What Are The Main Causes Of Parkinson’s Disease

Incidence Of Parkinsons Disease

Its estimated that approximately four people per 1,000 in Australia have Parkinsons disease, with the incidence increasing to one in 100 over the age of 60. In Australia, there are approximately 80,000 people living with Parkinsons disease, with one in five of these people being diagnosed before the age of 50. In Victoria, more than 2,225 people are newly diagnosed with Parkinsons every year.

How Does Environment Come Into It

Your environment is a hard one to pin down. Partly, that’s because it covers a lot of ground. It’s everything that’s not your genes, which could mean where you live, what you eat, chemicals you’ve come into contact with, and more.

Not only that, but it could take years for the effects from something in your environment to show up. So far, doctors have a lot of clues but no smoking gun. So you could have people who live or work in an area around chemicals tied to Parkinson’s, but many of them don’t get it.

Some research shows links between Parkinson’s and:

• Agent Orange, a chemical used to destroy trees and crops in the Vietnam War.
• Certain chemicals used in farming, such as insecticides, herbicides, and fungicides.
• Some metals and chemicals used in factories, such as manganese, lead, and trichlorethylene .

These can come into play based on where you live, what you do for work, or if you served in the military. Sometimes, these chemicals seep into well water, so that’s one more way they can affect you.

What Are The Symptoms Of Parkinson’s Disease

The symptoms of Parkinson’s disease include tremors or trembling difficulty maintaining balance and coordination trouble standing or walking stiffness and general slowness.

Over time, a person with Parkinson’s may have trouble smiling, talking, or swallowing. Their faces may appear flat and without expression, but people with Parkinson’s continue to have feelings even though their faces don’t always show it. Sometimes people with the disease can have trouble with thinking and remembering too.

Because of problems with balance, some people with Parkinson’s fall down a lot, which can result in broken bones. Some people with Parkinson’s may also feel sad or depressed and lose interest in the things they used to do.

The symptoms of Parkinson’s disease appear gradually and get worse over time. But because Parkinson’s disease usually develops slowly, most people who have it can live a long and relatively healthy life.

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What If I Carry The Gene

There are ongoing clinical trials testing therapies to treat people who have Parkinson’s and carry certain gene mutations. Proving that it can be important to know which gene mutation you carry. Consult with your doctor when considering a genetic test to determine if you are eligible to participate in gene-based clinical trials.

The Parkinsons Foundation study, PD GENEration: Mapping the Future of Parkinsons Disease, is the first national study to offer genetic testing and counseling at no cost for those with a confirmed Parkinsons diagnosis. Learn more and enroll at Parkinson.org/PDGENEration.

*Please note that not all content is available in both languages. If you are interested in receiving Spanish communications, we recommend selecting both” to stay best informed on the Foundation’s work and the latest in PD news.

Is Parkinsons Disease Hereditary

Hereditary diseases are passed from parents to their children, but cases of familial Parkinsons disease are very rare . The vast majority of Parkinsons cases are not transmissible.

Having Parkinsons disease does not affect your childrens risk of developing the disease. Similarly, your risk is not increased if your brother or sister has the disease. However, your risk may be increased if more than one person in your family has the disease.

Exposure to certain environmental factors or toxins may contribute to the development of Parkinsons disease.

The main environmental factors involved in Parkinsons disease are:

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What Treatments Are Available

Many Parkinson’s patients enjoy an active lifestyle and a normal life expectancy. Maintaining a healthy lifestyle by eating a balanced diet and staying physically active contributes to overall health and well-being. Parkinson’s disease can be managed with self-care, medication, and surgery.

Self careExercise is as important as medication in the treatment of PD. It helps maintain flexibility and improves balance and range of motion. Patients may want to join a support group and continue enjoyable activities to improve their quality of life. Equally important is the health and well being of the family and caregivers who are also coping with PD. For additional pointers, see Coping With Parkinsons Disease.

These are some practical tips patients can use:

Medications There are several types of medications used to manage Parkinson’s. These medications may be used alone or in combination with each other, depending if your symptoms are mild or advanced.

After a time on medication, patients may notice that each dose wears off before the next dose can be taken or erratic fluctuations in dose effect . Anti-Parkinsons drugs can cause dyskinesia, which are involuntary jerking or swaying movements that typically occur at peak dosage and are caused by an overload of dopamine medication. Sometimes dyskinesia can be more troublesome than the Parkinsons symptoms.

What Is Parkinsons Disease

Parkinsons Disease is a progressive neurological disorder which affects around 120,000 people in the UK. Progressive means that it typically worsens over time and neurological means that it affects the nervous system . The main symptoms of Parkinsons are slowness of movement , rigidity, tremor and postural instability . While Parkinsons is typically described as a movement disorder, a person with Parkinsons may experience a range of other symptoms including constipation, low mood, fatigue, sleep and memory problems. Symptoms of Parkinsons can be grouped into two major categories motor symptoms and non-motor symptoms .

Parkinsons typically strikes in middle age, with around 80% of cases presenting between ages of 40 and 70, and progression of symptoms is generally slow and continuous. Younger people who develop Parkinsons are more likely to have a relative with the illness suggesting a stronger genetic component. Symptoms usually begin gradually and motor symptoms are often preceded by non-motor symptoms such as fatigue, loss of smell, depression, constipation and sweating abnormalities.

If you are concerned that you or a friend or family member has symptoms of Parkinsons, you or they should see a GP immediately.

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What Causes Parkinsons Disease

Parkinsons disease is a chronic, progressive neurological disease that currently affects about 1 million Americans. Parkinsons disease involves a small, dark-tinged portion of the brain called the substantia nigra. This is where you produce most of the dopamine your brain uses. Dopamine is the chemical messenger that transmits messages between nerves that control muscle movements as well as those involved in the brains pleasure and reward centers. As we age, its normal for cells in the substantia nigra to die. This process happens in most people at a very slow rate.

But for some people, the loss happens rapidly, which is the start of Parkinsons disease. When 50 to 60 percent of the cells are gone, you begin to see the symptoms of Parkinsons.

Trouble Moving Or Walking

Do you feel stiff in your body, arms or legs? Have others noticed that your arms dont swing like they used to when you walk? Sometimes stiffness goes away as you move. If it does not, it can be a sign of Parkinson’s disease. An early sign might be stiffness or pain in your shoulder or hips. People sometimes say their feet seem stuck to the floor.

What is normal?If you have injured your arm or shoulder, you may not be able to use it as well until it is healed, or another illness like arthritis might cause the same symptom.

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Parkinson’s Diseasewhat Are The Causes Of Parkinson’s Disease

Symptoms manifest due to a malfunction of dopamine neurons

The brain is the central control tower that governs the condition of the body. Messages sent out by the brain are transmitted from one nerve cell to the next by neurotransmitters that pass the message on like a baton during a relay race, causing your body to move in reaction to the message. In Parkinson’s disease, levels of dopamine, a neurotransmitter in a part of the brain called the substantia nigra, decrease, causing a loss of control over body movement. It is still not fully understood what causes the amount of dopamine to decrease. Changes in the brain associated with age and, in some cases, changes related to a person’s genes, are presumed to be the cause. Supplementing the deficient dopamine with medication can lessen the symptoms of Parkinson’s disease.

Family History & Genetics

Researchers have been able to identify certain genetic mutations that can increase the risk of developing Parkinsons disease.

These are the two types of Parkinsons disease, from a genetic standpoint:

• Hereditary Parkinsons disease: Roughly 15% of all cases of Parkinsons disease are inherited. In these cases, mutations in certain genes are passed down through families and increase the individuals risk of developing this condition.
• Sporadic Parkinsons disease: On the other hand, cases in which people dont have a family history of Parkinsons disease are referred to as sporadic cases. These cases are in fact the majority. Scientists have found that alterations in certain genes may also play a role in sporadic cases, in addition to other environmental and lifestyle-related factors.

However, the role that these genetic mutations play in the development of the condition hasnt been fully understood yet.

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Medications And Parkinsons Symptoms

Taking certain medications, specifically ones that block the action of dopamine, could cause Parkinsons disease symptoms. This is a condition called drug-induced parkinsonism, and whilst it is not Parkinsons disease itself, it can look and feel a lot like it. These are some of the drugs that can cause Parkinsons disease symptoms:

• Antipsychotics
• Anti-nausea medications
• Drugs that treat hyperkinetic movement disorders

Even though these medications could cause symptoms similar to Parkinsons, they do not cause the disease itself. Most of the time, the symptoms go away within hours or days once you stop taking that drug, per the Parkinsons Disease Society.

Research on what causes Parkinsons disease continues to grow. As the NHS advises, if you experience symptoms of Parkinsons, such as a tremor, slowed movement, balance problems, or changes in your speech or writing, contact your GP straight away.

What Is The Outlook For Persons With Parkinsons Disease

Although there is no cure or absolute evidence of ways to prevent Parkinsons disease, scientists are working hard to learn more about the disease and find innovative ways to better manage it, prevent it from progressing and ultimately curing it.

Currently, you and your healthcare teams efforts are focused on medical management of your symptoms along with general health and lifestyle improvement recommendations . By identifying individual symptoms and adjusting the course of action based on changes in symptoms, most people with Parkinsons disease can live fulfilling lives.

The future is hopeful. Some of the research underway includes:

• Using stem cells to produce new neurons, which would produce dopamine.
• Producing a dopamine-producing enzyme that is delivered to a gene in the brain that controls movement.
• Using a naturally occurring human protein glial cell-line derived neurotrophic factor, GDNF to protect dopamine-releasing nerve cells.

Many other investigations are underway too. Much has been learned, much progress has been made and additional discoveries are likely to come.

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In The Loop: Staying Ahead Of Parkinsons Disease One Ping Pong Game At A Time

Since being diagnosed with Parkinson’s disease, Steve Grinnell has worked hard to stay active, stepping up his table tennis game and, thanks to co-workers, testing his skills outside his home.

Four years ago, Steve Grinnell’s life was forever changed when doctors at Mayo Clinic in Rochester diagnosed him with early-onset Parkinson’s disease. Since that time, the progressive nervous system disorder has begun to take a toll on Steve and his family, just as it does on the millions of other Americans living with the disease. “It has greatly diminished his quality of life, leaving him with tremors, physical exhaustion, impaired balance, troubled grasping things with his right hand, slow right-arm movement and problems sleeping,” the Rochester Post-Bulletin recently reported. “That’s to name just a few of his symptoms.”

Reading that, one might assume the disorder is winning. And to Steve, sometimes it feels like it is. But much of the time, he tells us he also feels like he’s staying one step ahead of the disease by staying as physically active as possible. “Parkinson’s presents such a conundrum because it wears you down physically, and yet exercise is so valuable,” Steve says. “My legs, feet and right arm are always cramping, so it takes mental effort to get moving.”

What Is Parkinson’s Disease

Parkinsons disease is a degenerative, progressive disorder that affects nerve cells in deep parts of the brain called the basal ganglia and the substantia nigra. Nerve cells in the substantia nigra produce the neurotransmitter dopamine and are responsible for relaying messages that plan and control body movement. For reasons not yet understood, the dopamine-producing nerve cells of the substantia nigra begin to die off in some individuals. When 80 percent of dopamine is lost, PD symptoms such as tremor, slowness of movement, stiffness, and balance problems occur.

Body movement is controlled by a complex chain of decisions involving inter-connected groups of nerve cells called ganglia. Information comes to a central area of the brain called the striatum, which works with the substantia nigra to send impulses back and forth from the spinal cord to the brain. The basal ganglia and cerebellum are responsible for ensuring that movement is carried out in a smooth, fluid manner .

The action of dopamine is opposed by another neurotransmitter called acetylcholine. In PD the nerve cells that produce dopamine are dying. The PD symptoms of tremor and stiffness occur when the nerve cells fire and there isn’t enough dopamine to transmit messages. High levels of glutamate, another neurotransmitter, also appear in PD as the body tries to compensate for the lack of dopamine.

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What Is The Number One Risk Factor For Parkinson’s

Age is the greatest risk factor. About 1% of those over 60 and 5% of those over 85 are diagnosed with it. The increased risk is due to decreasing levels of dopamine metabolism and other changes that make the neurons vulnerable.

The Genetics Of Parkinsons

A 2020 study including 1,676 people with Parkinsons in mainland China suggested that genes play a role in the development of the condition. An estimated 10 to 15 percent of people with Parkinsons have a family history of the condition.

In fact, a number of specific genes have been linked to the development of Parkinsons.

How do genetics factor into Parkinsons in some families? According to Genetics Home Reference, one possible way is through the mutation of genes responsible for producing dopamine and certain proteins essential for brain function.

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How Is Parkinson’s Disease Treated

If a doctor thinks a person has Parkinson’s disease, there’s reason for hope. Medicine can be used to eliminate or improve the symptoms, like the body tremors. And some experts think that a cure may be found soon.

For now, a medicine called levodopa is often given to people who have Parkinson’s disease. Called “L-dopa,” this medicine increases the amount of dopamine in the body and has been shown to improve a person’s ability to walk and move around. Other drugs also help decrease and manage the symptoms by affecting dopamine levels. In some cases, surgery may be needed to treat it. The person would get anesthesia, a special kind of medicine to prevent pain during the operation.

What Are The Symptoms

Symptoms of PD vary from person to person, as does the rate of progression. A person who has Parkinson’s may experience some of these more common “hallmark” symptoms:

• Bradykinesia – slowness of movement, impaired dexterity, decreased blinking, drooling, expressionless face.
• Tremor at rest – involuntary shaking that decreases with purposeful movement. Typically starts on one side of the body, usually the hand.
• Rigidity – stiffness caused by involuntary increase in muscle tone.
• Postural instability – sense of imbalance. Patients often compensate by lowering their center of gravity, which results in a stooped posture.

Other symptoms that may or may not occur:

Freezing or being stuck in place Shuffling gait or dragging of one foot Stooped posture Cognitive impairment

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Stooping Or Hunching Over

Are you not standing up as straight as you used to? If you or your family or friends notice that you seem to be stooping, leaning or slouching when you stand, it could be a sign of Parkinson’s disease .

What is normal?If you have pain from an injury or if you are sick, it might cause you to stand crookedly. Also, a problem with your bones can make you hunch over.

Is Parkinsons Disease Inherited

Scientists have discovered gene mutations that are associated with Parkinsons disease.

There is some belief that some cases of early-onset Parkinsons disease disease starting before age 50 may be inherited. Scientists identified a gene mutation in people with Parkinsons disease whose brains contain Lewy bodies, which are clumps of the protein alpha-synuclein. Scientists are trying to understand the function of this protein and its relationship to genetic mutations that are sometimes seen in Parkinsons disease and in people with a type of dementia called Lewy body dementia.

Several other gene mutations have been found to play a role in Parkinsons disease. Mutations in these genes cause abnormal cell functioning, which affects the nerve cells ability to release dopamine and causes nerve cell death. Researchers are still trying to discover what causes these genes to mutate in order to understand how gene mutations influence the development of Parkinsons disease.

Scientists think that about 10% to 15% of persons with Parkinsons disease may have a genetic mutation that predisposes them to development of the disease. There are also environmental factors involved that are not fully understood.

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