What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to amantadine.
If you are taking the extended-release tablets , you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and does not mean that you did not get your complete dose of medication.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
How Should I Take Symmetrel
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
If you take amantadine to treat influenza A, start taking the medicine within 24 to 48 hours after flu symptoms begin. Keep taking amantadine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.
If you take this medicine for Parkinson symptoms, your doctor may occasionally change your dose to make sure you get the best results.
Amantadine will not treat an infection caused by bacteria. Call your doctor if your symptoms do not improve, or if you have a fever with a headache, cough, skin rash, or other new symptoms.
If you take amantadine for Parkinson symptoms: You should not stop using amantadine suddenly or your condition may become worse.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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How Should This Medicine Be Used
Amantadine comes as a capsule, extended-release capsule , tablet, extended-release tablet , and liquid to take by mouth. The capsules, tablets, and liquid medications are usually taken once or twice a day. The extended-release capsules are usually taken once a day at bedtime. The extended-release tablets are usually taken once a day in the morning. Take amantadine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amantadine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release capsules and extended-release tablets whole do not split, chew, or crush them. If you have difficulty swallowing the extended-release capsule, you may open the capsule and sprinkle the entire contents on a teaspoonful of soft food, like applesauce. Eat the mixture right away and swallow without chewing.
If you are taking amantadine for Parkinson’s disease, your doctor may start you on a low dose of amantadine and gradually increase your dose.
Do not stop taking amantadine without talking to your doctor. If you suddenly stop taking amantadine, you may experience fever, confusion, changes in mental state, or severe muscle stiffness. Your doctor will probably decrease your dose gradually.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
What Are The Side Effects Of Amantadine
Amantadine is a drug that helps treat Parkinsons disease and other conditions. People can experience mild to severe side effects while taking this medication.
The most common side effects are nausea, dizziness, and sleeping problems. Some less common but more severe side effects include changes to the central nervous system and the heart, as well as suicidal thoughts or actions.
This article looks into the uses for amantadine and the side effects that a person might experience.
Amantadine can treat a few conditions, and doctors most often prescribe it to treat Parkinsons disease.
Amantadine can also help with movement-related side effects of antipsychotic medications. The medical name for these effects is extrapyramidal symptoms .
Extrapyramidal symptoms are similar to the movements that characterize Parkinsons disease. They may involve muscle spasms, jerkiness, tremors, and slowness.
The most common side effects of amantadine, affecting 510% of people who take the recommended dosage, include:
Infrequent side effects, affecting 0.1 to 1% of people, include:
Analysis Of Amantadine Formulations For Off And Dyskinesia In Parkinson Disease
W. Oertel, R. Pahwa, R. Hauser, M. Sale, G. Went
Objective: Evaluate the effects of amantadine formulations on the treatment of OFF and dyskinesia in Parkinsons patients.
Background: There are currently three formulations of amantadine available in the US: immediate release tablets, immediate release/extended release tablets and delayed release/extended release capsules. The DR/ER formulation is the only FDA-approved and effective medication for Parkinsons motor complications, decreasing both OFF time and dyskinesia compared to placebo. Clinical trials for other AMT IR and IR/ER formulations have demonstrated effects on dyskinesia in patients with Parkinsons disease, however, no published trials have compared efficacy amongst all three.
Method: An indirect treatment comparison was performed. The literature studies of AMT IR in PD patients with OFF and dyskinesia were utilized, along with data from pivotal trials of AMT DR/ER and AMT IR/ER. For each trial, where available, the mean treatment differences in diary states of OFF and ON with troublesome dyskinesia were obtained directly or calculated from the active and placebo arms, relative to baseline. The treatment effect magnitude was computed for each treatment option and reported as percentage. For AMT IR/ER, data for the two doses used in the phase 3 trials were pooled to increase the sample size using statistically weighted averages.
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What You Need To Know About Amantadine For Parkinson Disease
This guide includes everything you need to know about amantadine for the treatment of Parkinson disease and drug-induced extrapyramidal reactions in adults.
In February 2018, the FDA approved amantadine for the treatment of Parkinson disease and drug-induced extrapyramidal reactions in adults.1
Parkinson disease is a neurological disorder where patients have a lack of dopaminergic neurons in the substantia nigra. The affected population is estimated to extend toward 10 million worldwide.2 Drug-induced extrapyramidal reactions, mainly caused by antipsychotics, has led to many problematic symptoms such as dystonia, pseudo-parkinsonism, akathisia, and tardive dyskinesia. Anticholinergics, such as amantadine have been used to treat extrapyramidal symptoms caused by antipsychotics for many years now.3
Kidney Or Liver Disease
The kidneys primarily excrete amantadine via the urine. In people with impaired kidney function, the drug can build up in the body. The doctor will lower the dose of amantadine, as a result.
Amantadine can also increase liver enzyme numbers. Anyone with a history of liver disease should take amantadine with caution.
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Chemistry Mechanism Of Action Spectrum And Resistance
Amantadine and rimantadine are symmetric tricyclic amines with cagelike structures that are closely related structurally to one another. Amantadine was the first antiviral agent to be licensed for systemic use in the U.S. The activity of amantadine and rimantadine is limited to influenza A viruses. Rimantadine is 4- to 10-fold more active than amantadine.268 The target of the inhibitory action for both amantadine and rimantadine is the influenza A virus M2 protein. Resistance to amantadine and rimantadine results from a point mutation in the RNA sequence encoding for the M2 protein transmembrane domain.269 Resistance typically appears in the treated subject and his or her close contacts within 2 to 3 days of the initiation of therapy as many as one-third of treated adults and children shed resistant strains of influenza by the fifth day of treatment.270
Benjamin L. Walter M.D., Jerrold L. Vitek M.D., Ph.D., in, 2006
Amantadine For Dyskinesias In Parkinson’s Disease: A Randomized Controlled Trial
Affiliation Clinical Research Center, Utano National Hospital, Kyoto City, Japan
Affiliation Clinical Research Center, Utano National Hospital, Kyoto City, Japan
Affiliation National Center for Neurological and Psychiatric Disorders, Kodaira, Japan
Affiliation Department of Therapeutic Medicine, School of Medicine, Ehime University, Toon, Japan
Affiliation Clinical Research Center, Utano National Hospital, Kyoto City, Japan
Affiliation Department of Neurology, Kagawa Prefectural Central Hospital, Takamatsu, Japan
Affiliation Department of Neurology, Miyagi National Hospital, Watari-gun, Japan
Affiliation Student Health Center, Kyoto University, Kyoto City, Japan
¶Membership of the Amantadine Study Group is provided in the Acknowledgments.
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Suicidal Thoughts Or Actions
Suicidal thoughts or actions are a rare side effect of amantadine, occurring in fewer than 0.1% of people.
Many people affected in this way have taken amantadine for influenza prevention or treatment. This side effect can develop in people with no history of psychiatric illness.
People taking amantadine, and those close to them, should look carefully for any behavioral changes, including agitation, personality changes, paranoia, depression, and anxiety.
What Future Medications May Be Available For Parkinsons
There are numerous studies investigating new treatments for Parkinsons disease.
There has been new information about the role of autoimmunity and T-cells in the development of Parkinsons disease, possibly opening the door to a role for biologics.
Stem cells are also being investigated as a treatment option for Parkinsons disease.
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Impulsive And Compulsive Behaviours
Behaviours may involve gambling, becoming a shopaholic, binge eating or focusing on sexual feelings and thoughts. This can have a huge impact on peoples lives including family and friends.
Not everyone who takes Parkinsons medication will experience impulsive and compulsive behaviours, so these side effects should not put you off taking your medication to control your symptoms.
What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture .
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
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Symmetrel For Parkinson’s Disease
OverviewSymmetrel is a prescription medication approved by the Food and Drug Administration in 1976 for treating motor symptoms associated with all forms of Parkinsonism. Symmetrel is sometimes prescribed to treat dyskinesia in people who are taking Levodopa/Carbidopa. Symmetrel is also known by its drug name, amantadine.
Symmetrel is not suitable for use by people who are allergic to amantadine. Symmetrel should be used with caution in people with glaucoma, mental illness, depression, a history of seizures, low blood pressure, frequent rashes, or problems with the liver, kidney, or heart. Symmetrel may not be appropriate for women who are pregnant or breastfeeding.
Symmetrel is classified as an antiviral and anti-Parkinsonian drug. It is believed that Symmetrel works by increasing the amount of dopamine available in the brain.
How do I take it?Symmetrel is taken orally as a capsule or liquid once or twice a day. Take Symmetrel with food or milk. The best times to take Symmetrel are usually in the morning and at mid-day in order to avoid disrupting sleep.
Avoid alcohol while taking Symmetrel.
Always follow your doctors instructions exactly when taking Symmetrel.
ResultsA 2003 article reviewed the evidence from six clinical trials of amantadine as treatment for Parkinsonism. The trials involved a total of 215 participants. Researchers concluded that there is insufficient data supporting the efficacy and safety of amantadine as a Parkinsons medication.
Central Nervous System Effects
Some people who have taken amantadine have reported falling asleep while performing routine activities, such as driving. The risk is higher in people who take at least one other sedating medication and in people who experience sleep disorders.
Anyone with a history of epilepsy or another condition that causes seizures should monitor any change in seizure activity while taking amantadine.
Symptoms such as dizziness, low blood pressure, and feeling faint have occurred in people taking amantadine. Alcohol consumption could increase this risk.
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Proper Use Of This Medicine Take This Medicine Only As Directed By Your Doctor
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What Other Drugs Will Affect Symmetrel
Other drugs may interact with amantadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Date modified: October 13, 2017Last reviewed: November 25, 2015
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Some Side Effects Can Be Serious If You Experience Any Of These Symptoms Call Your Doctor Immediately:
- believing things that are not true
- not trusting others or feeling that others want to hurt you
- lack of interest, enthusiasm, or concern
- dizziness, lightheadedness, fainting, or blurred vision
- swelling of the hands, feet, ankles, or lower legs
- difficulty urinating
- shortness of breath
Amantadine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .
How To Use Symmetrel Capsule
Take this medication by mouth with or without food, usually once or twice daily or as directed by your doctor. If you are taking this medication twice a day and have trouble sleeping after taking it, take the second dose several hours before bedtime.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
Dosage is based on your medical condition and response to therapy. In children, the dosage is also based on body weight. Do not take more than prescribed by your doctor.
This medication works best when the amount of medicine in your body is kept at a constant level. Take this medication at evenly spaced intervals throughout the day and night.
If you are taking amantadine for a viral infection, begin taking it as soon as possible. Continue taking it until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a relapse of the infection.
In Parkinson’s disease, the effects of the medication may not be noticed for several weeks. Do not suddenly stop taking the medication because symptoms or side effects may worsen. Your doctor may want to reduce your dose gradually. This medication may not work as well after it has been taken for several months. Tell your doctor if this medication stops working well.
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