seeing a Doctor who specialises in Parkinsons
  • medication
  • multidisciplinary therapy provided for example, by nurses, allied health professionals and counsellors
  • deep brain stimulation surgery .

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Clinical Trials Often Fail

Did you know up to 10% of people taking part in clinical trials into early Parkinsons may not actually have the condition. And because they wont benefit from the treatment they are likely affecting results even leading to the failure of these trials.

Fortunately, through initiatives like the Critical Path for Parkinsons, were leading the way towards better clinical trials that are more likely to succeed.

Today, we are starting to identify what may be behind the loss of brain cells, and clinical trials are underway to try and tackle everything from the build up of alpha-synuclein to inflammation. But, without effective clinical trials, we risk failure simply because we are not testing treatments in the right way.

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