The Investigation In Mice
In their recent study paper, the scientists refer to research suggesting that neurotrophic factors molecules that help neurons survive and thrive could, in theory, restore the function of neurons that produce dopamine. However, the clinical benefit of these factors had yet to be proven.
The team focused on bone morphogenetic proteins 5 and 7 . They had previously shown that BMP5/7 has an important role in dopamine-producing neurons in mice.
In the latest study, the scientists wanted to see whether BMP5/7 could protect the neurons of mice against the damaging effects of misfolded alpha-synuclein proteins.
To do this, they injected one group of mice with a viral vector that caused misfolded alpha-synuclein proteins to form in their brains. They used other mice as a control group. The scientists then injected the mice with the BMP5/7 protein.
What New Treatments Are Being Developed
Thanks to the progress we’ve already made, new treatments are being tested in clinical trials that have the potential to slow, stop or even reverse Parkinson’s.
- stem cell therapies, which aim to use healthy, living cells to replace or repair the damage in the brains of people with Parkinson’s
- gene therapies, which use the power of genetics to reprogramme cells and change their behaviour to help them stay healthy and work better for longer
- growth factors , which are naturally occurring molecules that support the growth, development and survival of brain cells.
And we’re developing treatments that aim to improve life with the condition, including new drugs that can reduce dyskinesia.
How Can People Cope With Parkinson’s Disease
While PD usually progresses slowly, eventually daily routines may be affectedfrom socializing with friends to earning a living and taking care of a home. These changes can be difficult to accept. Support groups can help people cope with the diseases emotional impact. These groups also can provide valuable information, advice, and experience to help people with PD, their families, and their caregivers deal with a wide range of issues, including locating doctors familiar with the disease and coping with physical limitations. A list of national organizations that can help people locate support groups in their communities appears at the end of this information. Individual or family counseling may also help people find ways to cope with PD.
People with PD may also benefit from being proactive and finding out as much as possible about the disease in order to alleviate fear of the unknown and to take a positive role in maintaining their health. Many people with PD continue to work either full- or part-time, although they may need to adjust their schedule and working environment to accommodate their symptoms.
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I Am Willing To Fund The Work
Apart from offers of penis enlargers, this was the most obvious spam hed ever seen, Kwang-Soo Kim thought as he scrolled through his inbox on May 2, 2013. A name hed never heard of was atop an email that was effusive in its praise, calling Kims research at McLean, on stem-cell therapy for Parkinsons disease, the most promising hed ever come across.
I am willing to fund the work, the mysterious George Lopez had written, whatever it takes to go twice as fast. I hope to benefit from that work. If not me, mankind will be better.
Lopez, Kim would soon learn, had himself been diagnosed with Parkinsons nearly a decade earlier. One evening, while his wife was bedridden at their southern California home with the breast cancer that would take her life, Lopez told her hed been experiencing a tremor, a staccato shaking when his hands werent otherwise moving.
So? his wife, Diana Kostyra Lopez, asked. I think I have Parkinsons, Lopez said. You dont have Parkinsons, she said dismissively.
The way she said it, it made me feel stupid, Lopez recalled in a long discussion with STAT in 2018. It also made me feel better.
Soon, however, neurologist Carolyn Neff confirmed his dreaded hunch: He had Parkinsons disease.
Its prognosis is bleak. There is no cure and no treatment that can slow down or stop the disease process, Kim said.
I shouldnt have been afflicted with it if there is any fairness in the universe. But of course, there isnt.
Parkinson’s Disease Cause Found
RECOVERY FROM PARKINSONS DISEASE In 1995, John Coleman was diagnosed with Parkinson’s Disease by five practitioners . By August 1995, John had lost his power of speech. Suffering from Stage IV Parkinson’s Disease and Multi-System Atrophy symptoms, he was unable to walk 5 metres without assistance, and took an hour and a half to get dressed. Severely dissatisfied with western medical treatment and prognosis, John decided to pursue other methods. With the aid of Homeopathy, Aqua Hydration Therapy, Bowen Therapy, Craniosacral Therapy, Flower Essences, Counselling, Meditation and Spiritual Development, John was completely symptom free by April 1998.
He said that he believed that I had Parkinsons disease and was developing Multi System Atrophy. He thought I required some “Parkinsons disease treatment” but wanted a second opinion first.
Why did I recover when so many had tried and failed before me? Was it the Aquas that took a little while before their full benefit became apparent? Was it the accumulation of many therapies that just happened to coincide at that time? I am not sure. I am certain that the whole of my journey is important and it is almost impossible to separate the effect of each therapy/experience from the whole.
Alzheimer’s And Parkinson’s Disease Could Be Cured After Scientists Reverse Symptoms Of Conditions In New Study
The study successfully reversed symptoms by destroying two chemicals found in the brain of Alzheimer’s and Parkinson’s disease
The diseases are caused by the degeneration of neurons and cannot be cured.
But scientists who successfully blocked harmful compounds in fruit flies now hope symptoms in humans could also be reversed, since their brains – although much larger – are strikingly similar since they share many of the same genes.
Dr Carlo Breda, of Leicester University, said: “A key finding of our study is we can improve ‘symptoms’ in fruit fly models of Alzheimer’s and Parkinson’s disease by feeding them a drug-like chemical.”
The study published in Proceedings of the National Academy of Sciences focused on protecting brain cells lost in Alzheimer’s disease and Parkinson’s – and could provide a turning point in the fight against the two most common neurological conditions.
It used the common laboratory fruit fly Drosophila melanogaster in order to explore the role of molecules known as KMO and TMO, which Alzheimer’s and Parkinson’s patients have a raised level of, leading to a build-up of poisonous proteins.
They also lead to another, much rarer neuro-degenerative disease – Huntington’s.
This counteracts the effects of the toxic metabolites, reports Proceedings of the National Academy of Sciences.
What Causes The Disease
The precise cause of PD is unknown, although some cases of PD are hereditary and can be traced to specific genetic mutations. Most cases are sporadicthat is, the disease does not typically run in families. It is thought that PD likely results from a combination of genetics and exposure to one or more unknown environmental factors that trigger the disease.
The protein alpha-synuclein. The affected brain cells of people with PD contain Lewy bodiesdeposits of the protein alpha-synuclein. Researchers do not yet know why Lewy bodies form or what role they play in the disease. Some research suggests that the cells protein disposal system may fail in people with PD, causing proteins to build up to harmful levels and trigger cell death. Additional studies have found evidence that clumps of protein that develop inside brain cells of people with PD may contribute to the death of neurons.
Genetics. Several genetic mutations are associated with PD, including the alpha-synuclein gene, and many more genes have been tentatively linked to the disorder. The same genes and proteins that are altered in inherited cases may also be altered in sporadic cases by environmental toxins or other factors.
Environment. Exposure to certain toxins has caused parkinsonian symptoms in rare circumstances . Other still-unidentified environmental factors may also cause PD in genetically susceptible individuals.
If Replacing Dopamine In The Brain Via Carbidopa/levodopa Helps Reduce And Sometimes Completely Eliminate Parkinsons Symptoms Why Arent We Closer To Finding A Cure Is Parkinsons Truly Caused By A Lack Of Dopamine
Heres what he said:
In 1817, James Parkinson wrote the article that first described the disease, called An Essay on the Shaking Palsy. This essay, and our understanding of the disease from the earliest days until the 1970s, focused on the major clinical symptoms of Parkinsons that emerge from how the disease impacts the dopamine system, notably the dopamine-producing neurons of the part of the brain called the substantia nigra, which basically means, black stuff, named in the days when anatomists just cut up corpses and named what they saw with little insight.
In the late 1960s and 1970s, clinical researchers figured out that they could treat Parkinsons with dopamine replacement therapy. Parkinsons was thus a disease of dopamine and therefore, we could focus on the dopamine system in treatments of Parkinsons. End of story, right?
Focusing on dopamine for Parkinsons is like saying that global warming is a problem of temperature. Cooling the air wouldnt solve the problem of climate change and replacing dopamine doesnt cure Parkinsons. Parkinsons is largely a disease of neurons, and to stop/fix/cure Parkinsons, we need to stop that disease from making neurons sick.
The neurons are being made sick by being polluted with too much of a protein called alpha-synuclein. This protein seems to principally affect dopamine neurons in Parkinsons, but as the disease advances, it can harm other neurons, too.
Could You Possibly Do The Same And Reverse Your Parkinson’s Disease
I am not a doctor, nor have I ever had any medical training!I am merely a Parkinson’s Patient, who has had the good fortune to have been able to reverse many of his movement symptoms!
YES! You possibly can… and I urge you to follow this path!
- The unique lifestyle modification protocol I use.
- The unique Brain exercises I use.
- The exact physical exercises I use, to reverse my Parkinson’s.
- How you will see life, when you start to feel better, and why it is important to exercise.
- The special dietary advice I follow .
- The knowledge of the silent killer, that you might not even be aware of.
- How to improve your sleep, and in the process, have more energy.
- How to focus your mind, and take back control of your movements.
- What type of Parkinson’s medication is capable of slowing down the progression of your PD, and what types aren’t.
I am going to urge you again. These are the exact steps that I, John Pepper, and countless others, have followed to successfully reverse Parkinson’s disease.In all my research, which spans well over the last 20 years, and hundreds of hours of my own time – not even mentioning the countless hours other experts have put in – I have found this to be the only way I know of to successfully reverse Parkinson’s disease.
I offer every one of you the exact Blueprint, that I have followed, for Reversing my Parkinson’s disease.
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What Will A Cure For Parkinson’s Look Like
Because Parkinson’s varies so much from person to person, there may not be a single ‘cure’.
Instead we may need a range of different therapies to meet the needs of the individual and their specific form of the condition.
This mix may include treatments, therapies and strategies that can:
- slow or stop the progression of the condition
- replace or repair lost or damaged brain cells
- control and manage particular symptoms
- diagnose Parkinson’s at the earliest possible stage.
And this could involve medical treatments, such as drugs and surgical approaches, as well as lifestyle changes, for example to diet and exercise.
Why Is The Cost Low
People tell me that I should be charging hundreds of dollars for this work, but the purpose of creating the book and recording the meditations has nothing to do with money. It has everything to do with helping people who currently experience the symptoms of Parkinsons feel better. My true reward comes when I have been able to document the successful recovery of thousands of people with the symptoms of Parkinsons who have transformed their thought patterns. This is the work I have been doing on myself and I am here to tell you that the exercises and meditations have worked miracles on my own ability to manifest energy, health and happiness in my own life.
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What Research Is Being Done
The mission of the National Institute of Neurological Disorders and Stroke is to seek fundamental knowledge about the brain and nervous system and to use the knowledge to reduce the burden of neurological disease. NINDS is a component of the National Institutes of Health , the leading supporter of biomedical research in the world. NINDS conducts and supports three types of research: basicscientific discoveries in the lab, clinicaldeveloping and studying therapeutic approaches to Parkinsons disease, and translationalfocused on tools and resources that speed the development of therapeutics into practice. The goals of NINDS-supported research on Parkinsons disease are to better understand and diagnose PD, develop new treatments, and ultimately, prevent PD. NINDS also supports training for the next generation of PD researchers and clinicians and serves as an important source of information for people with PD and their families.
I Have Psp The Neurologist Said: ‘i Can’t Do Anything For You’
It was his eyes clamping shut that first prompted Keith Swankie to talk to his doctor. The supermarket manager was 38 years old and never imagined that the bouts of blindness were the first symptoms of a rare condition that will eventually kill him.
Swankie has a disease that hardly anyone has heard of: progressive supranuclear palsy . Often confused with other neuro-degenerative conditions such as Parkinson’s disease, PSP is more commonly found in postmortems than during life. It is the disease that actor Dudley Moore had, and is caused by the progressive death of nerve cells in the brain, causing difficulty with balance, movement, vision, speech and swallowing.
Diagnosing PSP before death involves piecing together a jigsaw of clues, ruling out other conditions and, in Swankie’s case, a perceptive GP. His initial referral to a specialist brought no answers. “The neurologist said: ‘I can’t do anything for you’,” recalls the father of two.
Then came new symptoms: falls, tremors, difficulty speaking, troubled sleep, irritability. It was only when Swankie’s GP was at a conference where a geriatrician was talking about PSP that the pieces started to fall into place. Tests followed and, in April 2012, more than two years after those initial eye problems, Swankie was finally diagnosed. At last he had a name to put to his list of increasingly distressing symptoms but the diagnosis meant having to accept that he was dying.
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Pregnant Woman Killed By Fleeing ‘robber’ But Miracle Baby Survives
An incredible video captures the precise moment a man stops shaking as his Parkinsons is cured.
In what doctors are calling a medical milestone, the video shows Filipino patient Jose Alvarez undergoing a groundbreaking brain operation at a hospital in Bengaluru, India, all while wide awake.
The YouTube video posted on SWOC Brain on Wednesday shows the mans hands and legs twitching uncontrollably due to the crippling disease, a progressive nervous system disorder defined by muscle rigidity, tremors and changes in speech and gait, according to the Mayo Clinic.
Then the unthinkable happens: Alvarez miraculously stops shaking post-operation.
My speech is better, says a stunned Alvarez, who can be seen raising his arms sans any spasms in front of the equally astonished surgical team.
Though hard to believe, the operation is supported by hard science. The surgeons performed a right-sided stereotactic MRI-guided pallidotomy, a cutting-edge procedure that involves burning a circuit into the patients brain, reports SWOC Brain.
Doctors have given me a new lease of life, says Alvarez. Life has been my best so far but I now experience freedom.
Does Any Evidence Support These Hypotheses
Parkinsons disease is currently defined as incurable. Anyone who recovers from Parkinsons is considered by the medical establishment to have been misdiagnosed. Ignoring this issue, our best evidence is that we have worked with Parkinsons patients whose symptoms are now completely, lastingly gone. Not only that, when the electrical circuits that cause Parkinsons turned off, the recovering patients experienced the highly specific, counter-intuitive, short-term symptoms that only occur when a person is recovering from Parkinsons: pins and needles in the face and feet in areas that have long been numb severely limp muscle tone in muscles that were previously rigid recovery dyskinesia spontaneous, gentle muscular repetition of certain moves in muscles that have long been rigid, repetitions lasting for up to twenty minutes per episode sensations as if the sides of the brain are shifting position relative to each other and many more.
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Complementary And Supportive Therapies
A wide variety of complementary and supportive therapies may be used for PD, including:
A healthy diet. At this time there are no specific vitamins, minerals, or other nutrients that have any proven therapeutic value in PD. The National Institute of Neurological Disorders and Stroke and other components of the National Institutes of Health are funding research to determine if caffeine, antioxidants, and other dietary factors may be beneficial for preventing or treating PD. A normal, healthy diet can promote overall well-being for people with PD just as it would for anyone else. Eating a fiber-rich diet and drinking plenty of fluids also can help alleviate constipation. A high protein diet, however, may limit levodopas absorption.
Exercise. Exercise can help people with PD improve their mobility, flexibility, and body strength. It also can improve well-being, balance, minimize gait problems, and strengthen certain muscles so that people can speak and swallow better. General physical activity, such as walking, gardening, swimming, calisthenics, and using exercise machines, can have other benefit. People with PD should always check with their doctors before beginning a new exercise program.
Alternative approaches that are used by some individuals with PD include: